Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene

Journal of Endocrinology

Volumn 167, Issue 2, 2000, Pages 253-263

  Walsh, L P ^a   Webster, D R ^a   Stocco, D M ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME P450; DIMETHOATE; INSECTICIDE; PROGESTERONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HORMONE SYNTHESIS; INFERTILITY; LEYDIG CELL; MALE FERTILITY; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; STEROIDOGENESIS; TRANSCRIPTION REGULATION;

EID: 0033769632     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1670253     Document Type: Article

References (37)

1. Influence of dimethoate on testicular and epididymal organs, testosterone plasma level and their tissue residues in rats
2. Noncoordinate regulation of de novo synthesis of cytochrome P-450 cholesterol side chain cleavage and cytochrome P-450 17 alpha- hydroxylase/C17-C20 lyase in mouse Leydig cell cultures: Relation to steroid production
3. Characterization of several clonal lines of cultured Leydig tumor cells: Gonadotropin receptors and steroidogenic responses
4. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
5. Diethylumbelliferyl phosphate inhibits steroidogenesis by interfering with a long-lived factor acting between protein kinase A activation and induction of the steroidogenic acute regulatory protein (StAR)
6. The effect of organophosphate insecticides on adrenal corticosterone formation
7. Studies on the mechanism of inhibition of adrenal steroidogenesis by organophosphate and carbamate compounds
8. The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)
9. Hormonal and developmental regulation of the steroidogenic acute regulatory protein
10. Inhibition of transcription affects synthesis of steroidogenic acute regulatory protein and steroidogenesis in MA-10 mouse Leydig tumor cells
11. Reproductive toxicity, of dimethyl methyl phosphonate (DMMP) in the male Fischer 344 rat
12. Studies on the role of protein synthesis in the regulation of corticosterone production by ACTH in vivo
13. Nuclear runoff transcription in mammalian cells
14. Effect of chlorpynfos on Holstein steers and testosterone-treated Holstein bulls
15. Influence of DDT, DDVP and malathion on FSH, LH and testosterone serum levels and testosterone concentration in testis
16. Alterations of the seminiferous epithelium and the Leydig cells of the mouse testis after the application of dichlorvos (DDVP)
17. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis
18. Mixtures of benomyl, pirimiphos-methyl, dimethoate, diazinon and azinphos-methyl affect protein synthesis in HL-60 cells differently
19. Effect of cholesterol transport inhibitors on steroidogenesis and plasma membrane cholesterol transport in cultured MA-10 Leydig tumor cells
20. Genotype at the P450 scc locus determines differences in the amount of P450 scc protein and maximal testosterone production in mouse Leydig cells
21. Structure, function and regulation of steroidogenic enzymes in the Leydig cell
22. Organophosphorus pesticides: Do they all have the same mechanism of toxicity?
23. Transcriptional regulation of the StAR gene
24. The relationship between progestins and gonadotropins during the late luteal phase of the menstrual cycle in rhesus monkeys
25. Effect of organophosphorus (dimethoate) and pyrethroid (deltamethrin) pesticides on semen characteristics in rabbits
26. Cholesterol side-chain cleavage, cytochrome P450, and the control of steroidogenesis
27. Induction of mitochondrial proteins in MA-10 Leydig tumor cells with human choriogonadotropin
28. The requirement of phosphorylation on a threonine residue in the acute regulation of steroidogenesis in MA-10 mouse Leydig cells
29. Regulation of the acute production of steroids in steroidogenic cells
30. Cystatin-related epididymal spermatogenic protein colocalizes with luteinizing hormone-beta protein in mouse anterior pituitary gonadotropes
31. Econazole and miconazole inhibit steroidogenesis through a post-transcriptional reduction in steroidogenic acute regulatory (StAR) protein expression and induction of Leydig cell apoptosis
32. The effects of Lindane on steroidogenesis and steroidogenic acute regulatory, protein expression
33. The role of the steroidogenic acute regulatory (StAR) protein in environmental endocrine disruptor inhibited steroidogenesis
34. Roundup inhibits steroidogenesis by disrupting StAR expression
35. Effect of truncated forms of the steroidogenic acute regulatory protein on intramitochondrial cholesterol transfer
36. Differential effects of tumor necrosis factor-alpha and interleukin-1 on 3 beta-hydroxysteroid dehydrogenase/delta 5→delta 4 isomerase expression in mouse Leydig cells