26-Week dermal oncogenicity study evaluating pure trans-capsaicin in Tg.AC hemizygous mice (FBV/N)

International Journal of Toxicology

Volumn 26, Issue 2, 2007, Pages 123-133

  Chanda, Sanjay ^a   Erexson, Gregory ^b,c   Frost, Denzil ^b   Babbar, Sunita ^a   Burlew, Jo Anne ^b   Bley, Keith ^a  

^a NeurogesX Inc   (United States)

^b UK   (United States)

^c BAXTER HEALTHCARE CORPORATION   (United States)

Author keywords

Capsaicin; Carcinogenicity; Dermal; Diethylene Glycol Monoethyl Ether; Tg.AC; Transgenic Mouse

Indexed keywords

CAPSAICIN; DIETHYLENE GLYCOL MONOETHYL ETHER; LIDOCAINE; LOCAL ANESTHETIC AGENT; PHORBOL 13 ACETATE 12 MYRISTATE;

ACANTHOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; DISEASE SEVERITY; DISSOLUTION; DOSE RESPONSE; FEMALE; HYPERKERATOSIS; MALE; MOUSE; NONHUMAN; PARAKERATOSIS; PRECANCER; RANDOMIZATION; SEX DIFFERENCE; SKIN CARCINOGENESIS; SKIN FIBROSIS; SKIN INFLAMMATION; SKIN PAPILLOMA; SKIN TOXICITY; SKIN ULCER; TOXICITY TESTING;

ADMINISTRATION, CUTANEOUS; ANIMALS; CAPSAICIN; CARCINOGENICITY TESTS; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLENE GLYCOLS; FEMALE; HETEROZYGOTE; LIDOCAINE; MALE; MICE; MICE, TRANSGENIC; SKIN; SKIN DISEASES; STEREOISOMERISM;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 34047157693     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1080/10915810701225281     Document Type: Article

References (53)

1. Agarwal S., J. Deschner, P. Long, A. Verma, C. Hofman, C. H. Evans, and N. Piesco. 2004. Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals. Arthritis Rheum. 50:3541-3548.
2. Agarwal, R. C., M. Wiessler, E. Hecker, and S. V. Bhide. 1986. Tumour-promoting effect of chilli extract in BALB/c mice. Int. J. Cancer 38:689-694.
3. Archer, V. E., and D. W. Jones. 2002. Capsaicin pepper, cancer and ethnicity. Med. Hypo. 59:450-457.
4. Azizan, A., and R. D. Blevins. 1995. Mutagenicity and antimutagenicity testing of six chemicals associated with the pungent properties of specific spices as revealed by the Ames Salmonella/microsomal assay. Arch. Environ. Contam. Toxicol. 28:248-258.
5. Blevins, R. D., and A. Azian. 1989. Mutagenicity and antimutagenicity testing of six chemicals associated with the pungent properties of specific spices. Environ. Mol. Mutagen. 14(Suppl.15):24 (abstract No. 63).
6. Bley, K. R. 2004. Recent developments in transient receptor potential vanilloid receptor 1 agonist-based therapies. Expert Opin. Investig. Drugs 13:1445-1456.
7. Buchanan, R. L., S. Goldstein, and J. D. Budroe. 1981. Examination of chili pepper and nutmeg oleoresins using the Salmonella/mammalian microsome mutagenicity assay. J. Food Sci. 47:330-333.
8. Chanda, S., G. Erexson, C. Riach, D. Innes, F. Stevenson, H. Murli, and K. Bley. 2004. Genotoxicity studies with pure trans-capsaicin. Mutat. Res. 557:85-97.
9. Chueh P. J., L. Y. Wu, D. M. Morre, and D. J. Morre. 2004. tNOX is both necessary and sufficient as a cellular target for the anticancer actions of capsaicin and the green tea catechin (?)-epigallocatechin-3-gallate. Biofactors 20:235-249.
10. Cordell, G. A., and O. E. Araujo. 1993. Capsaicin: Identification, nomenclature, and pharmacotherapy. Ann. Pharmacother. 27:330-336.
11. Cortright, D. N., and A. Szallasi. 2004. Biochemical pharmacology of the vanilloid receptor TRPV1. An update. Eur. J. Biochem. 271:1814-1819.
12. Damhoeri, A., A. Hosono, T. Itoh, andT. Matsuyama. 1985. In vitro mutagenicity tests on capsicum pepper, shallot and nutmeg oleoresins. Agric. Biol. Chem. 49:1519-1520.
13. Demirbilek S., M. O. Ersoy , S. Demirbilek, A. Karaman, N. Gurbuz, N. Bayraktar, and M. Bayraktar. 2004. Small-dose capsaicin reduces systemic inflammatory responses in septic rats. Anesth. Analg. 99:1501-1507.
14. Dunnett, C. W. 1955. A multiple comparison procedure for comparing several treatments with a control. J. Am. Stat. Assoc. 50:1096-1121.
15. Dunnett, C. W. 1964. New tables for multiple comparisons with a control. Biometrics 20:482-491.
16. Friedman, P. M., E. A. Mafong, E. S. Friedman, and R. G. Geronemus. 2001. Topical anesthetics update: EMLA and beyond. Dermatol. Surg. 27:1019-1026.
17. Gannett, P. M., D. L. Nagel, P. J. Reilly, T. Lawson, J. Sharpe, and B. Toth. 1988. The Capsaicinoids: Their separation, synthesis, and mutagenicity. J. Org. Chem. 53: 1064-1071.
18. Ghosh, B., L. H. Reddy, R. V. Kulkarni, and J. Khanam. 2000. Comparison of skin permeability of drugs in mice and human cadever skin. Indian J. Exp. Biol. 38:42-45.
19. Govindarajan, V. S., and M. N. Sathyanarayana. 1991. Capsicum - production, technology, chemistry, and quality. Part V. Impact on physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences. Crit. Rev. Food Sci. Nutr. 29:435-474.
20. Hagiwara, M., E. Watanabe, J. C. Barrett, and T. Tsutsui. 2006. Assessment of genotoxicity of 14 chemical agents used in dental practice: Ability to induce chromosome aberrations in Syrian hamster embryo cells. Mutat. Res. 603:111-120.
21. Hail, N., Jr., and R. Lotan. 2002. Examining the role of mitochondrial respiration in vanilloid-induced apoptosis. J. Natl. Cancer Inst. 94:1281-1292.
22. Ito, K., T. Nakazato, K. Yamato, Y. Miyakawa, T. Yamada, N. Hozumi, K. Segawa, Y. Ikeda, and M. Kizaki. 2004. Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res. 64:1071-1078.
23. Kang, H.-J., Y. Soh, M.-S. Kim, E.-J. Lee, Y.-J. Surh, H.-R. C. Kim, S. H. Kim, and A. Moon. 2003. Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells. Int. J. Cancer 103:475-482.
24. Kim, C. S., W. H. Park, J.Y. Park, J. H. Kang, M. O. Kim, T. Kawada, H. Yoo, I. S. Han, and R. Yu. 2004. Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor gamma in HT-29 human colon cancer cells. J. Med. Food 7:267-273.
25. 2+ release pathway mediates the capsaicin-induced apoptosis in HepG2 human hepatoma cells. Arch. Pharm. Res. 28:73-80.
26. Kornreich, M., and C. A. Montgomery, Jr. 1990. Toxicology and carcinogenesis studies of 2,6-xylidine (2,6-dimethylaniline) in Charles River CD rats. National Toxicology Program (NTP). NTP TR 278, NIH Publication No. 90-2534, pp. 1-138.
27. Lawson, T., and P. Gannett. 1989. The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells. Cancer Lett. 49:109-113.
28. Lee J. S., J. S. Chang, J. Y. Lee, and J. A Kim. 2004. Capsaicin-induced apoptosis and reduced release of reactive oxygen species in MBT-2 murine bladder tumor cells. Arch. Pharm. Res. 27:1147-1153.
29. Lehr, V.T., E. Cepeda, D. A. Frattarelli, R. Thomas, J. LaMothe, and J. V. Aranda. 2005. Lidocaine 4% cream compared with lidocaine 2.5% and prilocaine 2.5% or dorsal penile block for circumcision. Am. J. Perinatol. 22:231-237.
30. Lopez-Carrillo, L., M. H. Avila, and R. Dubrow. 1994. Chilli pepper consumption and gastric cancer in Mexico: A case-control study. Am. J. Epidemiol. 139:263-271.
31. Lopez-Carrillo, L., M. Lopez-Cervantes, G. Robles-Diaz, A. Ramirez-Espitia, A. Mphar-Betancourt, A. Meness-Garcia, Y. Lopez-Vidal, and A. Blair. 2003. Capsaicin consumption, Helicobactor pylori positivity and gastric cancer in Mexico. Int. J. Cancer 106:277-282.
32. Mahler, J. F., N. D. Flagler, D. E. Malarkey, P. C. Mann, J. K. Haseman, and W. Eastin. 1998. Spontaneous and chemically induced proliferative lesions in Tg.AC transgenic and p53-heterozygous mice. Toxicol. Pathol. 26:501-511.
33. Marques, S., N. G. Oliveira, T. Chaveca, and J. Rueff. 2002. Micronuclei and sister chromatid exchanges induced by capsaicin in human lymphocytes. Mutat. Res. 517:39-46.
34. Min, J.-K., K.-Y. Han, E.-C. Kim, Y.-M. Kim, S.-W. Lee, O.-H. Kim, K.-W. Kim, Y. S. Gho, and Y.-G. Kwon. 2004. Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res. 64:644-651.
35. Mori, A., S. Lehmann, J. O'Kelly, T. Kimagai, J. C. Desmond, M. Pervan, W. H. McBride, M. Kizaki, and H. P. Koeffler. 2006. Capsaicin, a component of red peppers, inhibits the growth of androgen-dependent, p53 mutant prostate cancer cells. Cancer Res. 66:3222-3229.
36. Nagabhushan, M., and S. V. Bhide. 1985. Mutagenicity of chili extract and capsaicin in short-term tests. Environ. Mutagen. 7:881-888.
37. Panchagnula, R., and W. A. Ritschel. 1991. Development and evaluation of an intracutaneous depot formulation of corticosteroids using Transcutol as a cosolvent: in-vitro, ex-vivo and in-vivo rat studies. J. Pharm. Pharmacol. 43:609-614.
38. Proudlock, R., C. Thompson, and E. Longstaff. 2004. Examination of the potential genotoxicity of pure capsaicin in bacterial mutation, chromosome aberration, and rodent micronucleus tests. Environ. Mol. Mutagen. 44:441-447.
39. Qiao, S., W. Li, R. Tsubouchi, M. Haneda, K. Murakami, and M. Yoshino. 2005. Involvement of peroxynitrite in capsaicin-induced apoptosis of C6 glioma cells. Neurosci. Res. 51:175-183.
40. Richeux, F., M. Cascante, M. R. Ennamany, D. Saboureau, and E. E. Creppy. 1999. Cytotoxicity and genotoxicity of capsaicin in human neuroblastoma cells SHSY-5Y. Arch. Toxicol. 73:403-409.
41. Sanchez, A. M., M. G. Sanchez, S. Malagarie-Cazenave, N. Olea, and I. Diaz-Laviada. 2006. Induction of apoptosis in prestate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilliod capsaicin. Apoptosis 11:89-99.
42. Scientific Committee on Food, European Commission, 2002. Opinion of the Scientific Committee on Food on Capsaicin.
43. Stoll, R. E., S. M. Furst, J. H. Stoltz, P. D. Lilly, and J. H. Mennear. 2001. Dermal carcinogenicity in transgenic mice: Effect of vehicle on responsiveness of hemizygous Tg.AC mice to phorbol 12-myristate 13-acetate. Toxicol. Pathol. 29:535-540.
44. Surh, Y.-J. 2002. More than spice: Capsaicin in hot chilli peppers makes tumor cells commit suicide. J. Natl. Cancer Inst. 94:1263-1265.
45. Surh, Y.-J., R. C.-J. Lee, K.-K. Park, S. T. Mayne, A. Liem, and J. A. Miller. 1995. Chemoprotective effects of capsaicin and diallyl sulfide against mutagenesis or tumorigenesis by vinyl carbamate and N- nitrosodimethylamine. Carcinogenesis 16:2467-2471.
46. Surh, Y.-J., and S. S. Lee. 1995. Capsaicin a double-edged sword: Toxicity, metabolism, and chemopreventive potential. Life Sci. 56:1845-1855.
47. Thompson, K. L., B. A. Rosenzweig, and F. D. Sistare. 1998. An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. II. A genotypic marker that predicts tumorigenic responsiveness. Toxicol. Pathol. 26:548-555.
48. Thompson, K. L., B. A. Rosenzweig, J. L. Weaver, K. K. Lin, and F. D. Sistare. 2003. Evaluation of the Tg.AC assay: Specificity testing with three non-carcinogenic pharmaceuticals that induce selected stress gene promoters in vitro and the inhibitory effects of solvent components. Toxicol. Sci. 74:271-278.
49. Torrey, C. E., H. G. Wall, J. A. Campbell, P. Kwanyuen, D. J. Hoivik, R. T. Miller, J. S. Allen, M. J. Jayo, K. Selinger, and M. J. Santostefano. 2005. Evaluation of carcinogenic potential of clofibrate in the FVB/Tg.AC mouse after dermal application - part II. Int. J. Toxicol. 24:327-339.
50. Toth, B., E. Rogan, and B. Walker. 1984. Tumorigenicity and mutagenicity studies with capsaicin of hot peppers. Anticancer Res. 4:117-120.
51. United States Pharmacopoeia, 28th edition; National Formulary, 23rd edition, 2005
52. Vinitketkumnuen U., C. Sasagawa, and T. Matsushima. 1991. Mutagenicity study of chili and its pungent principles, capsaicin and dihydrocapsaicin. Mutat. Res. 252:115 (abstract no. 81).
53. nd ed., ed. B. J. Winer, 149-260. New York: McGraw-Hill.