Intraotic administration of gentamicin: A new method to study ototoxicity in the crista ampullaris of the bullfrog

Laryngoscope

Volumn 107, Issue 1, 1997, Pages 137-143

  Carranza, Angelica ^a   Lopez, Ivan ^a   Castellano, Philip ^a   Hoffman, Larry ^a   Honrubia, Vincente ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bullfrog cristae ampullaris; Gentamicin ototoxicity; Hair cell regeneration

Indexed keywords

GENTAMICIN;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BULLFROG; CONTROLLED STUDY; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECT; HAIR CELL; NONHUMAN; OTOTOXICITY; PERILYMPH; PRIORITY JOURNAL;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-BACTERIAL AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GELATIN SPONGE, ABSORBABLE; GENTAMICINS; HAIR CELLS, VESTIBULAR; RANA CATESBEIANA; REGENERATION;

EID: 0031012792     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-199701000-00025     Document Type: Article

References (27)

1. Wersall J. Structural damage to the organ of Corti and vestibular epithelia caused by aminoglycoside ototoxicity in the guinea pig. In: Lerner SA, Matz GJ, Hawkins JE, eds. Aminoglycoside ototoxicity. Boston: Little, Brown and Co., 1981:197-214.
2. Wersall J. The ototoxic potential of netilmicin compared with amikacin. An animal study in guinea pigs. Scan J Infect Dis Suppl 1980;suppl23:104-13.
3. Aran JM. Current perspectives on inner ear toxicity. Otolaryngol Head Neck Surg 1995;112:133-44.
4. Baregi R, Grill V, Narducci ZR, et al. Gentamicin ototoxicity: histological and ultrastructural alterations after transtympanic administration. Pharmacol Res 1990;22:635-44.
5. Takumida M, Bagger-Sjoback D, Harada Y, et al. Sensory hair fusion and glycocalyx changes following gentamicin exposure in the guinea pig vestibular organs. Acta Otolaryngol Suppl (Stockh) 1989;suppl 107:39-47.
6. Weisleder P, Rubel EW. Hair cell regeneration after streptomycin toxicity in the avian vestibular epithelium. J Comp Neurol 1993;331:97-110.
7. Rubel EW, Dew LA, Roberson DW. Mammalian vestibular hair cell regeneration. Science 1995;267:701-3.
8. Baird RA, Torres MA, Shuff NR. Hair cell regeneration in the bullfrog vestibular otolith organs following aminoglycoside toxicity. Hear Res 1993;65:164-74.
9. Forge A, Li L, Corwin JT, et al. Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. Science 1993;259:1616-9.
10. Girod DA, Rubel EW. Hair cell regeneration in the avian cochlea: if it works in birds, why not in man? Ear Nose Throat J 1987;70:343-54.
11. Lippe WR, Westbrook EW, Ryal BM. Hair cell regeneration in the chicken cochlea following aminoglycoside toxicity. Hear Res 1991;56:203-10.
12. Kimura RS, Iverson NA, Southard RE. Selective lesions of the vestibular labyrinth. Ann Otol Rhinol Laryngol 1988; 97:577-84.
13. Omura R, Harada Y, Suzuki M, et al. Structural and physiological change of the bullfrog semicircular canal due to gentamicin intoxication. Acta Otolaryngol Suppl (Stockh) 1989;suppl468:41-7.
14. Carranza A, Castellano P, Lopez I, et al. Gentamicin ototoxicity and hair cell regeneration in the cristae ampullaris of Rana catesbeiana. Assoc for Research in Otolaryngology. 1994;17:Abstract No. 138.
15. Ramprashad F, Landolt JP, Money KE, et al. Comparative morphometric study of the vestibular system of the vertebrata: reptilia, aves, amphibian and pisces. Acta Otolaryngol Suppl (Stockh) 1986;suppl427:1-42.
16. Geisler C, Van Bereijk W, Frishkopf L. The inner ear of the bullfrog. J Morphol 1964;114:43-58.
17. Hillman DE. Morphology of peripheral and central vestibular system. In: Frog neurobiology. New York: Springer Verlag, 1976:452-80.
18. Tran Ba Huy P, Manuel C, Meulemans A. Kinetics of aminoglycoside antibiotics in perilymph and endolymph in animals. In: Aminoglycoside ototoxicity. Boston: Little, Brown and Co.; 1981:81-97.
19. Frishkopf LS, Goldstein MH. Responses to acoustic stimuli from single units in the eighth nerve of the bullfrog. J Acoust Soc Am 1963;35:1219-28.
20. Precht W, Llinas R, Clarke M. Physiological responses of frog vestibular fibers to horizontal angular rotation. Exp Brain Res 1971;13:378-407.
21. Lopez I, Carranza A, Castellano P, et al. Hair cell regeneration after local gentamicin administration in the crista ampullaris of the bullfrog. Otolaryngol Head Neck Surg 1994; 111:146. Abstract No. 60.
22. Hudsped AJ, Lewis RS. Kinetic analysis of voltage- and ion-dependent conductances in saccular hair cells of the bull-frog, Rana Catesbeiana. J Physiol (Lond) 1988;400:237-74.
23. Gillespie PG, Hudspeth AJ. High-purity isolation of bullfrog hair bundles and subcellular and topological localization of constituent proteins. J Cell Biol 1991;112:625-40.
24. Valli P, Botta L, Zucca G, et al. Functional organization of the peipheral efferent vestibular system in the frog. Brain Res 1986;362:92-7.
25. Honrubia V, Hoffman LF, Sitko S, et al. Anatomic and physiological correlates in the bullfrog vestibular nerve. J Neurophysiol 1989;62:688-701.
26. Honrubia V, Sitko S, Kimm J, et al. Physiological and anatomical characteristics of primary vestibular afferent neurons in the bullfrog. Int J Neurosci 1981;15: 197-206.
27. Newman A, Honrubia V. Regeneration of the eighth cranial nerve in the bullfrog, Rana Catesbeiana. Exp Neurol 1986; 115:115-20.