The origins of femtomolar protein-ligand binding: Hydrogen-bond cooperativity and desolvation energetics in the biotin-(strept)avidin binding site

Journal of the American Chemical Society

Volumn 129, Issue 17, 2007, Pages 5419-5429

  DeChancie, Jason ^a   Houk, K N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN BONDS; LIGANDS; MOLECULAR DYNAMICS; QUANTUM THEORY; UREA;

DESOLVATION; REVERSIBLE BINDING; UREIDO MOIETY;

PROTEINS;

ASPARTIC ACID; BIOTIN; STREPTAVIDIN; UREA; WATER;

AQUEOUS SOLUTION; ARTICLE; BINDING SITE; COOPERATION; ELECTRIC ACTIVITY; ENERGY TRANSFER; HYDROGEN BOND; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULE; POLARIZATION; PREDICTION; SOLVATION;

BICYCLO COMPOUNDS; BINDING SITES; BIOTIN; ENERGY TRANSFER; HYDROGEN BONDING; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEINS; QUANTUM THEORY; SOLVENTS; STREPTAVIDIN;

EID: 34247897078     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja066950n     Document Type: Article

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