Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells

International Journal of Cancer

Volumn 103, Issue 4, 2003, Pages 475-482

  Kang, Hye Jung ^a   Soh, Yunjo ^b   Kim, Mi Sung ^a   Lee, Eun Jung ^a   Surh, Young Joon ^c   Kim, Hyeong Reh Choi ^d   Kim, Seung Hee ^e   Moon, Aree ^a  

^a Duksung Women's University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Seoul National University   (South Korea)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Korea Food and Drug Administration   (South Korea)

Author keywords

Apoptosis; Capsaicin; H ras; MAPKs; MCF10A cells

Indexed keywords

CAPSAICIN; CASPASE 3; CASPASE INHIBITOR; DNA FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CELL TRANSFORMATION; CELL VIABILITY; CHEMOPROPHYLAXIS; CONTROLLED STUDY; ENZYME ACTIVITY; GENE ACTIVATION; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MODULATION; MOLECULAR MECHANICS; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BREAST; CAPSAICIN; CELL LINE, TRANSFORMED; CELL NUCLEUS; CYSTEINE PROTEINASE INHIBITORS; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; IMMUNOBLOTTING; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASES; OLIGOPEPTIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037428673     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10855     Document Type: Article

References (46)

1. Ferguson LR. Antimutagens as cancer chemopreventive agents in the diet. Mut Res 1994;307:395-410.
2. Stavric B. Role of chemopreventers in human diet. Clin Biochem 1994;27:319-32.
3. Suzuki T, Iwai K. Constitution of red pepper species: Chemistry, biochemistry, pharmacology, and food science of the pungent principle of capsicum species. In: Brosi A, ed. The Alkaloides. New York: Academic Press, 1984. 227-99.
4. Cordell GA, Araujo OE. Capsaicin: Identification, nomenclature, and pharmacotherapy. Ann Pharmacother 1993;27:330-6.
5. Surh YJ, Lee SS. Capsaicin in hot chili pepper: Carcinogen, cocarcinogen or anticarcinogen? Food Chem Toxic 1996;34:313-6.
6. Surh YJ, Lee E, Lee JM. Chemopreventive properties of some pungent ingredients present in red pepper and ginger. Mut Res 1998;402:259-67.
7. Morre DJ, Chuen PJ, Morre DM. Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture. Proc Natl Acad Sci USA 1995;92:1831-5.
8. Morre DJ, Sun E, Geilen C, Wu LY, De Cabo R, Krasgakis K, Orfanos CE, Morre DM. Capsaicin inhibits plasma membrane NADH oxidase and growth of human and mouse melanoma lines. Eur J Cancer 1996;32:1995-2003.
9. Jung MY, Kang HJ, Moon A. Capsaicin-induced apoptosis in SK- Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation. Cancer Lett 2001;165:139-45.
10. Clair T, Miller W, Cho-Chung Y. Prognostic significance of the expression of the ras protein with a molecular weight of 21,000 by human breast cancer. Cancer Res 1987;49:5290-3.
11. Barbacid M. Ras genes. Annu Rev Biochem 1987;56:779-827.
12. Clark GK, Der CJ. Oncogenic activation of Ras proteins. In: Dickey BF, Birnbaumer L, eds. GTPases in Biology I. Berlin: Springer Verlag, 1993. 259-88.
13. Denhardt DT. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: The potential for multiplex signalling. Biochem J 1996;318:729-47.
14. Robbins DJ, Cheng M, Zhen E, Vanderbilt CA, Feig LA, Cobb MH. Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proc Natl Acad Sci USA 1992;89:6924-8.
15. Lewis TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascades. Adv Cancer Res 1998;74:49-139.
16. Ruiter GA, Zerp SF, Bartelink H, van Blitterswijk WJ, Verheij M. Alkyl-lysopholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis. Cancer Res 1999;59,10:2457-63.
17. Schwenger P, Alpert D, Skolnik EY, Vilcek J. Cell-type-specific activation of c-Jun N-terminal kinase by salicylates. J Cell Physiol 1999;179:109-14.
18. 2-terminal kinase regulation of small cell lung cancer cells to ultraviolet radiation. J Biol Chem 1997;272:10110-6.
19. Zhang P, Hogan EL, Bhat NR. Activation of JNK/SAPK in primary glial cultures: II. Differential activation of kinase isoforms corresponds to their differential expression. Neurochem Res 1998;23:219-25.
20. Xia Z, Dickens M, Raingeaud J, Davis R, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995;270:1326-31.
21. 2-terminal kinase-mediated activation of interleukin-1beta converting enzyme/CED-3-like protease during anticancer. J Biol Chem 1997;272:4631-6.
22. 2 terminal kinase/p38 mitogen-activated protein kinases. Cancer Res 2001;61:8504-12.
23. Moon A, Kim MS, Kim TG, Kim SH, Kim HE, Chen YQ, Kim HR, Choi. H-ras, but not N-ras, induces an invasive phenotype in human breast epithelial cells: A role for MMP-2 in the H-ras induced invasive phenotype. Int J Cancer 2000;85:176-81.
24. Cardone MH, Salvesen GS, Widmann C, Johnson G, Frisch SM. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 1997;90:315-23.
25. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, Munday NA, Raju SM, et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 1995;376:37-43.
26. Los M, De Craen MV, Penning LC, Schenk H, Westendorp M, Baeuerle PA, Droge W, Krammer PH, Fiers W, Schulze-Osthoff K. Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature 1995;375:81-3.
27. Soule HD, Maloney TM, Wolman SR, Peterson WD, Brenz R, McGrath CM, Russo J, Pauley RJ, Jones RF, Brooks SC. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res 1990;50:6075-86.
28. Soh Y, Jeong KS, Lee IJ, Bae MA, Kim YC, Song BJ. Selective activation of the c-Jun N-terminal protein kinase pathway during 4-hydroxynonenal-induced apoptosis of PC-12 cells. Mol Pharmacol 2000;58:535-41.
29. Liu X, Gupta AK, Corry PM, Lee YJ. Hypoglycemia-induced c-jun phosphorylation is mediated by c-Jun N-terminal kinase 1 and Lyn kinase in drug-resistant human breast carcinoma MCF-7/ADR cells. J Biol Chem 1997;272:11690-3.
30. Sugimoto T, Stewart S, Han M, Guan KL. The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAPkinase activation. EMBO J 1998;17:1717-27.
31. Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, Davis RJ. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 1995;270:7420-6.
32. Alnemri ES. Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases. J Cell Biochem 1997;64:33-42.
33. Proter AG, Janicke RU. Emerging roles of caspase-3 on apoptosis. Cell Death Differ 1999;6:99-104.
34. Park DS, Stefanis L, Yan CYI, Farinelli SE, Greene LA. Ordering the cell death pathway. J Biol Chem 1996;271:21898-905.
35. Virdee K, Bannister AJ, Hunt SP, Tolkovsky AM. Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones. J Neurochem 1997;69:550-61.
36. Raff MC. Social control on cell survival and cell death. Nature 1992;356:397-400.
37. Kong AN, Yu R, Chen C, Mandlekar S and Primiano T. Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis. Arch Pharm Res 2000;23:1-16.
38. Bos JL. ras oncogenes in human cancer: A review. Cancer Res 1989; 49:4682-9.
39. Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E, Gilbert C, Coffer P, Downward J, Evan G. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 1997;385:544-8.
40. Morre DJ, Caldwell S, Mayorga A, Wu LY, Morre DM. NADH oxidase activity from sera altered by capsaicin is widely distributed among cancer patients. Arch Biochem Biophys 1997;342:224-30.
41. Kim JD, Kim JM, Pyo JO, Kim SY, Kim BS, Yu R, Han IS. Capsaicin can alter the expression of tumor forming-related genes which might be followed by induction of apoptosis of a Korean stomach cancer cell line, SNU-1. Cancer Lett 1997;120:235-41.
42. Wolvetang EJ, Larm JA, Moutsoulas P, Lawen A. Apoptosis induced by inhibitor of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin. Cell Growth Differ 1996;7:1315-25.
43. Macho A, Calzado MA, Munoz-Blanco J, Gomez-Diaz C. Gajate C, Mollinedo F, Navas P, Munoz E. Selective induction of apoptosis by capsaicin in transformed cells: The role of reactive oxygen species and calcium. Cell Death Differ 1999;6:155-65.
44. Macho A, Blazquez MV, Navas P, Munoz E. Induction of apoptosis by vanilloid compounds does not require de novo gene transcription and activator protein 1 activity. Cell Growth Differ 1998;9:277-86.
45. Schwieger A, Bauer L, Hanusch J, Sers C, Schafer R, Bauer G. ras oncogene expression determines sensitivity for intercellular induction of apoptosis. Carcinogenesis 2001;22:1385-92.
46. Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Fearon ER. Sundaresan M, Finkel T, Goldschmidt-Clermont PJ. Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts. Science 1997;275:1649-52.