Immunohistochemical expression of bcl-2 and p53 oncoproteins: Correlation with Ki67 proliferation index and prognostic histopathologic parameters in colorectal neoplasia

Applied Immunohistochemistry and Molecular Morphology

Volumn 8, Issue 3, 2000, Pages 175-182

  Saleh, H A ^a   Jackson, H ^a   Banerjee, M ^a  

^a SINAI GRACE HOSPITAL   (United States)

Author keywords

Adenoma; bcl 2; Colon carcinoma; Immunohistochemistry; Ki67; p53; Proliferation index

Indexed keywords

KI 67 ANTIGEN; MONOCLONAL ANTIBODY KI 67; PROTEIN BCL 2; PROTEIN P53;

ADULT; AGED; ARTICLE; COLORECTAL TUMOR; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LABELING INDEX; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

ADENOMA; AGED; ANTIBODIES, MONOCLONAL; CARCINOMA; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MIDDLE AGED; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033844202     PISSN: 10623345     EISSN: None     Source Type: Journal    
DOI: 10.1097/00022744-200009000-00002     Document Type: Article

References (43)

1. Cellular kinetics in Barrett's epithelium carcinogenic sequence: Roles of apoptosis, bcl-2 protein, and cellular proliferation
2. Expression of bcl-2 oncoprotein in benign and malignant spindle cell tumors of soft tissue, skin, serosal surfaces and gastrointestinal tract
3. bcl-2 and apoptosis in lymph node positive breast carcinoma
4. Inverse correlation between the expression of bcl-2 and p53 proteins in primary gastric lymphoma
5. Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas
6. Expression of bcl-2 oncoprotein in gastrointestinal and uterine carcinomas and their premalignant lesions
7. bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas
8. The role of p53, p21(WAFl/ClPl), and bcl-2 in radioresistant colorectal carcinoma
9. bcl-2: Role in epithelial differentiation and oncogenesis
10. The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model
11. Expression of proliferative cell nuclear antigen in hyperplastic polyps, adenoma and inflammatory cloacogenic polyps of the large intestine
12. Assessment of cell proliferation in colorectal carcinomas using the monoclonal antibody Ki-67. Correlation with pathohistologic criteria and influence of irradiation
13. Assessment of Ki67 derived tumor proliferative activity in colorectal adenocarcinomas
14. Prognosis in malignant mesothelioma related to MIB 1 proliferative index and histological subtype
15. Ki67 derived proliferative activity in colorectal adenocarcinoma with prognostic correlation
16. Ki67 antibody labeling index in colorectal carcinoma
17. Ki67 immunohistochemical evaluation in colorectal cancer and normal colonic mucosa. Possible clinical applications
18. Growth fraction of colorectal carcinoma (Ki67): A comparative study
19. Immunohistochemical assessment of growth fractions in colorectal adenocarcinomas with monoclonal antibody Ki67. Relation to clinical and pathologic variables
20. Determination of proliferative activity in colorectal carcinoma using monoclonal antibody Ki67
21. Immunohistochemical analysis of cell kinetic parameters in colonic adenocarcinomas, adenomas, and normal mucosa
22. Immunohistochemical detection of proliferating cells in colorectal carcinomas and adenomas with the monoclonal antibody Ki67. Preliminary data
23. The prognostic significance of p53 and bcl-2 expression in lung adenocarcinoma and its correlation with Ki67 growth fraction
24. Histological typing of intestinal tumors. International histological classification of tumors, vol 15. Geneva: World Health Organization
25. An immunohistochemical study of the simultaneous expression of bcl-2 and p53 oncoproteins in epithelial tumors of the colon and rectum
26. Ki67 and proliferating cell nuclear antigen tumor proliferative indices in DNA diploid colorectal adenocarcinomas. Correlation with histopathologic characteristics and cell cycle analysis with two-color DNA flow cytometry
27. Ki67 and other proliferating markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies
28. Evaluation of cell proliferation in breast carcinoma. Comparison of Ki67 immunohistochemical study, DNA flow cytometric analysis, and mitotic count
29. Ki67 staining as a means to simplify analysis of tumor cell proliferation
30. Growth kinetics of colorectal adenoma-carcinoma sequence: An immunohistochemical study of proliferating cell nuclear antigen expression
31. Evidence of reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas
32. Analysis of bcl-2 in sporadic breast carcinoma
33. Expression of bcl-2 and p53 in the colorectal adenoma-carcinoma sequence
34. Bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis
35. Pathological and genetic correlates of apoptosis in the progression of colorectal neoplasia
36. P53 protein immunohistochemical expression in colonic adenomas with and without associated carcinoma
37. Expression of p53 in human esophageal carcinoma: An immunohistochemical study with correlation to proliferating cell nuclear antigen expression
38. Clinical implications of the p53 tumor suppressor gene
39. Rapid communication: p53 expression in colorectal tumors
40. Molecular genetics of colorectal neoplasia
41. P53 protein expression in colorectal adenomas: An immunohistochemical study using an antigen retrieval system
42. The prognostic value of p53 nuclear overexpression and MIB-1 as a proliferative marker in transitional cell carcinoma of the bladder