NF-κB and apoptosis in colorectal tumourigenesis

European Journal of Clinical Investigation

Volumn 37, Issue 5, 2007, Pages 416-424

  Aranha, M M ^a   Borralho, P M ^a   Ravasco, P ^b   Moreira Da Silva, I B ^a   Correia, L ^c   Fernandes, A ^a   Camilo, M E ^b   Rodrigues, C M P ^a,d  

^a UNIVERSITY OF LISBON   (Portugal)

^b INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^c HOSPITAL DE SANTA MARIA   (Portugal)

^d NONE   (Portugal)

Author keywords

Apoptosis; Bax; Bcl 2; Colorectal tumours; NF B; p53

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; PROTEIN P53; PROTEIN BAX; PROTEIN BCL X; TUMOR MARKER;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; COLON ADENOCARCINOMA; COLON ADENOMA; COLON CARCINOGENESIS; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MALE; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TUMOR GROWTH; ADENOMA; AGED; COLORECTAL TUMOR; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY;

ADENOMA; AGED; AGED, 80 AND OVER; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; COLORECTAL NEOPLASMS; HUMANS; MIDDLE AGED; NF-KAPPA B; TUMOR MARKERS, BIOLOGICAL;

EID: 34247496831     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2007.01801.x     Document Type: Article

References (52)

1. Arnold CN, Goel A, Blum HE, Boland CR. Molecular pathogenesis of colorectal cancer. Cancer 2005 104 : 2035 47.
2. Dolcet X, Llobet D, Pallares J, Matias-Guiu X. NF-κB in development and progression of human cancer. Virchows Arch 2005 446 : 475 82.
3. Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996 14 : 649 83.
4. Chen ZJ, Parent L, Maniatis T. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 1996 84 : 853 62.
5. Smith G, Carey FA, Beattie J, Wilkie MJ, Lightfoot TJ, Coxhead J et al. Mutations in APC, Kirsten-ras, and p53 - alternative genetic pathways to colorectal cancer. Proc Natl Acad Sci U S A 2002 99 : 9433 8.
6. Nakano R. Apoptosis: gene-directed cell death. An overview. Horm Res 1997 48 (Suppl. 3 2 4.
7. Evertsson S, Bartik Z, Zhang H, Jansson A, Sun XF. Apoptosis in relation to proliferating cell nuclear antigen and Dukes' stage in colorectal adenocarcinoma. Int J Oncol 1999 15 : 53 8.
8. Saleh HA, Jackson H, Khatib G, Banerjee M. Correlation of bcl-2 oncoprotein immunohistochemical expression with proliferating index and histopathologic parameters in colorectal neoplasia. Pathol Oncol Res 1999 5 : 273 9.
9. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell 2003 11 : 577 90.
10. Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, surviving, expressed in cancer and lymphoma. Nat Med 1997 3 : 917 21.
11. McWilliams RR, Erlichman C. Novel therapeutics in colorectal cancer. Dis Colon Rectum 2005 48 : 1632 50.
12. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004 303 : 1010 4.
13. Miyashita T, Harigai M, Hanada M, Reed JC. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 1994 54 : 3131 5.
14. Fridman JS, Lowe SW. Control of apoptosis by p53. Oncogene 2003 22 : 9030 40.
15. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000 408 : 307 10.
16. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science 1991 253 : 49 53.
17. Selivanova G. p53: fighting cancer. Curr Cancer Drug Targets 2004 4 : 385 402.
18. Tan J, Zhuang L, Leong HS, Iyer NG, Liu ET, Yu Q. Pharmacologic modulation of glycogen synthase kinase-3β promotes p53-dependent apoptosis through a direct bax-mediated mitochondrial pathway in colorectal cancer cells. Cancer Res 2005 65 : 9012 20.
19. Hawkins N, Lees J, Hargrave R, O'Connor T, Meagher A, Ward R. Pathological and genetic correlates of apoptosis in the progression of colorectal neoplasia. Tumor Biol 1997 18 : 146 56.
20. Boland CR, Sato J, Appelman HD, Bresalier RS, Feinberg AP. Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression. Nat Med 1995 1 : 902 9.
21. Saleh HA, Jackson H, Banerjee M. Immunohistochemical expression of bcl-2 and p53 oncoproteins: correlation with Ki67 proliferation index and prognostic histopathologic parameters in colorectal neoplasia. Appl Immunohistochem Mol Morph 2000 8 : 175 82.
22. Li Q, Withoff S, Verma IM. Inflammation-associated cancer: NF-κB is the lynchpin. Trends Immunol 2005 26 : 318 25.
23. Silva D. Signaling pathways responsible for cancer cell invasion as targets for cancer therapy. Curr Cancer Drug Targets 2004 4 : 327 36.
24. Hougardy BM, Maduro JH, van der Zee AG, Willemse PH, de Jong S, de Vries EG. Clinical potential of inhibitors of survival pathways and activators of apoptotic pathways in treatment of cervical cancer: changing the apoptotic balance. Lancet Oncol 2005 6 : 589 98.
25. Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell 2002 108 : 153 64.
26. Yu HG, Yu LL, Yang Y, Luo HS, Yu JP, Meier JJ et al. Increased expression of RelA/nuclear factor-κB protein correlates with colorectal tumorigenesis. Oncology 2003 65 : 37 45.
27. Kawasaki H, Toyoda M, Shinohara H, Okuda J, Watanabe I, Yamamoto T et al. Expression of surviving correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis. Cancer 2001 91 : 2026 32.
28. Guicciardi ME, Gores GJ. Apoptosis: a mechanism of acute and chronic liver injury. Gut 2005 54 : 1024 33.
29. Kerr JF, Winterford CM, Harmon BV. Apoptosis. Its significance in cancer and cancer therapy. Cancer 1994 73 : 2013 26.
30. Aotake T, Lu C-D, Chiba Y, Muraoka R, Tanigawa N. Changes in angiogenesis and tumor cell apoptosis during colorectal carcinogenesis. Clin Cancer Researsh 1999 5 : 135 42.
31. Sinicrope FA, Roddey G, McDonnell TJ, Shen Y, Cleary KR, Stephens LC. Increased apoptosis accompanies neoplastic development in the human colorectum. Clin Cancer Res 1996 2 : 1999 2006.
32. Bedi A, Akhtar PJ, Barber JB, Bedi GC, Giardiello FM, Zehnbauer BA et al. Inhibition of apoptosis during development of colorectal cancer. Cancer Res 1995 55 : 1811 6.
33. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990 61 : 759 67.
34. Kabore AF, Johnston JB, Gibson SB. Changes in the apoptotic and survival signaling in cancer cells and their potential therapeutic implications. Curr Cancer Drug Targets 2004 4 : 147 63.
35. Bosari S, Moneghini L, Graziani D, Lee AK, Murray JJ, Coggi G et al. Bcl-2 Oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas. Hum Pathol 1995 26 : 534 40.
36. Hague A, Moorghen M, Hicks D, Chapman M, Paraskeva C. Bcl-2 expression in human colorectal adenomas and carcinomas. Oncogene 1994 9 : 3367 70.
37. Kaklamanis L, Savage A, Mortensen N, Tsiotos P, Doussis-Anagnostopoulou I, Biddolph S et al. Early expression of bcl-2 protein in the adenoma-carcinoma sequence of colorectal neoplasia. J Pathol 1996 179 : 10 4.
38. Lauwers GY, Kandemir O, Kulbilis PS, Scott GV. Cellular kinetics in Barrett's epithelium carcinogenic sequence: roles of apoptosis, bcl-2 protein, and cellular proliferation. Mod Pathol 1997 10 : 1201 8.
39. Attardi LD, Jacks T. The role of p53 in tumor suppression: lessons from mouse models. Cell Mol Life Sci 1999 55 : 48 63.
40. Ryan KM, Ohilips AC, Vousden KH. Regulation and function of p53 tumor suppressor protein. Curr Opin Cell Biol 2001 13 : 332 7.
41. Paul-Samojedny M, Kokocinska D, Samojedny A, Mazurek U, Partyka R, Lorenz Z et al. Expression of cell survival/death genes: Bcl-2 and Bax at the rate of colon cancer prognosis. Biochim Biophys Acta 2005 1741 : 25 9.
42. Magistrelli P, Coppola R, Tonini G, Vincenzi B, Santini D, Borzomati D et al. Apoptotic index or a combination of Bax/Bcl-2 expression correlate with survival after resection of pancreatic adenocarcinoma. J Cell Biochem 2006 97 : 98 108.
43. Nakshtri H, Bhat-Nakshatri P, Martin DA, Goulet RJJ, Sledge GWJ. Constitutive activation of NF-κB during progression of breast cancer to hormone-dependent growth. Mol Cell Biol 1997 17 : 3629 39.
44. Wang WX, Abbruzzese JL, Evans DB, Larry L, Cleary KR, Chiao JP. The nuclear factor-κB relA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 1999 5 : 119 27.
45. Bargou RC, Emmerich F, Krappmann D, Bommert K, Mapara MY, Arnold W et al. Constitutive nuclear factor-κB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest 1997 100 : 2961 9.
46. Sasaki N, Morisaki T, Hashizume K, Yao T, Tsuneyoshi M, Noshiro H et al. Nuclear factor-κB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue. Clin Cancer Res 2001 7 : 4136 42.
47. Sovak MA, Bellas RE, Kim DW, Zanieski GJ, Rogers AE, Traish AM et al. Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer. J Clin Invest 1997 100 : 2952 60.
48. Tai DI, Tsai SL, Chang YH, Huang SN, Chen TC, Chang KS et al. Constitutive activation of nuclear factor κB in hepatocellular carcinoma. Cancer 2000 89 : 2274 81.
49. Bartke T, Siegmund D, Peters N, Reichwein M, Henkler F, Scheurich P et al. p53 up-regulates cFLIP, inhibits transcription of NF-κB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. Oncogene 2001 20 : 571 80.
50. Matroule JY, Carthy CM, Granville DJ, Jolois O, Hunt DW, Piette J. Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization. Oncogene 2001 20 : 4070 84.
51. Dumont A, Hehner SP, Hofmann TG, Ueffing M, Droge W, Schmitz ML. Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB. Oncogene 1999 18 : 747 57.
52. Chen F, Wang M, O'Connor JP, He M, Tripathi T, Harrison LE. Phosphorylation of PPARγ via active ERK1/2 leads to its physical association with p65 and inhibition of NF-κB. J Cell Biochem 2003 90 : 732 44.