Dermal carcinogenicity in transgenic mice: Effect of vehicle on responsiveness of hemizygous Tg.AC mice to phorbol 12-myristate 13-acetate (TPA)

Toxicologic Pathology

Volumn 29, Issue 5, 2001, Pages 535-540

  Stoll, R E ^a   Furst, S M ^a   Stoltz, J H ^a   Lilly, P D ^a   Mennear, J H ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Acetone; Carcinogenicity bioassay; Dermal papilloma; Dimethyl sulfoxide; Ethanol; Methanol; Short term carcinogenesis models; TPA vehicles; Transgenic mice

Indexed keywords

ACETONE; ALCOHOL; DIMETHYL SULFOXIDE; METHANOL; PHORBOL 13 ACETATE 12 MYRISTATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CARCINOGENICITY; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DERMIS; FEMALE; MALE; MOUSE; NONHUMAN; PAPILLOMA; PRIORITY JOURNAL; SKIN CANCER; SKIN CARCINOGENESIS;

ADMINISTRATION, CUTANEOUS; ANIMALS; BODY WEIGHT; CARCINOGENICITY TESTS; FEMALE; HETEROZYGOTE; LONGEVITY; MALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; PAPILLOMA; SKIN NEOPLASMS; SOLVENTS; TETRADECANOYLPHORBOL ACETATE; VEHICLES;

ANIMALIA; MUS MUSCULUS;

EID: 0034760122     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/019262301317226339     Document Type: Article

References (14)

1. Dermal Carcinogenicity in transgenic mice: Relative responsiveness of male and female hemizygous and homozygous Tg.AC mice to 12-o-tetradecanoylphorbol 13-acetate (TPA) and benzene
2. Follicular origin of epidermal papillomas in v-Ha-ras transgenic TG.AC mouse skin
3. Genetic background alters the spectrum of tumors that develop in p53-deficient mice
4. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice
5. v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: Effects of phorbol esters and retinoic acid
6. The International Life Sciences Institute's role in the evaluation of alternative methodologies for the assessment of carcinogenic risk
7. Strain differences and solvent effects in mouse skin carcinogenesis experiments using carcinogens, tumor initiators and promoters
8. Development of a transgenic mouse model for carcinogenesis bioassays: Evaluation of chemically induced skin tumors in Tg.AC mice
9. Chemical induced skin carcinogenesis in a transgenic mouse line (Tg.AC) Carrying a v-Ha-ras transgene
10. Cancer hazard identification: Toward simplification and interpretability
11. Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models
12. Evaluation of transgenic mouse bioassays for identifying carcinogens and noncarcinogens
13. Genetically altered mouse models for identifying carcinogens
14. An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. II. A genotypic marker that predicts tumorigenic responsiveness