Differential binding properties of [3H]dextrorphan and [ 3H]MK-801 in heterologously expressed NMDA receptors

Neuropharmacology

Volumn 49, Issue 1, 2005, Pages 1-16

  LePage, K T ^a   Ishmael, J E ^b   Low, C M ^c   Traynelis, S F ^d   Murray, T F ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Binding; Dextrorphan; Glutamate; MK 801; Mutagenesis; NMDA receptor

Indexed keywords

DEXTRORPHAN; DIZOCILPINE; GLUTAMIC ACID; GLYCINE; ION CHANNEL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; RECEPTOR SUBUNIT; TRITIUM;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; MOLECULAR RECOGNITION; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; WILD TYPE;

ANIMALS; BINDING SITES; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COMPETITIVE BIDDING; COS CELLS; DEXTRORPHAN; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GLYCINE; MODELS, BIOLOGICAL; MUTAGENESIS; RADIOLIGAND ASSAY; RECEPTORS, N-METHYL-D-ASPARTATE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; TRANSFECTION; TRITIUM;

EID: 21344449723     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.01.029     Document Type: Article

References (41)

1. P. Avenet, J. Leonardon, F. Besnard, D. Graham, J. Frost, H. Depoortere, S.Z. Langer, and B. Scatton Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes Eur. J. Pharmacol. 296 1996 209 213
2. C. Beck, L.P. Wollmuth, P.H. Seeburg, B. Sakmann, and T. Kuner NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines Neuron 22 1999 559 570
3. 3H]MK-801 binding to N-methyl-d-aspartate receptors in cultured rat cerebellar granule neurons and involvement in glutamate-mediated toxicity J. Biochem. Toxicol. 11 5 1996 217 226
4. Burnashev Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor Science 257 5075 1992 1415 1419
5. Y. Cheng, and W.H. Prusoff Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction Biochem. Pharmacol. 22 1973 3099 3108
6. A.E. Cole, C.U. Eccles, J.J. Aryanpur, and R.S. Fisher Selective depression of N-methyl-d-aspartate-mediated responses by dextrorphan in the hippocampal slice in rat Neuropharmacology 28 1989 249 254
7. R. Dingledine, K. Borges, D. Bowie, and S.F. Traynelis The glutamate receptor ion channels Pharmacol. Rev. 51 1999 7 61
8. + conduction and selectivity Science 280 1998 69 77
9. A.V. Ferrer-Montiel, W. Sun, and M. Montal Molecular design of the N-methyl-d-aspartate receptor binding site for phencyclidine and dizolcipine Proc. Natl Acad. Sci. U.S.A. 92 1995 8021 8025
10. A.V. Ferrer-Montiel, J.M. Merino, R. Planells-Cases, W. Sun, and M. Montal Structural determinants of the blocker binding site in glutamate and NMDA receptor channels Neuropharmacology 37 1998 139 147
11. 3H]dextrorphan binding in rat brain is localized to a noncompetitive antagonist site of the activated N-methyl-d-aspartate receptor-cation channel Mol. Pharmacol. 41 1992 134 146
12. L.M. Hawkins, P.L. Chazot, and F.A. Stephenson Biochemical evidence for the co-association of three N-methyl-d-aspartate (NMDA) R2 subunits in recombinant NMDA receptors J. Biol. Chem. 274 1999 27211 27218
13. 2+ channels Mol. Pharmacol. 58 2000 1264 1270
14. S.G. Holtzman Phencyclidine-like discriminative effects of opioids in the rat J. Pharmacol. Exp. Ther. 214 1980 614 619
15. J.E. Huettner, and B.P. Bean Block of N-methyl-d-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels Proc. Natl Acad. Sci. U.S.A. 85 1988 1307 1311
16. J.E. Ishmael, P.H. Franklin, T.F. Murray, and M. Leid High level expression of the NMDAR1 glutamate receptor subunit in electroporated COS cells J. Neurochem. 67 1996 1500 1510
17. J.E. Ishmael, P.H. Franklin, and T.F. Murray Dextrorotatory opioids induce stereotyped behavior in Sprague-Dawley and Dark Agouti rats Psychopharmacology (Berl.) 140 1998 206 216
18. Y. Jiang, A. Lee, J. Chen, M. Cadene, B.T. Chait, and R. MacKinnon The open pore conformation of potassium channels Nature 417 2002 523 526
19. K. Kashiwagi, A.J. Pahk, T. Masuko, K. Igarashi, and K. Williams Block and modulation of N-methyl-d-aspartate receptors by polyamines and protons: role of amino acid residues in the transmembrane and pore forming regions of NR1 and NR2 subunits Mol. Pharmacol. 52 1997 701 713
20. K. Kashiwagi, T. Masuko, C.D. Nguyen, T. Kuno, I. Tanaka, K. Igarashi, and K. Williams Channel blockers acting at N-methyl-d-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore Mol. Pharmacol. 61 3 2002 533 545
21. S. Kawajiri, and R. Dingledine Multiple structural determinants of voltage-dependent magnesium block in recombinant NMDA receptors Neuropharmacology 32 1993 1203 1211
22. Y. Kloog, H. Lamdani-Itkin, and M. Sokolovsky The glycine site of the N-methyl-d-aspartate receptor channel: differences between the binding of HA-966 and of 7-chlorokynurenic acid J. Neurochem. 54 1990 1576 1583
23. R.T. Kroemer, E. Koutsilieri, P. Hecht, K.R. Liedl, P. Riederer, and J. Kornhuber Quantitative analysis of the structural requirements for blockade of the N-methyl-d-aspartate receptor at the phencyclidine binding site J. Med. Chem. 41 1998 393 400
24. K. Kohda, Y. Wang, and I. Yuzaki Mutation of a glutamate receptor motif reveals its role in gating and delta2 receptor channel properties Nat. Neurosci. 3 4 2000 315 322
25. T. Kuner, L.P. Wollmuth, A. Karlin, P.H. Seeburg, and B. Sakmann Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines Neuron 17 1996 343 352
26. M. Leid, M.I. Schimerlik, and T.F. Murray Characterization of agonist radioligand interactions with porcine atrial A1 adenosine receptors Mol. Pharmacol. 34 1988 334 339
27. C.M. Low, P. Lyuboslavsky, A. French, P. Le, K. Wyatte, W.H. Thiel, E.M. Marchan, K. Igarashi, K. Kashiwagi, K. Gernert, K. Williams, S.F. Traynelis, and F. Zheng Molecular determinants of proton-sensitive N-methyl-d-aspartate receptor gating Mol. Pharmacol. 63 6 2003 1212 1222
28. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with Folin phenol reagent J. Biol. Chem. 193 1951 266 275
29. D.R. Lynch, J.J. Lawrence, S. Lenz, N.J. Anegawa, M. Dichter, and D.B. Pritchett Pharmacological characterization of heterodimeric NMDA receptors composed of NR 1a and 2B subunits: differences with receptors formed from NR 1a and 2A J. Neurochem. 64 1995 1462 1468
30. 2+-block site of the NMDA receptor channel Nature 358 1992 673 675
31. K. Moriyoshi, M. Masu, T. Ishii, R. Shigemoto, N. Mizuno, and S. Nakanishi Molecular cloning and characterization of the rat NMDA receptor Nature 354 6348 1991 31 37
32. B.A. Orser, P.S. Pennefather, and J.F. MacDonald Multiple mechanisms of ketamine blockade of N-methyl-d-aspartate receptors Anesthesiology 86 1997 903 917
33. 3H]dextrorphan binding sites in rat brain determined by quantitative autoradiography J. Pharmacol. Exp. Ther. 277 1996 1823 1836
34. 2+ and channel blockers by a single amino acid substitution in the N-methyl-d-aspartate receptor J. Biol. Chem. 268 1993 410 415
35. R. Sprengel, R. Aronoff, M. Volkner, B. Schmitt, R. Mosbach, and T. Kuner Glutamate receptor channel signatures Trends Pharmacol. Sci. 22 1 2001 7 10
36. A.I. Sobolevsky, C. Beck, and L.P. Wollmuth Molecular rearrangements of the extracellular vesibule in NMDAR channels during gating Neuron 33 2002 75 85
37. A.I. Sobolevsky, and S. Koshelev Two blocking sites of amino-adamantane derivatives in open N-methyl-d-aspartate channels Biochim. Biophys. J. 74 1998 1305 1319
38. 2+ interacts with structural determinants of the narrow constriction contributed by the NR1-subunit in the NMDA receptor channel J. Physiol. 506 Pt 1 1998 33 52
39. T. Yamakura, and K. Shimoji Subunit- and site-specific pharmacology of the NMDA receptor channel Prog. Neurobiol. 59 1999 279 298
40. Yamazaki Cloning, expression and modulation of a mouse NMDA receptor subunit FEBS Lett. 300 1 1992 39 45
41. T. Yamakura, H. Mori, H. Masaki, K. Shimoji, and M. Mishina Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists Neuroreport 4 1993 687 690