Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the α-globin mRNA stability complex

Molecular and Cellular Biology

Volumn 17, Issue 8, 1997, Pages 4870-4876

  Kiledjian, Megerditch ^a   DeMaria, Christine T ^b   Brewer, Gary ^b   Novick, Kristine ^a  

^a RUTGERS UNIVERSITY   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; MESSENGER RNA; NUCLEAR RNA; POLYCYTIDYLIC ACID; RIBONUCLEOPROTEIN;

ARTICLE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN STABILITY; RNA METABOLISM;

EID: 0030856470     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.17.8.4870     Document Type: Article

References (72)

1. Aasheim, H.-C., T. Loukianova, A. Deggerdel, and E. B. Smeland. 1994. Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K. Nucleic Acids Res. 22:959-964.
2. Bastos, R. N., Z. Volloch, and H. Aviv. 1977. Messenger RNA population analysis during erythroid differentiation: a Kinetical approach. J. Mol. Biol. 110:191-203.
3. Beelman, C. A., and R. Parker. 1995. Degradation of mRNA in eukaryotes. Cell 81:179-183.
4. Brewer, G. 1991. An A+U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Mol. Cell. Biol. 11:2460-2466.
5. 4a.Brewer, G. Unpublished data.
6. Brewer, G., and J. Ross. 1990. Messenger RNA turnover in cell-free extracts. Methods Enzymol. 181:202-209.
7. Buckanovich, R. J., J. B. Posner, and R. B. Darnell. 1993. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Neuron 11:657-672.
8. Burd, C. G., and G. Dreyfuss. 1994. Conserved structure and diversity of functions of RNA-binding proteins. Science 265:615-621.
9. Caponigro, G., and R. Parker. 1996. Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae. Microbiol. Rev. 60:233-249.
10. Chen, C.-Y. A., and A.-B. Shyu. 1995. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20:465-470.
11. Choi, Y. D., and G. Dreyfuss. 1984. Monoclonal antibody characterization of the C proteins of heterogeneous nuclear ribonucleoprotein complexes in vertebrate cells. J. Cell Biol. 99:1997-2004.
12. Cobianchi, F., R. L. Karpel, K. R. Williams, V. Notario, and S. H. Wilson. 1988. Mammalian heterogeneous nuclear ribonucleoprotein complex protein A1. J. Biol. Chem. 263:1063-1071.
13. Decker, C. J., and R. Parker. 1994. Mechanisms of mRNA degradation in eukaryotes. Trends Biochem. Sci. 19:336-340.
14. Decker, C. J., and R. Parker. 1995. Diversity of cytoplasmic functions for the 3′ untranslated reuion of eukaryotic transcripts. Curr. Opin. Cell Biol. 7:386-392.
15. DeMaria, C. T., and G. Brewer. 1996. AUF1 binding affinity to A + U-rich elements correlates with rapid mRNA degradation. J. Biol. Chem. 271: 12179-12184.
16. Ebersole, T. A., Q. Chen, M. J. Justice, and K. Artzt. 1995. The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins. Nature Genet. 12:260-265.
17. Ehrenman, K., L. Long, B. J. Wagner, and G. Brewer. 1994. Characterization of cDNAs encoding the murine A + U-rich RNA-binding protein AUF1. Gene 149:315-319.
18. Feuerstein, R., X. Wang, D. Song, N. E. Cooke, and S. A. Liebhaber. 1994. The LIM/double zinc-finger motif functions as a protein dimerization domain. Proc. Natl. Acad. Sci. USA 91:10655-10659.
19. Eields, S., and O. Song. 1989. A novel genetic system to detect proteinprotein interactions. Nature 340:245-247.
20. Funke, B., B. Zulegar, R. Benavente, T. Schuster, M. Goller, J. Stevenin, and I. Horak. 1996. The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins. Nucleic Acids Res. 24:3821-3828.
21. Goller, M., B. Funke, C. Gehe-Becker, B. Kröger, F. Lottspeich, and I. Horak. 1994. Murine protein which binds preferentially to oligo-C-rich single stranded nucleic acids. Nucleic Acids Res. 22:1885-1889.
22. Greenberg, M. E., and J. G. Belasco. 1993. Control of the decay of labile protooncogene and cytokine mRNAs, p. 199-215. In J. G. Belasco and G. Brawerman (ed.), Control of mRNA stability. Academic Press, San Diego, Calif.
23. Greenleaf, A. L. 1993. Positive patches and negative noodles: linking RNA processing to transcription. Trends Biochem. Sci. 18:117-119.
24. Harford, J. B. 1993. Iron regulation of transferrin receptor mRNA stability, p. 239-262. In J. G. Belasco and G. Brawerman (ed.), Control of mRNA stability. Academic Press, San Diego, Calif.
25. Hentze, M. W. 1994. Enzymes as RNA-binding proteins: a role for (di)nucleotide-binding domains? Trends Biochem. Sci. 19:101-103.
26. Hentze, M. W., and P. Argos. 1991. Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase. Nucleic Acids Res. 19:1739-1740.
27. n. MoI. Cell. Bioll. 13: 4301-4310.
28. Ito, K., K. Sato, and H. Endo. 1994. Cloning and characterization of a single-stranded DNA binding protein that specifically recognizes deoxycytidine stretch. Nucleic Acids Res. 22:53-58.
29. Jackson, R. J. 1993. Cytoplasmic regulation of mRNA function: the importance of the 3′ untranslated region. Cell 74:9-14.
30. Jacobson, A. 1996. Poly(A) metabolism and translation: the closed loop model. In J. Hershey, M. Mathiews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
31. Jones, A. R., and T. Schedl. 1995. Mutations in gld-1, a female germ cell-specific tumor suppressor gene in Caenorhabditis elegans, effect a conserved domain also found in Src-associated protein Sam68. Genes Dev. 9:1491-1504.
32. Kajita, Y., J. Nakayama, M. Aizawas, and F. Ishikawa. 1995. The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein Do. J. Biol. Chem. 270:22167-22175.
33. Kaptain, S., W. E. Downey, C. Tang, C. Philpott, D. Haile, D. G. Orloff, J. B. Harford, T. A. Rouault, and R. D. Klausner. 1991. A regulated RNA binding protein also possesses aconitase activity. Proc. Natl. Acad. Sci. USA 88: 10109-10113.
34. Kearsey, S., and D. Kipling. 1991. Recombination and RNA processing: a common strand. Trends Cell Biol. 1:110-112.
35. Kennedy, M. C., L. Mende-Mueller, G. A. Blondin, and H. Beinert. 1992. Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein. Proc. Natl. Acad. Sci. USA 89:11730-11734.
36. Kiledjian, M., and G. Dreyfuss. 1992. Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box. EMBO J. 11: 2655-2664.
37. Kiledjian, M., C. G. Burd, M. Gorlach, D. S. Portman, and G. Dreyfuss. 1994. Structure and function of hnRNP proteins, p. 127-149. In K. Nagai and I. Mattaj (ed.), RNA-protein interactions: frontiers in molecular biology. Oxford University Press, Oxford, United Kingdom.
38. Kiledjian, M., X. Wang, and S. A. Liebhaber. 1995. Identification of two KH domain proteins in the α-globin mRNP stability complex. EMBO J. 14:4357-4364.
39. 37a.Kiledjian, M., and S. Liebhaber. Unpublished observations.
40. Klausner, R. D., T. A. Rouault, and J. B. Harford. 1993. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 72:19-28.
41. Lagnado, C. A., C. Y. Brown, and G. J. Goodall. 1994. AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence with AU-rich elements may be UUAUUUA(U/A)(U/A). Mol. Cell. Biol. 14:7984-7995.
42. Leffers, H., K. Deigaard, and J. E. Celis. 1995. Characterization of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains. Eur. J. Biochem. 230:447-453.
43. 4Oa.Liebhaber, S. Personal communication.
44. Liu, K., and M. M. Manna. 1995. NusA contacts nascent RNA in Esclierichia coli transcription complexes. J. Mol. Biol. 247:547-558.
45. Lodish, H. F., and B. Small. 1976. Different lifetimes of reticuloeyte messenger RNA. Cell 7:59-65.
46. Matunis, E. L., M. J. Matunis, and G. Dreyfuss. 1992. Characterization of the major hnRNP proteins from Drosophila melanogaster. J. Cell Biol. 116:257-269.
47. Peltz, S. W., and A. Jacobson. 1992. mRNA stability: in trans-it. Curr. Opin. Cell Biol. 4:979-983.
48. 44a.Piñol-Roma, S. Personal communication.
49. Piñol-Roma, S., Y. D. Choi, M. J. Matunis, and G. Dreyfuss. 1988. Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins. Genes Dev. 2:215-227.
50. Pollard, V. W., W. M. Michael, S. Nakielny, M. C. Siomi, F. Wang, and G. Dreyfuss. 1996. A novel receptor-mediated nuclear protein import pathway. Cell 86:985-994.
51. Ross, J. 1995. mRNA stability in mammalian cells. Microbiol. Rev. 59:423-450.
52. Rouault, T. A., C. D. Stout, S. Kaptain, J. B. Harford, and R. D. Klausner. 1991. Structural relationship between an iron-regulated RNA-binding protein (IRE-BP) and aconitase: functional implications. Cell 64:881-883.
53. Sachs, A. B. 1993. Messenger RNA degradation in eukaryotes. Cell 74:413-421.
54. Shatkin, A. 1985. mRNA cap binding proteins: essential factors for initiating translation. Cell 24:223-224.
55. Shyu, A.-B., J. G. Belasco, and M. E. Greenberg. 1991. Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. Genes Dev. 5:221-231.
56. Siomi, H., and G. Dreyfuss. 1995. A nuclear localization domain in the hnRNP A1 protein. J. Cell Biol. 129:551-559.
57. Siomi, H., M. C. Choi, R. L. Nussbaum, and G. Dreyfuss. 1994. Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome. Cell 77:33-39.
58. Siomi, M. C., H. Siomi, W. Sauer, S. Srinivasan, R. L. Nussbaum, and G. Dreyfuss. 1995. FXR1, an autosomal homolog of the fragile X mental retardation gene. EMBO J. 14:2401-2408.
59. Stevens, A. 1993. Eukaryotic nucleases and mRNA turnover, p. 449-467. In J. G. Belasco and G. Brawerman (ed.), Control of mRNA stability. Academic Press, San Diego, Calif.
60. Tafuri, S. R., M. Familari, and A. P. Wolffe. 1993. A mouse Y box protein, MSY1, is associated with paternal mRNA in spermatocytes. J. Biol. Chem. 268:12213-12220.
61. Tay, M., S.-H. Chan, and E.-C. Ren. 1992. Identiticalion and cloning of a novel heterogeneous nuclear ribonucleoprotein C-like protein that functions as a transcription activator of the hepatitis B virus enhancer II. J. Virol. 66:6841-6848.
62. Urlaub, H., V. Kruft, O. Bischof, E. C. Mueller, and B. Wittmann-Liebold. 1995. Protein-rRNA binding features and their structural and functional implications in ribosomes as determined by UV crosslinking studies. EMBO J. 14:4578-1588.
63. Verkerk, A. J., M. Pieretti, J. S. Sutcliffe, Y. H. Fu, D. P. Kuhl, A. Pizzuti, O. Reiner, S. Richards, M. F. Victoria, F. P. Zhang, B. E. Eussen, G.-J. B. van Ommen, L. A. J. Blonden, G. J. Riggins, J. L. Chastain, C. B. Kunst, H. Galijaard, C. T. Caskey, D. L. Nelson, B. A. Oostra, and S. T. Warren. 1991. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell 65:905-914.
64. Volloch, V., and D. Housman. 1981. Stability of globin mRNA in terminally differentiating murine erythroleukemia cells. Cell 23:509-514.
65. Wagner, B. J., L. Long, M. Pettenati, N. Rao, and G. Brewer. 1996. Localization and physical mapping of genes encoding the A + U-rich element RNA-binding proteins AUF1 to human chromosomes 4 and X. Genomics 34:219-222.
66. Wang, X., M. Kiledjian, I. M. Weiss, and S. A. Liebhaber. 1995 Detection and characterization of a 3′ untranslated region ribonucleoprotein complex associated with human α-globin mRNA stability. Mol. Cell. Biol. 15:1769-1777.
67. Weighardt, F., G. Biamonti, and S. Riva. 1995. Nucleo-cytoplasmic distribution of human hnRNP proteins: a search for the targeting domains in hnRNP Al. J. Cell Sci. 108:545-555.
68. Weiss, I. M., and S. A. Liebhaber. 1994. Erythroid cell-specific determinants of α-globin mRNA stability. Mol. Cell. Biol. 14:8123-8132.
69. Weiss, I. M., and S. A. Liebhaber. 1995. Erythroid cell-specific mRNA stability elements in the α2-globin 3′ nontranslated region. Mol. Cell. Biol. 15:2457-2465.
70. Zhang, W., B. Wagner, K. Ehrenman, A. W. Schaefer, C. T. DeMaria, D. Crater, K. DeHaven, L. Long, and G. Brewer. 1993. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol. Cell. Biol. 13:7652-7665.
71. Zhang, Y., J. P. O'Connor, M. C. Siomi, S. Srinivasan, A. Dutra, R. L. Nussbaum, and G. Dreyfuss. 1995. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. EMBO J. 14:5358-5366.
72. Zubiaga, A. M., J. G. Belasco, and M. E. Greenberg. 1995. The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol. Cell. Biol. 15:2219-2230.