Specialized roles of the two mitotic cyclins in somatic cells: Cyclin A as an activator of M phase-promoting factor

Molecular Biology of the Cell

Volumn 18, Issue 5, 2007, Pages 1861-1873

  Tsz, Kan Fung ^a   Hoi, Tang Ma ^a   Poon, Randy Y C ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN B; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1;

ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE REGULATION; CONTROLLED STUDY; DEREGULATION; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SOMATIC CELL;

EID: 34248184018     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E06-12-1092     Document Type: Article

References (58)

1. Aleem, E., Kiyokawa, H., and Kaldis, P. (2005). Cdc2-cyclin E complexes regulate the G1/S phase transition. Nat. Cell Biol. 7, 831-836.
2. Arooz, T., Yam, C. H., Siu, W. Y., Lau, A., Li, K. K., and Poon, R.Y.C. (2000). On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells. Biochemistry 39, 9494-9501.
3. Ausubel, F., Brent, R., Kingston, R., Moore, D., Seidman, J., Smith, J., and Struhl, K. (1991). Current Protocols in Molecular Biology, New York: John Wiley and Sons.
4. Ayad, N. G., Rankin, S., Murakami, M., Jebanathirajah, J., Gygi, S., and Kirschner, M. W. (2003). Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell 113, 101-113.
5. Bartek, J., Lukas, C., and Lukas, J. (2004). Checking on DNA damage in S phase. Nat. Rev. Mol. Cell Biol. 5, 792-804.
6. Berthet, C., Aleem, E., Coppola, V., Tessarollo, L., and Kaldis, P. (2003). Cdk2 knockout mice are viable. Curr. Biol. 13, 1775-1785.
7. Brandeis, M., Rosewell, I., Carrington, M., Crompton, T., Jacobs, M. A., Kirk, J., Gannon, J., and Hunt, T. (1998). Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. Proc. Natl. Acad. Sci. USA 95, 4344-4349.
8. Bulavin, D. V. et al. (2003). Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat. Cell Biol. 5, 545-551.
9. Chow, J. P., Siu, W. Y., Fung, T. K., Chan, W. M., Lau, A., Arooz, T., Ng, C. P., Yamashita, K., and Poon, R.Y.C. (2003a). DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase. Mol. Biol. Cell 14, 3989-4002.
10. Chow, J.P.H., Siu, W. Y., Ho, H.T.B., Ma, K.H.T., Ho, C. C., and Poon, R.Y.C. (2003b). Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints. J. Biol. Chem. 278, 40815-40828.
11. Clarke, P. R., Leiss, D., Pagano, M., and Karsenti, E. (1992). Cyclin A- and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts. EMBO J. 11, 1751-1761.
12. Devault, A., Fesquet, D., Cavadore, J. C., Garrigues, A. M., Labbe, J. C., Lorca, T., Picard, A., Philippe, M., and Doree, M. (1992). Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2. J. Cell Biol. 118, 1109-1120.
13. Doree, M., and Hunt, T. (2002). From Cdc2 to Cdk1, when did the cell cycle kinase join its cyclin partner? J. Cell Sci. 115, 2461-2464.
14. Ferrell, J. E., Jr. (2002). Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr. Opin. Cell Biol. 14, 140-148.
15. Fung, T. K., and Poon, R.Y.C. (2005). A roller coaster ride with the mitotic cyclins. Semin. Cell Dev. Biol. 16, 335-342.
16. Fung, T. K., Siu, W. Y., Yam, C. H., Lau, A., and Poon, R.Y.C. (2002). Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. J. Biol. Chem. 277, 35140-35149.
17. Fung, T. K., Yam, C. H., and Poon, R.Y.C. (2005). The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites. Cell Cycle 4, 1411-1420.
18. Furuno, N., den Elzen, N., and Pines, J. (1999). Human cyclin A is required for mitosis until mid prophase. J. Cell Biol. 147, 295-306.
19. Guadagno, T. M., and Newport, J. W. (1996). Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity. Cell 84, 73-82.
20. Harvey, S. L., Charlet, A., Haas, W., Gygi, S. P., and Kellogg, D. R. (2005). Cdk1-dependent regulation of the mitotic inhibitor Wee1. Cell 122, 407-420.
21. Hendzel, M. J., Wei, Y., Mancini, M. A., Van Hooser, A., Ranalli, T., Brinkley, B. R., Bazett-Jones, D. P., and Allis, C. D. (1997). Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106, 348-360.
22. Ho, C. C., Siu, W. Y., Chow, J. P., Lau, A., Arooz, T., Tong, H. Y., Ng, I. O., and Poon, R.Y.C. (2005). The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint. Exp. Cell Res. 304, 1-15.
23. Hu, B., Mitra, J., van den Heuvel, S., and Enders, G. H. (2001). S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human cells. Mol. Cell. Biol. 21, 2755-2766.
24. Hutchins, J. R., and Clarke, P. R. (2004). Many fingers on the mitotic trigger: post-translational regulation of the Cdc25C phosphatase. Cell Cycle 3, 41-45.
25. Inoue, D., and Sagata, N. (2005). The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs. EMBO J. 24, 1057-1067.
26. Li, K. K., Ng, I. O., Fan, S. T., Albrecht, J. H., Yamashita, K., and Poon, R.Y.C. (2002). Activation of cyclin-dependent kinases CDC2 and CDK2 in hepatocellular carcinoma. Liver 22, 259-268.
27. Liu, D., Matzuk, M. M., Sung, W. K., Guo, Q., Wang, P., and Wolgemuth, D. J. (1998). Cyclin A1 is required for meiosis in the male mouse. Nat. Genet. 20, 377-380.
28. Loog, M., and Morgan, D. O. (2005). Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature 434, 104-108.
29. Lorca, T., Labbe, J. C., Devault, A., Fesquet, D., Strausfeld, U., Nilsson, J., Nygren, P.A., Uhlen, M., Cavadore, J. C., and Doree, M. (1992). Cyclin A-cdc2 kinase does not trigger but delays cyclin degradation in interphase extracts of amphibian eggs. J. Cell Sci. 102(Pt 1), 55-62.
30. Ma, H. T., On, K. F., Tsang, Y. H., and Poon, R.Y.C. (2007). An inducible system for expression and validation of the specificity of short hairpin RNA in mammalian cells. Nucleic Acids Res. (in press).
31. Miller, M. E., and Cross, F. R. (2001). Cyclín specificity: how many wheels do you need on a unicycle? J. Cell Sci. 114, 1811-1820.
32. Mitra, J., and Enders, G. H. (2004). Cyclin A/Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells. Oncogene 23, 3361-3367.
33. Moore, J. D., Kirk, J. A., and Hunt, T. (2003). Unmasking the S-phase-promoting potential of cyclin B1. Science 300, 987-990.
34. Murphy, M., Stinnakre, M. G., Senamaud-Beaufort, C., Winston, N. J., Sweeney, C., Kubelka, M., Carrington, M., Brechot, C., and Sobczak-Thepot, J. (1997). Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat. Genet. 15, 83-86.
35. Nguyen, T. B., Manova, K., Capodieci, P., Lindon, C., Bottega, S., Wang, X. Y., Refik-Rogers, J., Pines, J., Wolgemuth, D. J., and Koff, A. (2002). Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin. J. Biol. Chem. 277, 41960-41969.
36. Ortega, S., Prieto, I., Odajima, J., Martin, A., Dubus, P., Sotillo, R., Barbero, J. L., Malumbres, M., and Barbacid, M. (2003). Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat. Genet. 35, 25-31.
37. Pomerening, J. R., Sontag, E. D., and Ferrell, J. E., Jr. (2003). Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat. Cell Biol. 5, 346-351.
38. Poon, R.Y.C., Chau, M. S., Yamashita, K., and Hunter, T. (1997). The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells. Cancer Res. 57, 5168-5178.
39. 160by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. Science 270, 90-93.
40. Poon, R.Y.C., and Hunter, T. (1998). Expression of a novel form of p21Cip1/ Waf1 in UV-irradiated and transformed cells. Oncogene 16, 1333-1343.
41. Poon, R.Y.C., Toyoshima, H., and Hunter, T. (1995). Redistribution of the CDK inhibitor p27 between different cyclin. CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol. Biol. Cell 6, 1197-1213.
42. Poon, R.Y.C., Yamashita, K., Adamczewski, J. P., Hunt, T., and Shuttleworth, J. (1993). The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2. EMBO J. 12, 3123-3132.
43. Siu, W. Y., Lau, A., Arooz, T., Chow, J. P., Ho, H. T., and Poon, R.Y.C. (2004). Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms. Mol. Cancer Ther. 3, 621-632.
44. Tetsu, O., and McCormick, F. (2003). Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell 3, 233-245.
45. Toyoshima-Morimoto, F., Taniguchi, E., and Nishida, E. (2002). Plk1 promotes nuclear translocation of human Cdc25C during prophase. EMBO Rep. 3, 341-348.
46. Toyoshima-Morimoto, F., Taniguchi, E., Shinya, N., Iwamatsu, A., and Nishida, E. (2001). Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase. Nature 410, 215-220.
47. van de Weerdt, B. C., van Vugt, M. A., Lindon, C., Kauw, J. J., Rozendaal, M. J., Klompmaker, R., Wolthuis, R. M., and Medema, R. H. (2005). Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1. Mol. Cell. Biol. 25, 2031-2044.
48. van Vugt, M. A., and Medema, R. H. (2004). Checkpoint adaptation and recovery: back with Polo after the break. Cell Cycle 3, 1383-1386.
49. Watanabe, N., Arai, H., Iwasaki, J., Shiina, M., Ogata, K., Hunter, T., and Osada, H. (2005). Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Proc. Natl. Acad. Sci. USA 102, 11663-11668.
50. Watanabe, N., Arai, H., Nishihara, Y., Taniguchi, M., Hunter, T., and Osada, H. (2004). M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc. Natl. Acad. Sci. USA 101, 4419-4424.
51. Woo, R. A., and Poon, R.Y.C. (2003). Cyclin-dependent kinases and S phase control in mammalian cells. Cell Cycle 2, 316-324.
52. Yam, C. H., Fung, T. K., and Poon, R.Y.C. (2002). Cyclin A in cell cycle control and cancer. Cell. Mol. Life Sci. 59, 1317-1326.
53. Yam, C. H., Ng, R. W., Siu, W. Y., Lau, A. W., and Poon, R.Y.C. (1999a). Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2. Mol. Cell. Biol. 19, 635-645.
54. Yam, C. H., Siu, W. Y., Arooz, T., Chiu, C. H., Lau, A., Wang, X. Q., and Poon, R.Y.C. (1999b). MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins. Cancer Res. 59, 5075-5078.
55. Yam, C. H., Siu, W. Y., Kaganovich, D., Ruderman, J. V., and Poon, R.Y.C. (2001). Cleavage of cyclin A at R70/R71 by the bacterial protease OmpT. Proc. Natl. Acad. Sci. USA 98, 497-501.
56. Yam, C. H., Siu, W. Y., Lau, A., and Poon, R.Y.C. (2000). Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2. J. Biol. Chem. 275, 3158-3167.
57. Yu, J. Y., DeRuiter, S. L., and Turner, D. L. (2002). RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc. Natl. Acad. Sci. USA 99, 6047-6052.
58. Yuan, J., Eckerdt, F., Bereiter-Hahn, J., Kurunci-Csacsko, E., Kaufmann, M., and Strebhardt, K. (2002). Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. Oncogene 21, 8282-8292.