Effects of antigen and genetic adjuvants on immune responses to human immunodeficiency virus DNA vaccines in mice

Journal of Virology

Volumn 76, Issue 1, 2002, Pages 243-250

  Moore, A C ^a   Kong, W P ^a   Chakrabarti, B K ^a   Nabel, G J ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DNA VACCINE; FLT3 LIGAND; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOPOIETIC GROWTH FACTOR; IMMUNOGLOBULIN G; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 2; NEF PROTEIN; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE EXPRESSION; GENE TARGETING; HUMAN IMMUNODEFICIENCY VIRUS; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; AIDS VACCINES; ANIMALS; ANTIGENS, VIRAL; FEMALE; GENE PRODUCTS, NEF; GENETIC VECTORS; HIV ENVELOPE PROTEIN GP160; HIV-1; IMMUNIZATION; MICE; MICE, INBRED BALB C; PLASMIDS; VACCINES, DNA;

EID: 0036132847     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.1.243-250.2002     Document Type: Article

References (34)

1. The ability of an oligomeric human immunodeficiency virus type I (HIV-1) envelope antigen to elicit neutralizing antibodies against primary HIV-1 isolates is improved following partial deletion of the second hypervariable region
2. Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys
3. Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration
4. HIV-1 DNA vaccines and chemokines
5. Enhanced cellular immunity to hepatitis C virus nonstructural proteins by codelivery of granulocyte macrophage-colony stimulating factor gene in intramuscular DNA immunization
6. Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes
7. Tumorigenicity and lysis by natural killers
8. Immune-mediated destruction of transfected muscle fibers after direct gene transfer with antigen-expressing plasmid DNA
9. DNA vaccines
10. DNA vaccines: Immunology, application, and optimization
11. Nucleic acid immunization: Concepts and techniques associated with third generation vaccines
12. Rectal and vaginal immunization with a macromolecular multicomponent peptide vaccine candidate for HIV-1 infection induces HIV-specific protective immune responses
13. Cytokine molecular adjuvants modulate immune responses induced by DNA vaccine constructs for HIV-1 and SIV
14. The timing of GM-CSF expression plasmid administration influences the Th1/Th2 response induced by an HIV-1-specific DNA vaccine
15. DNA and RNA-based vaccines: Principles, progress and prospects
16. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production
17. Progress in the development of an HIV-1 vaccine
18. Induction of dendritic cells (DC) by Fit3 Ligand (FL) promotes the generation of tumor-specific immune responses in vivo
19. Flt3 ligand induces tumor regression and antitumor immune responses in vivo
20. Dramatic increase in the numbers of functionally mature dendritic cells in Fit3 ligand-treated mice: Multiple dendritic cell subpopulations identified
21. HIV-1 env, nef, and gag-specific T-cell immunity in mice: Conserved epitopes in nef p27 and gag p25 proteins
22. Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens
23. Cytokines and costimulatory molecules as genetic adjuvants
24. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo
25. Prevention of peripheral tolerance by a dendritic cell growth factor: Flt3 ligand as an adjuvant
26. The promise of nucleic acid vaccines
27. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
28. Development of a preventive vaccine for Ebola virus infection in primates
29. Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
30. Heterologous protection against influenza by injection of DNA encoding a viral protein
31. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
32. DNA vaccination strategies against infectious diseases
33. Immunization for Ebola virus infection
34. Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins