A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase

Biochemistry

Volumn 46, Issue 17, 2007, Pages 5050-5062

  Kang, You Na ^a   Tran, Anh ^b   White, Robert H ^b   Ealick, Steven E ^a  

^a Cornell University ^*  (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOTIDE (AICAR); ACTIVE SITES; DE NOVO PURINE BIOSYNTHESIS; GENE PRODUCTS;

BACTERIA; BIOSYNTHESIS; CATALYSIS; CHROMOPHORES; CRYSTAL STRUCTURE; CYCLIZATION; GENES; LIGANDS; MUTAGENESIS; NUCLEOPHILES;

ENZYMES;

5 AMINOIMIDAZOLE 4 CARBOXAMIDE RIBONUCLEOTIDE; 5 FORMAMINOIMIDAZOLE 4 CARBOXAMIDE RIBONUCLEOTIDE; ARGININE; GENE PRODUCT; GLUTAMIC ACID; GREEN FLUORESCENT PROTEIN; HYDROLASE; INOSINE 5' MONOPHOSPHATE CYCLOHYDROLASE; LIGAND; MUTANT PROTEIN; PROTEIN PURH; PROTEIN PURO; PURINE; RIBONUCLEOTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARCHAEBACTERIUM; ARTICLE; BETA SHEET; CRYSTAL STRUCTURE; CYCLIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STRUCTURE; EUKARYOTE; METHANOCALDOCOCCUS JANNASCHII; METHANOTHERMOBACTER THERMOAUTOTROPHICUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FOLDING; PURINE SYNTHESIS; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, GEL; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; HYDROXYMETHYL AND FORMYL TRANSFERASES; METHANOBACTERIACEAE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NUCLEOTIDE DEAMINASES; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID;

ARCHAEA; EUKARYOTA; METHANOCALDOCOCCUS JANNASCHII; METHANOTHERMOBACTER THERMAUTOTROPHICUS;

EID: 34247645918     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061637j     Document Type: Article

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