Clonidine prolongation of lidocaine analgesia after sciatic nerve block in rats is mediated via the hyperpolarization-activated cation current, not by α-adrenoreceptors

Anesthesiology

Volumn 101, Issue 2, 2004, Pages 488-494

  Kroin, Jeffrey S ^a,b   Buvanendran, Asokumar ^a   Beck, Daniel R ^b   Topic, Julie E ^a   Watts, Daniel E ^a   Tuman, Kenneth J ^a  

^a Department of Anesthesiology ^*  (United States)

^b RUSH MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; 8 BROMO CYCLIC AMP; ADRENALIN; ALPHA ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; FORSKOLIN; LIDOCAINE; PRAZOSIN; XYLOCAINE MPF; YOHIMBINE;

ANALGESIA; ANESTHESIA DURATION; ARTICLE; CATION CURRENT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; HYPERPOLARIZATION; HYPERPOLARIZATION ACTIVATED CATION CURRENT; ION CURRENT; LIMB MOVEMENT; LOCAL ANESTHESIA; MALE; NERVE BLOCK; NONHUMAN; PHARMACODYNAMICS; PINPRICK TEST; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SENSORY ANALYSIS; SENSORY DYSFUNCTION; WITHDRAWAL REFLEX;

ADRENERGIC ALPHA-AGONISTS; ANESTHETICS, LOCAL; ANIMALS; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; EPINEPHRINE; FORSKOLIN; ION CHANNELS; LIDOCAINE; MALE; NERVE BLOCK; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA; SCIATIC NERVE;

EID: 3342875629     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200408000-00031     Document Type: Article

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