Co-localization of phosphorylated extracellular signal-regulated protein kinases 1/2 (ERK1/2) and phosphorylated eukaryotic initiation factor 2α (eIF2α) in response to a threonine-devoid diet

Journal of Comparative Neurology

Volumn 494, Issue 3, 2006, Pages 485-494

  Sharp, James W ^a   Ross Inta, Catherine M ^a   Hao, Shuzhen ^a   Rudell, J B ^a   Gietzen, Dorothy W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amino acid deficiency; Anterior piriform cortex; MAP kinase; Signaling Cascades

Indexed keywords

INITIATION FACTOR 2ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; THREONINE;

AMINO ACID DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; FEEDING BEHAVIOR; INSULA; MALE; MOTOR CORTEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PYRIFORM CORTEX; RAT; SENSORY NERVE CELL; SIGNAL TRANSDUCTION;

ANIMAL FEED; ANIMALS; CHEMORECEPTORS; EUKARYOTIC INITIATION FACTOR-2; IMMUNOHISTOCHEMISTRY; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; PARAHIPPOCAMPAL GYRUS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; THREONINE;

EID: 29044445753     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.20817     Document Type: Article

References (43)

1. Bellinger LL, Evans JF, Gietzen DW. 1998. Dorsomedial hypothalamic lesions alter intake of an imbalanced amino acid diet in rats. J Nutr 128:1213-1217.
2. Bellinger LL, Evans JF, Tillberg CM, Gietzen DW. 1999. Effects of dorsomedial hypothalamic nuclei lesions on intake of an imbalanced amino acid diet. Am J Physiol 277:R250-R262.
3. Berkeley JL, Levey AI, 2000. Muscarinic activation of mitogen-activated protein kinase in PC12 cells. J Neurochem 75:487-493.
4. Bernardis LL, Bellinger LL. 1987. The dorsomedial hypothalamic nucleus revisited: 1986 update. Brain Res Rev 12:321-381.
5. Beverly JL, Gietzen DW, Rogers QR. 1990. Effect of dietary limiting amino acid in prepyriform cortex on food intake. Am J Physiol 259:R709-R715.
6. Campbell LE, Wang X, Proud CG. 1999. Nutrients differentially regulate multiple translation factors and their control by insulin. Biochem J 344:433-441.
7. Chen HX, Otmakhov N, Strack S, Colbran RJ, Lisman JE. 2001. Is persistent activity of calcium/calmodulin-dependent kinase required for the maintenance of LTP? J Neurophysiol 85:1368-1376.
8. Ekstrand JJ, Domroese ME, Johnson DM, Feig SL, Knodel S, Behan M, Haberly LB. 2001. A new subdivision of anterior piriform cortex and associated deep nucleus with novel features of interest for olfaction and epilepsy. J Comp Neurol 434:289-307.
9. Gietzen DW. 1993. Neural mechanisms in the responses to amino acid deficiency. J Nutr 123:610-625.
10. Gietzen DW, Rogers QR, Leung PM, Semon B, Piechota T. 1987. Serotonin and feeding responses of rats to amino acid imbalance: initial phase. Am J Physiol 253:R763-R771.
11. Gietzen DW, Erecius LF, Rogers QR. 1998. Neurochemical changes after imbalanced diets suggest a brain circuit mediating anorectic responses to amino acid deficiency in rats. J Nutr 128:771-781.
12. Gietzen DW, Ross CM, Hao S, Sharp JW. 2004. Phosphorylation of eIF2alpha is involved in the signaling of indispensable amino acid deficiency in the anterior piriform cortex of the brain in rats. J Nutr 134:717-723.
13. Haberly LB. 2001. Parallel-distributed processing in olfactory cortex: new insights from morphological and physiological analysis of neuronal circuitry. Chem Senses 26:551-576.
14. Haberly LB, Price JL. 1978. Association and commissural fiber systems of the olfactory cortex of the rat. J Comp Neurol 178:711-740.
15. Hao S, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, Wek RC, Cavener DR, McGrath BC, Rudell JB, Koehnle TJ, Gietzen DW. 2005. Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science 307:1776-1778.
16. Hasan Z, Woolley D, Gietzen D. 1998. Responses to indispensable amino acid deficiency and replenishment recorded in the anterior piriform cortex of the behaving rat. Nutr Neurosci 1:373-381.
17. Hinnebusch AG. 1997. Translational regulation of yeast GCN4. A window on factors that control initiator-tRNA binding to the ribosome. J Biol Chem 272:21661-21664.
18. Huang CC, Hsu KS, Gean PW. 1996. Isoproterenol potentiates synaptic transmission primarily by enhancing presynaptic calcium influx via P- and/or Q-type calcium channels in the rat amygdala. J Neurosci 16:1026-1033.
19. Huang YY, Martin KC, Kandel ER. 2000. Both protein kinase A and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation. J Neurosci 20:6317-6325.
20. Illig KR, Haberly LB. 2003. Odor-evoked activity is spatially distributed in piriform cortex. J Comp Neurol 457:361-373.
21. Kanter ED, Haberly LB. 1990. NMDA-dependent induction of long-term potentiation in afferent and association fiber systems of piriform cortex in vitro. Brain Res 525:175-179.
22. Kennedy MB. 1999. On beyond LTP: long-term potentiation. Learn Mem 6:417-421.
23. Kita H, Oomura Y. 1982. An HRP study of the afferent connections to rat medial hypothalamic region. Mol Brain Res 8:53-62.
24. Koehnle TJ, Russell MC, Gietzen DW. 2003. Rats rapidly reject diets deficient in essential amino acids. J Nutr 133:2331-2335.
25. Leung PMB, Rogers QR. 1971. Importance of prepyriform cortex in food-intake response of rats to amino acids. Am J Physiol 221:929-935.
26. Monda M, Sullo A, De Luca V, Pellicano MP, Viggiano A. 1997. L-threonine injection into PPC modifies food intake, lateral hypothalamic activity, and sympathetic discharge. Am J Physiol 273:R554-R559.
27. Monnikes H, Lauer G, Bauer C, Tebbe J, Zittle TT, Arnold R. 1997. Pathways of fos expression in locus ceruleus, dorsal vagal complex, and PVN in response to intestinal lipid. Am J Physiol 273:R2059-R2071.
28. Paxinos G, Watson C. 2001. The rat brain in stereotaxic coordinates. San Diego: Academic Press.
29. Patel J, Wang X, Proud CG. 2001. Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1. Biochem J 358:497-503.
30. Proud CG. 2002. Regulation of mammalian translation factors by nutrients. Eur J Biochem 269:5338-5349.
31. Russell MC, Koehnle TJ, Barrett JA, Blevins JE, Gietzen DW. 2003. The rapid anorectic response to a threonine imbalanced diet is decreased by injection of threonine into the anterior piriform cortex of rats. Nutr Neurosci 6:247-251.
32. Sharp JW, Magrum LJ, Gietzen DW. 2002. Role of MAP kinase in signaling indispensable amino acid deficiency in the brain. Mol Brain Res 105:11-18.
33. Sharp JW, Ross CM, Koehnle TJ, Gietzen DW. 2004. Phosphorylation of Ca(2+)/calmodulin-dependent protein kinase type II and the alpha-amino-3- hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor in response to a threonine-devoid diet. Neuroscience 126:1053-1062.
34. Sonenberg N, Hershey JWB, Matthews MB. 2000. Translational control of gene expression. Plainview, NY: Cold Spring Harbor Press.
35. Struhl K. 1987. The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous. Cell 50:841-846.
36. Sweatt JD. 2001. The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem 76:1-10.
37. Wang Y, Cummings SL, Gietzen DW. 1996. Temporal-spatial pattern of c-fos expression in the rat brain in response to indispensable amino acid deficiency I. The intitial recognition phase. Brain Res 40:27-34.
38. Watabe AM, Zaki PA, O'Dell TJ. 2000. Coactivation of beta-adrenergic and cholinergic receptors enhances the induction of long-term potentiation and synergistically activates mitogen-activated protein kinase in the hippocampal CA1 region. J Neurosci 20:5924-5931.
39. Wek SA, Zhu S, Wek RC. 1995. The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids. Mol Cell Biol 15:4497-4506.
40. Williams G, Harrold JA, Cutler DJ. 2000. The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box. Proc Nutr Soc 59:385-396.
41. Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR. 2002. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol 22:6681-6688.
42. Zhu S, Sobolev AY, Wek RC. 1996. Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2. J Biol Chem 271:24989-24994.
43. Zoll WL, Horten LE, Komar AA, Hensold JO, Merrick WC. 2002. Characterization of mammalian eIF2a and identification of the yeast homolog. J Biol Chem 277:37079-37087.