Removal of the conserved disulfide bridges from the scFv fragment of an antibody: Effects on folding kinetics and aggregation

Journal of Molecular Biology

Volumn 290, Issue 2, 1999, Pages 535-546

  Ramm, Kathrin ^a   Gehrig, Peter ^a   Plückthun, Andreas ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Aggregation; Disulfide free scFv fragments; Hydrogen exchange; Kinetic trap; Protein folding

Indexed keywords

DEUTERIUM; DISULFIDE; HYDROGEN; PROLINE;

ANTIBODY STRUCTURE; ARTICLE; FLUORESCENCE ANALYSIS; GENETIC CONSERVATION; KINETICS; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STABILITY;

EID: 0033538557     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.2854     Document Type: Article

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