Cycloheximide: No ordinary bitter stimulus

Behavioural Brain Research

Volumn 180, Issue 1, 2007, Pages 4-17

  Hettinger, Thomas P ^a   Formaker, Bradley K ^a   Frank, Marion E ^a  

^a School of Dental Medicine   (United States)

Author keywords

Bitter taste evolution; Cycloheximide toxin; Golden hamster; Induced avoidance

Indexed keywords

CYCLOHEXIMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AVERSIVE BEHAVIOR; AVOIDANCE BEHAVIOR; BITTER TASTE; CHEMOSENSITIZATION; CHORDA TYMPANI; CONTROLLED STUDY; GENE CLUSTER; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; STIMULATION; SYRIAN HAMSTER;

ANALYSIS OF VARIANCE; ANIMALS; ANTIBIOTICS, ANTIFUNGAL; AVOIDANCE LEARNING; CHORDA TYMPANI NERVE; CRICETINAE; CYCLOHEXIMIDE; EVOLUTION, MOLECULAR; GENERALIZATION, STIMULUS; HUMANS; MALE; MESOCRICETUS; MICE; RATS; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; TASTE; TASTE BUDS;

EID: 34247476109     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2007.02.027     Document Type: Article

References (115)

1. Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., and Zuker C.S. A novel family of mammalian taste receptors. Cell 100 (2000) 693-702
2. Araneda R.C., Kini A.D., and Firestein S.K. The molecular receptive range of an odorant receptor. Nat Neurosci 3 (2000) 1248-1255
3. Araneda R.C., and Firestein S. The scents of androstenone in humans. J Physiol 554 (2003) 1
4. Arvola A., and Forsander O. Comparison between water and alcohol consumption in six animal species in free-choice experiments. Nature 191 (1961) 819-820
5. Beidler L.M., Fishman I.Y., and Hardiman C.W. Species differences in taste responses. Am J Physiol 181 (1955) 235-239
6. Berenbaum M.R. The chemistry of defense: theory and practice. Proc Natl Acad Sci USA 92 (1995) 2-8
7. Berenbaum M.R. Postgenomic chemical ecology: from genetic code to ecological interactions. J Chem Ecol 28 (2002) 873-896
8. Bermúdez-Rattoni F., Bures J., and Yamamoto T. Paradoxes, projections, and perspectives of CTA research. In: Bures J., Bermúdez-Rattoni F., and Yamamoto T. (Eds). Conditioned taste aversion: memory of a special kind (1998), Oxford University Press, New York 121-131
9. Berterethce M.-V., Boireau-Ducept N., Pillias A.-M., and Faurion A. Stimulus-induced increase of taste responses in the hamster chorda tympani by repeated exposure to 'novel' tastants. Appetite 45 (2005) 324-333
10. Booth D.A., and Simson P.C. Aversions to a cue acquired by its association with effects of an antibiotic in the rat. J Comp Physiol Psychol 63 (1973) 101-108
11. Boughter Jr. J.D., Raghow S., Nelson T.M., and Munger S.D. Inbred mouse strains C57Bl/6J and DBA/2j vary in sensitivity to a subset of bitter stimuli. BMC Genet 6 (2005) 36
12. Boughter Jr. J.D., and Whitney G. Behavioral specificity of the bitter taste gene Soa. Physiol Behav 63 (1998) 101-108
13. Brasser S.M., Mozhui K., and Smith D.V. Differential correlation in taste responsiveness to bitter stimuli in rats. Chem Senses 30 (2005) 793-799
14. Breslin P.A.S., and Tharp C.D. Reduction of saltiness and bitterness after a chlorhexidine rinse. Chem Senses 26 (2001) 105-116
15. Broadbent J., Muccino K.J., and Cunningham C.L. Ethanol-induced conditioned taste aversion in 15 inbred mouse strains. Behav Neurosci 116 (2002) 138-148
16. Bufe B., Breslin P.A.S., Kuhn C., Reed D.R., Tharp C.D., Slack J.P., et al. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Cur Biol 15 (2005) 322-327
17. Bufe B., Hofmann T., Krautworst D., Raguse J.-D., and Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to β-glucopyranosides. Nat Genet 32 (2002) 397-401
18. Bures J. Ethology, physiological psychology, and neurobiology of CTA. In: Bures J., Bermúdez-Rattoni F., and Yamamoto T. (Eds). Conditioned taste aversion: memory of a special kind (1998), Oxford University Press, New York 1-13
19. Caicedo A., and Roper S.D. Taste receptor cells that discriminate between bitter stimuli. Science 291 (2001) 1557-1560
20. Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., et al. T2Rs function as bitter taste receptors. Cell 100 (2000) 703-711
21. Cohen M.B., Schuler M.A., and Berenbaum M.R. A host inducible cytochrome P-450 from host-specific caterpillar: molecular cloning and evolution. Proc Natl Acad Sci USA 89 (1992) 10920-10924
22. Danilova V., and Hellekant G. Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice. BMC Neurosci 4 (2003) 5
23. Dess N.K. Responses to basic taste qualities in rats selectively bred for high versus low saccharin intake. Physiol Behav 69 (2000) 247-257
24. Dickman J.D., and Smith D.V. Response properties of fibers in the hamster superior laryngeal nerve. Brain Res 450 (1988) 25-38
25. Douzery E.J.P., and Huchon D. Rabbits, if anything, are likely Glires. Mol Phylogenet Evol 33 (2004) 922-935
26. Finger T.E., Bottger B., Hanson A., Anderson K.T., Alimohammadi H., and Silver W.L. Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration. Proc Natl Acad Sci USA 100 (2003) 8981-8986
27. Finger T.E., Danilova V., Barrows J., Bartel D.L., Vigers A.J., Stone L., et al. ATP signaling is crucial for communication from taste buds to gustatory nerves. Science 310 (2005) 1495-1499
28. Floriano W.B., Hall S., Vaidehi N., Kim U., Drayna D., and Goddard III W.A. Modeling the human PTC bitter-taste receptor interactions with bitter tastants. J Mol Model 12 (2006) 931-941
29. Frank M.E. Taste nerve recordings in rodents. In: Spielman A.I., and Brand J.G. (Eds). Experimental cell biology of taste and olfaction (1995), CRC Press, Boca Raton 263-270
30. Frank M.E. Neuron types, receptors, behavior, and taste quality. Physiol Behav 69 (2000) 53-62
31. Frank M.E., Bouverat B.P., MacKinnon B.I., and Hettinger T.P. The distinctiveness of ionic and nonionic bitter stimuli. Physiol Behav 80 (2004) 421-431
32. Frank M.E., Formaker B.K., and Hettinger T.P. Taste responses to mixtures: analytic processing of quality. Behav Neurosci 117 (2003) 228-235
33. Frank M.E., Formaker B.K., and Hettinger T.P. Peripheral gustatory processing of sweet stimuli by golden hamsters. Brain Res Bull 66 (2005) 70-84
34. Frank M.E., Gent J.F., and Hettinger T.P. Effects of chlorhexidine on human taste perception. Physiol Behav 74 (2001) 85-99
35. Frank M.E., and Hettinger T.P. What the tongue tells the brain about taste. Chem Senses 30 suppl. 1 (2005) i68-i69
36. Frank M.E., and Nowlis G.H. Learned aversions and taste qualities in hamsters. Chem Senses 14 (1989) 379-394
37. Frank M.E., Wada Y., Makino J., Mizutani M., Umezawa H., Katsuie Y., et al. Variation in intake of sweet and bitter solutions by inbred strains of hamsters. Behav Genet 34 (2004) 465-476
38. Fukami H., and Bradley R.M. Biophysical and morphological properties of parasympathetic neurons controlling the parotid and von Ebner salivary glands in rats. J Neurophysiol 93 (2005) 678-686
39. Fukushima N., Oikawa S., Yokouchi K., Kawagishi K., and Moriizumi T. The minimum number of neurons in the central olfactory pathway in relation to its function: a retrograde fiber tracing study. Chem Senses 27 (2002) 1-6
40. Ganchrow D., Ganchrow J.R., Verdin-Alcazar M., and Whitehead M.C. Brain-derived neurotrophic factor-, neurothrophin-3-, and tyrosine kinase receptor-like immunoreactivity in lingual taste bud fields of mature hamster after sensory denervation. J Comp Neurol 455 (2003) 25-39
41. Gattermann R., Fritzsche P., Neumann K., Al-Hussein I., Kayser A., Abiad M., et al. Notes on the current distribution and the ecology of wild golden hamsters (Mesocricetus auratus). J Zool Lond 254 (2001) 359-365
42. Geran L.C., and Travers S.P. Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli. J Neurophysiol 96 (2006) 2513-2527
43. Glendinning J.I., Brown H., Capoor M., Davis A., Gbenemah A., and Long E. A peripheral mechanism for behavioral adaptation to specific "bitter" taste stimuli in an insect. J Neurosci 21 (2001) 3688-3696
44. Gosselin R.E., Smith R.P., and Hodge H.C. Clinical toxicology of commercial products (1984), Williams & Witkins, Baltimore
45. Harder D.B., Maggio J.C., and Whitney G. Assessing gustatory detection capabilities using preference procedures. Chem Senses 14 (1989) 547-564
46. Hermans E., and Challis R.A.J. Structural, signaling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors. Biochem J 359 (2001) 465-484
47. Hill D.L., Formaker B.K., and White K.S. Perceptual characteristics of the amiloride-suppressed sodium chloride taste response in the rat. Behav Neurosci 104 (1990) 734-741
48. Houpt T.A., Philopena J.M., Joh T.H., and Smith G.P. c-Fos induction in the rat nucleus of the solitary tract by intraoral quinine infusion depends on prior contingent pairing of quinine with lithium chloride. Physiol Behav 60 (1996) 1535-1541
49. Inoue M., Li X., McCaughey S.A., Beauchamp G.K., and Bachmanov A.A. Soa genotype selectively affects mouse gustatory neural responses to sucrose octaacetate. Physiol Genomics 5 (2001) 181-186
50. Johnson F., Starkovsky N.A., Paton A.C., and Carlson A.A. The total synthesis of cycloheximide. J Am Chem Soc 88 (1966) 149-159
51. Keung W.M., and Vallee B.L. Kudzu root: an ancient Chinese source of modern antidipsotropic agents. Phytochemistry 47 (1998) 499-506
52. Kim J.W., Roberts C., Maruyama Y., Berg S., Roper S., and Chaudhari N. Faithful expression of GFP from the PLCB2 promoter in a functional class of taste receptor cells. Chem Senses 31 (2006) 213-219
53. Kim M., Chiego Jr. D.J., and Bradley R.M. Morphology of parasympathetic neurons innervating rat lingual salivary glands. Autonom Neurosci 111 (2004) 27-36
54. Kim U.K., and Drayna D. Genetics of individual differences in bitter taste perception: lessons from the PTC gene. Clin Genet 67 (2004) 275-280
55. Kim U., Jorgenson E., Coon H., Leppert M., Risch N., and Drayna D. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299 (2003) 1221-1225
56. Kim U., Wooding S., Ricci D., Jorde L.B., and Drayna D. Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum Mutat 26 (2005) 199-204
57. Kimura Y., Miwa T., Furakawa M., and Umeda R. Effect of topical application of steroid on olfactory disturbance in mice. Chem Senses 16 (1991) 297-302
58. King C.T., Garcea M., and Spector A.C. Glossopharyngeal nerve regeneration is essential for the complete recovery of quinine-stimulated oromotor rejection behaviors and central patterns of neuronal activity in the nucleus of the solitary tract in the rat. J Neurosci 20 (2000) 8426-8434
59. King CT, Garcea M, Stolzenberg DS, Spector AC. The consequences of cross-regeneration of the lingual gustatory nerves on quinine-stimulated gaping and Fos-like immunoreactivity in the nucleus of the solitary tract in rats. 14th International Symposium on Olfaction and Taste 2004, Kyoto, Japan, p. 118 (Abstracts).
60. Krautwurst D., Yau K.-W., and Reed R.R. Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell 95 (1998) 917-926
61. Kulkosky P.J., and Cornell N.W. Free-choice ethanol intake and ethanol metabolism in the hamster and rat. Pharmacol Biochem Behav 11 (1979) 439-444
62. Lee S.-F., Chen Z.-Y., and Fong W.-P. Gender difference in enzymes related with alcohol consumption in hamster, an avid consumer of alcohol. Comp Biochem Physiol C 129 (2001) 285-293
63. Lemon C.H., and Smith D.V. Neural representation of bitter taste in the nucleus of the solitary tract. J Neurophysiol 94 (2005) 3719-3729
64. Li C.S., Cho Y.K., and Smith D.V. Modulation of parabrachial taste neurons by electrical and chemical stimulation of the lateral hypothalamus and amygdala. J Neurophysiol 93 (2005) 1183-1196
65. Lindemann B. Receptors and transduction in taste. Nature 413 (2001) 219-225
66. Lush I.E. The genetics of tasting in mice. I. Sucrose octaacetate. Genet Res 38 (1981) 93-95
67. Lush I.E. Differences between mouse strains in their consumption of phenylthiourea (PTC). Heredity 57 (1986) 319-323
68. Lush I.E., and Holland G. The genetics of tasting in mice. V. Glycine and cycloheximide. Genet Res 52 (1988) 207-212
69. Makalowski W., Zhang J., and Boguski M.S. Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences. Genome Res 6 (1996) 846-857
70. Mark M., and Herlitze S. G-protein mediated gating of inward-rectifier K+ channels. Eur J Biochem 267 (2000) 5830-5836
71. Matsunami H., Montmayeur J.-P., and Buck L.B. A family of candidate taste receptors in human and mouse. Nature 404 (2000) 601-604
72. In: Windholz M., Budavari S., Stroumtsos L.Y., and Fertig M.N. (Eds). Merck index. 9th ed. (1976), Merck & Co #2733, p.357
73. Moriizumi T., Tsukatani T., Sakashita H., and Miwa T. Olfactory disturbance induced by deafferentation of serotonergic fibers in the olfactory bulb. Neuroscience 61 (1994) 733-788
74. Mueller K.L., Hoon M.A., Erlenbach I., Chandrashekar J., Zuker C.S., and Ryba N.J.P. The receptors and coding logic for bitter taste. Nature 434 (2005) 225-229
75. Nachman M. Learned aversions to the taste of lithium chloride and generalization to other salts. J Comp Physiol Psychol 56 (1963) 343-349
76. Nachman M., and Ashe J.H. Learned taste aversions in rats as a function of dosage, concentration, and route of administration of LiCl. Physiol Behav 10 (1973) 73-78
77. Nebert D.W., and Russell D.W. Clinical importance of the cytochromes P450. Lancet 360 (2002) 1155-1162
78. Nelson T.M., Munger S.D., and Boughter Jr. J.D. Taste sensitivities to PROP and PTC vary independently in mice. Chem Senses 28 (2003) 695-704
79. Nelson T.M., Munger S.D., and Boughter Jr. J.D. Haplotypes at the Tas2r locus on chromosome 6 vary with quinine taste sensitivity in inbred mice. BMC Genet 6 (2005) 32
80. Neumann K., Michaux J., Ledbedev V., Yigit N., Colak E., Ivanova N., et al. Molecular phylogeny of the Cricetinae subfamily based on the mitochondrial cytochrome b and 12S rRNA genes and the nuclear vWF gene. Mol Phylogenet Evol 29 (2006) 135-148
81. Ninomiya Y., Higashi T., Katsukawa H., Mizukoshi T., and Funakoshi M. Qualitative discrimination of gustatory stimuli in three different strains of mice. Brain Res 322 (1984) 83-92
82. Nowlis G.H. Conditioned stimulus intensity and acquired alimentary aversions in the rat. J Comp Physiol Psychol 86 (1974) 1173-1184
83. Nowlis G.H., Frank M.E., and Pfaffmann C. Specificity of acquired aversions to taste qualities in hamsters and rats. J Comp Physiol Psychol 94 (1980) 932-942
84. Omura K., Takagi S.F., and Harada O. Mechanism of the repellent action of naramycin to rats. Gunma J Med Sci 10 (1961) 217-227
85. Poor A. Cricetinae, Animal Diversity Web; 2005. Accessed at http://animaldiversity.ummz.umich.edu/site/accounts/information/Cricetinae.html.
86. Prapaipong H., Berenbaum M.R., and Schuler M.A. Transcriptional regulation of the Papilio polyxenes CYPB1 gene. Nuc Acids Res 22 (1994) 3210-3217
87. Rehnberg B.G., Hettinger T.P., and Frank M.E. The role of sucrose-sensitive neurons in ingestion of sweet stimuli by hamsters. Physiol Behav 48 (1990) 459-466
88. Renwick J.A.A. Variable diets and changing taste in plant-insect relationships. J Chem Ecol 27 (2001) 1063-1076
89. Risinger F.O., and Boyce J.M. Conditioning tastant and the acquisition of conditioned taste avoidance to drugs of abuse in DBA/2J mice. Psychopharmacology 160 (2002) 225-232
90. Rodgers D.A., and McClearn G.E. Sucrose versus ethanol appetite in inbred strains of mice. Q J Stud Alc 25 (1964) 26-35
91. Sbarati A., and Osculati F. The taste cell-related diffuse chemosensory system. Prog Neurobiol 75 (2005) 295-307
92. Sewards T.V. Dual sensory pathways for sensory and hedonic aspects of taste. Brain Res Bull 62 (2004) 271-283
93. Shi P., and Zhang J. Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes. Mol Biol Evol 23 (2006) 292-300
94. Shi P., Zhang J., Yang H., and Zhang Y. Adaptive diversification of bitter taste receptor genes in mammalian evolution. Mol Biol Evol 20 (2003) 805-814
95. Steppan SJ. Muroidea. Murid rodents. The Tree of Life Web Project, 2001. Accessed at http://tolweb.org/Muroidea/16461.
96. Steppan S.J., Adkins R.M., and Anderson J. Phylogeny and divergence-date estimates of rapid radiations in muroid rodents based on multiple nuclear genes. Syst Biol 53 (2004) 533-553
97. St John S.J., Pour L., and Boughter Jr. J.D. Phenylthiocarbamide produces conditioned taste aversions in mice. Chem Senses 30 (2005) 377-382
98. St John S.J., and Spector A.C. Behavioral discrimination between quinine and KCl is dependent on the seventh cranial nerve: implications for the functional roles of the gustatory nerves in rats. J Neurosci 18 (1998) 4353-4362
99. Sugita M., and Shiba Y. Genetic tracing shows segregation of taste neuronal circuitries for bitter and sweet. Science 309 (2005) 781-785
100. Taketo M., Schroeder A.C., Mobraaten L.E., Gunning K.B., Hanten G., Fox R.R., et al. FVB/N: an inbred mouse strain preferable for transgenic analyses. Proc Natl Acad Sci USA 88 (1991) 2065-2069
101. Tobach E., Bellin J.S., and Das D.K. Differences in bitter taste perception in three strains of rats. Behav Genet 4 (1974) 405-410
102. Waksman S.A., and Lechavalier H.A. The actinomycetes, antibiotics of actinomycetes vol. III (1962), Williams & Wilkins, Baltimore pp. 248-252
103. Wang L., Chen L., and Jacob T. Evidence for peripheral plasticity in human odour response. J Physiol 554 (2003) 236-244
104. Wang H., Wysocki C.J., and Gold J.H. Induction of olfactory receptor sensitivity in mice. Science 260 (1993) 998-1000
105. Weir T.L., Park S.-W., and Vivanco J.M. Biochemical and physiological mechanisms mediated by allelochemicals. Cur Opin Plant Biol 7 (2004) 472-479
106. Welch J.F. Rodent control: a review of chemical repellents for rodents. J Agric Food Chem 2 (1954) 142-149
107. Wilson-Pauwels L., Akesson E.J., and Stewart P.A. Cranial nerves, anatomical and clinical comments (1988), BC Decker Inc., Philadelphia
108. Wong R. Response latency of gerbils and hamsters to nuts flavoured with bitter tasting substances. Q J Exp Psychol B 47 (1994) 173-186
109. Wu S.V., Chen M.C., and Rozengurt E. Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat. Physiol Genomics 22 (2005) 139-149
110. Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., and Rozengurt E. Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci (USA) 99 (2002) 2392-2397
111. Yamamoto T. Electrophysiology of CTA. In: Bures J., Bermudez-Rattoni F., and Yamamoto T. (Eds). Conditioned taste aversion: memory of a special kind (1998), Oxford University Press, New York 76-91
112. Zhang X., and Firestein S. The olfactory receptor gene superfamily of the mouse. Nat Neurosci (2002) 124-133
113. Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112 (2003) 293-301
114. Zhao G.G., Zhang Y., Hoon M.A., Chandrashekar J., Erlenbach I., Ryba N.J.P., et al. The receptors for mammalian sweet and umami taste. Cell 115 (2003) 255-266
115. Zhou P. Determining protein half-lives. Methods Mol Biol 284 (2004) 67-77