Effect of different lipid emulsions on the immunological function in humans: A systematic review with meta-analysis

Clinical Nutrition

Volumn 26, Issue 3, 2007, Pages 302-313

  Wirtitsch, Melanie ^a   Wessner, Barbara ^a   Spittler, Andreas ^a   Roth, Erich ^a   Volk, Thomas ^b   Bachmann, Lucas ^c   Hiesmayr, Michael ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Emulsion; Immunological system; Intravenous; Lipid; Meta analysis; Systematic review

Indexed keywords

FISH OIL; GLUCOSE; LIPID EMULSION; LONG CHAIN TRIACYLGLYCEROL; MONOUNSATURATED FATTY ACID; PLACEBO; SOYBEAN OIL;

ARTICLE; CLINICAL TRIAL; DATA EXTRACTION; EFFECT SIZE; HOSPITALIZATION; HUMAN; IMMUNE SYSTEM; IMMUNOLOGICAL PARAMETERS; INFORMATION RETRIEVAL; INTENSIVE CARE UNIT; LENGTH OF STAY; META ANALYSIS; MORTALITY; PARENTERAL NUTRITION; STATISTICAL ANALYSIS; SYSTEMATIC REVIEW;

CYTOKINES; ENTERAL NUTRITION; FAT EMULSIONS, INTRAVENOUS; FOOD, FORMULATED; HUMANS; IMMUNE SYSTEM; LENGTH OF STAY; LYMPHOCYTE COUNT; RANDOMIZED CONTROLLED TRIALS; TRIGLYCERIDES;

EID: 34248523518     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2007.02.001     Document Type: Article

References (75)

1. Bach A.C., and Babayan V.K. Medium-chain triglycerides: an update. Am J Clin Nutr 36 (1982) 950-962
2. Mingrone G., De Gaetano A., Greco A.V., Capristo E., Castagneto M., and Gasbarrini G. Medium-chain triglycerides for parenteral nutrition: kinetic profile in humans. Nutrition 11 (1995) 418-422
3. Adolph M. Lipid emulsions in parenteral nutrition. Ann Nutr Met 43 (1999) 1-13
4. Chan S., McCowen K.C., and Bistrian B. Medium-chain triglyceride and n-3 polyunsaturated fatty acid-containing emulsions in intravenous nutrition. Curr Opin Clin Nutr Metab Care 1 (1998) 163-169
5. Morlion B., Torwesten E., Lessire H., et al. The effect of parenteral fish oil on leukocyte membrane fatty acid composition and leukotriene-synthesizing capacity in patients with postoperative trauma. Metabolism 45 (1996) 1208-1213
6. Belluzzi A., Boschi S., Brignola C., Munarini A., Cariani G., and Miglio F. Polyunsaturated fatty acids and inflammatory bowel disease. Am J Clin Nutr 71 (2000) 339S-342S
7. James M.J., Gibson R.A., and Cleland L.G. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 71 (2000) 343S-348S
8. Yaqoob P., Knapper J.A., Webb D.H., Williams C.M., Newsholme E.A., and Calder P.C. Effect of olive oil on immune function in middle-aged men. Am J Clin Nutr 67 (1998) 129-135
9. Moussa M., Le Boucher J., Garcia J., et al. In vivo effects of olive oil-based lipid emulsion on lymphocyte activation in rats. Clin Nutr 19 (2000) 49-54
10. Gobel Y., Koletzko B., Bohles H.J., et al. Parenteral fat emulsions based on olive and soybean oils: a randomized clinical trial in preterm infants. J Pediatr Gastroenterol Nutr 37 (2003) 161-167
11. Schlotzer E., and Kanning U. Elimination and tolerance of a new parenteral lipid emulsion (SMOF)-a double-blind cross-over study in healthy male volunteers. Ann Nutr Met 48 (2004) 263-268
12. Antebi H., Mansoor O., Ferrier C., et al. Liver function and plasma antioxidant status in intensive care unit patients requiring total parenteral nutrition: comparison of 2 fat emulsions. J Parenter Enteral Nutr 28 (2004) 142-148
13. Grimm H., Mertes N., Goeters C., et al. Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients. Eur J Nutr 45 (2006) 55-60
14. Nanni G., Siegel J.H., Coleman B., Fader P., and Castiglione R. Increased lipid fuel dependence in the critically ill septic patient. J Trauma 24 (1984) 14-30
15. Bistrian B.R. Novel lipid sources in parenteral and enteral nutrition. Proc Nutr Soc 56 (1997) 471-477
16. Heyland D.K., MacDonald S., Keefe L., and Drover J.W. Total parenteral nutrition in the critically ill patient: a meta-analysis. J Am Med Assoc 280 (1998) 2013-2019
17. Jarstrand C., Berghem L., and Lahnborg G. Human granulocyte and reticuloendothelial system function during intralipid infusion. J Parenter Enteral Nutr 2 (1978) 663-670
18. Nordenstrom J., Jarstrand C., and Wiernik A. Decreased chemotactic and random migration of leukocytes during intralipid infusion. Am J Clin Nutr 32 (1979) 2416-2422
19. Fischer G.W., Hunter K.W., Wilson S.R., and Mease A.D. Diminished bacterial defences with intralipid. Lancet 2 (1980) 819-820
20. Wiernik A., Jarstrand C., and Julander I. The effect of intralipid on mononuclear and polymorphonuclear phagocytes. Am J Clin Nutr 37 (1983) 256-261
21. Seidner D.L., Mascioli E.A., Istfan N.W., et al. Effects of long-chain triglyceride emulsions on reticuloendothelial system function in humans. J Parenter Enteral Nutr 13 (1989) 614-619
22. Sedman P., Somers S., Ramsden C., Brennan T., and Guillou P. Effects of different lipid emulsions on lymphocyte function during total parenteral nutrition. Br J Surg 78 (1991) 1396-1399
23. Battistella F., Widergren J., Anderson J., Siepler J., Weber J., and MacColl K. A prospective, randomized trial of intravenous fat emulsion administration in trauma victims requiring total parenteral nutrition. J Trauma 43 (1997) 52-58
24. Palmblad J., Brostrom O., Lahnborg G., Uden A., and Venizelos N. Neutrophil functions during total parenteral nutrition and intralipid infusion. Am J Clin Nutr 35 (1982) 1430-1436
25. Ota D., Jessup J., Babcock G., et al. Immune function during intravenous administration of a soybean oil emulsion. J Parenter Enteral Nutr 9 (1985) 23-27
26. Dahlstrom K., Goulet O., Roberts R., Ricour C., and Ament M. Lipid tolerance in children receiving long-term parenteral nutrition: a biochemical and immunologic study. J Pediatr 113 (1988) 985-990
27. Herson V., Block C., Eisenfeld L., Maderazo E., and Krause P. Effects of intravenous fat infusion on neonatal neutrophil and platelet function. J Parenter Enteral Nutr 13 (1989) 620-622
28. Hutchinson M. Prospective trial of Liposyn 20% in patients undergoing bone marrow transplantation. Clin Nutr 3 (1984) 5-9
29. Gogos C., Kalfarentzos F., and Zoumbos N. Effect of different types of total parenteral nutrition on T-lymphocyte subpopulations and NK cells. Am J Clin Nutr 51 (1990) 119-122
30. Smirniotis V., Kostopanagiotou G., Vassiliou J., et al. Long chain versus medium chain lipids in patients with ARDS: effects on pulmonary haemodynamics and gas exchange. Intens Care Med 24 (1990) 1029-1033
31. Ikehata A., Hiwatashi N., Kinouchi Y., et al. Effect of intravenously infused eicosapentaenoic acid on the leukotriene generation in patients with active Crohn's disease. Am J Clin Nutr 56 (1992) 938-942
32. Sandstrom R. Structured triglycerides to postoperative patients: a safety and tolerance study. J Parenter Enteral Nutr 17 (1993) 153-157
33. Da Pont M., Pezzana A., Demagistris A., and Balzola F. Total parenteral nutrition in critical patients. The metabolic-nutritional aspects and effects on immune function of 2 different isocaloric-isonitrogenous regimens. Minerva Gastroenterol Dietol 40 (1994) 17-26
34. Gogos C., Zoumbos N., Makri M., and Kalfarentzos F. Medium- and long-chain triglycerides have different effects on the synthesis of tumor necrosis factor by human mononuclear cells in patients under total parenteral nutrition. J Am Coll Nutr 13 (1994) 40-44
35. Gelas P., Cotte L., Poitevin-Later F., et al. Effect of parenteral medium- and long-chain triglycerides on lymphocytes subpopulations and functions in patients with acquired immunodeficiency syndrome: a prospective study. J Parenter Enteral Nutr 22 (1996) 67-71
36. Wachtler P., Konig W., Senkal M., Kemen M., and Koller M. Influence of a total parenteral nutrition enriched with omega-3 fatty acids on leukotriene synthesis of peripheral leukocytes and systemic cytokine levels in patients with major surgery. J Trauma 42 (1997) 191-198
37. Mayser P., Mrowietz U., Arenberger P., et al. Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial. J Am Acad Dermatol 38 (1998) 539-547
38. Nijveldt R., Tan A., Prins H., et al. Use of a mixture of medium-chain triglycerides and longchain triglycerides versus long-chain triglycerides in critically ill surgical patients: a randomized prospective double-blind study. Clin Nutr 17 (1998) 23-29
39. Furukawa K., Tashiro T., Yamamori H., et al. Effects of soybean oil emulsion and eicosapentaenoic acid on stress response and immune function after a severely stressful operation. Ann Surg 229 (1999) 255-261
40. Goulet O., de-Potter S., Antebi H., et al. Long-term efficacy and safety of a new olive oil-based intravenous fat emulsion in pediatric patients: a double-blind randomized study. Am J Clin Nutr 70 (1999) 338-345
41. Sane S., Baba M., Kusano C., Shirao K., Kamada T., and Aikou T. Fat emulsion administration in the early postoperative period in patients undergoing esophagectomy for carcinoma depresses arachidonic acid metabolism in neutrophils. Nutrition 15 (1999) 341-346
42. Furukawa K., Yamamori H., Takagi K., et al. Influences of soybean oil emulsion on stress response and cell-mediated immune function in moderately or severely stressed patients. Nutrition 18 (2002) 235-240
43. Garnacho-Montero J., Ortiz-Leyba C., Jimenez-Jimenez F., et al. Clinical and metabolic effects of two lipid emulsions on the parenteral nutrition of septic patients. Nutrition 18 (2002) 134-138
44. Mayser P. A double-blind, randomized, placebo-controlled trial of n-3 versus n-6 fatty acid based lipid infusion in atopic dermatitis. J Parenter Enteral Nutr 26 (2002) 151-158
45. Weiss G., Meyer F., Matthies B., Pross M., Koenig W., and Lippert H. Immunomodulation by perioperative administration of n-3 fatty acids. Br J Nutr 87 (2002) S89-S94
46. Mayer K., Gokorsch S., Fegbeutel C., et al. Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. Am J Resp Crit Care Med 167 (2003) 1321-1328
47. Mayer K., Fegbeutel C., Hattar K., et al. Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation. Intens Care Med 29 (2003) 1472-1481
48. Mayer K., Meyer S., Reinholz-Muhly M., et al. Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans. J Immunol 171 (2003) 4837-4843
49. Chen F.M., Wang J.Y., Sun L.C., Juang R.F., Huang T.J., and Hsieh J.S. Efficacy of medium-chain triglycerides compared with long-chain triglycerides in total parenteral nutrition in patients with digestive tract cancer undergoing surgery. Kaohsiung J Med Sci 21 (2005) 487-494
50. Garcia-de-Lorenzo A., Denia R., Atlan P., et al. Parenteral nutrition providing a restricted amount of linoleic acid in severely burned patients: a randomised double-blind study of an olive oil-based lipid emulsion v. medium/long-chain triacylglycerols. Br J Nutr 94 (2005) 221-230
51. Cano N.J.M., Saingra Y., Dupuy A.M., et al. Intradialytic parenteral nutrition: comparison of olive oil versus soybean oil-based lipid emulsions. Br J Nutr 95 (2006) 152-159
52. Mertes N., Grimm H., Furst P., and Stehle P. Safety and efficacy of a new parenteral lipid emulsion (SMOF lipid) in surgical patients: a randomized, double-blind, multicenter study. Ann Nutr Met 50 (2006) 253-259
53. Gogos C., Zoumbos N., Makri M., and Kalfarentzos F. Tumor necrosis factor production by human mononuclear cells during total parenteral nutrition containing long-chain triglycerides. Nutrition 8 (1992) 26-29
54. Loo L.S., Tang J.P., and Kohl S. Inhibition of cellular cytotoxicity of leukocytes for herpes simplex virus-infected cells in vitro and in vivo by intralipid. J Infect Dis 146 (1982) 64-70
55. Sobrado J., Moldawer L.L., Pomposelli J.J., et al. Lipid emulsions and reticuloendothelial system function in healthy and burned guinea pigs. Am J Clin Nutr 42 (1985) 855-863
56. Monson J.R., Sedman P.C., Ramsden C.W., Brennan T.G., and Guillou P.J. Total parenteral nutrition adversely influences tumour-directed cellular cytotoxic responses in patients with gastrointestinal cancer. Eur J Surg Oncol 14 (1988) 935-943
57. Freeman J., Goldmann D., Smith N., Sidebottom D., Epstein M., and Platt R. Association of intravenous lipid emulsion and coagulase-negative staphylococcal bacteremia in neonatal intensive care units. N Engl J Med 323 (1990) 301-308
58. Escudier E., Escudier B., Henry-Amar M., et al. Effects of infused intralipid on neutrophil chemotaxis during total parenteral nutrition. J Parenter Enteral Nutr 10 (1986) 596-598
59. Rasmussen A. The effect of intralipid on polymorphonuclear leukocytes. Clin Nutr 7 (1988) 37-41
60. Jensen G., Mascioli E., Seidner D., et al. Parenteral infusion of long- and medium-chain triglycerides and reticuloendothelial system function in man. J Parenter Enteral Nutr 14 (1990) 467-471
61. Bellinati-Pires R., Waitzberg D.L., Salgado M.M., and Carneiro-Sampaio M.M. Effect of medium- and long-chain triglycerides on human neutrophil migration. Braz J Med Biol Res 25 (1992) 369-373
62. Bellinati-Pires R., Waitzberg D.L., Salgado M.M., and Carneiro-Sampaio M.M. Functional alterations of human neutrophils by medium-chain triglyceride emulsions: evaluation of phagocytosis, bacterial killing, and oxidative activity. J Leukocyte Biol 53 (1993) 404-410
63. Lenssen P., Bruemmer B., Bowden R., Gooley T., Aker S., and Mattson D. Intravenous lipid dose and incidence of bacteremia and fungemia in patients undergoing bone marrow transplantation. Am J Clin Nutr 67 (1998) 927-933
64. Helms R., Herrod H., Burckart G., and Christensen M. E-rosette formation, total T-cells, and lymphocyte transformation in infants receiving intravenous safflower oil emulsion. J Parenter Enteral Nutr 7 (1983) 541-545
65. Monson J., Ramsden C., MacFie J., Brennan T., and Guillou P. Immunorestorative effect of lipid emulsions during total parenteral nutrition. Br J Surg 73 (1986) 843-846
66. Clouva-Molyvdas P., Peck M.D., and Alexander J.W. Short-term dietary lipid manipulation does not affect survival in two models of murine sepsis. J Parenter Enteral Nutr 16 (1992) 343-347
67. Tashiro T., Yamamori H., Takagi K., Hayashi N., Furukawa K., and Nakajima N. n-3 versus n-6 polyunsaturated fatty acids in critical illness. Nutrition 14 (1998) 551-553
68. Chao C.Y., Yeh S.L., Lin M.T., and Chen W.J. Effects of parenteral infusion with fish-oil or safflower-oil emulsion on hepatic lipids, plasma amino acids, and inflammatory mediators in septic rats. Nutrition 16 (2000) 284-288
69. Grimminger F., Fuhrer D., Papavassilis C., et al. Influence of intravenous n-3 lipid supplementation on fatty acid profiles and lipid mediator generation in a patient with severe ulcerative colitis. Eur J Clin Invest 23 (1993) 706-715
70. Mayer K., Seeger W., and Grimminger F. Clinical use of lipids to control inflammatory disease. Curr Opin Clin Nutr Metab Care 1 (1998) 179-184
71. Zadak Z., and Cervinkova Z. PUFA n-3 lipid emulsion-a promising agent in ARDS treatment. Nutrition 13 (1997) 232-233
72. Juni P., Altman D.G., and Egger M. Systematic reviews in health care: assessing the quality of controlled clinical trials. Br Med J 323 (2001) 42-46
73. Simpson F., and Doig G.S. Parenteral vs. enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle. Intens Care Med 31 (2005) 12-23
74. Faller H. Intention-to-treat. Die Rehabilitation 43 (2004) 52-55
75. Montori V.M., and Guyatt G.H. Intention-to-treat principle. Can Med Assoc J 165 (2001) 1339-1341