메뉴 건너뛰기




Volumn 2, Issue 2, 2006, Pages 53-59

Molecular genetics of colorectal cancer: An overview

Author keywords

[No Author keywords available]

Indexed keywords


EID: 34247894942     PISSN: 15563790     EISSN: 15563804     Source Type: Journal    
DOI: 10.1007/s11888-006-0002-2     Document Type: Review
Times cited : (29)

References (65)
  • 1
    • 84873375790 scopus 로고    scopus 로고
    • American Cancer Society: Cancer Facts & Figures Accessed January 31, 2006
    • American Cancer Society: Cancer Facts & Figures 2005 http://www.cancer.org/downloads/STT CAFF2005f4PWSecured.pdf. Accessed January 31, 2006.
    • (2005)
  • 2
    • 25144450836 scopus 로고    scopus 로고
    • Genetics of colorectal cancer
    • Hisamuddin IM, Yang VW: Genetics of colorectal cancer. MedGenMed 2004, 6:13-19.
    • (2004) MedGenMed , vol.6 , pp. 13-19
    • Hisamuddin, I.M.1    Yang, V.W.2
  • 3
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 1990, 61:759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 4
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW, Vogelstein B: Lessons from hereditary colorectal cancer. Cell 1996, 87:159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 5
    • 0032521433 scopus 로고    scopus 로고
    • Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
    • Sparks AB, Morin PJ, Vogelstein B, et al.: Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res 1998, 58:1130-1134.
    • (1998) Cancer Res , vol.58 , pp. 1130-1134
    • Sparks, A.B.1    Morin, P.J.2    Vogelstein, B.3
  • 6
    • 4944240144 scopus 로고    scopus 로고
    • Genetic predisposition to colorectal cancer
    • de la Chapelle A: Genetic predisposition to colorectal cancer. Nat Rev Cancer 2004, 4:769-780.
    • (2004) Nat Rev Cancer , vol.4 , pp. 769-780
    • De La Chapelle, A.1
  • 7
    • 0032524104 scopus 로고    scopus 로고
    • Landscaping the cancer terrain
    • Kinzler KW, Vogelstein B: Landscaping the cancer terrain. Science 1998, 280:1036-1037.
    • (1998) Science , vol.280 , pp. 1036-1037
    • Kinzler, K.W.1    Vogelstein, B.2
  • 9
    • 0025817880 scopus 로고
    • Identification of FAP locus genes from chromosome 5q21
    • Kinzler KW, Nilbert MC, Su LK, et al.: Identification of FAP locus genes from chromosome 5q21. Science 1991, 253:661-665.
    • (1991) Science , vol.253 , pp. 661-665
    • Kinzler, K.W.1    Nilbert, M.C.2    Su, L.K.3
  • 10
    • 0025899162 scopus 로고
    • Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    • Nishisho I, Nakamura Y, Miyoshi Y, et al.: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 1991, 253:665-669.
    • (1991) Science , vol.253 , pp. 665-669
    • Nishisho, I.1    Nakamura, Y.2    Miyoshi, Y.3
  • 11
    • 0025938038 scopus 로고
    • Identification and characterization of the familial adenomatous polyposis coli gene
    • Groden J, Thliveris A, Samowitz W, et al.: Identification and characterization of the familial adenomatous polyposis coli gene. Cell 1991, 66:589-600.
    • (1991) Cell , vol.66 , pp. 589-600
    • Groden, J.1    Thliveris, A.2    Samowitz, W.3
  • 12
    • 0031781181 scopus 로고    scopus 로고
    • Genotype-phenotype correlations in attenuated adenomatous polyposis coli
    • Soravia C, Berk T, Madlensky L, et al.: Genotype-phenotype correlations in attenuated adenomatous polyposis coli. Am J Hum Genet 1998, 62:1290-1301.
    • (1998) Am J Hum Genet , vol.62 , pp. 1290-1301
    • Soravia, C.1    Berk, T.2    Madlensky, L.3
  • 13
    • 16944365288 scopus 로고    scopus 로고
    • Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC
    • Laken SJ, Petersen GM, Gruber SB, et al.: Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nat Genet 1997, 17:79-83.
    • (1997) Nat Genet , vol.17 , pp. 79-83
    • Laken, S.J.1    Petersen, G.M.2    Gruber, S.B.3
  • 14
    • 0032934336 scopus 로고    scopus 로고
    • Cancer, crash sites, and the new genetics of neoplasia
    • Gruber SB, Petersen GM, Kinzler KW, et al.: Cancer, crash sites, and the new genetics of neoplasia. Gastroenterology 1999, 116:210-212.
    • (1999) Gastroenterology , vol.116 , pp. 210-212
    • Gruber, S.B.1    Petersen, G.M.2    Kinzler, K.W.3
  • 15
    • 0037468517 scopus 로고    scopus 로고
    • Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH
    • Sieber OM, Lipton L, Crabtree M, et al.: Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N Engl J Med 2003, 348:791-799.
    • (2003) N Engl J Med , vol.348 , pp. 791-799
    • Sieber, O.M.1    Lipton, L.2    Crabtree, M.3
  • 16
    • 0037408432 scopus 로고    scopus 로고
    • Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers
    • Halford SE, Rowan AJ, Lipton L, et al.: Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers. Am J Pathol 2003, 162:1545-1548.
    • (2003) Am J Pathol , vol.162 , pp. 1545-1548
    • Halford, S.E.1    Rowan, A.J.2    Lipton, L.3
  • 17
    • 0026088343 scopus 로고
    • Tumor spectrum in cancer family syndrome (hereditary nonpolyposis colorectal cancer)
    • Mecklin J P, Jarvinen HJ: Tumor spectrum in cancer family syndrome (hereditary nonpolyposis colorectal cancer). Cancer 1991, 68:1109-1112.
    • (1991) Cancer , vol.68 , pp. 1109-1112
    • Mecklin, J.P.1    Jarvinen, H.J.2
  • 18
    • 0030739106 scopus 로고    scopus 로고
    • Molecular basis of HNPCC: Mutations of MMR genes
    • Papadopoulos N, Lindblom A: Molecular basis of HNPCC: mutations of MMR genes. Hum Mutat 1997, 10:89-99.
    • (1997) Hum Mutat , vol.10 , pp. 89-99
    • Papadopoulos, N.1    Lindblom, A.2
  • 19
    • 0029066689 scopus 로고
    • Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
    • Markowitz S, Wang J, Myeroff L, et al.: Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 1995, 268:1336-1338.
    • (1995) Science , vol.268 , pp. 1336-1338
    • Markowitz, S.1    Wang, J.2    Myeroff, L.3
  • 20
    • 16144368515 scopus 로고    scopus 로고
    • Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours
    • Souza RF, Appel R, Yin J, et al.: Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. Nat Genet 1996, 14:255-257.
    • (1996) Nat Genet , vol.14 , pp. 255-257
    • Souza, R.F.1    Appel, R.2    Yin, J.3
  • 21
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • Rampino N, Yamamoto H, Ionov Y, et al.: Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997, 275:967-969.
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3
  • 22
    • 0032495530 scopus 로고    scopus 로고
    • A serine/thre-onine kinase gene defective in Peutz-Jeghers syndrome
    • Hemminki A, Markie D, Tomlinson I, et al.: A serine/thre-onine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998, 391:184-187.
    • (1998) Nature , vol.391 , pp. 184-187
    • Hemminki, A.1    Markie, D.2    Tomlinson, I.3
  • 23
    • 0031974516 scopus 로고    scopus 로고
    • Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
    • Jenne DE, Reimann H, Nezu J, et al.: Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 1998, 18:38-43.
    • (1998) Nat Genet , vol.18 , pp. 38-43
    • Jenne, D.E.1    Reimann, H.2    Nezu, J.3
  • 24
    • 0036842005 scopus 로고    scopus 로고
    • Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis
    • Sayed MG, Ahmed AF, Ringold JR, et al.: Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis. Ann Surg Oncol 2002, 9:901-906.
    • (2002) Ann Surg Oncol , vol.9 , pp. 901-906
    • Sayed, M.G.1    Ahmed, A.F.2    Ringold, J.R.3
  • 26
    • 0032853452 scopus 로고    scopus 로고
    • PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome
    • Marsh DJ, Kum JB, Lunetta KL, et al.: PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome. Hum Mol Genet 1999, 8:1461-1472.
    • (1999) Hum Mol Genet , vol.8 , pp. 1461-1472
    • Marsh, D.J.1    Kum, J.B.2    Lunetta, K.L.3
  • 27
    • 0036727472 scopus 로고    scopus 로고
    • APC as a checkpoint gene: The beginning or the end?
    • Yang VW: APC as a checkpoint gene: the beginning or the end? Gastroenterology 2002, 123:935-939.
    • (2002) Gastroenterology , vol.123 , pp. 935-939
    • Yang, V.W.1
  • 28
    • 0031006251 scopus 로고    scopus 로고
    • APC expression in normal human tissues
    • Midgley CA, White S, Howitt R, et al.: APC expression in normal human tissues. J Pathol 1997, 181:426-433.
    • (1997) J Pathol , vol.181 , pp. 426-433
    • Midgley, C.A.1    White, S.2    Howitt, R.3
  • 29
    • 8444236025 scopus 로고    scopus 로고
    • The adenomatous polyposis coli protein: The Achilles heel of the gut epithelium
    • Nathke IS: The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium. Annu Rev Cell Dev Biol 2004, 20:337-366.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 337-366
    • Nathke, I.S.1
  • 30
    • 0035835826 scopus 로고    scopus 로고
    • The many faces of the tumor suppressor gene APC
    • van Es JH, Giles RH, Clevers HC: The many faces of the tumor suppressor gene APC. Exp Cell Res 2001, 264:126-134.
    • (2001) Exp Cell Res , vol.264 , pp. 126-134
    • Van Es, J.H.1    Giles, R.H.2    Clevers, H.C.3
  • 31
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signaling in stem cells and cancer
    • Reya T, Clevers H: Wnt signaling in stem cells and cancer. Nature 2005, 434:843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 32
    • 17444423289 scopus 로고    scopus 로고
    • Wnt signaling in the intestinal epithelium: From endoderm to cancer
    • Gregorieff A, Clevers H: Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev 2005, 19:877-890.
    • (2005) Genes Dev , vol.19 , pp. 877-890
    • Gregorieff, A.1    Clevers, H.2
  • 33
    • 0029994517 scopus 로고    scopus 로고
    • A new member of the frizzled family from Drosophila functions as a Wingless receptor
    • Bhanot P, Brink M, Samos CH, et al.: A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 1996, 382:225-230.
    • (1996) Nature , vol.382 , pp. 225-230
    • Bhanot, P.1    Brink, M.2    Samos, C.H.3
  • 34
    • 0034727104 scopus 로고    scopus 로고
    • LDL-receptor-related proteins in Wnt signal transduction
    • Tamai K, Semenov M, Kato Y, et al.: LDL-receptor-related proteins in Wnt signal transduction. Nature 2000, 407:530-535.
    • (2000) Nature , vol.407 , pp. 530-535
    • Tamai, K.1    Semenov, M.2    Kato, Y.3
  • 35
    • 0034727078 scopus 로고    scopus 로고
    • An LDL-receptor-related protein mediates Wnt signalling in mice
    • Pinson KI, Brennan J, Monkley S, et al.: An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 2000, 407:535-538.
    • (2000) Nature , vol.407 , pp. 535-538
    • Pinson, K.I.1    Brennan, J.2    Monkley, S.3
  • 36
    • 0029781509 scopus 로고    scopus 로고
    • Functional interaction of beta-catenin with the transcription factor LEF-1
    • Behrens J, von Kries JP, Kuhl M, et al.: Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 1996, 382:638-642.
    • (1996) Nature , vol.382 , pp. 638-642
    • Behrens, J.1    Von Kries, J.P.2    Kuhl, M.3
  • 37
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • He TC, Sparks AB, Rago C, et al.: Identification of c-MYC as a target of the APC pathway. Science 1998, 281:1509-1512.
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1    Sparks, A.B.2    Rago, C.3
  • 38
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu O, McCormick F: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999, 398:422-426.
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 39
    • 0026894053 scopus 로고
    • Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
    • Miyoshi Y, Nagase H, Ando H, et al.: Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1992, 1:229-233.
    • (1992) Hum Mol Genet , vol.1 , pp. 229-233
    • Miyoshi, Y.1    Nagase, H.2    Ando, H.3
  • 40
    • 0242268881 scopus 로고    scopus 로고
    • Detection of point mutations of the Axin1 gene in colorectal cancers
    • Jin LH, Shao QJ, Luo W, et al.: Detection of point mutations of the Axin1 gene in colorectal cancers. Int J Cancer 2003, 107:696-699.
    • (2003) Int J Cancer , vol.107 , pp. 696-699
    • Jin, L.H.1    Shao, Q.J.2    Luo, W.3
  • 41
    • 0033948526 scopus 로고    scopus 로고
    • Sequence variants of the axin gene in breast, colon, and other cancers: An analysis of mutations that interfere with GSK3 binding
    • Webster MT, Rozycka M, Sara E, et al.: Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. Genes Chromosomes Cancer 2000, 28:443-453.
    • (2000) Genes Chromosomes Cancer , vol.28 , pp. 443-453
    • Webster, M.T.1    Rozycka, M.2    Sara, E.3
  • 42
    • 0027991585 scopus 로고
    • Wild-type but not mutant APC associates with the microtubule cytoskeleton
    • Smith KJ, Levy DB, Maupin P, et al.: Wild-type but not mutant APC associates with the microtubule cytoskeleton. Cancer Res 1994, 54:3672-3675.
    • (1994) Cancer Res , vol.54 , pp. 3672-3675
    • Smith, K.J.1    Levy, D.B.2    Maupin, P.3
  • 43
    • 0029066006 scopus 로고
    • APC binds to the novel protein EB1
    • Su LK, Burrell M, Hill DE, et al.: APC binds to the novel protein EB1. Cancer Res 1995, 55:2972-2977.
    • (1995) Cancer Res , vol.55 , pp. 2972-2977
    • Su, L.K.1    Burrell, M.2    Hill, D.E.3
  • 44
    • 9344271549 scopus 로고    scopus 로고
    • Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein
    • Matsumine A, Ogai A, Senda T, et al.: Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science 1996, 272:1020-1023.
    • (1996) Science , vol.272 , pp. 1020-1023
    • Matsumine, A.1    Ogai, A.2    Senda, T.3
  • 45
    • 0035070046 scopus 로고    scopus 로고
    • Mutations in the APC tumor suppressor gene cause chromosomal instability
    • Fodde R, Kuipers J, Rosenberg C, et al.: Mutations in the APC tumor suppressor gene cause chromosomal instability. Nat Cell Biol 2001, 3:433-438.
    • (2001) Nat Cell Biol , vol.3 , pp. 433-438
    • Fodde, R.1    Kuipers, J.2    Rosenberg, C.3
  • 46
    • 0035067391 scopus 로고    scopus 로고
    • A role for the adenomatous polyposis coli protein in chromosome segregation
    • Kaplan KB, Burds AA, Swedlow JR, et al.: A role for the adenomatous polyposis coli protein in chromosome segregation. Nat Cell Biol 2001, 3:429-432.
    • (2001) Nat Cell Biol , vol.3 , pp. 429-432
    • Kaplan, K.B.1    Burds, A.A.2    Swedlow, J.R.3
  • 47
    • 30544448075 scopus 로고    scopus 로고
    • Chromosomal changes in colorectal adenomas: Relationship to gene mutations and potential for clinical utility
    • Leslie A, Stewart A, Baty DU, et al.: Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility. Genes Chromosomes Cancer 2005, 45:126-135.
    • (2005) Genes Chromosomes Cancer , vol.45 , pp. 126-135
    • Leslie, A.1    Stewart, A.2    Baty, D.U.3
  • 49
    • 0024536654 scopus 로고
    • Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
    • Baker SJ, Fearon ER, Nigro JM, et al.: Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 1989, 244:217-221.
    • (1989) Science , vol.244 , pp. 217-221
    • Baker, S.J.1    Fearon, E.R.2    Nigro, J.M.3
  • 51
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, et al.: The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992, 69:1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3
  • 52
    • 0033521621 scopus 로고    scopus 로고
    • Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
    • Honda R, Yasuda H: Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. Embo J 1999, 18:22-27.
    • (1999) Embo J , vol.18 , pp. 22-27
    • Honda, R.1    Yasuda, H.2
  • 53
    • 1342347878 scopus 로고    scopus 로고
    • How the nucleolar sequestration of p53 protein or its interplayers contributes to its (re)-acti-vation
    • Wsierska-Gadek J, Horky M: How the nucleolar sequestration of p53 protein or its interplayers contributes to its (re)-acti-vation. Ann N Y Acad Sci 2003, 1010:266-272.
    • (2003) Ann N y Acad Sci , vol.1010 , pp. 266-272
    • Wsierska-Gadek, J.1    Horky, M.2
  • 55
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • Harris SL, Levine AJ: The p53 pathway: positive and negative feedback loops. Oncogene 2005, 24:2899-2908.
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 56
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • el-Deiry WS, Tokino T, Velculescu VE, L et al.: WAF1, a potential mediator of p53 tumor suppression. Cell 1993, 75:817-825.
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.S.1    Tokino, T.2    Velculescu, V.E.3
  • 57
    • 0035810054 scopus 로고    scopus 로고
    • Regulation of the G2/M transition by p53
    • Taylor WR, Stark GR: Regulation of the G2/M transition by p53. Oncogene 2001, 20:1803-1815.
    • (2001) Oncogene , vol.20 , pp. 1803-1815
    • Taylor, W.R.1    Stark, G.R.2
  • 58
    • 0031310665 scopus 로고    scopus 로고
    • 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression
    • Hermeking H, Lengauer C, Polyak K, et al.: 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell 1997, 1:3-11.
    • (1997) Mol Cell , vol.1 , pp. 3-11
    • Hermeking, H.1    Lengauer, C.2    Polyak, K.3
  • 59
    • 0037805547 scopus 로고    scopus 로고
    • RAS oncogenes: The first 30 years
    • Malumbres M, Barbacid M: RAS oncogenes: the first 30 years. Nat Rev Cancer 2003, 3:459-465.
    • (2003) Nat Rev Cancer , vol.3 , pp. 459-465
    • Malumbres, M.1    Barbacid, M.2
  • 60
    • 0034175984 scopus 로고    scopus 로고
    • Understanding Ras "it ain't over 'til it's over.'"
    • Shields JM, Pruitt K, McFall A, et al.: Understanding Ras: "it ain't over 'til it's over.'" Trends Cell Biol 2000, 10:147-154.
    • (2000) Trends Cell Biol , vol.10 , pp. 147-154
    • Shields, J.M.1    Pruitt, K.2    McFall, A.3
  • 61
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos JL: Ras oncogenes in human cancer: a review. Cancer Res 1989, 49:4682-4689.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 62
    • 0035444798 scopus 로고    scopus 로고
    • Kirsten ras mutations in patients with colorectal cancer: The "rASCAL II" study
    • Andreyev HJ, Norman AR, Cunningham D, et al.: Kirsten ras mutations in patients with colorectal cancer: the "RASCAL II" study. Br J Cancer 2001, 85:692-696.
    • (2001) Br J Cancer , vol.85 , pp. 692-696
    • Andreyev, H.J.1    Norman, A.R.2    Cunningham, D.3
  • 63
    • 0037194728 scopus 로고    scopus 로고
    • Tumorigen-esis: RAF/RAS oncogenes and mismatch-repair status
    • Rajagopalan H, Bardelli A, Lengauer C, et al.: Tumorigen-esis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002, 418:934.
    • (2002) Nature , vol.418 , pp. 934
    • Rajagopalan, H.1    Bardelli, A.2    Lengauer, C.3
  • 64
    • 11144356354 scopus 로고    scopus 로고
    • Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects
    • Tuveson DA, Shaw AT, Willis NA, et al.: Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 2004, 5:375-387.
    • (2004) Cancer Cell , vol.5 , pp. 375-387
    • Tuveson, D.A.1    Shaw, A.T.2    Willis, N.A.3
  • 65
    • 0036328995 scopus 로고    scopus 로고
    • Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice
    • Janssen KP, el-Marjou F, Pinto D, et al.: Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice. Gastroenterology 2002, 123:492-504.
    • (2002) Gastroenterology , vol.123 , pp. 492-504
    • Janssen, K.P.1    El-Marjou, F.2    Pinto, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.