Ototoxicity of Ototopical Drops-An Update

Otolaryngologic Clinics of North America

Volumn 40, Issue 3, 2007, Pages 669-683

  Haynes, David S ^a   Rutka, John ^b   Hawke, Michael ^b   Roland, Peter S ^c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; BETAMETHASONE; BETAMETHASONE PLUS GENTAMICIN; CHLORAMPHENICOL; CHLORHEXIDINE; CIPROFLOXACIN; CLOTRIMAZOLE; CRYSTAL VIOLET; DEXAMETHASONE; EAR DROPS; GARASONE; GENTAMICIN; HYDROCORTISONE; META CRESYL ACETATE; MICONAZOLE; NEOMYCIN; NYSTATIN; OFLOXACIN; POLYMYXIN B; QUINOLINE DERIVED ANTIINFECTIVE AGENT; STREPTOMYCIN; TOLNAFTATE; UNCLASSIFIED DRUG; VOSOL;

DIARRHEA; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HYPERSENSITIVITY; EARDRUM PERFORATION; EVIDENCE BASED MEDICINE; HEARING LOSS; HUMAN; INNER EAR; MYRINGOTOMY; NAUSEA; NEPHROTOXICITY; NONHUMAN; OTITIS MEDIA; OTORRHEA; OTOTOXICITY; PERCEPTION DEAFNESS; REVIEW; TYMPANOSTOMY TUBE; UNITED KINGDOM; VESTIBULAR SYSTEM; VOMITING;

ADMINISTRATION, TOPICAL; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; HUMANS; OTITIS MEDIA WITH EFFUSION; PRACTICE GUIDELINES; TYMPANIC MEMBRANE PERFORATION;

EID: 34249743702     PISSN: 00306665     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.otc.2007.03.010     Document Type: Review

References (115)

1. Rutka J. Topical aminoglycosides? No. The case against using these agents in chronic ear disease. Ear Nose Throat J 82 Suppl 1 (2003) 9-12
2. Roland P.S., Stewart M.G., Hannley M., et al. Consensus panel on the role of potentially ototoxic antibiotics for topical middle ear use: introduction, methodology and recommendations. Otolaryngol Head Neck Surg 130 Suppl 3 (2004) S51-S56
3. Ho E.C., Alanni A., and Irving R. Topical antibiotic ototoxicity: does it influence our practice?. J Laryngol Otol (2006) 1-5
4. Cantor R.M. Otitis externa and otitis media: a new look at old problems. Emerg Med Clin North Am 13 (1995) 445-455
5. Hannley M.T., Denneny J.C., and Holzer S.S. Use of ototopical antibiotics in treating 3 common ear diseases. Otolaryngol Head Neck Surg 122 (2000) 934-940
6. Bluestone C.D. Efficacy of ofloxacin and other ototopical preparations for chronic suppurative otitis media in children. Pediatr Infect Dis J 20 (2001) 111-115
7. Poehlman G.S. Chronic otitis media with effusion. Prim Care 23 (1996) 687-699
8. Nelson J.D. Chronic suppurative otitis media. Pediatr Infect Dis J 7 (1988) 446-448
9. Mandel E.M., Casselbrant M.L., and Kurs-Lasky M. Acute otorrhea: bacteriology of a common complication of tympanostomy tubes. Ann Otol Rhinol Laryngol 103 (1994) 713-718
10. Herzon F.S. Tympanostomy tubes: infectious complications. Arch Otolaryngol 106 (1980) 645-647
11. Hochman J., Blakeley B., Abdoh A., et al. Post-tympanostomy tube otorrhea: a meta-analysis. Otolaryngol Head Neck Surg 135 1 (2006) 8-11
12. Klein J.O. In vitro and in vivo antimicrobial activity of topical ofloxacin and other ototopical agents. Pediatr Infect Dis J 20 (2001) 102-103
13. Gehanno P., Panajotopoulos A., Barry B., et al. Microbiology of otitis media in the Paris, France, area from 1987 to 1997. Pediatr Infect Dis J 20 (2001) 570-573
14. Giebink G.S. The microbiology of otitis media. Pediatr Infect Dis J 8 (1989) S18-S20
15. Roland P.S., Parry D.A., and Stroman D.W. Microbiology of acute otitis media with tympanostomy tubes. Otolaryngol Head Neck Surg 133 4 (2005) 585-595
16. Yuen A.P., Chau P.Y., and Wei W.I. Bacteriology of chronic suppurative otitis media: ofloxacin susceptibility. J Otolaryngol 24 (1995) 206-208
17. Bluestone C.D. Current management of chronic suppurative otitis media in infants and children. Pediatr Infect Dis J 7 (1988) S137-S140
18. Agro A.S., Garner E.T., Wright III J.W., et al. Clinical trial of ototopical oflixacin for treatment of chronic suppurative otitis media. Clin Ther 20 4 (1998) 744-759
19. Schneider M.L. Bacteriology of otorrhea from tympanostomy tubes. Arch Otolaryngol Head Neck Surg 115 (1989) 1225-1226
20. Goldblatt E.L., Dohar J., Nozza R.J., et al. Topical ofloxacin versus systemic amoxicillin/clavulanate in purulent otorrhea in children with tympanostomy tubes. Int J Pediatr Otorhinolaryngol 46 (1998) 91-101
21. Lundy L.B., and Graham M.D. Ototoxicity and ototopical medications: a survey of otolaryngologists. Am J Otol 14 (1993) 141-146
22. Linder T.E., Zwicky S., and Brandle P. Ototoxicity of ear drops: a clinical perspective. Am J Otol 16 (1995) 653-657
23. Saunders M.W., and Robinson P.J. How easily do topical antibiotics pass through tympanostomy tubes? An in vitro study. Int J Pediatr Otorhinolaryngol 50 (1999) 45-50
24. Lancaster J.L., Mortimore S., McCormick M., et al. Systemic absorption of gentamicin in the management of active mucosal chronic otitis media. Clin Otolaryngol 24 (1999) 435-439
25. Wong D.L., and Rutka J.A. Do aminoglycoside otic preparations cause ototoxicity in the presence of tympanic membrane perforations?. Otolaryngol Head Neck Surg 116 (1997) 404-410
26. Bath A.P., Walsh R.M., Bance M.L., et al. Ototoxicity of topical gentamicin preparations. Laryngoscope 109 (1999) 1088-1093
27. Marais J., and Rutka J.A. Ototoxicity and topical eardrops. Clin Otolaryngol 23 (1998) 360-367
28. Kaplan D.M., Hehar S.S., Bance M.L., et al. Intentional ablation of vestibular function using commercially available topical gentamicin-betamethasone eardrops in patients with Meniere's disease: further evidence for topical eardrop ototoxicity. Laryngoscope 112 (2002) 689-695
29. Hellström S., Johansson U., and Anniko M. Structure of the round window membrane. Acta Otolaryngol Suppl Suppl 457 (1988) 33-42
30. Juhn S.K., Hamaguchi Y., and Goycoolea M. Review of round window membrane permeability. Acta Otolaryngol Suppl 457 (1989) 43-48
31. Goycoolea M.V., Muchow D., and Schachern P. Experimental studies on round window structure: function and permeability. Laryngoscope 98 Suppl 44 (1988) 1-20
32. Ikeda K., and Morizono T. Changes of the permeability of round window membrane in otitis media. Arch Otolaryngol Head Neck Surg 114 (1988) 895-897
33. Ikeda K., Sakagami M., Morizono T., et al. Permeability of the round window membrane to middle-sized molecules in purulent otitis media. Arch Otolaryngol Head Neck Surg 116 (1990) 57-60
34. Waksman S.A. Streptomycin: background, isolation, properties and utilization. Science 18 (1953) 259-266
35. Waksman S.A. Antimicrobial properties of neomycin. J Lab Clin Med 36 (1950) 93-99
36. Weinstein M.J. Gentamicin: a new broad spectrum antibiotic complex. Antimicrob Agents Chemother 3 (1963) 1-7
37. Fischel-Ghodsian N., Prezant T.R., Chaltraw W.E., et al. Mitochondrial gene mutation is a significant predisposing factor in aminoglycoside ototoxicity. Am J Otolaryngol 18 (1997) 173-178
38. Fischel-Ghodsian N., Prezant T.R., Bu X., et al. Mitochondrial ribosomal RNA gene mutation in a patient with sporadic aminoglycoside ototoxicity. Am J Otolaryngol 14 (1993) 399-403
39. English W.P., and Williams M.D. Should aminoglycoside antibiotics be abandoned?. Am J Surg 180 (2000) 512-516
40. Schuknecht H.F. Ablation therapy in the management of Menière's disease. Acta Otolaryngol Suppl 47 Suppl 132 (1957) 1-42
41. Carranza A., Lopez I., Castellano P., et al. Intraotic administration of gentamicin: a new method to study ototoxicity in the crista ampullaris of the bullfrog. Laryngoscope 107 (1997) 137-143
42. i in apical and basal outer hair cells from guinea pigs. Hear Res 154 (2001) 81-87
43. Marco-Algarra J., and Honrubia V. Comparative study of the effect of gentamicin on the vestibulo-ocular and visual vestibulo-ocular reflexes in the cat. Acta Otolaryngol 111 (1991) 162-168
44. Nakagawa T., Yamane H., Shibata S., et al. Cell death caused by the acute effects of aminoglycoside and zinc in the ampullary cristae of guinea pigs. Eur Arch Otorhinolaryngol 254 (1997) 153-157
45. Frank T.C., Dye B.J., Newlands S.D., et al. Streptomycin ototoxicity and hair cell regeneration in the adult pigeon utricle. Laryngoscope 109 (1999) 356-361
46. Wanamaker H.H., Slepecky N.B., Cefaratti L.K., et al. Comparison of vestibular and cochlear ototoxicity from transtympanic streptomycin administration. Am J Otol 20 (1999) 457-464
47. Tom L.W. Ototoxicity of common topical antimycotic preparations. Laryngoscope 110 (2000) 509-516
48. Conlon B.J., and Smith D.W. Topical aminoglycoside ototoxicity: attempting to protect the cochlea. Acta Otolaryngol 120 (2000) 596-599
49. Kohonen A., and Tarkkanen J. Cochlear damage from ototoxic antibiotics by intratympanic application. Acta Otolaryngol 68 (1969) 90-97
50. Russell P.T., Church C.A., Jinn T.H., et al. Effects of common topical otic preparations on the morphology of isolated cochlear outer hair cells. Acta Otolaryngol 121 (2001) 135-139
51. Barlow D.W., Duckert L.G., Kreig C.S., et al. Ototoxicity of topical otomicrobial agents. Acta Otolaryngol 115 (1995) 231-235
52. Wright C.G., Halama A.R., and Meyerhoff W.L. Ototoxicity of an ototopical preparation in a primate. Am J Otol 8 (1987) 56-60
53. Wright C.G., Meyerhoff W.L., and Halama A.R. Ototoxicity of neomycin and polymyxin B following middle ear application in the chinchilla and baboon. Am J Otol 8 (1987) 495-499
54. García V.P., and Asenjo V.P. Are some ear drops ototoxic or potentially ototoxic?. Acta Otolaryngol 121 (2001) 565-568
55. García V.P., Martínez A.F., Agustí E.B., et al. Drug-induced ototoxicity: current status. Acta Otolaryngol 121 (2001) 569-572
56. Nedzelski J.M., Bryce G.E., and Pfleiderer A.G. Treatment of Ménière's disease with topical gentamicin: a preliminary report. J Otolaryngol 21 (1992) 95-101
57. Hoffer M.E., Kopke R.D., Weisskopf P., et al. Microdose gentamicin administration via the round window microcatheter: results in patients with Meniere's disease. Ann N Y Acad Sci 942 (2001) 46-51
58. Quaranta A., Aloisi A., De Benedittis G., et al. Intratympanic therapy for Ménière's disease: high-concentration gentamicin with round-window protection. Ann N Y Acad Sci 884 (1999) 410-424
59. Becvarovski Z., Bojrab D.I., Michaelides E.M., et al. Round window gentamicin absorption: an in vivo human model. Laryngoscope 112 (2002) 1610-1613
60. Berenholz L.P., Burkey J.M., Farmer T.L., et al. Topical otic antibiotics: clinical ototoxicity and cost consideration. Otolaryngol Head Neck Surg 135 2 (2006) 291-294
61. Kellerhals G. Horschaden durch ototoxische ohrtopfen. HNO 26 (1978) 49-52
62. Paparella M.M. Insidious labyrinthine changes in otitis media. Acta Otolaryngol 92 (1981) 513-520
63. Tommerup B., and Moller K. A case of profound hearing impairment following the prolonged use of framycetin ear drops. J Laryngol Otol 98 (1984) 1135-1137
64. Dumas G., Bessard G., Gavend M., et al. Risk of deafness following ototopical administration of aminoglycoside antibiotic (author's translation) [French]. Therapie 35 (1980) 357-363
65. Lind O., and Kristiansen B. Deafness after treatment with ear drops containing neomycin, gramicidin and dexamethasone: a case report. ORL J Otorhinolaryngol Relat Spec 48 (1986) 52-54
66. Martin H., and Martin C. [Ototoxicity of ear drops]. J Fr Otorhinolaryngol Audiophonol Chir Maxillofac 29 (1980) 19-37
67. Leliever W.C. Topical gentamicin-induced positional vertigo. Otolaryngol Head Neck Surg 93 (1985) 553-555
68. Longridge N.S. Topical gentamicin vestibular toxicity. J Otolaryngol 23 (1994) 444-446
69. Hui Y., Park A., Crysdale W.S., et al. Ototoxicity from ototopical aminoglycosides. J Otolaryngol 26 (1997) 53-56
70. Roland P.S. Clinical ototoxicity of topical antibiotic drops. Otolaryngol Head Neck Surg 110 (1994) 598-602
71. Hélal A. Aminoglycoside ear drops and ototoxicity. CMAJ 156 (1997) 1056-1058
72. Health Canada. Gentamicin ear drops and ototoxicity: update. Canadian Adverse Drug Reaction Newsletter 11 1 (2001) 1-8
73. Patterson W.C., and Gulick W.L. The effects of chloramphenical upon the electrical activity of the ear. Ann Otol Rhinol Laryngol 72 (1963) 50-55
74. Morizono T., and Johnstone B.M. Ototoxicity of chloramphenicol ear drops with propylene glycol as solvent. Med J Aust 2 (1975) 634-638
75. Brown O.E., Wright C.G., Masaki M., et al. Ototoxicity of Vasocidin drops applied to the chinchilla middle ear. Arch Otolaryngol Head Neck Surg 114 (1988) 56-59
76. Schneider M.L. Merthiolate in treatment of otomycosis. Laryngoscope 91 (1981) 1194-1195
77. Mercury compounds in drugs and food. Fed Regist 63 (1998) 68775-68777
78. Spandow O., Anniko M., and Moller A.R. The round window as access route for agents injurious to the inner ear. Am J Otolaryngol 9 (1988) 327-335
79. Marsh R.R., and Tom L.W.C. Ototoxicity of antimycotics. Otolaryngol Head Neck Surg 100 (1989) 134-136
80. Morizono T. Toxicity of ototopical drugs: animal modeling. Ann Otol Rhinol Laryngol Suppl 148 (1990) 42-45
81. Jinn T.H., Kim P.D., Russell P.T., et al. Determination of ototoxicity of common otic drops using isolated cochlear outer hair cells. Laryngoscope 111 (2001) 2105-2108
82. Rohn G.N., Meyerhoff W.L., and Wright C.G. Ototoxicity of topical agents. Otolaryngol Clin North Am 26 (1993) 747-758
83. Aursnes J. Vestibular damage from chlorhexidine in guinea pigs. Acta Otolaryngol 92 (1981) 89-100
84. Chandrasekhar S.S. Intratympanic dexamethasone for sudden sensorineural hearing loss: clinical and laboratory evaluation. Otol Neurotol 22 (2001) 18-23
85. Spandow O., Anniko M., and Hellström S. Hydrocortisone applied into the round window niche causes electrophysiological dysfunction of the inner ear. ORL J Otorhinolaryngol Relat Spec 51 (1989) 94-102
86. Song B.B., Anderson D.J., and Schacht J. Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo. J Pharmacol Exp Ther 282 (1997) 369-377
87. Song B.-B., Sha S.-H., and Schacht J. Iron chelators protect from aminoglycoside-induced cochleo- and vestibulo-toxicity. Free Radic Biol Med 25 (1998) 189-195
88. Lautermann J., McLaren J., and Schacht J. Glutathione protection against gentamicin ototoxicity depends on nutritional status. Hear Res 86 (1995) 15-24
89. Himeno C., Komeda M., Izumikawa M., et al. Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig. Hear Res 167 (2002) 61-70
90. Sha S.H., and Schacht J. Salicylate attenuates gentamicin-induced ototoxicity. Lab Invest 79 (1999) 807-813
91. Suzuki M., Yagi M., Brown J.N., et al. Effect of transgenic GDNF expression on gentamicin-induced cochlear and vestibular toxicity. Gene Ther 7 (2000) 1046-1054
92. Yagi M., Magal E., Sheng Z., et al. Hair cell protection from aminoglycoside ototoxicity by adenovirus-mediated overexpression of glial cell line-derived neurotrophic factor. Hum Gene Ther 10 (1999) 813-823
93. Ding D., Stracher A., and Salvi R.J. Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity. Hear Res 164 (2002) 115-126
94. Basile A.S., Huang J.M., Xie C., et al. N-methyl-d-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. Nat Med 2 (1996) 1338-1343
95. Yuen P.W., Lau S.K., Chau P.Y., et al. Ofloxacin eardrop treatment for active chronic suppurative otitis media: prospective randomized study. Am J Otol 15 (1994) 670-673
96. Supiyaphun P., Kerekhanjanarong V., Koranasophonepun J., et al. Comparison of ofloxacin otic solution with oral amoxycillin plus chloramphenicol ear drop in treatment of chronic suppurative otitis media with acute exacerbation. J Med Assoc Thai 83 (2000) 61-68
97. Sumitsawan Y., Tharavichitkul P., Prawatmuang W., et al. Ofloxacin otic solution as treatment of chronic suppurative otitis media and diffuse bacterial otitis externa. J Med Assoc Thai 78 (1995) 455-459
98. Tutkun A., Özagar A., Koç A., et al. Treatment of chronic ear disease: topical ciprofloxacin vs topical gentamicin. Arch Otolaryngol Head Neck Surg 121 (1995) 1414-1416
99. Goldblatt E.L. Efficacy of ofloxacin and other otic preparations for acute otitis media in patients with tympanostomy tubes. Pediatr Infect Dis J 20 (2001) 116-119
100. Force R.W., Hart M.C., Plummer S.A., et al. Topical ciprofloxacin for otorrhea after tympanostomy tube placement. Arch Otolaryngol Head Neck Surg 121 (1995) 880-884
101. Claes J., Govaerts P.J., Van de Heyning P.H., et al. Lack of ciprofloxacin ototoxicity after repeated ototopical application. Antimicrob Agents Chemother 35 (1991) 1014-1016
102. Lutz H., Lenarz T., and Gotz R. Ototoxicity of gyrase antagonist ciprofloxacin?. Adv Otorhinolaryngol 45 (1990) 175-180
103. Esposito S., Noviello S., D'Errico G., et al. Topical ciprofloxacin vs intramuscular gentamicin for chronic otitis media. Arch Otolaryngol Head Neck Surg 118 (1992) 842-844
104. Brownlee R.E., Hulka G.F., Prazma J., et al. Ciprofloxacin: use as a topical otic preparation. Arch Otolaryngol Head Neck Surg 118 (1992) 392-396
105. Esposito S., D'Errico G., and Montanaro C. Topical and oral treatment of chronic otitis media with ciprofloxacin: a preliminary study. Arch Otolaryngol Head Neck Surg 116 (1990) 557-559
106. Wintermeyer S.M., Hart M.C., and Nahata M.C. Efficacy of ototopical ciprofloxacin in pediatric patients with otorrhea. Otolaryngol Head Neck Surg 116 (1997) 450-453
107. Dohar J.E., Garner E.T., Nielsen R.W., et al. Topical ofloxacin treatment of otorrhea in children with tympanostomy tubes. Arch Otolaryngol Head Neck Surg 125 (1999) 537-545
108. Macfadyen C.A., Acuin J.M., Gamble C., et al. Systemic antibiotics versus topical treatments for chronically discharging ears with underlying eardrum perforations. Cochrane Database Syst Rev 1 (2006) CD005608
109. Dohar J., Giles W., Roland P., et al. Topical ciprofloxacin/dexamethasone superior to oral amoxicillin/clavulanic acid in acute otitis media with otorrhea through tympanostomy tubes. Pediatrics 118 3 (2006) E561-E569
110. Roland P.S., Kreister L.S., Reese B., et al. Topical ciprofloxacin otic suspension is superior to oflaxacin otic solution in the treatment of children with acute otitis media with otorrhea through tympanostomy tubes. Pediatrics 113 1 Pt 1 (2004) E40-E46
111. Fradis M., Brodsky A., Ben-David J., et al. Chronic otitis media treated topically with ciprofloxacin or tobramycin. Arch Otolaryngol Head Neck Surg 123 (1997) 1057-1060
112. Lang R., Goshen S., Raas-Rothschild A., et al. Oral ciprofloxacin in the management of chronic suppurative otitis media without cholesteatoma in children: preliminary experience in 21 children. Pediatr Infect Dis J 11 (1992) 925-929
113. Kiris M., Berktas M., Egeli E., et al. The efficacy of topical ciprofloxacin in the treatment of chronic suppurative otitis media. Ear Nose Throat J 77 (1998) 904-905, 909
114. Agro A.S., Garner E.T., Wright J.W., et al. Clinical trial of ototopical ofloxacin for treatment of chronic suppurative otitis media. Clin Ther 20 (1998) 744-759
115. Supiyaphun P., Tonsakulrungruang K., Chochaipanichnon L., et al. The treatment of chronic suppurative otitis media and otitis externa with 0.3 per cent ofloxacin otic solution: a clinico-microbiological study. J Med Assoc Thai 78 (1995) 18-21