Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media

Infection and Immunity

Volumn 75, Issue 5, 2007, Pages 2562-2571

  Furukawa, Masayuki ^a,b   Ebmeyer, Jörg ^a,c   Pak, Kwang ^a   Austin, Darrell A ^a   Melhus, Åsa ^d   Webster, Nicholas J G ^a   Ryan, Allen F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CEP 11004; CLOSTRIDIUM DIFFICILE TOXIN B; CYCLINE; ISOENZYME; PROTEIN CDC42; PROTEIN INHIBITOR; RAC PROTEIN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; CELL PROLIFERATION; CLOSTRIDIUM DIFFICILE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GUINEA PIG; HAEMOPHILUS INFLUENZAE; IMMUNOHISTOCHEMISTRY; INOCULATION; MALE; MIDDLE EAR MUCOSA; NONHUMAN; OTITIS MEDIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STROMA CELL; WESTERN BLOTTING;

ANIMALS; EAR, MIDDLE; GUINEA PIGS; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; HYPERPLASIA; MALE; MAP KINASE KINASE 4; MUCOUS MEMBRANE; OTITIS MEDIA; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 34248370548     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01656-06     Document Type: Article

References (41)

1. 2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-kinase and Syk-mediated pathways. J. Biol. Chem. 279:10883-10891.
2. Bennett, B. L., D. T. Sasaki, B. W. Murray, E. C. O'Leary, S. T. Sakata, W. Xu, J. C. Leisten, A. Motiwala, S. Pierce, Y. Satoh, S. S. Bhagwat, A. M. Manning, and D. W. Anderson. 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA 98:13681-13686.
3. Bennett, K. E., M. P. Haggard, P. A. Silva, and I. A. Stewart. 2001. Behaviour and developmental effects of otitis media with effusion into the teens. Arch. Dis. Child. 85:91-95.
4. Busch, C., and K. Aktories. 2000. Microbial toxins and the glycosylation of rho family GTPases. Curr. Opin. Struct. Biol. 10:528-535.
5. Davis, R. J. 2000. Signal transduction by the JNK group of MAP kinases. Cell 103:239-252.
6. El-Sayed, Y. 1998. Bone conduction impairment in uncomplicated chronic suppurative otitis media. Am. J. Otolaryngol. 19:149-153.
7. Fanger, G. R., N. L. Johnson, and G. L. Johnson. 1997. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J. 16: 4961-4972.
8. Gerwins, P., J. L. Blank, and G. L. Johnson. 1997. Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J. Biol. Chem. 272:8288-8295.
9. Gupta, S., T. Barrett, A. J. Whitmarsh, J. Cavanagh, H. K. Sluss, B. Derijard, and R. J. Davis. 1996. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15:2760-2770.
10. Han, Z., D. L. Boyle, L. Chang, B. Bennet, M. Karin, L. Yang, A. M. Manning, and G. S. Firestein. 2001. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J. Clin. Investig. 108:73-81.
11. Hibi, M., A. Lin, T. Smeal, A. Minden, and M. Karin. 1993. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7:2135-2148.
12. Hoefen, R. J., and B. C. Berk. 2002. The role of MAP kinases in endothelial activation. Vasc. Pharmacol. 38:271-273.
13. Ip, Y. T., and R. J. Davis. 1998. Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Curr. Opin. Cell Biol. 10:205-219.
14. Jono, H., H. Xu, H. Kai, D. J. Lim, Y. S. Kim, X. H. Feng, and J. D. Li. 2003. Transforming growth factor-beta-Smad signaling pathway negatively regulates nontypeable Haemophilus inftuenzae-induced MUC5AC mucin transcription via mitogen-activated protein kinase (MAPK) phosphatase-1-dependent inhibition of p38 MAPK. J. Biol. Chem. 278:27811-27819.
15. Lawler, S., Y. Fleming, M. Goedert, and P. Cohen. 1998. Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro. Curr. Biol. 8:1387-1390.
16. Leppa, S., and D. Bohmann. 1999. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene 18:6158-6162.
17. Lim, D. J., and H. Birck. 1971. Ultrastructural pathology of the middle ear mucosa in serous otitis media. Ann. Otol. Rhinol. Laryngol. 80:838-853.
18. Lin, A. 2003. Activation of the JNK signaling pathway: breaking the brake on apoptosis. Bioessays 25:17-24.
19. Magnuson, K., A. Hermansson, A. Melhus, and S. Hellstrom. 1997. The tympanic membrane and middle ear mucosa during non-typeable Haemophilus influenzae and Haemophilus influenzae type b acute otitis media: a study in the rat. Acta Otolaryngol. 117:396-405.
20. Matsuguchi, T., A. Masuda, K. Sugimoto, Y. Nagai, and Y. Yoshikai. 2003. JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation. EMBO J. 22:4455-4464.
21. Maw, R., J. Wilks, I. Harvey, T. J. Peters, and J. Golding. 1999. Early surgery compared with watchful waiting for glue ear and effect on language development in preschool children: a randomised trial. Lancet 353:960-963.
22. Mohit, A. A., J. H. Martin, and C. A. Miller. 1995. p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. Neuron 14:67-78.
23. Murakata, C., M. Kaneko, G. Gessner, T. S. Angeles, M. A. Ator, T. M. O'Kane, B. A. McKenna, B. A. Thomas, J. R. Mathiasen, M. S. Saporito, D. Bozyczko-Coyne, and R. L. Hudkins. 2002. Mixed lineage kinase activity of indolocarbazole analogues. Bioorg. Med. Chem. Lett. 12:147-150.
24. Palacios, S. D., K. Pak, A. G. Kayali, A. Z. Rivkin, C. Aletsee, Å. Melhus, N. J. Webster, and A. F. Ryan. 2002. Participation of Ras and extracellular regulated kinase in the hyperplastic response of middle-ear mucosa during bacterial otitis media. J. Infect. Dis. 186:1761-1769.
25. Palacios, S. D., K. Pak, A. Z. Rivkin, A. G. Kayali, D. A. Austin, C. Aletsee, Å. Melhus, N. J. Webster, and A. F. Ryan. 2004. The role of p38 MAPK in middle ear mucosa hyperplasia during bacterial otitis media. Infect. Immun. 72:4662-4667.
26. Piglansky, L., E. Leibovitz, S. Raiz, D. Greenberg, J. Press, A. Leiberman, and R. Dagan. 2003. Bacteriologic and clinical efficacy of high dose amoxicillin for therapy of acute otitis media in children. Pediatr. Infect. Dis. J. 22:405-413.
27. Potapova, O., M. Gorospe, F. Bost, N. M. Dean, W. A. Gaarde, D. Mercola, and N. J. Holbrook. 2000. c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells. J. Biol. Chem. 275:24767-24775.
28. Prieskorn, D. M., and J. M. Miller. 2000. Technical report: chronic and acute intracochlear infusion in rodents. Hear. Res. 140:212-215.
29. Ridley, A. J. 2001. Rho family proteins: coordinating cell responses. Trends Cell Biol. 11:471-477.
30. Russell, M., C. A. Lange-Carter, and G. L. Johnson. 1995. Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1). J. Biol. Chem. 270:11757-11760.
31. Schreiber, M., A. Kolbus, F. Piu, A. Szabowski, U. Mohle-Steinlein, J. Tian, M. Karin, P. Angel, and E. F. Wagner. 1999. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 13:607-619.
32. Schuknecht, H. F. 1993. Pathology of the ear. Lea & Febiger, Philadelphia, PA.
33. Schwabe, R. F., C. A. Bradham, T. Uehara, E. Hatano, B. L. Bennett, R. Schoonhoven, and D. A. Brenner. 2003. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 37: 824-832.
34. Surapisitchat, J., R. J. Hoefen, X. Pi, M. Yoshizumi, C. Ya, and B. C. Berk. 2001. Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: inhibitory crosstalk among MAPK family members. Proc. Natl. Acad. Sci. USA 98:6476-6481.
35. Teramoto, H., O. A. Coso, H. Miyata, T. Igishi, T. Miki, and J. S. Gutkind. 1996. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J. Biol. Chem. 271:27225-27228.
36. Tos, M., and K. Bak-Pedersen. 1997. Goblet cell population in the pathological middle ear and eustachian tube of children and adults. Ann. Otol. Rhinol. Laryngol. 86:209-218.
37. Tseng, H., T. E. Peterson, and B. C. Berk. 1995. Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells. Circ. Res. 77:869-878.
38. Wang, L. H., C. G. Besirli, and E. M. Johnson, Jr. 2004. Mixed-lineage kinases: a target for the prevention of neurodegeneration. Annu. Rev. Pharmacol. Toxicol. 44:451-474.
39. Wright, C. G., and W. L. Meyerhoff. 1994. Pathology of otitis media. Ann. Otol. Rhinol. Laryngol. 163(Suppl.):24-26.
40. Xu, Z., A. C. Maroney, P. Dobrzanski, N. V. Kukekov, and L. A. Greene. 2001. The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol. Cell. Biol. 21:4713-4724.
41. Yan, C., M. Takahashi, M. Okuda, J. D. Lee, and B. C. Berk. 1999. Fluid shear stress stimulates big mitogen-activated protein kinase 1 (BMK1) activity in endothelial cells. Dependence on tyrosine kinases and intracellular calcium. J. Biol. Chem. 274:143-150.