You say ITAM and I say ITIM, let's call the whole thing off: The ambiguity of immunoreceptor signalling

European Journal of Immunology

Volumn 36, Issue 7, 2006, Pages 1646-1653

  Barrow, Alexander David ^a   Trowsdale, John ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cellular activation; Immune regulation; Inhibitory receptors; Signal transduction

Indexed keywords

ADAPTOR PROTEIN; BACTERIAL PROTEIN; CD3 ANTIGEN; CD79A ANTIGEN; CD79B ANTIGEN; EZRIN; IMMUNOGLOBULIN A; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; MERLIN; MOESIN; PHOSPHATASE; RADIXIN; TYROSINE KINASE RECEPTOR; VIRUS PROTEIN;

AMINO ACID SEQUENCE; BONE DEVELOPMENT; BRAIN DEVELOPMENT; CELL MATURATION; ENZYME ACTIVATION; ENZYME INHIBITION; EPSTEIN BARR VIRUS; HEMATOPOIETIC CELL; IMMUNOCOMPETENT CELL; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS; SHORT SURVEY; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TYROSINE;

EID: 33746256913     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636195     Document Type: Short Survey

References (50)

1. Humphrey, M. B., Lanier, L. L. and Nakamura, M. C., Role of ITAM-containing adapter proteins and their receptors in the immune system and bone. Immunol. Rev. 2005. 208: 50-65.
2. Tomasello, E. and Vivier, E., KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions. Eur. J. Immunol. 2005. 35: 1670-1677.
3. Samelson, L. E., Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu. Rev. Immunol. 2002. 20: 371-394.
4. Ravetch, J. V. and Lanier, L. L., Immune inhibitory receptors. Science 2000. 290: 84-89.
5. Lin, S. Y., Raval, S., Zhang, Z., Deverill, M., Siminovitch, K. A., Branch, D. R. and Haimovich, B., The protein-tyrosine phosphatase SHP-1 regulates the phosphorylation of alpha-actinin . J. Biol. Chem. 2004. 279: 25755-25764.
6. van Egmond, M., Damen, C. A., van Spriel, A. B., Vidarsson, G., van Garderen, E. and van de Winkel, J. G., IgA and the IgA Fc receptor. Trends Immunol. 2001. 22: 205-211.
7. Ravetch, J. V. and Bolland, S., IgG Fc receptors. Annu. Rev. Immunol. 2001. 19: 275-290.
8. van Egmond, M., van Vuuren, A. J., Morton, H. C., van Spriel, A. B., Shen, L., Hofhuis, F. M., Saito, T. et al., Human immunoglobulin A receptor (FcalphaRI, CD89) function in transgenic mice requires both FcR gamma chain and CR3 (CD11b/CD18). Blood 1999. 93: 4387-4394.
9. Pasquier, B., Launay, P., Kanamaru, Y., Moura, I. C., Pfirsch, S., Ruffie, C., Henin, D. et al., Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcR-γ ITAM. Immunity 2005. 22: 31-42.
10. Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T. et al., Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 2004. 428: 758-763.
11. Hamerman, J. A., Tchao, N. K., Lowell, C. A. and Lanier, L. L., Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat. Immunol. 2005. 6: 579-586.
12. Bouchon, A., Facchetti, F., Weigand, M. A. and Colonna, M., TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001. 410: 1103-1107.
13. Turnbull, I. R., McDunn, J. E., Takai, T., Townsend, R. R., Cobb, J. P. and Colonna, M., DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis. J. Exp. Med 2005. 202: 363-369.
14. Sanjuan, M. A., Rao, N., Lai, K. T., Gu, Y., Sun, S., Fuchs, A., Fung-Leung, W. P. et al., CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion. J. Cell Biol. 2006. 172: 1057-1068.
15. Gray, P., Dunne, A., Brikos, C., Jefferies, C. A., Doyle, S. L. and O'Neill, L. A., MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J. Biol. Chem. 2006. 281: 10489-10495.
16. Osborne, M. A., Zenner, G., Lubinus, M., Zhang, X., Songyang, Z., Cantley, L. C., Majerus, P. et al., The inositol 5′-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation. J. Biol. Chem 1996. 271: 29271-29278.
17. Kimura, T., Sakamoto, H., Appella, E. and Siraganian, R. P., The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE receptor. J. Biol. Chem 1997. 272: 13991-13996.
18. Ganesan, L. P., Fang, H., Marsh, C. B. and Tridandapani, S., The protein-tyrosine phosphatase SHP-1 associates with the phosphorylated immunoreceptor tyrosine-based activation motif of Fc gamma RIIa to modulate signaling events in myeloid cells. J. Biol. Chem 2003. 278: 35710-35717.
19. Vitale, M., Bottino, C., Sivori, S., Sanseverino, L., Castriconi, R., Marcenaro, E., Augugliaro, R. et al., NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J. Exp. Med. 1998. 187: 2065-2072.
20. Fuchs, A., Cella, M., Kondo, T. and Colonna, M., Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44. Blood 2005. 106: 2076-2082.
21. Campbell, K. S., Yusa, S., Kikuchi-Maki, A. and Catina, T. L., NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence. J. Immunol. 2004. 172: 899-906.
22. Blasius, A. L., Cella, M., Maldonado, J., Takai, T. and Colonna, M., Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12. Blood 2006. 107: 2474-2476.
23. Dzionek, A., Sohma, Y., Nagafune, J., Cella, M., Colonna, M., Facchetti, F., Gunther, G. et al., BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J. Exp. Med 2001. 194: 1823-1834.
24. Monroe, J.G., ITAM-mediated tonic signalling through pre-BCR and BCR complexes. Nat. Rev. Immunol 2006. 6: 283-294.
25. Thorley-Lawson, D. A., Epstein-Barr virus: exploiting the immune system. Nat. Rev. Immunol. 2001. 1: 75-82.
26. Morrison, J. A., Raab-Traub, N., Chen, F., Liu, C., Lindvall, C., Xu, D. and Ernberg, I., Epstein-Barr virus latent membrane 2A (LMP2A) down-regulates telomerase reverse transcriptase (hTERT) in epithelial cell lines. Int. J. Cancer 2005. 113: 284-289.
27. Morrison, J. A. and Raab-Traub, N., Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of β-catenin signaling. J. Virol 2005. 79: 2375-2382.
28. Staub, E., Rosenthal, A. and Hinzmann, B., Systematic identification of immunoreceptor tyrosine-based inhibitory motifs in the human proteome. Cell Signal. 2004. 16: 435-456.
29. Barrow, A. D., Astoul, E., Floto, A., Brooke, G., Relou, I. A., Jennings, N. S., Smith, K. G. et al., Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2. J. Immunol 2004. 172: 5838-5842.
30. Falati, S., Patil, S., Gross, P. L., Stapleton, M., Merrill-Skoloff, G., Barrett, N. E., Pixton, K. L. et al., Platelet PECAM-1 inhibits thrombus formation in vivo. Blood 2006. 107: 535-541.
31. Newton-Nash, D. K. and Newman, P. J., A new role for platelet-endothelial cell adhesion molecule-1 (CD31): inhibition of TCR-mediated signal transduction. J. Immunol. 1999. 163: 682-688.
32. Newman, D. K., Hamilton, C. and Newman, P. J., Inhibition of antigen-receptor signaling by platelet endothelial cell adhesion molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56(lck). Blood 2001. 97: 2351-2357.
33. Wee, J. L. and Jackson, D. E., The Ig-ITIM superfamily member PECAM-1 regulates the "outside-in" signaling properties of integrin alpha(IIb)beta3 in platelets. Blood. 106: 3816-3823.
34. O'Brien, C. D., Cao, G., Makrigiannakis, A. and DeLisser, H. M.Role of immunoreceptor tyrosine-based inhibitory motifs of PECAM-1 in PECAM-1-dependent cell migration. Am. J. Physiol. Cell. Physiol. 2004. 287: C1103-1113.
35. Schenkel, A. R., Chew, T. W. and Muller, W. A.Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains. J. Immunol. 2004. 173: 6403-6408.
36. Oda, T., Ohka, S. and Nomoto, A., Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts. Biochem. Biophys. Res. Commun. 2004. 319: 1253-1264.
37. Tzima, E., Irani-Tehrani, M., Kiosses, W. B., Dejana, E., Schultz, D. A., Engelhardt, B., Cao, G. et al., A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 2005. 437: 426-431.
38. Rajagopalan, S. and Long, E. O.A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells. J. Exp. Med 1999. 189: 1093-1100.
39. Kikuchi-Maki, A., Catina, T. L. and Campbell, K. S., Cutting edge: KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein. J. Immunol. 2005. 174: 3859-3863.
40. Rajagopalan, S., Fu, J. and Long, E. O.Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells. J. Immunol. 2001. 167: 1877-1881.
41. Yusa, S., Catina, T. L. and Campbell, K. S.SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells. J. Immunol. 2002. 168: 5047-5057.
42. Rajagopalan, S., Bryceson, Y. T., Kuppusamy, S. P., Geraghty, D. E., van der Meer, A., Joosten, I. and Long, E. O., Activation of NK cells by an endocytosed receptor for soluble HLA-G. PLoS Biol 2006. 4: e9.
43. Kim, S., Poursine-Laurent, J., Truscott, S. M., Lybarger, L., Song, Y. J., Yang, L., French, A. R. et al., Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 2005. 436: 709-713.
44. Fernandez, N. C., Treiner, E., Vance, R. E., Jamieson, A. M., Lemieux, S. and Raulet, D. H., A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules. Blood 2005. 105: 4416-1423.
45. Yokoyama, W. M. and Kim, S., How do natural killer cells find self to achieve tolerance? Immunity 2006. 24: 249-257.
46. Hatakeyama, M., Oncogenic mechanisms of the Helicobacter pylori CagA protein. Nat. Rev. Cancer 2004. 4: 688-694.
47. Agazie, Y. M. and Hayman, M. J., Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling. Mol. Cell. Biol 2003. 23: 7875-7886.
48. Zhang, S. Q., Yang, W., Kontaridis, M. I., Bivona, T. G., Wen, G., Araki, T., Luo, J. et al., Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol. Cell 2004. 13: 341-355.
49. Yu, W. M., Hawley, T. S., Hawley, R. G. and Qu, C. K., Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling. Oncogene 2003. 22: 5995-6004.
50. Pasquet, J. M., Quek, L., Pasquet, S., Poole, A., Matthews, J. R., Lowell, C. and Watson, S. P., Evidence of a role for SHP-1 in platelet activation by the collagen receptor glycoprotein VI. J. Biol. Chem 2000. 275: 28526-28531.