Catalytic Mechanism of the Cyclohydrolase Activity of Human Aminoimidazole Carboxamide Ribonucleotide Formyltransferase/Inosine Monophosphate Cyclohydrolase

Biochemistry

Volumn 43, Issue 5, 2004, Pages 1184-1192

  Vergis, James M ^a,d   Beardsley, G Peter ^b,c  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LMP 3096A ^*  (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CRYSTAL STRUCTURE; ENZYMES; MUTAGENESIS; PHOSPHORUS COMPOUNDS;

CYCLOHYDROLASE ACTIVITY;

BIOCHEMISTRY;

AMINOIMIDAZOLE CARBOXAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE; ASPARTIC ACID; HYDROLASE; INOSINE MONOPHOSPHATE CYCLOHYDROLASE; LYSINE; TRANSFERASE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEADY STATE;

ALANINE; ANIMALS; ARGININE; ASPARTIC ACID; BINDING SITES; BIRDS; CATALYSIS; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; HYDROXYMETHYL AND FORMYL TRANSFERASES; KINETICS; LYSINE; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; NUCLEOTIDE DEAMINASES; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TYROSINE;

EID: 0842348744     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035139b     Document Type: Article

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