APC as a checkpoint gene: The beginning or the end?

Gastroenterology

Volumn 123, Issue 3, 2002, Pages 935-939

  Yang, Vincent W ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; WNT PROTEIN;

COLORECTAL CANCER; DOWN REGULATION; EDITORIAL; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

EID: 0036727472     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.35773     Document Type: Article

References (33)

1. Colon cancer screening
2. Identification and characterization of the familial adenomatous polyposis coli gene
3. Identification of FAP locus genes from chromosome 5q21
4. APC mutations occur early during colorectal tumorigenesis
5. Landscaping the cancer terrain
6. APC expression in normal human tissues
7. The many faces of the tumor suppressor gene APC
8. Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A
9. Asef, a link between the tumor suppressor APC and G-protein signaling
10. Association of the APC gene product with beta-catenin
11. Association of the APC tumor suppressor protein with catenins
12. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
13. Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
14. APC binds to the novel protein EB1
15. Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm
16. Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover
17. Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
18. Beta-catenin is a target for the ubiquitin-proteasome pathway
19. Dishevelled: At the crossroads of divergent intracellular signaling pathways
20. Functional interaction of beta-catenin with the transcription factor LEF-1
21. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
22. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors
23. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
24. The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/Rb pathway
25. Identification of c-MYC as a target of the APC pathway
26. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
27. Cancer cell cycles
28. Genetic instabilities in human cancers
29. A role for the adenomatous polyposis coli protein in chromosome segregation
30. Mutations in the APC tumour suppressor gene cause chromosomal instability
31. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
32. Apc1638T: A mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development