Proposed occupational exposure limits for select ethylene glycol ethers using PBPK models and Monte Carlo simulations

Toxicological Sciences

Volumn 62, Issue 1, 2001, Pages 124-139

  Sweeney, L M ^a   Tyler, T R ^b   Kirman, C R ^c   Corley, R A ^d   Reitz, R H ^e   Paustenbach, D J ^f   Holson, J F ^g   Whorton, M D ^h   Thompson, K M ⁱ   Gargas, M L ^a  

^a Sapphire Group   (United States)

^b UNION CARBIDE CORPORATION   (United States)

^c The Sapphire Group Inc   (United States)

^d BATTELLE MEMORIAL INSTITUTE   (United States)

^e RHR Toxicology   (United States)

^f EXPONENT INC   (United States)

^g WIL RESEARCH LABORATORIES   (United States)

^h M Donald Whorton Inc   (United States)

ⁱ HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

EGEE; EGEEA; EGME; Ethoxyethanol; Ethoxyethyl acetate; Methoxyethanol; Models; Monte Carlo simulation; Occupational exposure limit; PBPK

Indexed keywords

2 ETHOXYETHANOL; 2 METHOXYETHANOL; 2 METHOXYETHANOL ACETATE; ETHYLENE GLYCOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL OBSERVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DRUG SURVEILLANCE PROGRAM; EXPERIMENTAL ANIMAL; HUMAN; METABOLIC PARAMETERS; METHODOLOGY; MODEL; NONHUMAN; OCCUPATIONAL EXPOSURE; PHYSIOLOGY; PROBABILITY; PROTECTION; RAT; SIMULATION; SYSTEM ANALYSIS; THERMODYNAMICS; TIME; TOXICOKINETICS; TOXICOLOGY; WORKER;

ADMINISTRATION, INHALATION; ANIMALS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLENE GLYCOLS; HUMANS; INHALATION EXPOSURE; MODELS, BIOLOGICAL; MONTE CARLO METHOD; NO-OBSERVED-ADVERSE-EFFECT LEVEL; OCCUPATIONAL EXPOSURE; SPECIES SPECIFICITY; THRESHOLD LIMIT VALUES;

ANIMALIA;

EID: 17844393637     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/62.1.124     Document Type: Article

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