Systemic absorption of gentamicin in the management of active mucosal chronic otitis media

Clinical Otolaryngology and Allied Sciences

Volumn 24, Issue 5, 1999, Pages 435-439

  Lancaster, Jeffrey L ^a,b   Mortimore, S ^a   McCormick, M ^a   Hart, C A ^a  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^b NONE   (United Kingdom)

Author keywords

Gentamicin; Ototoxicity

Indexed keywords

ANTIBIOTIC AGENT; GENTAMICIN; GENTISONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUDIOMETRY; BONE CONDUCTION; CHRONIC OTITIS MEDIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; FEMALE; HUMAN; MALE; OTOTOXICITY; PERILYMPH; PRIORITY JOURNAL; TOPICAL DRUG ADMINISTRATION; VESTIBULAR SYSTEM;

ABSORPTION; ADULT; ANTI-BACTERIAL AGENTS; CHRONIC DISEASE; FEMALE; GENTAMICINS; HUMANS; MALE; OTITIS MEDIA; PERILYMPH; PROSPECTIVE STUDIES;

EID: 0032869891     PISSN: 03077772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2273.1999.00288.x     Document Type: Article

References (20)

1. LANCASTER J.L., MAKURA Z.G.G., PORTER G. et al. (1999) Topical Aminoglycosides in the management of active mucosal chronic suppurative otitis media. J. Laryngol. Otol. 113, 10-12
2. YUEN A.P.W., CHAU P.Y. & WEI W.I. (1995) Bacteriology of chronic suppurative otitis media: Ofloxacin susceptibility. J. Otolaryngol. 24, 206-208
3. GEHANNO P. & COHEN B. (1993) Effectiveness and safety of Ofloxacin in chronic otitis media and chronic sinusitis in adult outpatients. Eur. Arch. Otorhinolaryngol. 250, 13-14
4. BROWNING G.G. (1984) The unsafeness of safe ears. J. Laryngol. Otol. 98, 23-26
5. PODOSHIN L., FRADIS M. & BEN DAVID J. (1989) Ototoxicity of ear drops in patients suffering from chronic otitis media. J. Laryngol. Otol. 103, 46-50
6. HARADA T., IWAMORI M., NAGAI Y. et al. (1986) Ototoxicity of Neomycin and its penetration through the round window membrane into the perilymph. Ann. Otol. Rhinol. Laryngol. 95, 404-408.
7. JACKSON G. G. & ARCIERI G. (1971) Ototoxicity of gentamicin in man: a survey and controlled analysis of clinical experience in the United States. J. Infectious Dis 124 (Suppl), 5130-5137
8. MYERS R.M. (1970) Ototoxic effects of gentamicin. Arch. Otolaryngol. 92, 160-162
9. COMMITTEE ON SAFETY OF MEDICINES (1997) Reminder: ototoxicity with aminoglycoside eardrops. Curr. Prob. Pharmacovigilance 23, 14
10. Marais J. & Rutka J.A. (1998) Ototoxicity and topical ear drops. Clin. Otolaryngol. 23, 360-367
11. ANON. (1998) Ototoxic ear drops. BAORL Newsletter 98/2, 1-2
12. GREEN K.M.J., LAPPIN D.W.P., CURLEY J.W.A. et al. (1997) Systemic absorption of gentamicin ear drops. J. Laryngol. Otol. 111, 960-962
13. WEINSTEIN M.J., ODEN E.M., ZEMAN W.V. et al. (1965) Antibiotic absorption after otic administration in dogs. Antimicrob. Agents Chemother. 239-244
14. FRIEDLANDER I.R. (1979) Ototoxic drugs and the detection of ototoxicity. N. Engl. J. Med. 301, 213
15. TRAN BA HUY P., MANUEL C., MEULEMANS A. et al. (1981) Pharmacokinetics of Gentamicin in perilymph and endolymph in the rat as determined by radioimmunoassay. J. Infectious Dis. 143, 476-486
16. HARPUS E.S. & GONDA I. (1982) Analysis of the pharmacokinetics of Ribostamycin in serum and perilymph of guinea pigs after single and multiple doses. Br. J. Audiol. 16, 95-99
17. TRAM BA HUY P., BERNARD P. & SCHACHT J. (1986) Kinetics of gentamicin uptake and release in the rat: comparison of inner ear tissues and fluids with other organs. J. Clin. Invest. 77, 1492-1500
18. HENLEY C.M. & SCHACHT J. (1988) Pharmacokinetics of aminoglycoside antibiotics in blood, inner ear fluids and tissues and their relationship to ototoxicity. Audiology 27, 137-146
19. HALMAGYI G.M., FATORE C.M., CURTHOYS I.S. et al. (1994) Gentamicin Vestibulotoxicity. Otolaryngol. Head Neck Surg. 111, 571-574
20. WRIGHT T. (1998) Ototoxicity. In Diseases of the Ear, pp. 505-510, Arnold, London