Physiochemical characterization of the Alzheimer's disease-related peptides Aβ1-42Arctic and Aβ1-42wt

FEBS Journal

Volumn 273, Issue 12, 2006, Pages 2618-2630

  Johansson, Ann Sofi ^a,c   Berglind Dehlin, Fredrik ^a   Karlsson, Göran ^b   Edwards, Katarina ^b   Gellerfors, Pär ^a   Lannfelt, Lars ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Amyloid ; Arctic; Fibrillization; Oligomerization; Protofibrils

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN[1-42]; MONOMER;

ALZHEIMER DISEASE; ARTICLE; CENTRIFUGATION; CONCENTRATION RESPONSE; FAMILIAL DISEASE; GEL PERMEATION CHROMATOGRAPHY; GENE MUTATION; IONIC STRENGTH; MICROENVIRONMENT; OLIGOMERIZATION; PATHOGENESIS; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; SEPARATION TECHNIQUE; TEMPERATURE DEPENDENCE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CRYOELECTRON MICROSCOPY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MUTATION; OSMOLAR CONCENTRATION; PEPTIDE FRAGMENTS; TEMPERATURE;

EID: 33745272215     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2006.05263.x     Document Type: Article

References (37)

1. Fratiglioni L Launer LJ Andersen K Breteler MM Copeland JR Dartigues JF Lobo A Martinez-Lage J Soininen H Hofman A ( 2000) Incidence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 54, S10 S15.
2. Walsh DM Lomakin A Benedek GB Condron MM Teplow DB ( 1997) Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. J Biol Chem 272, 22364 22372.
3. Harper JD Wong SS Lieber CM Lansbury PT ( 1997) Observation of metastable Abeta amyloid protofibrils by atomic force microscopy. Chem Biol 4, 119 125.
4. Klein WL ( 2002) ADDLs & protofibrils - the missing links?. Neurobiol Aging 23, 231 235.
5. Rochet JC Lansbury PT Jr. ( 2000) Amyloid fibrillogenesis: themes and variations. Curr Opin Struct Biol 10, 60 68.
6. Walsh DM Hartley DM Kusumoto Y Fezoui Y Condron MM Lomakin A Benedek GB Selkoe DJ Teplow DB ( 1999) Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J Biol Chem 274, 25945 25952.
7. Hartley DM Walsh DM Ye CP Diehl T Vasquez S Vassilev PM Teplow DB Selkoe DJ ( 1999) Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci 19, 8876 8884.
8. Nilsberth C Westlind-Danielsson A Eckman CB Condron MM Axelman K Forsell C Stenh C Luthman J Teplow DB Younkin SG et al. ( 2001) The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat Neurosci 4, 887 893.
9. Klyubin I Walsh DM Cullen WK Fadeeva JV Anwyl R Selkoe DJ Rowan MJ ( 2004) Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo. Eur J Neurosci 19, 2839 2846.
10. Selkoe DJ ( 2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81, 741 766.
11. Lashuel HA Lai Z Kelly JW ( 1998) Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation. Biochemistry 37, 17851 17864.
12. Lashuel HA Petre BM Wall J Simon M Nowak RJ Walz T Lansbury PT Jr. ( 2002) Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J Mol Biol 322, 1089 1102.
13. Conway KA Harper JD Lansbury PT ( 1998) Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat Med 4, 1318 1320.
14. El-Agnaf OM Nagala S Patel BP Austen BM ( 2001) Non-fibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils. J Mol Biol 310, 157 168.
15. Poirier MA Li H Macosko J Cai S Amzel M Ross CA ( 2002) Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization. J Biol Chem 277, 41032 41037.
16. Whalen BM Selkoe DJ Hartley DM ( 2005) Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degeneration. Neurobiol Dis 20, 254 266.
17. Lashuel HA Hartley DM Petre BM Wall JS Simon MN Walz T Lansbury PT Jr. ( 2003) Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. J Mol Biol 332, 795 808.
18. Van Nostrand WE Melchor JP Cho HS Greenberg SM Rebeck GW ( 2001) Pathogenic effects of D23N Iowa mutant amyloid beta-protein. J Biol Chem 276, 32860 32866.
19. Paivio A Jarvet J Graslund A Lannfelt L Westlind-Danielsson A ( 2004) Unique physicochemical profile of beta-amyloid peptide variant abeta1-40E22G protofibrils: conceivable neuropathogen in Arctic mutant carriers. J Mol Biol 339, 145 159.
20. Harper JD Wong SS Lieber CM Lansbury PT Jr. ( 1999) Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease. Biochemistry 38, 8972 8980.
21. Snyder SW Ladror US Wade WS Wang GT Barrett LW Matayoshi ED Huffaker HJ Krafft GA Holzman TF ( 1994) Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths. Biophys J 67, 1216 1228.
22. Stine WB Jr. Dahlgren KN Krafft GA LaDu MJ ( 2003) In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. J Biol Chem 278, 11612 11622.
23. Naiki H Nakakuki K ( 1996) First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro. Lab Invest 74, 374 383.
24. Kusumoto Y Lomakin A Teplow DB Benedek GB ( 1998) Temperature dependence of amyloid beta-protein fibrillization. Proc Natl Acad Sci USA 95, 12277 12282.
25. Gursky O Aleshkov S ( 2000) Temperature-dependent beta-sheet formation in beta-amyloid Abeta (1-40) peptide in water: uncoupling beta-structure folding from aggregation. Biochim Biophys Acta 1476, 93 102.
26. Jarvet J Damberg P Danielsson J Johansson I Eriksson LE Graslund A ( 2003) A left-handed 3(1) helical conformation in the Alzheimer Abeta (12-28) peptide. FEBS Lett 555, 371 374.
27. Nichols MR Moss MA Reed DK Lin WL Mukhopadhyay R Hoh JH Rosenberry TL ( 2002) Growth of beta-amyloid (1-40) protofibrils by monomer elongation and lateral association. Characterization of distinct products by light scattering and atomic force microscopy. Biochemistry 41, 6115 6127.
28. Jarrett JT Lansbury PT Jr. ( 1993) Seeding 'one-dimensional crystallization' of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell 73, 1055 1058.
29. Pallitto MM Murphy RM ( 2001) A mathematical model of the kinetics of beta-amyloid fibril growth from the denatured state. Biophys J 81, 1805 1822.
30. Harper JD Lansbury PT Jr. ( 1997) Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. Annu Rev Biochem 66, 385 407.
31. Barrow CJ Yasuda A Kenny PT Zagorski MG ( 1992) Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra. J Mol Biol 225, 1075 1093.
32. Su Y Chang PT ( 2001) Acidic pH promotes the formation of toxic fibrils from beta-amyloid peptide. Brain Res 893, 287 291.
33. Kirkitadze MD Condron MM Teplow DB ( 2001) Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis. J Mol Biol 312, 1103 1119.
34. Moore SA Huckerby TN Gibson GL Fullwood NJ Turnbull S Tabner BJ El-Agnaf OM Allsop D ( 2004) Both the D-(+) and L-(-) enantiomers of nicotine inhibit Abeta aggregation and cytotoxicity. Biochemistry 43, 819 826.
35. Bush AI ( 2003) The metallobiology of Alzheimer's disease. Trends Neurosci 26, 207 214.
36. Fraser PE Nguyen JT Inouye H Surewicz WK Selkoe DJ Podlisny MB Kirschner DA ( 1992) Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein. Biochemistry 31, 10716 10723.
37. Almgren M Edwards K Karlsson G ( 2000) Cryo transmission electron microscopy of liposomes and related structures. Colloids Surfaces A: Physicochem Engineering Aspects 174, 3 21.