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Volumn 228, Issue 2, 2003, Pages 143-151

The effects of dietary n-3 polyunsaturated fatty acids delivered in chylomicron remnants on the transcription of genes regulating synthesis and secretion of very-low-density lipoprotein by the liver: Modulation by cellular oxidative state

Author keywords

Cellular redox state; Chylomicron remnants; Dietary n 3 PUFA; Hepatocytes; VLDL secretion

Indexed keywords

CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ESTER; CHYLOMICRON; LIPOPROTEIN LIPASE; OMEGA 3 FATTY ACID; VERY LOW DENSITY LIPOPROTEIN;

EID: 0037317305     PISSN: 15353702     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020322800203     Document Type: Article
Times cited : (32)

References (56)
  • 1
    • 0022980592 scopus 로고
    • Serum cholesterol, blood pressure, and mortality, implications from a cohort of 361.662 men
    • Martin MJ, Hulley SB, Browner WS, Kuller IH, Wentworth D. Serum cholesterol, blood pressure, and mortality, implications from a cohort of 361.662 men. Lancet 2:933-936, 1986.
    • (1986) Lancet , vol.2 , pp. 933-936
    • Martin, M.J.1    Hulley, S.B.2    Browner, W.S.3    Kuller, I.H.4    Wentworth, D.5
  • 3
    • 0033899952 scopus 로고    scopus 로고
    • Current perspectives on the management of hypertriglyceridemia
    • Miller M. Current perspectives on the management of hypertriglyceridemia. Am Heart J 140:232-240, 2000.
    • (2000) Am Heart J , vol.140 , pp. 232-240
    • Miller, M.1
  • 4
    • 0345620788 scopus 로고    scopus 로고
    • Hypertriglyceridemia: Changes in the plasma lipoproteins associated with an increased risk of cardiovascular disease
    • Brewer HB. Hypertriglyceridemia: changes in the plasma lipoproteins associated with an increased risk of cardiovascular disease. Am J Cardiol 83:3F-12F, 1999.
    • (1999) Am J Cardiol , vol.83
    • Brewer, H.B.1
  • 5
    • 0018858731 scopus 로고
    • Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man
    • Shepherd J, Packard CJ, Grundy SM, Yeshurun AM, Gotto AM, Taunton OD. Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man. J Lipid Res 21:91-99, 1980.
    • (1980) J Lipid Res , vol.21 , pp. 91-99
    • Shepherd, J.1    Packard, C.J.2    Grundy, S.M.3    Yeshurun, A.M.4    Gotto, A.M.5    Taunton, O.D.6
  • 6
    • 0026587511 scopus 로고
    • How do polyunsaturated fatty acids lower lipids?
    • Thornberg JT, Rudel LL. How do polyunsaturated fatty acids lower lipids? Curr Opin Lipidol 3:17-21, 1992.
    • (1992) Curr Opin Lipidol , vol.3 , pp. 17-21
    • Thornberg, J.T.1    Rudel, L.L.2
  • 8
    • 0021821575 scopus 로고
    • Reduction of plasma lipids, lipoproteins and apoproteins by dietary fish oils in patients with hypertriglyceridemia
    • Philipson BE, Rothrock DW, Connor WE, Harris WS, Illingworth DR. Reduction of plasma lipids, lipoproteins and apoproteins by dietary fish oils in patients with hypertriglyceridemia. N Engl J Med 312:1210-1216, 1985.
    • (1985) N Engl J Med , vol.312 , pp. 1210-1216
    • Philipson, B.E.1    Rothrock, D.W.2    Connor, W.E.3    Harris, W.S.4    Illingworth, D.R.5
  • 9
    • 0020653918 scopus 로고
    • Formation and metabolism of chylomicrons
    • Redgrave TG. Formation and metabolism of chylomicrons, Int J Physiol 28:103-130, 1983.
    • (1983) Int J Physiol , vol.28 , pp. 103-130
    • Redgrave, T.G.1
  • 10
    • 0028068361 scopus 로고
    • Chylomicrons or their remnants penetrate rabbit thoracic aorta as efficiently as do smaller macromolecules, including low density lipoprotein, high density lipoprotein and albumin
    • Mamo JCL, Wheeler JR. Chylomicrons or their remnants penetrate rabbit thoracic aorta as efficiently as do smaller macromolecules, including low density lipoprotein, high density lipoprotein and albumin. Coronary Artery Dis 5:695-705, 1994.
    • (1994) Coronary Artery Dis , vol.5 , pp. 695-705
    • Mamo, J.C.L.1    Wheeler, J.R.2
  • 11
    • 0031814147 scopus 로고    scopus 로고
    • Retention of fluorescent-labelled chylomicron remnants within the intima of the arterial wall - Evidence that plaque cholesterol may be derived from post-prandial lipoproteins
    • Proctor SD, Mamo JCL. Retention of fluorescent-labelled chylomicron remnants within the intima of the arterial wall - evidence that plaque cholesterol may be derived from post-prandial lipoproteins. Eur J Clin Invest 28:497-503, 1998.
    • (1998) Eur J Clin Invest , vol.28 , pp. 497-503
    • Proctor, S.D.1    Mamo, J.C.L.2
  • 12
    • 0031877652 scopus 로고    scopus 로고
    • The influence of chylomicron remnants on endothelial cell function in the isolated perfused rat aorta
    • Grieve DJ, Avella MA, Elliott J, Botham KM. The influence of chylomicron remnants on endothelial cell function in the isolated perfused rat aorta. Atherosclerosis 139:273-281, 1998.
    • (1998) Atherosclerosis , vol.139 , pp. 273-281
    • Grieve, D.J.1    Avella, M.A.2    Elliott, J.3    Botham, K.M.4
  • 16
    • 0024334111 scopus 로고
    • Fish oils and plasma lipids and lipoprotein metabolism in humans: A critical review
    • Harris WS. Fish oils and plasma lipids and lipoprotein metabolism in humans: a critical review. J Lipid Res 30:785-807, 1989.
    • (1989) J Lipid Res , vol.30 , pp. 785-807
    • Harris, W.S.1
  • 17
    • 0021333269 scopus 로고
    • The adaptive changes of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver
    • Wong SH, Nestel PJ, Trimble RP, Storer GB, Illman RJ, Topping DL. The adaptive changes of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver. Biochim Biophys Acta 792:103-109, 1984.
    • (1984) Biochim Biophys Acta , vol.792 , pp. 103-109
    • Wong, S.H.1    Nestel, P.J.2    Trimble, R.P.3    Storer, G.B.4    Illman, R.J.5    Topping, D.L.6
  • 19
  • 20
    • 0030989832 scopus 로고    scopus 로고
    • Changes in fatty acid metabolism in rat hepatocytes in response to dietary n-3 fatty acids are associated with changes in the intracellular metabolism and secretion of apolipoprotein B48
    • Brown A-M, Baker PW, Gibbons GF. Changes in fatty acid metabolism in rat hepatocytes in response to dietary n-3 fatty acids are associated with changes in the intracellular metabolism and secretion of apolipoprotein B48. J Lipid Res 38:469-481, 1999.
    • (1999) J Lipid Res , vol.38 , pp. 469-481
    • Brown, A.-M.1    Baker, P.W.2    Gibbons, G.F.3
  • 21
    • 0035878708 scopus 로고    scopus 로고
    • Comparison of the effects of dietary n-3 and n-6 polyunsaturated fatty acids on very-low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants
    • Zheng X, Avella M, Botham KM. Comparison of the effects of dietary n-3 and n-6 polyunsaturated fatty acids on very-low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants. Biochem J 357:481-487, 2001.
    • (2001) Biochem J , vol.357 , pp. 481-487
    • Zheng, X.1    Avella, M.2    Botham, K.M.3
  • 22
    • 0028068186 scopus 로고
    • Free radicals, antioxidants and human disease: Curiosity, cause or consequence?
    • Halliwell B. Free radicals, antioxidants and human disease: curiosity, cause or consequence? Lancet 344:721-724, 1994.
    • (1994) Lancet , vol.344 , pp. 721-724
    • Halliwell, B.1
  • 23
    • 0033231351 scopus 로고    scopus 로고
    • Gene expression and thiol redox state
    • Arrigo A-P. Gene expression and thiol redox state. Free Radic Biol Med 27:916-921, 1999.
    • (1999) Free Radic Biol Med , vol.27 , pp. 916-921
    • Arrigo, A.-P.1
  • 24
    • 0031975264 scopus 로고    scopus 로고
    • Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: In vitro and in vivo studies
    • Rosenblat M, Aviram M. Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: in vitro and in vivo studies. Free Radic Biol Med 24:305-317, 1998.
    • (1998) Free Radic Biol Med , vol.24 , pp. 305-317
    • Rosenblat, M.1    Aviram, M.2
  • 25
    • 0032427173 scopus 로고    scopus 로고
    • Mechanisms of signal transduction in the stress response of hepatocytes
    • Bhattacharya S. Mechanisms of signal transduction in the stress response of hepatocytes. Int Rev Cytol 184:109-156, 1998.
    • (1998) Int Rev Cytol , vol.184 , pp. 109-156
    • Bhattacharya, S.1
  • 26
    • 0029898866 scopus 로고    scopus 로고
    • Susceptibility to hepatic oxidative stress in rabbits fed different animal and plant fats
    • Slim RM, Toborek M, Watkins BA, Boissoneault GA, Hennig B. Susceptibility to hepatic oxidative stress in rabbits fed different animal and plant fats. J Am Coll Nutr 15:289-294, 1996.
    • (1996) J Am Coll Nutr , vol.15 , pp. 289-294
    • Slim, R.M.1    Toborek, M.2    Watkins, B.A.3    Boissoneault, G.A.4    Hennig, B.5
  • 28
    • 0033026052 scopus 로고    scopus 로고
    • Dietary polyunsaturated fatty acids and hepatic gene expression
    • Jump DB, Thelen A, Mater M. Dietary polyunsaturated fatty acids and hepatic gene expression. Lipids 34(Suppl):S219-S212. 1999.
    • (1999) Lipids , vol.34 , Issue.SUPPL.
    • Jump, D.B.1    Thelen, A.2    Mater, M.3
  • 29
    • 0036591857 scopus 로고    scopus 로고
    • The effects of chylomicron remnants enriched in n-3 or n-6 polyunsaturated fatty acids on the transcription of genes regulating their uptake and metabolism by the liver: Influence of cellular oxidative state
    • Zheng X, Rivabene R, Cavallari C, Napolitano M, Avella M, Bravo E, Botham KM. The effects of chylomicron remnants enriched in n-3 or n-6 polyunsaturated fatty acids on the transcription of genes regulating their uptake and metabolism by the liver: influence of cellular oxidative state. Free Radic Biol Med 32:1123-1131, 2002.
    • (2002) Free Radic Biol Med , vol.32 , pp. 1123-1131
    • Zheng, X.1    Rivabene, R.2    Cavallari, C.3    Napolitano, M.4    Avella, M.5    Bravo, E.6    Botham, K.M.7
  • 30
    • 0035085155 scopus 로고    scopus 로고
    • Very-low-density lipoprotein assembly and secretion
    • Shelness GS, Sellers JA. Very-low-density lipoprotein assembly and secretion. Curr Opin Lipidol 12:151-157, 2001.
    • (2001) Curr Opin Lipidol , vol.12 , pp. 151-157
    • Shelness, G.S.1    Sellers, J.A.2
  • 31
    • 0031668845 scopus 로고    scopus 로고
    • The assembly of triacylglycerol-rich lipoproteins: An essential role for the microsomal triacylglycerol transfer protein
    • White DA, Bennett AJ, Billett MA, Salter AM. The assembly of triacylglycerol-rich lipoproteins: an essential role for the microsomal triacylglycerol transfer protein. Br J Nutr 80:219-229, 1998.
    • (1998) Br J Nutr , vol.80 , pp. 219-229
    • White, D.A.1    Bennett, A.J.2    Billett, M.A.3    Salter, A.M.4
  • 32
    • 0032437765 scopus 로고    scopus 로고
    • The role of factors that regulate the synthesis and secretion of very-low-density lipoprotein by hepatocytes
    • Mason TM. The role of factors that regulate the synthesis and secretion of very-low-density lipoprotein by hepatocytes. Crit Rev Clin Lab Sci 35:461-487, 1998.
    • (1998) Crit Rev Clin Lab Sci , vol.35 , pp. 461-487
    • Mason, T.M.1
  • 34
    • 0034520194 scopus 로고    scopus 로고
    • Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates
    • Lee RG, Willingham MC, Davis MA, Skinner KA, Rudel LL. Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates. J Lipid Res 41:1991-2001, 2000.
    • (2000) J Lipid Res , vol.41 , pp. 1991-2001
    • Lee, R.G.1    Willingham, M.C.2    Davis, M.A.3    Skinner, K.A.4    Rudel, L.L.5
  • 37
    • 0029780538 scopus 로고    scopus 로고
    • Modification of the composition of dietary oils and fats upon incorporation into chylomicron remnants
    • Lambert MS, Botham KM, Mayes PA. Modification of the composition of dietary oils and fats upon incorporation into chylomicron remnants. Br J Nutr 76:435-445, 1996.
    • (1996) Br J Nutr , vol.76 , pp. 435-445
    • Lambert, M.S.1    Botham, K.M.2    Mayes, P.A.3
  • 38
    • 0034836496 scopus 로고    scopus 로고
    • The fatty acid composition of chylomicron remnants influences their binding and internalization by isolated hepatocytes
    • Lambert MS, Avella MA, Berhane Y, Shervill E, Botham KM. The fatty acid composition of chylomicron remnants influences their binding and internalization by isolated hepatocytes. Eur J Biochem 268:3983-3992, 2001.
    • (2001) Eur J Biochem , vol.268 , pp. 3983-3992
    • Lambert, M.S.1    Avella, M.A.2    Berhane, Y.3    Shervill, E.4    Botham, K.M.5
  • 39
    • 0022410906 scopus 로고
    • Characterisation of rat hepatocyte monolayers for investigation of the metabolism of bile salts
    • Ford RP, Botham KM, Suckling KE, Boyd GS. Characterisation of rat hepatocyte monolayers for investigation of the metabolism of bile salts. Biochim Biophys Acta 836:185-191, 1985.
    • (1985) Biochim Biophys Acta , vol.836 , pp. 185-191
    • Ford, R.P.1    Botham, K.M.2    Suckling, K.E.3    Boyd, G.S.4
  • 40
    • 0032894409 scopus 로고    scopus 로고
    • Administration of n-3 fatty acids in the diet of rats or directly to hepatocyte cultures results in different effects on hepatocellular apoB metabolism and secretion
    • Brown A-M, Castle J, Hebbachi A-M, Gibbons GF. Administration of n-3 fatty acids in the diet of rats or directly to hepatocyte cultures results in different effects on hepatocellular apoB metabolism and secretion. Atrerioscler Thromb Vasc Biol 19:106-114, 1999.
    • (1999) Atrerioscler Thromb Vasc Biol , vol.19 , pp. 106-114
    • Brown, A.-M.1    Castle, J.2    Hebbachi, A.-M.3    Gibbons, G.F.4
  • 41
    • 0028939823 scopus 로고
    • Differential effects of eicosapentaenoic acid on glycerolipid and apolipoprotein B metabolism in primary human hepatocytes compared to HepG2 cells and primary rat hepatocytes
    • Lin Y, Smit MJ, Havinga R, Verkade HJ, Vonk RJ, Kuipers F. Differential effects of eicosapentaenoic acid on glycerolipid and apolipoprotein B metabolism in primary human hepatocytes compared to HepG2 cells and primary rat hepatocytes. Biochim Biophys Acta 1256:88-96, 1995.
    • (1995) Biochim Biophys Acta , vol.1256 , pp. 88-96
    • Lin, Y.1    Smit, M.J.2    Havinga, R.3    Verkade, H.J.4    Vonk, R.J.5    Kuipers, F.6
  • 42
    • 0032861798 scopus 로고    scopus 로고
    • The assembly and secretion of apolipoprotein B-containing lipoproteins
    • Olofsson SO, Asp L, Borèn J. The assembly and secretion of apolipoprotein B-containing lipoproteins. Curr Opin Lipidol 10:341-346, 1999.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 341-346
    • Olofsson, S.O.1    Asp, L.2    Borèn, J.3
  • 43
    • 0025749693 scopus 로고
    • Apolipoprotein B editing is an intranuclear event that occurs post-transcriptionally coincident with splicing and polyadenylation
    • Lau PP, Xiong W, Zhu H-J, Chen S-H, Chan L. Apolipoprotein B editing is an intranuclear event that occurs post-transcriptionally coincident with splicing and polyadenylation. J Biol Chem 266:20550-20554, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 20550-20554
    • Lau, P.P.1    Xiong, W.2    Zhu, H.-J.3    Chen, S.-H.4    Chan, L.5
  • 44
    • 0032927776 scopus 로고    scopus 로고
    • Apolipoprotein B in the rough endoplasmic reticulum: Translation, translocation and the initiation of lipoprotein assembly
    • Shelness GS, Ingram MF, Huang XF, Delozier AJ. Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assembly. J Nutr 129:456S-462S, 1999.
    • (1999) J Nutr , vol.129
    • Shelness, G.S.1    Ingram, M.F.2    Huang, X.F.3    Delozier, A.J.4
  • 45
    • 0021969805 scopus 로고
    • Regulated biosynthesis and divergent metabolism of three forms of hepatic apolipoprotein B in the rat
    • Windmueller HG, Spaeth AE. Regulated biosynthesis and divergent metabolism of three forms of hepatic apolipoprotein B in the rat. J Lipid Res 26:70-81, 1985.
    • (1985) J Lipid Res , vol.26 , pp. 70-81
    • Windmueller, H.G.1    Spaeth, A.E.2
  • 46
    • 0029090898 scopus 로고
    • Regulation of hamster hepatic microsomal triglyceride transfer protein mRNA levels by dietary fats
    • Bennett AJ, Billett MA, Salter AM, White DA. Regulation of hamster hepatic microsomal triglyceride transfer protein mRNA levels by dietary fats. Biochem Biophys Res Commun 212:473-478, 1995.
    • (1995) Biochem Biophys Res Commun , vol.212 , pp. 473-478
    • Bennett, A.J.1    Billett, M.A.2    Salter, A.M.3    White, D.A.4
  • 47
    • 0032724029 scopus 로고    scopus 로고
    • Eicosapentacnoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference
    • Madsen L, Rustan AC, Vaagenes H, Berge K, Dyroy E, Berge RK. Eicosapentacnoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference. Lipids 34:951-963, 1999.
    • (1999) Lipids , vol.34 , pp. 951-963
    • Madsen, L.1    Rustan, A.C.2    Vaagenes, H.3    Berge, K.4    Dyroy, E.5    Berge, R.K.6
  • 48
    • 0025870248 scopus 로고
    • Effect of n-3 fatty acids on the key enzymes involved in cholesterol and triglyceride turnover in rat liver
    • al-Shurbaji A, Larsson-Backstrom C, Berglund L, Eggertsen G, Bjorkhem I. Effect of n-3 fatty acids on the key enzymes involved in cholesterol and triglyceride turnover in rat liver. Lipids 26:385-389, 1991.
    • (1991) Lipids , vol.26 , pp. 385-389
    • Al-Shurbaji, A.1    Larsson-Backstrom, C.2    Berglund, L.3    Eggertsen, G.4    Bjorkhem, I.5
  • 49
    • 0035977458 scopus 로고    scopus 로고
    • The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: Comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids
    • Botham KM, Maldonado E, Chico Y, Zheng X, Avella M, Ochoa B. The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids. Biochim Biophys Acta 1534:96-109, 2001.
    • (2001) Biochim Biophys Acta , vol.1534 , pp. 96-109
    • Botham, K.M.1    Maldonado, E.2    Chico, Y.3    Zheng, X.4    Avella, M.5    Ochoa, B.6
  • 51
    • 0023555623 scopus 로고
    • Effect of cupric ions on serum and liver cholesterol metabolism
    • Tanaka M, Iio T, Tabata T. Effect of cupric ions on serum and liver cholesterol metabolism. Lipids 22:1016-1019, 1987.
    • (1987) Lipids , vol.22 , pp. 1016-1019
    • Tanaka, M.1    Iio, T.2    Tabata, T.3
  • 52
    • 0031791330 scopus 로고    scopus 로고
    • Effects of dietary unsaturated fatty acids and chronic carbon tetrachloride treatment on the accumulation of oxidation products, α-tocopherol and liver injury in mice
    • Yasuda S, Watanabe S, Kobayashi T, Okuyama H. Effects of dietary unsaturated fatty acids and chronic carbon tetrachloride treatment on the accumulation of oxidation products, α-tocopherol and liver injury in mice. Biol Pharm Bull 21:1050-1056, 1998.
    • (1998) Biol Pharm Bull , vol.21 , pp. 1050-1056
    • Yasuda, S.1    Watanabe, S.2    Kobayashi, T.3    Okuyama, H.4
  • 53
    • 0028217431 scopus 로고
    • Effects of dietary oils and methyl ethyl ketone peroxide on in vivo lipid peroxidation and antioxidants in rat heart and liver
    • Skuladottir GV, Shia-Hua D, Brodie AE, Reed DJ, Wander RC. Effects of dietary oils and methyl ethyl ketone peroxide on in vivo lipid peroxidation and antioxidants in rat heart and liver. Lipids 29:351-357, 1994.
    • (1994) Lipids , vol.29 , pp. 351-357
    • Skuladottir, G.V.1    Shia-Hua, D.2    Brodie, A.E.3    Reed, D.J.4    Wander, R.C.5
  • 54
    • 0028243086 scopus 로고
    • High peroxidative susceptibility of fish oil polyunsaturated fatty acid in cultured rat hepatocytes
    • Sugihara N, Tsuruta Y, Date Y, Furuno K, Kohashi K. High peroxidative susceptibility of fish oil polyunsaturated fatty acid in cultured rat hepatocytes. Toxicol Appl Pharmacol 126:124-128, 1994.
    • (1994) Toxicol Appl Pharmacol , vol.126 , pp. 124-128
    • Sugihara, N.1    Tsuruta, Y.2    Date, Y.3    Furuno, K.4    Kohashi, K.5
  • 56
    • 0344604268 scopus 로고    scopus 로고
    • Effects of dietary fats (fish, olive and high-oleic acid sunflower oils) on lipid composition and antioxidant enzymes in rat liver
    • Ruiz-Gutierrez V, Perez-Espinosa A, Vazquez CM, Santa-Maria C. Effects of dietary fats (fish, olive and high-oleic acid sunflower oils) on lipid composition and antioxidant enzymes in rat liver. Br J Nutr 82:233-241. 1999.
    • (1999) Br J Nutr , vol.82 , pp. 233-241
    • Ruiz-Gutierrez, V.1    Perez-Espinosa, A.2    Vazquez, C.M.3    Santa-Maria, C.4


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