Effects of Perioperative Oral Amantadine on Postoperative Pain and Morphine Consumption in Patients after Radical Prostatectomy: Results of a Preliminary Study

Anesthesiology

Volumn 100, Issue 1, 2004, Pages 134-141

  Snijdelaar, Dirk G ^a,b   Koren, Gideon ^c,d   Katz, Joel ^c,e,f  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF TORONTO   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e MOUNT SINAI HOSPITAL   (Canada)

^f YORK UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; DRUG METABOLITE; MORPHINE; MORPHINE 3 GLUCURONIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PLACEBO;

ADULT; AGED; ARTICLE; BLADDER SPASM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG TOLERANCE; DRUG USE; HUMAN; INFUSION PUMP; INSOMNIA; MALE; MECHANICAL STRESS; NAUSEA; NERVOUSNESS; NOCICEPTION; PATIENT CONTROLLED ANALGESIA; PERIOPERATIVE PERIOD; PHARMACODYNAMICS; PILOT STUDY; PLASMA CLEARANCE; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROSTATECTOMY; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SEDATION; SIDE EFFECT; SURGICAL WOUND; VISUAL ANALOG SCALE; VOMITING; XEROSTOMIA;

ADOLESCENT; ADULT; AGED; AMANTADINE; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ANESTHESIA, GENERAL; BIOTRANSFORMATION; DOUBLE-BLIND METHOD; HUMANS; MALE; MIDDLE AGED; MORPHINE; PAIN MEASUREMENT; PAIN THRESHOLD; PAIN, POSTOPERATIVE; PATIENT SATISFACTION; PILOT PROJECTS; POSTOPERATIVE NAUSEA AND VOMITING; PROSTATECTOMY; PRURITUS; QUESTIONNAIRES; TREATMENT OUTCOME;

EID: 0347993739     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200401000-00022     Document Type: Article

References (31)

1. Coderre TJ, Katz J, Vaccarino AL, Melzack R: Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence. Pain 1993; 52:259-85
2. Dickenson AH, Sullivan AF: Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation. Neuropharmacology 1987; 26:1235-8
3. Woolf CJ, Thompson SW: The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation: Implications for the treatment of post-injury pain hypersensitivity states. Pain 1991; 44:293-9
4. Celerier E, Rivat C, Jun Y, Laulin JP, Larcher A, Reynier P, Simonnet G: Long-lasting hyperalgesia induced by fentanyl in rats: Preventive effect of ketamine. ANESTHESIOLOGY 2000; 92:465-72
5. Kissin I, Bright CA, Bradley EL: The effect of ketamine on opioid-induced acute tolerance: Can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations? Anesth Analg 2000; 91:1483-8
6. Schmid RL, Sandler AN, Katz J: Use and efficacy of low-dose ketamine in the management of acute postoperative pain: A review of current techniques and outcomes. Pain 1999; 82:111-25
7. Ilkjaer S, Bach LF, Nielsen PA, Wernberg M, Dahl JB: Effect of preoperative oral dextromethorphan on immediate and late postoperative pain and hyperalgesia after total abdominal hysterectomy. Pain 2000; 86:19-24
8. Henderson DJ, Withington BS, Wilson JA, Morrison LM: Perioperative dextromethorphan reduces postoperative pain after hysterectomy. Anesth Analg 1999; 89:399-402
9. Kornhuber J, Weller M, Schoppmeyer K, Riederer P: Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties. J Neural Transm Suppl 1994; 43:91-104
10. Danysz W, Parsons CG, Kornhuber J, Schmidt WJ, Quack G: Aminoada-mantanes as NMDA receptor antagonists and antiparkinsonian agents: Preclinical studies. Neurosci Biobehav Rev 1997; 21:455-68
11. Dallal GE: PITMAN: A FORTRAN program for exact randomization tests. Comput Biomed Res 1988; 21:9-15
12. Katz J, Melzack R: Measurement of pain. Surg Clin North Am 1999; 79:231-52
13. Melzack R: The McGill Pain Questionnaire: Major properties and scoring methods. Pain 1975; 1:277-99
14. Fischer AA: Documentation of myofascial trigger points. Arch Phys Med Rehabil 1988; 69:286-91
15. De Kock M, Crochet B, Morimont C, Scholtes JL: Intravenous or epidural clonidine for intra- and postoperative analgesia. ANESTHESIOLOGY 1993; 79:525-31
16. Bras AP, Hoff HR, Aoki FY, Sitar DS: Amantadine acetylation may be effected by acetyltransferases other than NAT1 or NAT2. Can J Physiol Pharmacol 1998; 76:701-6
17. Gerostamoulos J, Drummer OH: Solid phase extraction of morphine and its metabolites from postmortem blood. Forensic Sci Int 1996; 77:53-63
18. Meng QC, Cepeda MS, Kramer T, Zou H, Matoka DJ, Farrar J: High-performance liquid chromatographic determination of morphine and its 3- and 6-glucuronide metabolites by two-step solid-phase extraction. J Chromatogr B Biomed Sci Appl 2000; 742:115-23
19. Glantz SA: Primer of Biostatistics: The Program. New York, McGraw-Hill, 1997
20. Hardman JG, Limbird LE, Editors: Goodman & Gilman's the Pharmacological Basis of Therapeutics, 9th edition. New York, McGraw-Hill, 1996, p 1762
21. Milne RW, Nation RL, Somogyi AA: The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine. Drug Metab Rev 1996; 28:345-472
22. Goralski KB, Sitar DS: Tetraethylammonium and amantadine identify distinct organic cation transporters in rat renal cortical proximal and distal tubules. J Pharmacol Exp Ther 1999; 290:295-302
23. Goralski KB, Stupack DG, Hatch GM, Sitar DS: Perturbation of rat renal tubule transport of the organic cation amantadine in recent onset streptozotocin-induced diabetes and in uninephrectomy. Can J Physiol Pharmacol 2001; 79: 18-24
24. Van Crugten JT, Sallustio BC, Nation RL, Somogyi AA: Renal tubular transport of morphine, morphine-6-glucuronide, and morphine-3-glucuronide in the isolated perfused rat kidney. Drug Metab Dispos 1991; 19:1087-92
25. Castroman PJ, Ness TJ: Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the spinal neuronal responses to distension of the rat urinary bladder. ANESTHESIOLOGY 2002; 96:1410-9
26. Castroman PJ, Ness TJ: Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the reflex responses to distension of the rat urinary bladder. ANESTHESIOLOGY 2002; 96:1401-9
27. Gottschalk A, Schroeder F, Ufer M, Oncu A, Buerkle H, Standl T: Amantadine, a N-methyl-D-aspartate receptor antagonist, does not enhance postoperative analgesia in women undergoing abdominal hysterectomy. Anesth Analg 2001; 93:192-6
28. Pud D, Eisenberg E, Spitzer A, Adler R, Fried G, Yarnitsky D: The NMDA receptor antagonist amantadine reduces surgical neuropathic pain in cancer patients: A double blind, randomized, placebo controlled trial. Pain 1998; 75:349-54
29. Medrik-Goldberg T, Lifschitz D, Pud D, Adler R, Eisenberg E: Intravenous lidocaine, amantadine, and placebo in the treatment of sciatica: A double-blind, randomized, controlled study. Reg Anesth Pain Med 1999; 24:534-40.
30. Gagliese L, Jackson M, Ritvo P, Wowk A, Katz J: Age is not an impediment to effective use of patient-controlled analgesia by surgical patients. ANESTHESIOLOGY 2000; 93:601-10
31. Aida S, Fujihara H, Taga K, Fukuda S, Shimoji K: Involvement of presurgical pain in preemptive analgesia for orthopedic surgery: A randomized double blind study. Pain 2000; 84:169-73