Design and biological activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl}imidazol-1- ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency

Journal of Medicinal Chemistry

Volumn 44, Issue 18, 2001, Pages 2933-2949

  Bell, I M ^a   Gallicchio, S N ^a   Abrams, M ^a   Beshore, D C ^a   Buser, C A ^a   Culberson, J C ^a   Davide, J ^a   Ellis Hutchings, M ^a   Fernandes, C ^a   Gibbs, J B ^a   Graham, S L ^a   Hartman, G D ^a   Heimbrook, D C ^a   Homnick, C F ^a   Huff, J R ^a   Kassahun, K ^a   Koblan, K S ^a   Kohl, N E ^a   Lobell, R B ^a   Lynch Jr , J J ^a   Miller, P A ^a   Omer, C A ^a,b   Rodrigues, A D ^a   Walsh, E S ^a   Williams, T M ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 [[1 (3 CHLOROBENZYL) 2 OXOPYRROLIDIN 3 YLAMINO]METHYL]IMIDAZOL 1 YLMETHYL]BENZONITRILE; IMIDAZOLE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DOG; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE K RAS; STRUCTURE ACTIVITY RELATION; TRANSGENIC MOUSE; TUMOR CELL LINE;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; BINDING, COMPETITIVE; BIOLOGICAL AVAILABILITY; CELL LINE, TRANSFORMED; DOGS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; GENES, RAS; IMIDAZOLES; LACTAMS; MICE; MICE, TRANSGENIC; MODELS, MOLECULAR; NEOPLASMS, EXPERIMENTAL; NITRILES; PYRROLIDINONES; RADIOLIGAND ASSAY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035974740     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010156p     Document Type: Article

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