Useful adjuvants for postoperative pain management

Best Practice and Research: Clinical Anaesthesiology

Volumn 21, Issue 1, 2007, Pages 31-49

  Buvanendran, Asokumar ^b   Kroin, Jeffrey S ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

acetylcholine esterase inhibitors; adjuvants; alpha 2 adrenergic agonists; anticonvulsants; corticosteroids; NMDA antagonists; opioids; postoperative pain

Indexed keywords

ADJUVANT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; AMANTADINE; BENZODIAZEPINE DERIVATIVE; BUPIVACAINE; CELECOXIB; CHOLINESTERASE INHIBITOR; CLONIDINE; CORTICOSTEROID; CYCLOOXYGENASE 2 INHIBITOR; DEXAMETHASONE; DEXMEDETOMIDINE; DEXTROMETHORPHAN; FENTANYL; GABAPENTIN; GLUCOCORTICOID; KETAMINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MAGNESIUM ION; MAGNESIUM SULFATE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NARCOTIC ANALGESIC AGENT; OPIATE DERIVATIVE; PETHIDINE; PREGABALIN; PROPOFOL; ROPIVACAINE; UNINDEXED DRUG;

ANALGESIA; BRADYCARDIA; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONFUSION; CONTINUOUS INFUSION; DIPLOPIA; DIZZINESS; DROWSINESS; DRUG ABSORPTION; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG MEGADOSE; DRUG POTENCY; DRUG POTENTIATION; DYSPHORIA; FOCAL EPILEPSY; HALLUCINATION; HEART ARRHYTHMIA; HUMAN; HYPERALGESIA; HYPERTENSION; HYPOTENSION; LOW DRUG DOSE; META ANALYSIS; MONOTHERAPY; NAUSEA AND VOMITING; NERVE BLOCK; NEUROPATHIC PAIN; NONHUMAN; NYSTAGMUS; PARKINSON DISEASE; POSTHERPETIC NEURALGIA; POSTOPERATIVE NAUSEA AND VOMITING; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PRURITUS; REPEATED DRUG DOSE; REVIEW; SEDATION; SIDE EFFECT; SINGLE DRUG DOSE; STEREOTYPY; SYSTEMATIC REVIEW; UNPLEASANT DREAM; UNSPECIFIED SIDE EFFECT; VOMITING;

AMINES; CLONIDINE; CYCLOHEXANECARBOXYLIC ACIDS; DEXAMETHASONE; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; KETAMINE; NEOSTIGMINE; PAIN, POSTOPERATIVE; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 33947722227     PISSN: 15216896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpa.2006.12.003     Document Type: Review

References (120)

1. Samad T.A., Moore K.A., Sapirstein A., et al. Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 410 (2001) 471-475
2. White P.F. The changing role of non-opioid analgesic techniques in the management of postoperative pain. Anesthesia and Analgesia 101 (2005) S5-S22
3. Woolf C.J. Intrathecal high dose morphine produces hyperalgesia in the rat. Brain Research 209 (1981) 491-495
4. Mercadante S., Ferrera P., Villari P., and Arcuri E. Hyperalgesia: an emerging iatrogenic syndrome. Journal of Pain and Symptom Management 26 (2003) 769-775
5. Chia Y.T., Liu K., Wang J.J., et al. Intraoperative high dose fentanyl induces postoperative fentanyl tolerance. Canadian Journal of Anaesthesia 48 (1999) 872-877
6. Larcher A., Laulin J.P., Celerier E., et al. Acute tolerance associated with a single opiate administration: involvement of N-methyl-d-aspartate-dependent pain facilatory systems. Neuroscience 84 (1998) 583-589
7. Dunbar S.A., Karamian I., and Zhang J. Ketorolac prevents recurrent withdrawal induced hyperalgesia but does not inhibit tolerance to spinal morphine in the rat. European Journal of Pain (London, England) (2006) Jan 27 [Epub]
8. Buckenmaier III C.C., and Bleckner L.L. Anaesthetic agents for advanced regional anaesthesia. Drugs 65 (2005) 745-759
9. Salter M.W. Cellular signaling pathways of signal pain neuroplasticity as targets for analgesic development. Current Topics in Medicinal Chemistry 5 (2005) 557-567
10. Ault B., Evans R.H., Francis A.A., et al. Selective depression of excitatory amino acids induced depolarizations by magnesium ions in isolated spinal cord preparations. The Journal of Physiology 307 (1980) 413-428
11. Kew J.N., and Kemp J.A. Ionotropic and metabotrophic glutamate receptor structure and pharmacology. Psychopharmacology 179 (2005) 4-29
12. Nishimura W., Muratani T., Tatsumi S., et al. Characterization of N-methyl-d-aspartate receptor subunits responsible for postoperative pain. European Journal of Pharmacology 503 (2004) 71-75
13. Burton A.W., Lee D.H., Saab C., and Chung J.M. Preemptive intrathecal ketamine injection produces a long-lasting decrease in neuropathic pain behavior in a rat model. Regional Anesthesia and Pain Medicine 24 (1999) 208-213
14. McCartney C.J., Sinha A., and Katz J. A qualitative systemic review of the role of N-methyl-d-aspartate receptor antagonists in preventive analgesia. Anesthesia and Analgesia 98 (2004) 1385-1400
15. Woolf C.J., and Thompson S.W. The induction and maintenance of central sensitization is dependent on N-methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain 44 (1991) 293-299
16. Subramaniam K., Subramaniam B., and Steinbrook R.A. Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systemic review. Anesthesia and Analgesia 99 (2004) 482-495
17. Ong C.K., Lirk P., Seymour R.A., and Jenkins B.J. The efficacy of preemptive analgesia for acute postoperative pain management: a meta-analysis. Anesthesia and Analgesia 100 (2005) 754-756
18. Bell R.F., Dahl J.B., Moore R.A., and Kalso E. Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systemic review. Acta Anaesthesiologica Scandinavica 49 (2005) 1405-1428
19. Elia N., and Tramer M.R. Ketamine and postoperative pain-a quantitative systematic review of randomised trials. Pain 113 (2005) 61-70
20. Suzuki M., Haraguti S., Sugimoto, et al. Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy. Anesthesiology 105 (2006) 111-119
21. De Kock M., Lavand'homme P., and Waterloos H. 'Balanced analgesia' in the perioperative period: is there a place for ketamine?. Pain 92 (2001) 373-380
22. Subramaniam K., Subramaniam B., Pawar D.K., and Sennaraj B. Preoperative epidural ketamine in combination with morphine does not have a clinically relevant intra- and postoperative opioid-sparing effect. Anesthesia and Analgesia 93 (2001) 1321-1326
23. Zahn P.K., and Brennan T.J. Lack of intrathecal NMDA receptor antagonists in a rat model for postoperative pain. Anesthesiology 88 (1998) 143-156
24. Hawksworth C., and Serpell M. Intrathecal anesthesia with ketamine. Regional Anesthesia and Pain Medicine 23 (1998) 283-288
25. Kathirvel S., Sadhasivam S., Saxena A., et al. Effects of intrathecal ketamine added to bupivacaine for spinal anaesthesia. Anaesthesia 55 (2000) 899-904
26. Poyhia R., and Vainio A. Topically administered ketamine reduces capsaicin-evoked mechanical hyperalgesia. The Clinical Journal of Pain 22 (2006) 32-36
27. Dal D., Tetik O., Altunkaya H., et al. The efficacy of intra-articular ketamine for postoperative analgesia in outpatient arthroscopic surgery. Arthroscopy 20 (2004) 300-305
28. Pedersen T. Ketamine as continuous intravenous infusion combined with diazepam in non-abdominal surgery. A randomized double-blind study. Anaesthesist 30 (1981) 111-114
29. Wong B.Y., Coulter D.A., Choi D.W., and Prince D.A. Dextrorphan and dextromethorphan, common antitussives, are antiepliptic and antagonize N-methyl-d-aspartate in brain slices. Neuroscience Letters 85 (1988) 261-266
30. 3H]MK-801 in heterologously expressed NMDA receptors. Neuropharmacology 49 (2005) 1-16
31. Duedahl T.H., Dirks J., Petersen K.B., et al. Intravenous dextromethorphan to human volunteers: relationship between pharmacokinetics and anti-hyperalgesic effect. Pain 113 (2005) 360-368
32. Yeh C.C., Wu C.T., Lee M.S., et al. Analgesic effects of preincisional administration of dextromethorphan and tenoxican following laproscopic cholecystectomy. Acta Anaesthesiologica Scandinavica 48 (2004) 1049-1053
33. Weinbroum A.A., Bender B., Bickels J., et al. Preoperative and postoperative dextromethorphan provides sustained reduction in postoperative pain and patient-controlled epidural analgesia requirement: a randomized, placebo-controlled, double-blind study in lower-body bone malignancy-operated patients. Cancer 97 (2003) 2334-2340
34. Wadhwa A., Clarke D., Goodchild C.S., and Young D. Large-dose oral dextromethorphan as an adjunct to patient-controlled analgesia with morphine after knee surgery. Anesthesia and Analgesia 92 (2001) 448-454
35. Duedahl T.H., Romsing J., Moniche S., and Dahl J.B. A qualitative systemic review of peri-operative dextromethorphan in post-operative pain. Acta Anaesthesiologica Scandinavica 50 (2006) 1-13
36. Tramer M.R., Schneider J., Marti R.-A., et al. Role of magnesium sulfate in postoperative analgesia. Anesthesiology 84 (1996) 340-347
37. Koinig H., Wallner T., Marhofer P., et al. Magnesium sulfate reduces intra- and postoperative analgesic requirements. Anesthesia and Analgesia 87 (1998) 206-210
38. Seyhan T.O., Tugrul M., and Sunmgur M.O. Effects of three different dose regimes of magnesium on propofol requirements, haemodynamic variables and postoperative pain relief in gynaecological surgery. British Journal of Anaesthesia 96 (2006) 247-252
39. Thurnau G.R., Kemp D.B., and Jarvis A. Cerebrospinal fluid levels of magnesium in patients with preeclampsia after treatment with intravenous magnesium sulfate: a preliminary report. American Journal of Obstetrics and Gynecology 157 (1987) 1435-1438
40. Kroin J.S., McCarthy R.J., Van Roenn N., et al. Magnesium sulfate potentiates morphine antinociception at the spinal level. Anesthesia and Analgesia 90 (2000) 913-917
41. Buvanendran A., McCarthy R.J., Kroin J.S., et al. Intrathecal magnesium prolongs fentanyl analgesia: a prospective, randomized, controlled trial. Anesthesia and Analgesia 95 (2002) 661-666
42. Gottschalk A., Schroeder F., Ufer M., et al. Amantadine, a N-methyl-d-aspartate receptor antagonist, does not enhance postoperative analgesia in women undergoing abdominal hysterectomy. Anesthesia and Analgesia 93 (2001) 192-196
43. Snijdelaar D.G., Koren G., and Katz J. Effects of perioperative oral amantadine on postoperatiave pain and morphine consumption in patients after radical prostatectomy: results of a preliminary study. Anesthesiology 100 (2004) 134-141
44. Unnerstall Jr., Kopejtic T.A., and Kahr M.J. Distribution of alpha 2 agonist binding sites in the rat and human central nervous system: analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenegic agents. Brain Research 319 (1984) 69-101
45. Yaksh T.L. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacology, Biochemistry and Behavior 22 (1985) 845-858
46. 2 adrenergic agonists. Anesthsiology 74 (1991) 766-771
47. Kahn Z.P., Ferguson C.N., and Jones R.M. Alpha-2 and imidazoline receptor agonists. Anaesthesia 54 (1999) 146-165
48. Duflo F., Boselli E.M., Ryvlin P., et al. Spinal muscarinic and nicotinic subtypes activated by clonidine in postincisional pain. Anesthesiology 103 (2005) 1253-1258
49. Mayson K.V., Gofton E.A., and Chambers K.G. Premedication with low dose oral clonidine does not enhance postoperative analgesia of intrathecal morphine. Canadian Journal of Anaesthesia 47 (2000) 752-757
50. Yanagidate R., Hamaya Y., and Dohi S. Clonidine premedication reduces maternal requirement for intravenous morphine after cesarean delivery without affecting newborn's outcome. Regional Anesthesia and Pain Medicine 26 (2001) 461-467
51. Hidalgo M.P., Auzani J.A., Rumpel L.C., et al. The clinical effect of small oral clonidine doses on perioperative outcomes in patients undergoing abdominal hysterectomy. Anesthesia and Analgesia 100 (2005) 795-802
52. Bonnet F., Boico O., and Rostaing S. Postoperative analgesia with extradural clonidine. British Journal of Anaesthesia 63 (1989) 465-469
53. Eisenach J., Detweiler D., and Hood D. Hemodymanic and analgesic actions of epidurally administered clonidine. Anesthesiology 78 (1993) 277-287
54. Rostaing S., Bonnet F., Leveron J.C., et al. Effect of epidural clonidine on analgesia and pharmacokinetics of epidural fentanyl in postoperative patients. Anesthesiology 75 (1991) 420-425
55. Dobrydnjov I., Axelsson K., Gupta A., et al. Improved analgesia with clonidine when added to local anesthetic during combined spinal-epidural anesthesia for hip arthroplasty: a double-blind, randomized and placebo-controlled study. Acta Anaesthesiologica Scandinavica 49 (2005) 538-545
56. De Negri P., Ivani G., Viscounti C., et al. The dose-response relationship for clonidine added to a postoperative continuous epidural infusion of ropivacaine in children. Anesthesia and Analgesia 93 (2001) 71-76
57. Onttonen T., and Pertovaara A. The mechanical antihyperalgesic effect of intrathecally administered MPV-2426, a novel alpha2- adrenoreceptors agonists, in a rat model of postoperative pain. Anesthesiology 92 (2000) 1740-1745
58. Dulfo F., Conklin D., Li X., and Eisenach J.C. Spinal adrenergic and cholinergic receptor interactions activated by clonidine in postincisional pain. Anesthesiology 98 (2003) 1237-1242
59. Kroin J.S., Buvanendran A., Nagella S.K.S., and Tuman K.J. Postoperative pain and analgesic responses are similar in male and female Sprague-Dawley rats. Canadian Journal of Anaesthesia 50 (2003) 904-908
60. Fogarty D.J., Carabine U.A., and Milligan K.R. Comparison of the analgesic effects of intrathecal clonidine and intrathecal morphine after spinal anaesthesia in patients undergoing total hip replacement. British Journal of Anaesthesia 71 (1993) 661-664
61. Grace D., Bunting H., Milligan K.R., and Fee J.P. Postoperative analgesia after co-administration of clonidine and morphine by the intrathecal route in patients undergoing hip replacement. Anesthesia and Analgesia 80 (1995) 86-91
62. Sites B.D., Beach M., Biggs R., et al. Intrathecal clonidine added to a bupivacaine-morphine spinal anesthetic improves postoperative analgesia for total knee arthroplasty. Anesthesia and Analgesia 96 (2003) 1083-1088
63. De Kock M., Lavand'homme P., and Waterloos H. The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery. Anesthesia and Analgesia 101 (2005) 566-572
64. Gaumann D., Forster A., Griessen M., et al. Comparison between clonidine and epinephrine admixture to lidocaine in brachial plexus block. Anesthesia and Analgesia 75 (1992) 69-74
65. Kroin J.S., Buvanendran A., Beck D.R., et al. Clonidine prolongation of lidocaine analgesia after sciatic nerve block in rats is mediated via the hyperpolarization-activated cation current, but by α-adrenoreceptors. Anesthesiology 101 (2004) 488-494
66. Bernard J.M., and Macaire P. Dose-range effects of clonidine added to lidocaine for brachial plexus block. Anesthesiology 87 (1997) 277-284
67. Gentili M., Juhel A., and Bonnet F. Peripheral analgesic effect of intra-articular clonidine. Pain 64 (1996) 593-596
68. Alagol A., Calpur O.U., Usar P.S., et al. Intraarticular analgesia after arthroscopic knee surgery: comparison of neostigmine, clonidine, tenoxican, morphine and bupivacaine. Knee Surgery, Sports Traumatology, Arthroscopy 13 (2005) 658-663
69. Ruben S.S., and Connelly N.R. Postoperative analgesia for outpatient arthroscopic knee surgery with intraarticular clonidine. Anesthesia and Analgesia 88 (1999) 729-733
70. Brill S., and Plaza M. Non-narcotic adjuvants may improve the duration and quality of analgesia after knee arthroscopy: a brief review. Canadian Journal of Anaesthesia 51 (2004) 975-978
71. Coursin D.B., Coursin D.B., and Macciolo G.A. Dexmedetomidine. Current Opinion in Critical Care 7 (2001) 221-226
72. Arain S.R., Ruehlow R.M., Uhrich T.D., and Ebert T.J. The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery. Anesthesia and Analgesia 98 (2004) 153-158
73. Gurbet A., Basagan-Mogol E., Turker G., et al. Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements. Canadian Journal of Anaesthesia 53 (2006) 646-652
74. Wahlander S., Frumento R.J., Wagener G., et al. A prospective, double-blind, randomized, placebo-controlled study of dexmedetomidine as an adjunct to epidural analgesia after thoracic surgery. Journal of Cardiothoracic and Vascular Anesthesia 19 (2005) 630-635
75. Yaksh T.L. Calcium channels as therapeutic targets in neuropathic pain. Journal of Pain 7 supplement 1 (2006) S13-S30
76. 2δ subunit of a calcium channel. The Journal of Biological Chemistry 271 (1996) 5768-5776
77. Field M.J., Hollomanb E.F., McCleary S., et al. Evaluation of gabapentin and S-(+)-3-isobutylgaba in a rat model of postoperative pain. The Journal of Pharmacology and Experimental Therapeutics 282 (1997) 1242-1246
78. Pandey C.K., Singhal V., Kumar M., et al. Gabapentin provides effective postoperative analgesia whether administered pre-emptively or post-incision. Canadian Journal of Anaesthesia 52 (2005) 827-831
79. Radhakrishnan N., Pithal P.K., and Charturvedi A. Effect of preemptive gabapentin on postoperative pain relief and morphine consumption following lumbar laminectomy and disectomy: a randomized, double-blinded, placebo-controlled study. Journal of Neurosurgical Anesthesiology 17 (2005) 172-173
80. Dahl J.B., Mathiesen O., and Moiniche S. 'Protective premedication': an option with gabapentin and related drugs?. Acta Anaesthesiologica Scandinavica 48 (2004) 1130-1136
81. Menigaux C., Adam F., Guignard B., et al. Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery. Anesthesia and Analgesia 100 (2005) 1394-1395
82. Gilron I., Orr E., Tu D., et al. A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-evoked pain after abdominal hysterectomy. Pain 113 (2005) 191-200
83. Ho K.Y., Gan T.J., and Habib A.S. Gabapentin and postoperative pain - a systematic review of randomized controlled trials. Pain (2006) [Epub]
84. Hurley R.W., Cohen S.P., Williams K.A., et al. The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis. Regional Anesthesia and Pain Medicine 31 (2006) 237-247
85. Fassoulaki A., Stamatakis E., Petropoulos G., et al. Gabapentin attenuates late but not acute pain after abdominal hysterectomy. European Journal of Anaesthesiology 23 (2006) 136-141
86. Danshaw C.B. An anesthetic approach to amputation and pain syndromes. Physical Medicine and Rehabilitation Clinics of North America 11 (2000) 553-557
87. Bian F., Li Z., Offord J., et al. Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice. Brain Research 1075 (2006) 68-80
88. Randinitis E.J., Posvar E.L., and Alvey C.W. Pharmacokinetics of pregabalin in subjects with various degrees of renal function. Journal of Clinical Pharmacology 43 (2003) 277-283
89. Reuben S.S., Buvanendran A., Kroin J.S., and Raghunathan K. The analgesic efficacy of celecoxib, pregabalin, and their combination for spinal fusion surgery. Anesthesia and Analgesia 103 (2006) 1-6
90. Rhen T., and Cidlowski J.A. Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. The New England Journal of Medicine 353 (2005) 1711-1723
91. Fleischli J.W., and Adams W.R. Use of postoperative steroids to reduce pain and inflammation. The Journal of Foot and Ankle Surgery 38 (1999) 232-237
92. Holte K., and Kehlet H. Perioperative single-dose glutcocorticoid administration: pathophysiologic effects and clinical implications. Journal of the American College of Surgeons 195 (2002) 694-712
93. Gilron I. Corticosteroids in postoperative pain management: future research directions for a multifaceted therapy. Acta Anaesthesiologica Scandinavica 48 (2004) 1221-1222
94. Salerno A., and Hermann R. Efficacy and safety of steroid use for postoperative pain relief. The Journal of Bone and Joint Surgery 88-A (2006) 1361-1372
95. Masferrer J.L., Zweifel B.S., Mannning P.T., et al. Selective inhibition of inducible cyclooxygenase 2 in vivo is anti-inflammatory and nonulcerogenic. Proceedings of the National Academy of Sciences of the United States of America 91 (1994) 3228-3232
96. Hay C.H., and de Belleroche J.S. Dexamethasone prevents the induction of COX-2 mRNA and prostaglandins in the lumbar spinal cord following intraplantar FCA in parallel with inhibition of oedema. Neuropharmacology 37 (1998) 739-744
97. Dionne R.A., Gordon S.M., Rowan J., et al. Dexamethasone suppresses peripheral prostanoid levels without analgesia in a clinical model of acute inflammation. Journal of Oral and Maxillofacial Surgery 61 (2003) 997-1003
98. Feo C.V., Sortini D., Ragazzi R., et al. Randomized clinical trial of the effect of preoperative dexamethasone on nausea and vomiting after laparoscopic cholecystectomy. The British Journal of Surgery 93 (2006) 295-299
99. Bigat A., Boztug N., Hadimioglu N., et al. Does dexamethasone improve the quality of intravenous regional anesthesia and analgesia? A randomized, controlled clinical study. Anesthesia and Analgesia 102 (2006) 605-609
100. Hartvig P., Gillberg P.G., Gordh Jr. T., and Post C. Cholinergic mechanisms in pain and analgesia. Trends in Pharmacological Sciences supplement (1989) 75-79
101. Eisenach J.C. Muscarinic-mediated analgesia. Life Sciences 64 (1999) 549-554
102. Decker M.W., Reuter L.E., and Bitner R.S. Nicotinic acetylcholine receptor agonists: a potential new class of analgesics. Current Topics in Medicinal Chemistry 4 (2004) 369-384
103. Naguib M., and Yaksh T.L. Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with my and alpha 2 receptor systems. Anesthesiology 80 (1994) 1338-1348
104. Ho K.M., Ismail H., Lee K.C., and Branch R. Use of intrathecal neostigmine as an adjunct to other spinal medications in perioperative and peripartum analgesia: a meta-analysis. Anaesthesia and Intensive Care 33 (2005) 41-53
105. Omais M., Laureetti G.R., and Paccola C.A. Epidural morphine and neostigmine for postoperative analgesia after orthopedic surgery. Anesthesia and Analgesia 95 (2002) 1698-1701
106. Kaya F.N., Sahin S., Owen M.D., and Eisenach J.C. Epidural neostigmine produces analgesia but also sedation in women after cesarean delivery. Anesthesiology 100 (2004) 381-385
107. Lauretti G.R., de Oliveira R., Reis M.P., et al. Study of three different doses of epidural neostigmine coadministered with lidocaine for postoperative analgesia. Anesthesiology 90 (1999) 1534-1538
108. Van Elstraete A.C., Pastureau F., Lebrun T., and Mehdaoui H. Neostigmine added to lidocaine axillary plexus block for postoperative analgesia. European Journal of Anaesthesiology 18 (2001) 257-260
109. Bouaziz H., Paqueron X., and Bur M.L. No enhancement of sensory and motor blockade by neostigmine added to mepivacaine axillary plexus block. Anesthesiology 91 (1999) 1207-1208
110. McCartney C.J., Brill S., Rawson R., et al. No anesthetic or analgesic benefit of neostigmine 1 mg added to intravenous regional anesthesia with lidocaine 0.5% for hand surgery. Regional Anesthesia and Pain Medicine 28 (2003) 414-417
111. Yang L.C., Chen L.M., Wang C.J., and Buerkle H. Postoperative analgesia by intra-articular neostigmine in patients undergoing knee arthroscopy. Anesthesiology 88 (1998) 334-339
112. Gentili M., Enel D., Szymskiewicz O., et al. Postoperative analgesia by intraarticular clonidine and neostigmine in patients undergoing knee arthroscopy. Regional Anesthesia and Pain Medicine 26 (2001) 342-347
113. Dogan N., Erdem A.F., Erman Z., and Kizilkaya M. The effects of bupivacaine and neostigmine on articular cartilage and synovium in the rabbit knee joint. The Journal of International Medical Research 32 (2004) 513-519
114. Brennan T.J., Zahn P.K., and Pogatzki-Zahn E.M. Mechanisms of incisional pain. Anesthesiology Clinics of North America 23 (2005) 1-20
115. Kehlet H., Jensen T.S., and Woolf C.J. Persistent postsurgical pain: risk factors and prevention. Lancet 367 (2006) 1618-1625
116. Kroin J.S., Buvanedran A., Watts D.E., et al. Upregulation of cerebrospinal fluid and peripheral prostaglandin E2 in a rat postoperative pain model. Anesthesia and Analgesia 103 (2006) 334-343
117. Buvanendran A., Kroin J.S., and Berger R.A. Upregulation of prostaglandin E2 and interleukins in the central nervous system and peripheral tissue during and after surgery in humans. Anesthesiology 104 (2006) 403-410
118. Buvanendran A., Kroin J.S., Tuman K.J., et al. Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor on pain management and recovery of function after knee replacement: a randomized controlled trial. The Journal of the American Medical Association 290 (2003) 2411-2418
119. Straube S., Derry S., McQuay H.J., et al. Effect of preoperative COX-II-selective NSAIDs (coxibs) on postoperative outcomes. Acta Anaesthesiologica Scandinavica 49 (2005) 601-613
120. Gajraj N.M., and Joshi G.P. Role of cyclooxygenase-2 inhibitors in postoperative pain management. Anesthesiology Clinics of North America 23 (2005) 49-72