DNA vaccine against NgR promotes functional recovery after spinal cord injury in adult rats

Brain Research

Volumn 1147, Issue 1, 2007, Pages 66-76

  Yu, Panpan ^a   Huang, Lidong ^a   Zou, Jian ^a   Zhu, Huiqing ^a   Wang, Xiaofei ^a   Yu, Zhihua ^a   Xu, Xiao Ming ^a,b   Lu, Pei Hua ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b University of Louisville School of Medicine   (United States)

Author keywords

DNA vaccine; Functional recovery; Myelin associated inhibitor; NgR; Spinal cord injury

Indexed keywords

ANTISERUM; DNA VACCINE; MEMBRANE PROTEIN; MYELIN ASSOCIATED GLYCOPROTEIN; NGR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CONVALESCENCE; DRUG INHIBITION; FEMALE; HISTOLOGY; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RAT; SPINAL CORD INJURY; THREE DIMENSIONAL IMAGING;

ANALYSIS OF VARIANCE; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; IMMUNITY, CELLULAR; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PEPTIDE; RECOVERY OF FUNCTION; SPINAL CORD INJURIES; TREATMENT OUTCOME; VACCINES, DNA;

RATTUS;

EID: 34247153805     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.02.013     Document Type: Article

References (46)

1. Ahmed Z., Dent R.G., Suggate E.L., Barrett L.B., Seabright R.J., Berry M., and Logan A. Disinhibition of neurotrophin-induced dorsal root ganglion cell neurite outgrowth on CNS myelin by siRNA-mediated knockdown of NgR, p75NTR and Rho-A. Mol. Cell Neurosci. 28 (2005) 509-523
2. Bareyre F.M., Haudenschild B., and Schwab M.E. Long-lasting sprouting and gene expression changes induced by the monoclonal antibody IN-1 in the adult spinal cord. J. Neurosci. 22 (2002) 7097-7110
3. Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., and Nikolov D.B. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. EMBO J. 22 (2003) 3291-3302
4. Basso D.M., Beattie M.S., and Bresnahan J.C. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp. Neurol. 139 (1996) 244-256
5. Buffo A., Zagrebelsky M., Huber A.B., Skerra A., Schwab M.E., Strata P., and Rossi F. Application of neutralizing antibodies against NI-35/250 myelin-associated neurite growth inhibitory proteins to the adult rat cerebellum induces sprouting of uninjured purkinje cell axons. J. Neurosci. 20 (2000) 2275-2286
6. Chen M.S., Huber A.B., Van Der Haar M.E., Frank M., Schnell L., Spillmann A.A., Christ F., and Schwab M.E. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403 (2000) 434-439
7. De M.L., Freed W.J., and Wyatt R.J. An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp. Neurol. 77 (1982) 634-643
8. Fouad K., Dietz V., and Schwab M.E. Improving axonal growth and functional recovery after experimental spinal cord injury by neutralizing myelin associated inhibitors. Brain Res. Brain Res. Rev. 36 (2001) 204-212
9. Fournier A.E., Gould G.C., Liu B.P., and Strittmatter S.M. Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin. J. Neurosci. 22 (2002) 8876-8883
10. GrandPre T., Nakamura F., Vartanian T., and Strittmatter S.M. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403 (2000) 439-444
11. GrandPre T., Li S., and Strittmatter S.M. Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 417 (2002) 547-551
12. Hauben E., Butovsky O., Nevo U., Yoles E., Moalem G., Agranov E., Mor F., Leibowitz-Amit R., Pevsner E., Akselrod S., Neeman M., Cohen I.R., and Schwartz M. Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion. J. Neurosci. 20 (2000) 6421-6430
13. Hauben E., Ibarra A., Mizrahi T., Barouch R., Agranov E., and Schwartz M. Vaccination with a Nogo-A-derived peptide after incomplete spinal-cord injury promotes recovery via a T-cell-mediated neuroprotective response: comparison with other myelin antigens. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 15173-15178
14. He X.L., Bazan J.F., Mcdermott G., Park J.B., Wang K., Tessier-Lavigne M., He Z., and Garcia K.C. Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron 38 (2003) 177-185
15. Henke A. DNA immunization-a new chance in vaccine research?. Med. Microbiol. Immunol. (Berl) 191 (2002) 187-190
16. Hickey W.F., Hsu B.L., and Kimura H. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28 (1991) 254-260
17. Hofstetter H.H., Sewell D.L., Liu F., Sandor M., Forsthuber T., V.Lehmann P., and Fabry Z. Autoreactive T cells promote post-traumatic healing in the central nervous system. J. Neuroimmunol. 134 (2003) 25-34
18. Huang D.W., Mckerracher L., Braun P.E., and David S. A therapeutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord. Neuron 24 (1999) 639-647
19. Hunt D., Coffin R.S., and Anderson P.N. The Nogo receptor, its ligands and axonal regeneration in the spinal cord; a review. J. Neurocytol. 31 (2002) 93-120
20. Kipnis J., Mizrahi T., Hauben E., Shaked I., Shevach E., and Schwartz M. Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 15620-15625
21. Kottis V., Thibault P., Mikol D., Xiao Z.C., Zhang R., Dergham P., and Braun P.E. Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth. J. Neurochem. 82 (2002) 1566-1569
22. Li W., Walus L., Rabacchi S.A., Jirik A., Chang E., Schauer J., Zheng B.H., Benedetti N.J., Liu B.P., Choi E., Worley D., Silvian L., Mo W., Mullen C., Yang W., Strittmatter S.M., Sah D.W., Pepinsky B., and Lee D.H. A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin. J. Biol. Chem. 279 (2004) 43780-43788
23. Liu B.P., Fournier A., GrandPre T., and Strittmatter S.M. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297 (2002) 1190-1193
24. Liu R., Zhou C., Wang D., Ma W., Lin C., Wang Y., Liang X., Li J., Guo S., Wang Y., Zhang Y., and Zhang S. Enhancement of DNA vaccine potency by sandwiching antigen-coding gene between secondary lymphoid tissue chemokine (SLC) and IgG Fc fragment genes. Cancer Biol. Ther. 5 (2006) 427-434
25. McGee A.W., and Strittmatter S.M. The Nogo-66 receptor: focusing myelin inhibition of axon regeneration. Trends Neurosci. 26 (2003) 193-198
26. Merkler D., Metz G.A., Raineteau O., Dietz V., Schwab M.E., and Fouad K. Locomotor recovery in spinal cord-injured rats treated with an antibody neutralizing the myelin-associated neurite growth inhibitor Nogo-A. J. Neurosci. 21 (2001) 3665-3673
27. Metz G.A., Merkler D., Dietz V., Schwab M.E., and Fouad K. Efficient testing of motor function in spinal cord injured rats. Brain Res. 883 (2000) 165-177
28. Mi S., Lee X., Shao Z., Thill G., Ji B., Relton J., Levesque M., Allaire N., Perrin S., Sands B., Crowell T., Cate R.L., McCoy J.M., and Pepinsky R.B. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat. Neurosci. 7 (2004) 221-228
29. Moalem G., Monsonego A., Shani Y., Cohen I.R., and Schwartz M. Differential T cell response in central and peripheral nerve injury: connection with immune privilege. FASEB J. 13 (1999) 1207-1217
30. Moalem G., Gdalyahu A., Shani Y., Otten U., Lazarovici P., Cohen I.R., and Schwartz M. Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity. J. Autoimmun. 15 (2000) 331-345
31. Moore A.C., Kong W.P., Chakrabarti B.K., and Nabel G.J. Effects of antigen and genetic adjuvants on immune responses to human immunodeficiency virus DNA vaccines in mice. J. Virol. 76 (2002) 243-250
32. Mukhopadhyay G., Doherty P., Walsh F.S., Crocker P.R., and Filbin M.T. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13 (1994) 757-767
33. Qin H., Zhou C., Wang D., Ma W., Liang X., Lin C., Zhang Y., and Zhang S. Enhancement of antitumour immunity by a novel chemotactic antigen DNA vaccine encoding chemokines and multiepitopes of prostate-tumour-associated antigens. Immunology 117 (2006) 419-430
34. Regnault A., Lankar D., Lacabanne V., Rodriguez A., Thery C., Rescigno M., Saito T., Verbeek S., Bonnerot C., Ricciardi-Castagnoli P., and Amigorena S. Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J. Exp. Med. 189 (1999) 371-380
35. Rubin B.P., Dusart I., and Schwab M.E. A monoclonal antibody (IN-1) which neutralizes neurite growth inhibitory proteins in the rat CNS recognizes antigens localized in CNS myelin. J. Neurocytol. 23 (1994) 209-217
36. Sicotte M., Tsatas O., Jeong S.Y., Cai C.Q., He Z., and David S. Immunization with myelin or recombinant Nogo-66/MAG in alum promotes axon regeneration and sprouting after corticospinal tract lesions in the spinal cord. Mol. Cell Neurosci. 23 (2003) 251-263
37. Teng F.Y., and Tang B.L. Why do Nogo/Nogo-66 receptor gene knockouts result in inferior regeneration compared to treatment with neutralizing agents?. J. Neurochem. 94 (2005) 865-874
38. Ulmer J.B., Wahren B., and Liu M.A. Gene-based vaccines: recent technical and clinical advances. Trends Mol. Med. 12 (2006) 216-222
39. Wang K.C., Kim J.A., Sivasankaran R., Segal R., and He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 420 (2002) 74-78
40. Wang K.C., Koprivica V., Kim J.A., Sivasankaran R., Guo Y., Neve R.L., and He Z. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417 (2002) 941-944
41. Wang X.F., Huang L.D., Yu P.P., Hu J.G., Yin L., Wang L., Xu X.M., and Lu P.H. Upregulation of type I interleukin-1 receptor after traumatic spinal cord injury in adult rats. Acta Neuropathol (Berl). 111 (2006) 220-228
42. Wang X.F., Yin L., Hu J.G., Huang L.D., Yu P.P., Jiang X.Y., Xu X.M., and Lu P.H. Expression and localization of p80 interleukin-1 receptor protein in the rat spinal cord. J. Mol. Neurosci. 29 (2006) 45-53
43. Wolf S.A., Fisher J., Bechmann I., Steiner B., Kwidzinski E., and Nitsch R. Neuroprotection by T-cells depends on their subtype and activation state. J. Neuroimmunol. 133 (2002) 72-80
44. Xu G., Nie D.Y., Chen J.T., Wang C.Y., Yu F.G., Sun L., Luo X.G., Ahmed S., David S., and Xiao Z.C. Recombinant DNA vaccine encoding multiple domains related to inhibition of neurite outgrowth: a potential strategy for axonal regeneration. J. Neurochem. 91 (2004) 1018-1023
45. Yan P., Liu N., Kim G.M., Xu J., Xu J., Li Q., Hsu C.Y., and Xu X.M. Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats. Exp. Neurol. 183 (2003) 286-297
46. Zheng B., Atwal J., Ho C., Case L., He X.L., Garcia K.C., Steward O., and Tessier-Lavigne M. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 1205-1210