hnRNP E1 and E2 have distinct roles in modulating HIV-1 gene expression

Retrovirology

Volumn 4, Issue , 2007, Pages

  Woolaway, Kathryn ^a   Asai, Kengo ^a   Emili, Andrew ^a   Cochrane, Alan ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN E1; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN E2; MESSENGER RNA PRECURSOR; REV PROTEIN; STRUCTURAL PROTEIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA; DNA BINDING PROTEIN; GAG PROTEIN; GLYCOPROTEIN GP 120; KHDRBS1 PROTEIN, HUMAN; KHDRBS2 PROTEIN, HUMAN; MESSENGER RNA; REV PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; REV PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS-1; RNA BINDING PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EXON; GENE DELETION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INTRON; MUTAGENESIS; NONHUMAN; POLYADENYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RNA CLEAVAGE; RNA METABOLISM; RNA PROCESSING; RNA SPLICING; RNA TRANSLATION; TRANSCRIPTION REGULATION; VIRAL GENETICS; AMINO ACID SEQUENCE; BIOSYNTHESIS; GENETICS; HELA CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REGULATOR GENE; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; BASE SEQUENCE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, REV; GENES, REV; HELA CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HIV CORE PROTEIN P24; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; RNA SPLICING; RNA, MESSENGER; RNA, VIRAL; RNA-BINDING PROTEINS;

EID: 34248212743     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-4-28     Document Type: Article

References (66)

1. Bentley D The mRNA assembly line: Transcription and processing machines in the same factory Current Opinion in Cell Biology 2002 14 336-342 10.1016/S0955-0674(02)00333-2 12067656
2. Dirks RW Hattinger CM Molenaar C Snaar SP Synthesis, processing, and transport of RNA within the three-dimensional context of the cell nucleus Critical Reviews in Eukaryotic Gene Expression 1999 9 191-201 10651236
3. Jimenez-Garcia LF Spector DL In Vivo Evidence That Transcription and Splicing Are Coordinated by a Recruiting Mechanism. Cell 1993 73 47-59 10.1016/0092-8674(93)90159-N 8462102
4. Neugebauer KM On the importance of being co-transcriptional Journal of Cell Science 2002 115 3865-3871 10.1242/jcs.00073 12244124
5. Proudfoot NJ Furger A Dye MJ Integrating mRNA processing with transcription Cell 2002 108 501-512 10.1016/S0092-8674(02)00617-7 11909521
6. Hammell CM Gross S Zenklusen D Heath CV Stutz F Moore C Cole CN Coupling of termination, 3′ processing, and mRNA export Molecular & Cellular Biology 2002 22 6441-6457 10.1128/MCB.22.18.6441-6457.2002
7. Hector RE Nykamp KR Dheur S Anderson JT Non PJ Urbinati CR Wilson SM Minvielle-Sebastia L Swanson MS Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export EMBO Journal 2002 21 1800-1810 125947 11927564 10.1093/emboj/21.7.1800
8. Hilleren P McCarthy T Rosbash M Parker R Jensen T Quality control of mRNA 3′-end processing is linked to to the nuclear exosome. Nature 2001 413 538-542 10.1038/35097110 11586364
9. Dunn EF Hammell CM Hodge CA Cole CN Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export Genes & Development 2005 19 90-103 540228 15630021 10.1101/gad.1267005
10. Brune C Munchel SE Fischer N Podtelejnikov AV Weis K Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export Rna-A Publication of the Rna Society 2005 11 517-531
11. Tang H Kuhen KL Wong-Staal F Lentivirus replication and regulation. Annual Review of Genetics 1999 33 133-170 10.1146/annurev.genet.33.1.133 10690406
12. Pollard V Malim M The HIV-1 Rev Protein. Annual Review of Microbiology 1998 52 491-532 10.1146/annurev.micro.52.1.491 9891806
13. Hope TJ The ins and outs of HIV Rev. Archives of Biochemistry & Biophysics 1999 365 186-191 10.1006/abbi.1999.1207
14. Reddy TR Xu W Wong-Staal F General effect of Sam68 on Rev/Rex regulated expression of complex retroviruses. Oncogene 2000 19 4071-4074 10.1038/ sj.onc.1203749 10962565
15. Reddy T Xu W Mau J Goodwin C Suhasini M Tang H Frimpong K Rose D Wong-Staal F Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev. Nature Medicine 1999 5 635-642 10.1038/9479 10371501
16. Soros V Valderrarama Carvajal H Richard S Cochrane A Inhibition of Human Immunodeficiency Virus Type 1 Rev Function by a Dominant-Negative Mutant of Sam68 through Sequestration of Unspliced RNA at Perinuclear Bundles. J Virol 2001 75 8203-8215 115065 11483766 10.1128/ JVI.75.17.8203-8215.2001
17. McLaren M Asai K Cochrane A A novel function for Sam68: Enhancement of HIV-1 RNA 3′ end processing. RNA 2004 10 1119-1129 1370602 15208447 10.1261/rna.5263904
18. Chatel-Chaix L Clement JF Martel C Beriault V Gatignol A DesGroseillers L Mouland AJ Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles Molecular & Cellular Biology 2004 24 2637-2648 10.1128/MCB.24.7.2637-2648.2004
19. Mouland AJ Mercier J Luo M Bernier L DesGroseillers L Cohen EA The double-stranded RNA-binding protein Staufen is incorporated in human immunodeficiency virus type 1: Evidence for a role in genomic RNA encapsidation Journal of Virology 2000 74 5441-5451 112028 10823848 10.1128/JVI.74.12.5441-5451.2000
20. Junker U Bevec D Barske C Kalfoglou C Escaich S Dobrovnik M Hauber J Bohnlein E Intracellular expression of cellular eIF-5A mutants inhibits HIV-1 replication in human T cells: A feasibility study Human Gene Therapy 1996 7 1861-1869 8894678
21. Ruhl M Himmelspach M Bahr G Hammarschmid F Jaksche H Wolff B Aschauer H Farrington G Probst H Bevec D Hauber J Eukaryotic Initiation Factor 5A Is a Cellular Target of the Human Immunodeficiency Virus Type I Rev Activation Domain Mediating Trans-Activation. Journal of Cell Biology 1993 123 1309-1320 10.1083/jcb.123.6.1309 8253832
22. Sanchez-Velas N Udofia I Yu Z Zapp M hRIP, a cellular cofactor for Rev function, promotes release of HIV-1 RNAs from the perinuclear region. Genes & Dev 2004 18 23-34 314270 14701878 10.1101/gad.1149704
23. Dreyfuss G Matunis MJ Pinol-Roma S Burd CG hnRNP proteins and the biogenesis of mRNA Annual Review of Biochemistry 1993 62 289-321 10.1146/ annurev.bi.62.070193.001445 8352591
24. Caceres J Krainer A Mammalian pre-mRNA splicing factors. Eukaryotic pre-mRNA Processing Oxford, Oxford University Press Krainer A 1997 174-212
25. Mayeda A Krainer AR Regulation of alternative pre-mRNA splicing by hnRNPA1 and splicing factor SF2. Cell 1992 68 365-375 10.1016/ 0092-8674(92)90477-T 1531115
26. Asai K Platt C Cochrane A Control of HIV-1 env RNA splicing and transport: Investigating the role of hnRNP A1 in exon splicing silencer(ESS3a) function Virology 2003 314 229-242 10.1016/ S0042-6822(03)00400-8 14517076
27. Suh D Seguin B Atkinson S Ozdamar B Staffa A Emili A Mouland A Cochrane A Mapping of determinants required for the function of the HIV-1 env nuclear retention sequence Virology 2003 310 85-99 10.1016/ S0042-6822(03)00073-4 12788633
28. Tange TO Damgaard CK Guth S Valcarcel J Kjems J The hnRNP A1 protein regulates HIV-1 tat splicing via a novel intron silencer element EMBO Journal 2001 20 5748-5758 125679 11598017 10.1093/emboj/20.20.5748
29. Marchand V Mereau A Jacquenet S Thomas D Mougin A Gattoni R Stevenin J Branlant C A Janus splicing regulatory element modulates HIV-1 tat and rev mRNA production by coordination of hnRNP A1 cooperative binding Journal of Molecular Biology 2002 323 629-652 10.1016/ S0022-2836(02)00967-1 12419255
30. Bilodeau PS Domsic JK Mayeda A Krainer AR Stoltzfus CM RNA splicing at human immunodeficiency virus type 1 3′ splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element Journal of Virology 2001 75 8487-8497 115094 11507194 10.1128/ JVI.75.18.8487-8497.2001
31. Caputi M Mayeda A Krainer A Zahler A hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing. EMBO Journal 1999 18 4060-4067 1171481 10406810 10.1093/emboj/18.14.4060
32. Makeyev AV Liebhaber SA The poly(C)-binding proteins: A multiplicity of functions and a search for mechanisms Rna 2002 8 265-278 1370249 12003487 10.1017/S1355838202024627
33. Ostareck-Lederer A Ostareck DH Hentze MW Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2 Trends in Biochemical Sciences 1998 23 409-411 10.1016/S0968-0004(98)01301-2 9852755
34. Ostareck-Lederer A Ostareck D Control of mRNA translation and stability in haematopoetic cells: The function of hnRNPs K and E1/E2. Biol Cell 2004 96 407-411 10.1016/j.biolcel.2004.03.010 15384226
35. Makeyev AV Liebhaber SA Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins Genomics 2000 67 301-316 10.1006/geno.2000.6244 10936052
36. Tommerup N Leffers H Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A Genomics 1996 32 297-298 10.1006/geno.1996.0121 8833161
37. Blyn LB Swiderek KM Richards O Stahl DC Semler BL Ehrenfeld E Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5′ noncoding region: Identification by automated liquid chromatography-tandem mass spectrometry Proceedings of the National Academy of Sciences of the United States of America 1996 93 11115-11120 38293 8855318 10.1073/pnas.93.20.11115
38. Collier B Goobar-Larsson L Sokolowski M Schwartz S Translational inhibition in vitro of human papillomavirus type 16 L2 mRNA mediated through interaction with heterogenous ribonucleoprotein K and poly(rC)-binding proteins 1 and 2 Journal of Biological Chemistry 1998 273 22648-22656 10.1074/jbc.273.35.22648 9712894
39. Gamarnik AV Andino R Two functional complexes formed by KH domain containing proteins with the 5′ noncoding region of poliovirus RNA Rna 1997 3 882-892 1369533 9257647
40. Chkheidze AN Liebhaber SA A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins Molecular & Cellular Biology 2003 23 8405-8415 10.1128/MCB.23.23.8405-8415.2003
41. Leffers H Dejgaard K Celis JE Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains European Journal of Biochemistry 1995 230 447-453 10.1111/ j.1432-1033.1995.tb20581.x 7607214
42. Makeyev AV Chkheidze AN Liebhaber SA A set of highly conserved RNA-binding proteins, alphaCP-1 and alphaCP-2, implicated in mRNA stabilization, are coexpressed from an intronless gene and its intron-containing paralog Journal of Biological Chemistry 1999 274 24849-24857 10.1074/jbc.274.35.24849 10455157
43. Purcell D Martin MA Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity. J Virol 1993 67 6365-6378 238071 8411338
44. Malim MH Hauber J Le SY Maizel JV Cullen BR The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA Nature 1989 338 254-257 10.1038/ 338254a0 2784194
45. Pongoski J Asai K Cochrane A Positive and Negative Modulation of Human Immunodeficiency Virus Type 1 Rev Function by cis and trans Regulators of Viral RNA Splicing. J Virol 2002 76 5108-5120 136130 11967326 10.1128/ JVI.76.10.5108-5120.2002
46. Huang Y Carmichael GC Role of polyadenylation in nucleocytoplasmic transport of mRNA Molecular & Cellular Biology 1996 16 1534-1542
47. Malim MH Bohnlein S Hauber J Cullen BR Functional dissection of the HIV-1 rev trans-activator - derivation of a trans-dominant repressor of rev function Cell 1989 58 205-214 10.1016/0092-8674(89)90416-9 2752419
48. Chertova E Chertov O Coren LV Roser JD Trubey CM Bess JW Jr. Sowder RC 2nd Barsov E Hood BL Fisher RJ Nagashima K Conrads TP Veenstra TD Lifson JD Ott DE Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages J Virol 2006 80 9039-9052 1563931 16940516 10.1128/ JVI.01013-06
49. Kosturko LD Maggipinto MJ Korza G Lee JW Carson JH Barbarese E Heterogeneous nuclear ribonucleoprotein (hnRNP) E1 binds to hnRNP A2 and inhibits translation of A2 response element mRNAs Mol Biol Cell 2006 17 3521-3533 1525244 16775011 10.1091/mbc.E05-10-0946
50. Cochrane AW McNally MT Mouland AJ The retrovirus RNA trafficking granule: From birth to maturity Retrovirology 2006 3 18 1475878 16545126 10.1186/1742-4690-3-18
51. Stoltzfus CM Madsen JM Role of viral splicing elements and cellular RNA binding proteins in regulation of HIV-1 alternative RNA splicing Current HIV Research 2006 4 43-55 10.2174/157016206775197655 16454710
52. Ostareck DH Ostareck-Lederer A Wilm M Thiele BJ Mann M Hentze MW mRNA silencing in erythroid differentiation: HnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end Cell 1997 89 597-606 10.1016/ S0092-8674(00)80241-X 9160751
53. Ostareck DH Ostareck-Lederer A Shatsky IN Hentze MW Lipoxygenase mRNA silencing in erythroid differentiation: The 3′UTR regulatory complex controls 60S ribosomal subunit joining Cell 2001 104 281-290 10.1016/S0092-8674(01)00212-4 11207368
54. Paillard L Maniey D Lachaume P Legagneux V Osborne HB Identification of a C-rich element as a novel cytoplasmic polyadenylation element in Xenopus embryos Mechanisms of Development 2000 93 117-125 10.1016/ S0925-4773(00)00279-3 10781945
55. Weiss IM Liebhaber SA Erythroid cell-specific determinants of alpha-globin mRNA stability Molecular & Cellular Biology 1994 14 8123-8132
56. Weiss IM Liebhaber SA Erythroid cell-specific mRNA stability elements in the alpha 2-globin 3′ nontranslated region Molecular & Cellular Biology 1995 15 2457-2465
57. Kong J Ji X Liebhaber SA The KH-domain protein alpha CP has a direct role in mRNA stabilization independent of its cognate binding site Molecular & Cellular Biology 2003 23 1125-1134 10.1128/ MCB.23.4.1125-1134.2003
58. Wang Z Kiledjian M The poly(A)-binding protein and an mRNA stability protein jointly regulate an endoribonuclease activity Molecular & Cellular Biology 2000 20 6334-6341 10.1128/MCB.20.17.6334-6341.2000
59. Wang Z Day N Trifillis P Kiledjian M An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro Molecular & Cellular Biology 1999 19 4552-4560
60. Morales J Russell JE Liebhaber SA Destabilization of human alpha-globin mRNA by translation anti-termination is controlled during erythroid differentiation and is paralleled by phased shortening of the poly(A) tail Journal of Biological Chemistry 1997 272 6607-6613 10.1074/ jbc.272.48.30371 9045690
61. Kiledjian M DeMaria CT Brewer G Novick K Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex.[erratum appears in Mol Cell Biol 1997 Oct;17(10):6202] Molecular & Cellular Biology 1997 17 4870-4876
62. Zhu Y Sun Y Mao XO Jin KL Greenberg DA Expression of poly(C)-binding proteins is differentially regulated by hypoxia and ischemia in cortical neurons Neuroscience 2002 110 191-198 10.1016/S0306-4522(01)00522-X 11958862
63. Kriegler M Gene Transfer and Expression: A Laboratory Manual. New York, Stockton Press 1 1990
64. Chomczynski P Sacchi N Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 1987 162 156-159 10.1016/0003-2697(87)90021-2 2440339
65. Perkins A Cochrane AW Ruben SM Rosen CA Structural and functional characterization of the human immunodeficiency virus rev protein Journal of Acquired Immune Deficiency Syndromes 1989 2 256-263 2656990
66. Kislinger T Rahman K Radulovic D Cox B Rossant J Emili A PRISM, a generic large scale proteomic investigation strategy for mammals Molecular & Cellular Proteomics 2003 2 96-106 10.1074/ mcp.M200074-MCP200