Ototoxicity and topical eardrops

Clinical Otolaryngology and Allied Sciences

Volumn 23, Issue 4, 1998, Pages 360-367

  Marais, J ^a   Rutka, J A ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Eardrops; Iatrogenic ototoxicity; Oscillopsia; Topical; Vertigo; Vestibulotoxity

Indexed keywords

AMINOGLYCOSIDE; BETAMETHASONE SODIUM PHOSPHATE; EAR DROPS; GARASONE; GENTAMICIN; UNCLASSIFIED DRUG;

ADULT; AGED; CLINICAL ARTICLE; DRUG MIXTURE; EARDRUM PERFORATION; FEMALE; HUMAN; LONG TERM CARE; MALE; OTOTOXICITY; PRIORITY JOURNAL; REVIEW; TOPICAL DRUG ADMINISTRATION; VESTIBULAR DISORDER;

ADMINISTRATION, TOPICAL; ADULT; ANTI-BACTERIAL AGENTS; DEAFNESS; FEMALE; GENTAMICINS; HUMANS; MALE; MIDDLE AGED; TYMPANIC MEMBRANE PERFORATION; VESTIBULE;

EID: 0031704990     PISSN: 03077772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2273.1998.00161.x     Document Type: Review

References (35)

1. HARADA T., NAGAI Y., IWAMORI M. et al. (1986) Ototoxicity of neomycin and its penetration through the round window membrane into the perilymph. Ann. Otol. Rhinol. Laryngol. 95, 404-408
2. SMITH S.M. & MYERS M.G. (1979) The penetration of gentamicin and neomycin into perilymph across the round window membrane. Otolaryngol. Head Neck Surg. 87, 888-891
3. WRIGHT C.G., HALAMA A.R. & MEYERHOF W.L. (1987) Ototoxicity of an otottopical preparation in a primate. Am. J. Otol. 8, 56-60
4. GOYCOOLEA M.V., PAPARELLA M.M., GOLDBERG B. et al. (1980) Permeability of the round window in otitis media. Arch. Otolaryngol. 106, 430-433
5. HUI Y., PARK A., CRYSDALE W.S. et al. (1997) Ototoxicity from ototopical aminoglycosides. J. Otolaryngol. 26, 53-56
6. LIND O. & KRISTIANSEN B. (1986) Deafness after treatment with eardrops containing neomycin, geramicidin and germathasone: a case report. Otorhinolaryngol. 48, 52-54
7. LELIEVER W.C. (1985) Topical gentamicin-induced positional vertigo. Otolaryngol. Head Neck Surg. 93, 553-555
8. MURPHY K.W. (1970) Deafness after topical neomycin. Br. Med. J. 2, 114
9. TOMMERKUP B. & MOLLER K. (1984) A case of profound hearing impairment following the primary use of framycetin eardrops. J. Laryngol. Otol. 98, 1135-1137
10. LONGRIDGE N.S. (1994) Topical gentamicin vestibular toxicity. J. Otolaryngol. 23, 444-446
11. HALMAGYI G.M. & CURTHOYS I.S. (1988) A clinical sign of canal paresis. Arch. Neurol. 45, 737
12. WONG D.L.H. & RUTKA J.A. (1997) Do aminoglycoside otic preparations cause ototoxicity in the presence of tympanic membrane perforations? Otolaryngol. Head Neck Surg. 116, 404-410
13. HAIN T.C., FETTER M. & ZEE D.S. (1987) Head-shaking nystagmus in patients with unilateral vestibular lesions. Am. J Otolaryngol. 8, 36-47
14. BICKERTON R.C., ROBERTS C. & LITTLE J.T. (1988) Survey of general practitioners treatment of the discharging ear. Br. Med. J. 296, 1649-1650
15. LUNDY L.B. & GRAHAM M.D. (1993) Ototoxicity and ototopical medications: A survey of otolaryngologists. Am. J. Otol., 14, 141-146.
16. ROLAND P.S. & ???? Clinical ototoxicity of topical antibiotic drops. Otolaryngol. Head Neck Surg., 110, 598-602.
17. CARPENTER A.M., MUCHOW D. & GOYCOOLEA M.V. (1989) Ultrastructural studies of the human round window membrane. Arch. Otolaryngol. Head Neck Surg., 115, 585-590.
18. KWABATA I. & PAPARELLA M.M. (1971) Fine structure of the round window membrane. Ann. Otol. Rhinol. Laryngol., 80, 13-27.
19. GOYCOOLEA M.V., MUCHOW D. & SCHACHERN P. (1988) Experimental studies of round window structure, function and permeability. Laryngoscope, 98 (Suppl. 44) 1-20.
20. HARADA T., IWAMORI M. & NAGAI Y. (1986) Ototoxicity of neomycin and its penetration through the round window membrane into the perilymph. Ann. Otol. Rhinol. Laryngol., 95, 404-407.
21. IKEDA K. & MORIZONO T. (1988) Changes in permeability of the round window membrane in otitis media. Arch. Otolaryngol. Head Neck Surg. 114, 895-897
22. TRAN B.A., HUY P., MEULEMANS A. et al. (1983) Gentamycin persistence in rat endolymph after two day constant infusion. Antimicrob. Agents Chemother. 23, 344-346
23. KOHONEN A. & TARKANNEN J. (1969) Cochlear damage from ototoxic antibiotics by intratympanic application. Acta Otolaryngol. (Stockh.) 68, 90-97
24. HARRISON R.V., STANTON S.G. & NAGASAWA A. (1993)The effects of long-term cochlear hearing loss on the functional organisation of central auditory pathways. J. Otolaryngol. 22, 4-11
25. MORIZONO T. & JOHNSTONE B.M. (1975) Ototoxicity of topically applied eardrops: Statistical analysis of electrophysiological measurement. Acta. Otolaryngol. (Stockh.) 80, 389-393
26. RUDNICK M.D., GINSBERG I.A. & HUBER P.S. (1980) Aminoglycoside ototoxicity follwing middle ear infection. Ann. Otol. Rhinol. Laryngol. 89 (Suppl. 77), 1-9
27. OMURA R., HARADA Y. & SUZUKI M. (1989) Structural and physiological change of the bullfrog semicircular canals due to gentamicin intoxication. Acta. Otolaryngol. (Stockh.) 468(Suppl.), 41-47
28. SCHUCKNECHT H.F. (1957) Ablation therapy in the management of Menière's disease. Acta Otolaryngol. (Stockh.) 132(Suppl.), 1-42
29. NEDZELSKI J.N., BRYCE G.E. & PFLEIDERER A.G (1992) Treatment of Menière's disease with topical gentamicin: a preliminary report. J. Otolaryngol. 21, 95-101
30. PAPARELLA M.M., MORIZONO T. & LE C.T. (1984) Sensorineural hearing loss in otilis media. Ann. Otorhinolaryngol. 93, 623-629
31. THOMAS K. & HARRISON M.S. (1971) Long-term follow-up of 610 cases of Menière's disease. Proc. R. Soc. Med. 64, 853-856
32. (1997) British National Formulary 33, 455-458
33. HELAL A. (1997) Aminoglycoside eardops and ototoxicity. Can. Med. Ass. J. 156, 1056
34. COMMITTEE FOR SAFETY OF MEDICINES AND THE MEDICINES CONTROL (1997) Current problems in pharmacovigilance. Agency 23, 14-16
35. ESPOSITO S., D'ERRICO G. & MONTANARO C. (1990) Topical and oral treatment of chronic otitis media with ciprofloxacin. Arch. Otolaryngol. Head Neck Surg. 116, 557-559