An analysis of the origins of a cooperative binding energy of dimerization

Science

Volumn 280, Issue 5364, 1998, Pages 711-714

  Williams, Dudley H ^a   Maguire, Alison J ^b   Tsuzuki, Wakako ^c   Westwell, Martin S ^d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG BINDING PROTEIN; VANCOMYCIN;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DIMERIZATION; DRUG PROTEIN BINDING; LIGAND BINDING; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN CONFORMATION;

EID: 0032076269     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5364.711     Document Type: Article

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17. We thank BBSRC for financial support. A.J.M. gratefully acknowledges SmithKline Beecham, and M.S.W. thanks GlaxoWellcome Research and Lincoln College, Oxford. W.T. thanks the National Institute of Food Research, Ministry of Agriculture, Food, and Fisheries, Japan. Vancomycin, dechlorovancomycin (LY223997), chloroeremomycin (LY264826), and phenylbenzylchloroeremomycin (LY307599) were generously donated by Eli Lilly (Indianapolis, IN). Eremomycin was a gift from SmithKline Beecham (Harlow, UK).