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Volumn 18, Issue 3, 2007, Pages 283-288

Oxysterols: Functional significance in fetal development and the maintenance of normal retinal function

Author keywords

Cytochrome P450; Oxysterols; Photooxidation; Retina; Sonic hedgehog protein

Indexed keywords

7 DEHYDROCHOLESTEROL; 7 OXOCHOLESTEROL; CHOLESTANETRIOL 26 MONOOXYGENASE; CYTOCHROME P450; CYTOCHROME P450 46A1; OXYSTEROL; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

EID: 34248343047     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e328133851e     Document Type: Review
Times cited : (19)

References (40)
  • 1
    • 0033374783 scopus 로고    scopus 로고
    • The A and B isoforms of the human progesterone receptor: Two functionally different transcription factors encoded by a single gene
    • Giangrande PH, McDonnell DP. The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. Recent Prog Horm Res 1999; 54:291-313.
    • (1999) Recent Prog Horm Res , vol.54 , pp. 291-313
    • Giangrande, P.H.1    McDonnell, D.P.2
  • 4
    • 33645983221 scopus 로고    scopus 로고
    • LXRS and FXR: The yin and yang of cholesterol and fat metabolism
    • This study was a comprehensive review of oxysterols that function as ligands for nuclear receptors and the physiologic events that they regulate
    • Kalaany NY, Mangelsdorf DJ. LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol 2006; 68:159-191. This study was a comprehensive review of oxysterols that function as ligands for nuclear receptors and the physiologic events that they regulate.
    • (2006) Annu Rev Physiol , vol.68 , pp. 159-191
    • Kalaany, N.Y.1    Mangelsdorf, D.J.2
  • 5
    • 0242606382 scopus 로고    scopus 로고
    • Novel sterols synthesized via the CYP27A1 metabolic pathway
    • Pikuleva I, Javitt NB. Novel sterols synthesized via the CYP27A1 metabolic pathway. Arch Biochem Biophys 2003; 420:35-39.
    • (2003) Arch Biochem Biophys , vol.420 , pp. 35-39
    • Pikuleva, I.1    Javitt, N.B.2
  • 6
    • 0041666303 scopus 로고    scopus 로고
    • 27-Hydroxylation of 7- and 8-dehydrocholesterol in Smith-Lemli-Opitz syndrome: A novel metabolic pathway
    • Wassif CA, Yu J, Cui J, et al. 27-Hydroxylation of 7- and 8-dehydrocholesterol in Smith-Lemli-Opitz syndrome: a novel metabolic pathway. Steroids 2003; 68:497-502.
    • (2003) Steroids , vol.68 , pp. 497-502
    • Wassif, C.A.1    Yu, J.2    Cui, J.3
  • 7
    • 0036250159 scopus 로고    scopus 로고
    • 25R,26-Hydroxycholesterol revisited: Synthesis, metabolism, and biologic roles
    • Javitt NB. 25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles. J Lipid Res 2002; 43:665-670.
    • (2002) J Lipid Res , vol.43 , pp. 665-670
    • Javitt, N.B.1
  • 8
    • 33646864114 scopus 로고    scopus 로고
    • Membrane and protein interactions of oxysterols
    • Massey JB. Membrane and protein interactions of oxysterols. Curr Opin Lipidol 2006; 17:296-301.
    • (2006) Curr Opin Lipidol , vol.17 , pp. 296-301
    • Massey, J.B.1
  • 9
    • 26844547130 scopus 로고    scopus 로고
    • 7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death
    • Rho MC, Kim YK, Chang JS, et al. 7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death. J Mol Cell Cardiol 2005; 39:823-832.
    • (2005) J Mol Cell Cardiol , vol.39 , pp. 823-832
    • Rho, M.C.1    Kim, Y.K.2    Chang, J.S.3
  • 10
    • 20144388767 scopus 로고    scopus 로고
    • 7-Ketocholesterol favors lipid accumulation and colocalizes with Nile Red positive cytoplasmic structures formed during 7-ketocholesterol-induced apoptosis: Analysis by flow cytometry, FRET biphoton spectral imaging microscopy, and subcellular fractionation
    • Vejux A, Kahn E, Dumas D, et al. 7-Ketocholesterol favors lipid accumulation and colocalizes with Nile Red positive cytoplasmic structures formed during 7-ketocholesterol-induced apoptosis: analysis by flow cytometry, FRET biphoton spectral imaging microscopy, and subcellular fractionation. Cytometry A 2005; 64:87-100.
    • (2005) Cytometry A , vol.64 , pp. 87-100
    • Vejux, A.1    Kahn, E.2    Dumas, D.3
  • 12
    • 33747329092 scopus 로고    scopus 로고
    • Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects
    • Larsson DA, Baird S, Nyhalah JD, et al. Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects. Free Radic Biol Med 2006; 41:902-910.
    • (2006) Free Radic Biol Med , vol.41 , pp. 902-910
    • Larsson, D.A.1    Baird, S.2    Nyhalah, J.D.3
  • 13
    • 0032890337 scopus 로고    scopus 로고
    • Oxysterols and atherosclerosis
    • Brown AJ, Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 1999; 142:1-28.
    • (1999) Atherosclerosis , vol.142 , pp. 1-28
    • Brown, A.J.1    Jessup, W.2
  • 14
    • 0033995604 scopus 로고    scopus 로고
    • Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes
    • Brown AJ, Mander EL, Gelissen IC, et al. Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes. J Lipid Res 2000; 41:226-237.
    • (2000) J Lipid Res , vol.41 , pp. 226-237
    • Brown, A.J.1    Mander, E.L.2    Gelissen, I.C.3
  • 15
    • 33744904197 scopus 로고    scopus 로고
    • Lee JW, Fuda H, Javitt NB, et al. Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina. Exp Eye Res 2006; 83:465-469. Expression of CYP27A1 in the retina focuses on local metabolism for the detoxification of photooxidation products.
    • Lee JW, Fuda H, Javitt NB, et al. Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina. Exp Eye Res 2006; 83:465-469. Expression of CYP27A1 in the retina focuses on local metabolism for the detoxification of photooxidation products.
  • 16
    • 0036085695 scopus 로고    scopus 로고
    • Membrane-bound enzymes of cholesterol synthesis from lanosterol
    • Gaylor JL. Membrane-bound enzymes of cholesterol synthesis from lanosterol. Biochem Biophys Res Commun 2002; 292:1139-1146.
    • (2002) Biochem Biophys Res Commun , vol.292 , pp. 1139-1146
    • Gaylor, J.L.1
  • 17
    • 0345255889 scopus 로고    scopus 로고
    • Human malformation syndromes due to inborn errors of cholesterol synthesis
    • Porter FD. Human malformation syndromes due to inborn errors of cholesterol synthesis. Curr Opin Pediatr 2003; 15:607-613.
    • (2003) Curr Opin Pediatr , vol.15 , pp. 607-613
    • Porter, F.D.1
  • 18
    • 0033524420 scopus 로고    scopus 로고
    • Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta
    • Janowski BA, Grogan MJ, Jones SA, et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A 1999; 96:266-271.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 266-271
    • Janowski, B.A.1    Grogan, M.J.2    Jones, S.A.3
  • 19
    • 0030610365 scopus 로고    scopus 로고
    • 7 alpha-hydroxylation of 27-hydroxycholesterol: Biologic role in the regulation of cholesterol synthesis
    • Martin KO, Reiss AB, Lathe R, Javitt NB. 7 alpha-hydroxylation of 27-hydroxycholesterol: biologic role in the regulation of cholesterol synthesis. J Lipid Res 1997; 38:1053-1058.
    • (1997) J Lipid Res , vol.38 , pp. 1053-1058
    • Martin, K.O.1    Reiss, A.B.2    Lathe, R.3    Javitt, N.B.4
  • 20
    • 0034623160 scopus 로고    scopus 로고
    • Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture
    • Brown AJ, Watts GF, Burnett JR, et al. Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture. J Biol Chem 2000; 275:27627-27633.
    • (2000) J Biol Chem , vol.275 , pp. 27627-27633
    • Brown, A.J.1    Watts, G.F.2    Burnett, J.R.3
  • 21
    • 0032545281 scopus 로고    scopus 로고
    • cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
    • Lund EG, Kerr TA, Sakai J, et al. cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. J Biol Chem 1998; 273:34316-34327.
    • (1998) J Biol Chem , vol.273 , pp. 34316-34327
    • Lund, E.G.1    Kerr, T.A.2    Sakai, J.3
  • 22
    • 0342316532 scopus 로고    scopus 로고
    • Oxysterols: Modulators of cholesterol metabolism and other processes
    • Schroepfer GJ Jr. Oxysterols: modulators of cholesterol metabolism and other processes. Physiol Rev 2000; 80:361-554.
    • (2000) Physiol Rev , vol.80 , pp. 361-554
    • Schroepfer Jr., G.J.1
  • 23
    • 0033386688 scopus 로고    scopus 로고
    • Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1
    • Wu Z, Martin KO, Javitt NB, Chiang JY. Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1. J Lipid Res 1999; 40:2195-2203.
    • (1999) J Lipid Res , vol.40 , pp. 2195-2203
    • Wu, Z.1    Martin, K.O.2    Javitt, N.B.3    Chiang, J.Y.4
  • 24
    • 0034595650 scopus 로고    scopus 로고
    • Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol
    • Li-Hawkins J, Lund EG, Bronson AD, Russell DW. Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. J Biol Chem 2000; 275:16543-16549.
    • (2000) J Biol Chem , vol.275 , pp. 16543-16549
    • Li-Hawkins, J.1    Lund, E.G.2    Bronson, A.D.3    Russell, D.W.4
  • 25
    • 0030906963 scopus 로고    scopus 로고
    • High levels of (24S)-24-hydroxycholesterol 3-sulfate, 24-glucuronide in the serum and urine of children with severe cholestatic liver disease
    • Meng LJ, Griffiths WJ, Nazer H, et al. High levels of (24S)-24-hydroxycholesterol 3-sulfate, 24-glucuronide in the serum and urine of children with severe cholestatic liver disease. J Lipid Res 1997; 38:926-934.
    • (1997) J Lipid Res , vol.38 , pp. 926-934
    • Meng, L.J.1    Griffiths, W.J.2    Nazer, H.3
  • 26
    • 0032832986 scopus 로고    scopus 로고
    • Rapid hepatic metabolism of 7-ketocholesterol in vivo: Implications for dietary oxysterols
    • Lyons MA, Samman S, Gatto L, Brown AJ. Rapid hepatic metabolism of 7-ketocholesterol in vivo: implications for dietary oxysterols. J Lipid Res 1999; 40:1846-1857.
    • (1999) J Lipid Res , vol.40 , pp. 1846-1857
    • Lyons, M.A.1    Samman, S.2    Gatto, L.3    Brown, A.J.4
  • 27
    • 0035372651 scopus 로고    scopus 로고
    • Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: Implications for the development and treatment of atherosclerosis
    • Song C, Hiipakka RA, Liao S. Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis. Steroids 2001; 66:473-479.
    • (2001) Steroids , vol.66 , pp. 473-479
    • Song, C.1    Hiipakka, R.A.2    Liao, S.3
  • 28
    • 0035060475 scopus 로고    scopus 로고
    • Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: Abnormal levels of 24S- and 27-hydroxycholesterol
    • Bjorkhem I, Starck L, Andersson U, et al. Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. J Lipid Res 2001; 42:366-371.
    • (2001) J Lipid Res , vol.42 , pp. 366-371
    • Bjorkhem, I.1    Starck, L.2    Andersson, U.3
  • 29
    • 33750027681 scopus 로고    scopus 로고
    • Cytochrome P450s and cholesterol homeostasis
    • Pikuleva IA. Cytochrome P450s and cholesterol homeostasis. Pharmacol Ther 2006; 112:761-773.
    • (2006) Pharmacol Ther , vol.112 , pp. 761-773
    • Pikuleva, I.A.1
  • 30
    • 18544378347 scopus 로고    scopus 로고
    • Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol
    • Song BL, Javitt NB, DeBose-Boyd RA. Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. Cell Metab 2005; 1:179-189.
    • (2005) Cell Metab , vol.1 , pp. 179-189
    • Song, B.L.1    Javitt, N.B.2    DeBose-Boyd, R.A.3
  • 31
    • 19444366276 scopus 로고    scopus 로고
    • Residual cholesterol synthesis and simvastatin induction of cholesterol synthesis in Smith-Lemli-Opitz syndrome fibroblasts
    • Wassif CA, Krakowiak PA, Wright BS, et al. Residual cholesterol synthesis and simvastatin induction of cholesterol synthesis in Smith-Lemli-Opitz syndrome fibroblasts. Mol Genet Metab 2005; 85:96-107.
    • (2005) Mol Genet Metab , vol.85 , pp. 96-107
    • Wassif, C.A.1    Krakowiak, P.A.2    Wright, B.S.3
  • 32
    • 33748297599 scopus 로고    scopus 로고
    • Engelking LJ, Evers BM, Richardson JA, et al. Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. J Clin Invest 2006; 116:2356-2365. This milestone study addressed the question of whether the dysmorphism is attributable to the decrease in cholesterol synthesis or the increase in sterol intermediates in cholesterol synthesis? Their findings incriminate the intermediates.
    • Engelking LJ, Evers BM, Richardson JA, et al. Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. J Clin Invest 2006; 116:2356-2365. This milestone study addressed the question of whether the dysmorphism is attributable to the decrease in cholesterol synthesis or the increase in sterol intermediates in cholesterol synthesis? Their findings incriminate the intermediates.
  • 33
    • 33744788672 scopus 로고    scopus 로고
    • Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
    • Corcoran RB, Scott MP. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc Natl Acad Sci U S A 2006; 103:8408-8413.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 8408-8413
    • Corcoran, R.B.1    Scott, M.P.2
  • 34
    • 3242881654 scopus 로고    scopus 로고
    • Cytotoxicity of oxidized low-density lipoprotein in cultured RPE cells is dependent on the formation of 7-ketocholesterol
    • Rodriguez IR, Alam S, Lee JW. Cytotoxicity of oxidized low-density lipoprotein in cultured RPE cells is dependent on the formation of 7-ketocholesterol. Invest Ophthalmol Vis Sci 2004; 45:2830-2837.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 2830-2837
    • Rodriguez, I.R.1    Alam, S.2    Lee, J.W.3
  • 35
    • 0037409921 scopus 로고    scopus 로고
    • Oxysterol-induced toxicity in R28 and ARPE-19 cells
    • Ong JM, Aoki AM, Seigel GM, et al. Oxysterol-induced toxicity in R28 and ARPE-19 cells. Neurochem Res 2003; 28:883-891.
    • (2003) Neurochem Res , vol.28 , pp. 883-891
    • Ong, J.M.1    Aoki, A.M.2    Seigel, G.M.3
  • 37
    • 29844442746 scopus 로고    scopus 로고
    • Light-induced damage to the retina: Role of rhodopsin chromophore revisited
    • Rozanowska M, Sarna T. Light-induced damage to the retina: role of rhodopsin chromophore revisited. Photochem Photobiol 2005; 81:1305-1330.
    • (2005) Photochem Photobiol , vol.81 , pp. 1305-1330
    • Rozanowska, M.1    Sarna, T.2
  • 38
    • 28844447280 scopus 로고    scopus 로고
    • Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin
    • Jang YP, Matsuda H, Itagaki Y, et al. Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin. J Biol Chem 2005; 280:39732-39739.
    • (2005) J Biol Chem , vol.280 , pp. 39732-39739
    • Jang, Y.P.1    Matsuda, H.2    Itagaki, Y.3
  • 39
    • 33644763001 scopus 로고    scopus 로고
    • Age-related maculopathy and the impact of blue light hazard
    • Algvere PV, Marshall J, Seregard S. Age-related maculopathy and the impact of blue light hazard. Acta Ophthalmol Scand 2006; 84:4-15.
    • (2006) Acta Ophthalmol Scand , vol.84 , pp. 4-15
    • Algvere, P.V.1    Marshall, J.2    Seregard, S.3
  • 40
    • 33646078329 scopus 로고    scopus 로고
    • ABC A-subfamily transporters: Structure, function and disease
    • Kaminski WE, Piehler A, Wenzel JJ. ABC A-subfamily transporters: structure, function and disease. Biochim Biophys Acta 2006; 1762:510-524.
    • (2006) Biochim Biophys Acta , vol.1762 , pp. 510-524
    • Kaminski, W.E.1    Piehler, A.2    Wenzel, J.J.3


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