Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker

FEBS Letters

Volumn 558, Issue 1-3, 2004, Pages 52-56

  Taddei, Alessandro ^a   Folli, Chiara ^a   Zegarra Moran, Olga ^a   Fanen, Pascale ^b   Verkman, A S ^c   Galietta, Luis J V ^a  

^a G GASLINI INSTITUTE   (Italy)

^b HENRI MONDOR HOSPITAL   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Channel blocker; Chloride channel; Chloride secretion; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator

Indexed keywords

3 [(3 TRIFLUOROMETHYL)PHENYL] 5 [(3 CARBOXYPHENYL)METHYLENE] 2 THIOXO 4 THIAZOLIDINONE; CHLORIDE; CHLORIDE CHANNEL; GLIBENCLAMIDE; MUTANT PROTEIN; PROTEIN INHIBITOR; THIAZOLE DERIVATIVE; THIAZOLIDINE DERIVATIVE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CHANNEL GATING; COMPARATIVE STUDY; CONTROLLED STUDY; CYSTIC FIBROSIS; DOSE RESPONSE; DRUG EFFECT; EMBRYO; FIBROBLAST; GENETICS; MEMBRANE CONDUCTANCE; METABOLISM; MOUSE; MUTATION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROBABILITY; PROTEIN EXPRESSION; RAT; RAT STRAIN; SHORT CIRCUIT CURRENT; WILD TYPE;

EID: 0842324677     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(04)00011-0     Document Type: Article

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