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Volumn 178, Issue 7, 2007, Pages 4284-4295

TGF-β suppresses IFN-γ-STAT1-dependent gene transcription by enhancing STAT1-PIAS1 interactions in epithelia but not monocytes/macrophages

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN INHIBITOR OF ACTIVATED STAT; PROTEIN INHIBITOR OF ACTIVATED STAT 1; SERINE; SMAD7 PROTEIN; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; TYROSINE; UNCLASSIFIED DRUG;

EID: 33947684488     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.7.4284     Document Type: Article
Times cited : (32)

References (57)
  • 1
    • 0035843993 scopus 로고    scopus 로고
    • Commensal host-bacterial relationships in the gut
    • Hooper, L. V., and J. I. Gordon. 2001. Commensal host-bacterial relationships in the gut. Science 292: 1115-1118.
    • (2001) Science , vol.292 , pp. 1115-1118
    • Hooper, L.V.1    Gordon, J.I.2
  • 2
    • 2942625911 scopus 로고    scopus 로고
    • Interactions between commensal intestinal bacteria and the immune system
    • MacPherson, A. J., and N. L. Harris. 2004. Interactions between commensal intestinal bacteria and the immune system. Nat. Rev. Immunol. 4: 478-485.
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 478-485
    • MacPherson, A.J.1    Harris, N.L.2
  • 5
    • 0027245531 scopus 로고
    • IFN-γ modulation of epithelial barrier function
    • Adams, R. B., S. M. Planchon, and J. K. Roche. 1993. IFN-γ modulation of epithelial barrier function. J. Immunol. 150: 2356-2363.
    • (1993) J. Immunol , vol.150 , pp. 2356-2363
    • Adams, R.B.1    Planchon, S.M.2    Roche, J.K.3
  • 6
    • 0024553788 scopus 로고
    • Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers
    • Madara, J. L., and J. Stafford. 1989. Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers. J. Clin. Invest. 83: 724-727.
    • (1989) J. Clin. Invest , vol.83 , pp. 724-727
    • Madara, J.L.1    Stafford, J.2
  • 7
    • 0031227976 scopus 로고    scopus 로고
    • Superantigen-activation of immune cells evokes epithelial (T84) transport and barrier abnormalities via interferon γ and tumour necrosis factor α: Inhibition of increased permeability, but not diminished secretory responses by transforming growth factor β2
    • McKay, D. M., and P. K. Singh. 1997. Superantigen-activation of immune cells evokes epithelial (T84) transport and barrier abnormalities via interferon γ and tumour necrosis factor α: inhibition of increased permeability, but not diminished secretory responses by transforming growth factor β2. J. Immunol. 159: 2382-2390.
    • (1997) J. Immunol , vol.159 , pp. 2382-2390
    • McKay, D.M.1    Singh, P.K.2
  • 8
    • 0030870251 scopus 로고    scopus 로고
    • Differential and regulated expression of C-X-C, C-C and C-chemokines by human colon epithelial cells
    • Yang, S.-K., L. Eckmann, A. Panja, and M. F. Kagnoff. 1997. Differential and regulated expression of C-X-C, C-C and C-chemokines by human colon epithelial cells. Gastroenterology 113: 1214-1223.
    • (1997) Gastroenterology , vol.113 , pp. 1214-1223
    • Yang, S.-K.1    Eckmann, L.2    Panja, A.3    Kagnoff, M.F.4
  • 10
    • 0034600789 scopus 로고    scopus 로고
    • Treatment of experimental (trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-β1 plasmid: TGF-β1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor β2 chain downregulation
    • Kitani, A., I. J. Fuss, K. Nakamura, O. M. Schwartz, T. Usui, and W. Strober. 2000. Treatment of experimental (trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-β1 plasmid: TGF-β1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor β2 chain downregulation. J. Exp. Med. 192: 41-52.
    • (2000) J. Exp. Med , vol.192 , pp. 41-52
    • Kitani, A.1    Fuss, I.J.2    Nakamura, K.3    Schwartz, O.M.4    Usui, T.5    Strober, W.6
  • 11
    • 0029995799 scopus 로고    scopus 로고
    • Experimental granulomatous colitis in mice is abrogated by induction of TGF-β mediated oral tolerance
    • Neurath, M. F., I. Fuss, B. L. Kelsall, D. H. Presky, W. Waegell, and W. Strober. 1996. Experimental granulomatous colitis in mice is abrogated by induction of TGF-β mediated oral tolerance. J. Exp. Med. 183: 2605-2616.
    • (1996) J. Exp. Med , vol.183 , pp. 2605-2616
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Presky, D.H.4    Waegell, W.5    Strober, W.6
  • 12
    • 28244493047 scopus 로고    scopus 로고
    • TGFβ regulation of epithelial tight junction proteins enhances barrier function and blocks EHEC-induced increased permeability
    • Howe, K. L., C. Reardon, A. Wang, A. Nazli, and D. M. McKay. 2005. TGFβ regulation of epithelial tight junction proteins enhances barrier function and blocks EHEC-induced increased permeability. Am. J. Pathol. 167: 1587-1597.
    • (2005) Am. J. Pathol , vol.167 , pp. 1587-1597
    • Howe, K.L.1    Reardon, C.2    Wang, A.3    Nazli, A.4    McKay, D.M.5
  • 13
    • 0032813033 scopus 로고    scopus 로고
    • Transforming growth factor β1 preserves epithelial barrier function: Identification of receptors, biochemical intermediates, and cytokine antagonists
    • Planchon, S. M., C. Fiocchi, V. Takafuji, and J. K. Roche. 1999. Transforming growth factor β1 preserves epithelial barrier function: identification of receptors, biochemical intermediates, and cytokine antagonists. J. Cell. Physiol. 181: 55-66.
    • (1999) J. Cell. Physiol , vol.181 , pp. 55-66
    • Planchon, S.M.1    Fiocchi, C.2    Takafuji, V.3    Roche, J.K.4
  • 14
    • 0033602101 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor β/SMAD signalling by the interferon γ/STAT pathway
    • Ulloa, L., J. Doody, and J. Massague. 1999. Inhibition of transforming growth factor β/SMAD signalling by the interferon γ/STAT pathway. Nature 397: 710-713.
    • (1999) Nature , vol.397 , pp. 710-713
    • Ulloa, L.1    Doody, J.2    Massague, J.3
  • 15
    • 0037592269 scopus 로고    scopus 로고
    • Transforming growth factor β1 inhibits nonpathogenic Gram negative bacteria-induced NF-κB recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation
    • Haller, D., L. Holt, S. C. Kim, R. F. Schwabe, R. B. Sartor, and C. Jobin. 2003. Transforming growth factor β1 inhibits nonpathogenic Gram negative bacteria-induced NF-κB recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation. J. Biol. Chem. 278: 23851-23860.
    • (2003) J. Biol. Chem , vol.278 , pp. 23851-23860
    • Haller, D.1    Holt, L.2    Kim, S.C.3    Schwabe, R.F.4    Sartor, R.B.5    Jobin, C.6
  • 16
    • 85014210290 scopus 로고    scopus 로고
    • Down-regulation of IL-6-induced STAT3 ryrosine phosphorylation by TGF-β1 is mediated by caspase-dependent and -independent processes
    • Wierenga, A. T. J., J. J. Schuringa, B. J. L. Eggen, W. Kruijer, and E. Vellenga. 2002. Down-regulation of IL-6-induced STAT3 ryrosine phosphorylation by TGF-β1 is mediated by caspase-dependent and -independent processes. Leukemia 16: 675-682.
    • (2002) Leukemia , vol.16 , pp. 675-682
    • Wierenga, A.T.J.1    Schuringa, J.J.2    Eggen, B.J.L.3    Kruijer, W.4    Vellenga, E.5
  • 17
    • 0035868908 scopus 로고    scopus 로고
    • Enteropathogenic Escherichia coli mediates anti-phagocytosis through the inhibition of PI 3-kinase-dependent pathways
    • Celli, J., M. Olivier, and B. B. Finlay. 2001. Enteropathogenic Escherichia coli mediates anti-phagocytosis through the inhibition of PI 3-kinase-dependent pathways. EMBO J. 20: 1245-1258.
    • (2001) EMBO J , vol.20 , pp. 1245-1258
    • Celli, J.1    Olivier, M.2    Finlay, B.B.3
  • 19
    • 0037372652 scopus 로고    scopus 로고
    • Enterohemorrhagic Escherichia coli O157:H7 disrupts stat1-mediated γ interferon signal transduction in epithelial cells
    • Ceponis, P. J. M., D. M. McKay, C. Y. Ching, P. Pereia, and P. M. Sherman. 2003. Enterohemorrhagic Escherichia coli O157:H7 disrupts stat1-mediated γ interferon signal transduction in epithelial cells. Infect. Immun. 71: 1396-1404.
    • (2003) Infect. Immun , vol.71 , pp. 1396-1404
    • Ceponis, P.J.M.1    McKay, D.M.2    Ching, C.Y.3    Pereia, P.4    Sherman, P.M.5
  • 20
    • 0042889451 scopus 로고    scopus 로고
    • PKCζ participates in activation of inflammatory response induced by enteropathogenic E. coli
    • Savkovic, S. D., A. Koutsouris, and G. Hecht. 2003. PKCζ participates in activation of inflammatory response induced by enteropathogenic E. coli. Am. J. Physiol. 285: C512-C521.
    • (2003) Am. J. Physiol , vol.285
    • Savkovic, S.D.1    Koutsouris, A.2    Hecht, G.3
  • 21
    • 0035861637 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-dependent pathways oppose Fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells: Implications for inflammatory diarrheal states
    • Abreu, M. T., E. T. Arnold, J. Y. Chow, and K. E. Barrett. 2001. Phosphatidylinositol 3-kinase-dependent pathways oppose Fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells: implications for inflammatory diarrheal states. J. Biol. Chem. 276: 47563-47574.
    • (2001) J. Biol. Chem , vol.276 , pp. 47563-47574
    • Abreu, M.T.1    Arnold, E.T.2    Chow, J.Y.3    Barrett, K.E.4
  • 22
    • 7044253578 scopus 로고    scopus 로고
    • Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-γ but not by IL-4
    • Watson, J. L., S. Ansari, H. Cameron, A. Wang, M. Akhtar, and D. M. McKay. 2004. Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-γ but not by IL-4. Am. J. Physiol. 287: G954-G961.
    • (2004) Am. J. Physiol , vol.287
    • Watson, J.L.1    Ansari, S.2    Cameron, H.3    Wang, A.4    Akhtar, M.5    McKay, D.M.6
  • 23
    • 0034666165 scopus 로고    scopus 로고
    • Interleukins 4 and 13 increase intestinal epithelial permeability via a phosphatidyl-inositol-3′ kinase dependent pathway: Lack of evidence for stat-6 involvement
    • Ceponis, P. J. M., F. Botelho, C. D. Richards, and D. M. McKay. 2000. Interleukins 4 and 13 increase intestinal epithelial permeability via a phosphatidyl-inositol-3′ kinase dependent pathway: lack of evidence for stat-6 involvement. J. Biol. Chem. 275: 29132-29137.
    • (2000) J. Biol. Chem , vol.275 , pp. 29132-29137
    • Ceponis, P.J.M.1    Botelho, F.2    Richards, C.D.3    McKay, D.M.4
  • 24
    • 0033662859 scopus 로고    scopus 로고
    • Superantigen immune stimulation activates epithelial STAT-1 and PI 3-K: PI 3-K regulation of permeability
    • McKay, D. M., F. Botelho, P. J. Ceponis, and C. D. Richards. 2000. Superantigen immune stimulation activates epithelial STAT-1 and PI 3-K: PI 3-K regulation of permeability. Am. J. Physiol. 279: G1094-G1103.
    • (2000) Am. J. Physiol , vol.279
    • McKay, D.M.1    Botelho, F.2    Ceponis, P.J.3    Richards, C.D.4
  • 25
    • 0033956131 scopus 로고    scopus 로고
    • Signaling inputs converge on nuclear effectors in TGF-β signaling
    • Ten Dijke, P., K. Mizazonon, and C.-H. Heldin. 2000. Signaling inputs converge on nuclear effectors in TGF-β signaling. Trends Biochem. Sci. 25: 64-70.
    • (2000) Trends Biochem. Sci , vol.25 , pp. 64-70
    • Ten Dijke, P.1    Mizazonon, K.2    Heldin, C.-H.3
  • 26
    • 0031922969 scopus 로고    scopus 로고
    • Modified Hirt procedure for rapid purification of extra-chromosomal DNA from mammalian cells
    • Arad, U. 1998. Modified Hirt procedure for rapid purification of extra-chromosomal DNA from mammalian cells. Biotechniques 24: 760-762.
    • (1998) Biotechniques , vol.24 , pp. 760-762
    • Arad, U.1
  • 28
  • 29
    • 3242674162 scopus 로고    scopus 로고
    • TGFβ down-regulation of the CFTR: A means to limit epithelial chloride secretion
    • Howe, K. L., A. Wang, M. M. Hunter, B. A. Stanton, and D. M. McKay. 2004. TGFβ down-regulation of the CFTR: a means to limit epithelial chloride secretion. Exp. Cell Res. 298: 473-484.
    • (2004) Exp. Cell Res , vol.298 , pp. 473-484
    • Howe, K.L.1    Wang, A.2    Hunter, M.M.3    Stanton, B.A.4    McKay, D.M.5
  • 30
    • 0027493650 scopus 로고
    • A single phosphotyrosine residue of Stat91 required for gene activation by interferon γ
    • Shuai, K., G. R. Stark, I. M. Kerr, and J. E. Darnell, Jr. 1993. A single phosphotyrosine residue of Stat91 required for gene activation by interferon γ. Science 261: 1744-1746.
    • (1993) Science , vol.261 , pp. 1744-1746
    • Shuai, K.1    Stark, G.R.2    Kerr, I.M.3    Darnell Jr., J.E.4
  • 31
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen, Z., Z. Zhong, and J. E. Darnell, Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82: 241-250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell Jr., J.E.3
  • 32
    • 85047692249 scopus 로고    scopus 로고
    • Impaired Smad7-Smurf-mediated negative regulation of TGFβ signaling in scleroderma fibroblasts
    • Asano, Y., H. Ihn, K. Yamane, M. Kubo, and K. Tamaki. 2004. Impaired Smad7-Smurf-mediated negative regulation of TGFβ signaling in scleroderma fibroblasts. J. Clin. Invest. 113: 253-264.
    • (2004) J. Clin. Invest , vol.113 , pp. 253-264
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Kubo, M.4    Tamaki, K.5
  • 33
    • 16844377774 scopus 로고    scopus 로고
    • Interleukin 6 regulation of transforming growth factor (TGF)-β receptor compartmentalization and turnover enhances TGF-β1 signalling
    • Zhang, X. L., N. Topley, T. Ito, and A. Phillips. 2005. Interleukin 6 regulation of transforming growth factor (TGF)-β receptor compartmentalization and turnover enhances TGF-β1 signalling. J. Biol. Chem. 280: 12239-12245.
    • (2005) J. Biol. Chem , vol.280 , pp. 12239-12245
    • Zhang, X.L.1    Topley, N.2    Ito, T.3    Phillips, A.4
  • 34
    • 8844266055 scopus 로고    scopus 로고
    • Arginine methylation of STAT1: A reassessment
    • Meissner, T., E. Krause, I. Lodige, and U. Vinkerneier. 2004. Arginine methylation of STAT1: a reassessment. Cell 119: 587-539.
    • (2004) Cell , vol.119 , pp. 587-539
    • Meissner, T.1    Krause, E.2    Lodige, I.3    Vinkerneier, U.4
  • 37
    • 0035718217 scopus 로고    scopus 로고
    • Clinical perspectives-biologies in IBD: What's all the fuss?
    • Steinhart, H. 2001. Clinical perspectives-biologies in IBD: what's all the fuss? Can. J. Gastroenterol. 15: 799-804.
    • (2001) Can. J. Gastroenterol , vol.15 , pp. 799-804
    • Steinhart, H.1
  • 38
    • 17544365995 scopus 로고    scopus 로고
    • The IκB/NF-κB system: A key determinant of mucosal inflammation and protection
    • Jobin, C., and R. B. Sartor. 2000. The IκB/NF-κB system: a key determinant of mucosal inflammation and protection. Am. J. Physiol. 278: C451-C462
    • (2000) Am. J. Physiol , vol.278
    • Jobin, C.1    Sartor, R.B.2
  • 39
    • 0031093495 scopus 로고    scopus 로고
    • TGF-β suppresses IFN-γ induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression
    • Lee, Y.-J., Y. Han, H.-T. Lu, V. Nguyen, H. Qin, P. H. Howe, B. A. Hocevar, J. M. Boss, R. M. Ransohoff, and E. N. Benveniste. 1997. TGF-β suppresses IFN-γ induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression. J. Immunol. 158: 2065-2076.
    • (1997) J. Immunol , vol.158 , pp. 2065-2076
    • Lee, Y.-J.1    Han, Y.2    Lu, H.-T.3    Nguyen, V.4    Qin, H.5    Howe, P.H.6    Hocevar, B.A.7    Boss, J.M.8    Ransohoff, R.M.9    Benveniste, E.N.10
  • 40
    • 0029093152 scopus 로고
    • Collagen synthesis by human liver (myo)fibroblasts in culture: Evidence for a regulatory role of IL-1β, IL-4, TGFβ and IFN-γ
    • Tiggelman, A., W. Boers, C. Linthorst, M. Sala, and R. Chamuleau. 1995. Collagen synthesis by human liver (myo)fibroblasts in culture: evidence for a regulatory role of IL-1β, IL-4, TGFβ and IFN-γ. J. Hepatol. 23: 307-317.
    • (1995) J. Hepatol , vol.23 , pp. 307-317
    • Tiggelman, A.1    Boers, W.2    Linthorst, C.3    Sala, M.4    Chamuleau, R.5
  • 42
    • 0029972194 scopus 로고    scopus 로고
    • The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase
    • Haspel, R. L., M. Salditt-Georgieff, and J. E. Darnell, Jr. 1996. The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. EMBO J. 15: 6262-6268.
    • (1996) EMBO J , vol.15 , pp. 6262-6268
    • Haspel, R.L.1    Salditt-Georgieff, M.2    Darnell Jr., J.E.3
  • 43
    • 0032529220 scopus 로고    scopus 로고
    • TGF-β inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes
    • Bright, J. J., and S. Sriram. 1998. TGF-β inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes. J. Immunol. 161: 1772-1777.
    • (1998) J. Immunol , vol.161 , pp. 1772-1777
    • Bright, J.J.1    Sriram, S.2
  • 44
    • 0033106371 scopus 로고    scopus 로고
    • TGF-β does not inhibit IL-12- and IL-2-induced activation of Janus kinases and STATs
    • Sudarshan, C., J. Galon, Y.-J. Zhou, and J. J. O'Shea. 1999. TGF-β does not inhibit IL-12- and IL-2-induced activation of Janus kinases and STATs. J. Immunol. 162: 2974-2981.
    • (1999) J. Immunol , vol.162 , pp. 2974-2981
    • Sudarshan, C.1    Galon, J.2    Zhou, Y.-J.3    O'Shea, J.J.4
  • 45
    • 0035823494 scopus 로고    scopus 로고
    • Roles of phosphatidylinositol 3′-kinase in interferon γ-independent phosphorylation of STAT1 on serine 727 and activation of gene transcription
    • Nguyen, H., C. V. Ramana, J. Bayes, and G. R. Stark. 2001. Roles of phosphatidylinositol 3′-kinase in interferon γ-independent phosphorylation of STAT1 on serine 727 and activation of gene transcription. J. Biol. Chem. 276: 33361-33368.
    • (2001) J. Biol. Chem , vol.276 , pp. 33361-33368
    • Nguyen, H.1    Ramana, C.V.2    Bayes, J.3    Stark, G.R.4
  • 46
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen, Z., Z. Zhong, and J. E. Darnell, Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82: 241-250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell Jr., J.E.3
  • 47
    • 0033580393 scopus 로고    scopus 로고
    • Cross-talk between the Smad1 and Ras/MEK signaling pathways for TGFβ
    • Yue, J., R. S. Frey, and K. M. Mulder. 1999. Cross-talk between the Smad1 and Ras/MEK signaling pathways for TGFβ. Oncogene 18: 2033-2037.
    • (1999) Oncogene , vol.18 , pp. 2033-2037
    • Yue, J.1    Frey, R.S.2    Mulder, K.M.3
  • 48
    • 0032442852 scopus 로고    scopus 로고
    • Smads: Transcriptional activators of TGF-β responses
    • Derynck, R., Y. Zhang, and X.-H. Feng. 1998. Smads: transcriptional activators of TGF-β responses. Cell 95: 737-740.
    • (1998) Cell , vol.95 , pp. 737-740
    • Derynck, R.1    Zhang, Y.2    Feng, X.-H.3
  • 49
    • 16844377774 scopus 로고    scopus 로고
    • Zhang, X. L., N. Topley, T. Ito, and A. Phillips, A. 2005. Interleukin 6 regulation of transforming growth factor (TGF)-β receptor compartmentalization and turnover enhances TGF-β1 signaling. J. Biol. Chem. 280: 12239-12245.
    • Zhang, X. L., N. Topley, T. Ito, and A. Phillips, A. 2005. Interleukin 6 regulation of transforming growth factor (TGF)-β receptor compartmentalization and turnover enhances TGF-β1 signaling. J. Biol. Chem. 280: 12239-12245.
  • 50
    • 0034517389 scopus 로고    scopus 로고
    • Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGFβ receptor for degradation
    • Kavsak, P., R. K. Rasmussen, C. G. Causing, S. Bonni, H. Zhu, G. H. Thomsen, and J. L. Wrana. 2000. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGFβ receptor for degradation. Mol. Cell 6: 1365-1375.
    • (2000) Mol. Cell , vol.6 , pp. 1365-1375
    • Kavsak, P.1    Rasmussen, R.K.2    Causing, C.G.3    Bonni, S.4    Zhu, H.5    Thomsen, G.H.6    Wrana, J.L.7
  • 51
    • 0037598870 scopus 로고    scopus 로고
    • Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
    • Di Guglielmo, G. M., C. Le Roy, A. F. Goodfellow, and J. L. Wrana. 2003. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover. Nat. Cell Biol. 5: 410-421.
    • (2003) Nat. Cell Biol , vol.5 , pp. 410-421
    • Di Guglielmo, G.M.1    Le Roy, C.2    Goodfellow, A.F.3    Wrana, J.L.4
  • 54
    • 20944444925 scopus 로고    scopus 로고
    • STAT1-independent down-regulation of interferon γ-induced class II transactivator and HLA-DR expression by transforming growth factor β1 in human glomerular endothelial cells
    • Yang, W. S., N. J. Han, C. S. Kim, H. Ahn, S. K. Lee, K. U. Lee, and S. K. Park. 2005. STAT1-independent down-regulation of interferon γ-induced class II transactivator and HLA-DR expression by transforming growth factor β1 in human glomerular endothelial cells. Nephron. Exp. Nephrol. 100: E124-E131.
    • (2005) Nephron. Exp. Nephrol , vol.100
    • Yang, W.S.1    Han, N.J.2    Kim, C.S.3    Ahn, H.4    Lee, S.K.5    Lee, K.U.6    Park, S.K.7
  • 55
    • 0035815696 scopus 로고    scopus 로고
    • Antagonistic regulation of type I collagen gene expression by interferon γ and transforming growth factor β: Integration at the level of p300/CBP transcriptional coactivators
    • Ghosh, A. K., W. Yuan, Y. Mori, S. J. Chen, and J. Varga. 2001. Antagonistic regulation of type I collagen gene expression by interferon γ and transforming growth factor β: integration at the level of p300/CBP transcriptional coactivators. J. Biol. Chem. 276: 11041-11048.
    • (2001) J. Biol. Chem , vol.276 , pp. 11041-11048
    • Ghosh, A.K.1    Yuan, W.2    Mori, Y.3    Chen, S.J.4    Varga, J.5
  • 56
    • 0347719405 scopus 로고    scopus 로고
    • Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)
    • Long, J., G. Wang, I. Matsuura, D. He, and F. Liu. 2004. Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3). Proc. Natl. Acad Sci. USA 101: 99-104.
    • (2004) Proc. Natl. Acad Sci. USA , vol.101 , pp. 99-104
    • Long, J.1    Wang, G.2    Matsuura, I.3    He, D.4    Liu, F.5
  • 57
    • 0043194033 scopus 로고    scopus 로고
    • Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT
    • Long, J., I. Matsuura, D. He, G. Wang, K. Shuai, and F. Liu. 2003. Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT. Proc. Natl. Acad. Sci. USA 100: 9791-9796.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9791-9796
    • Long, J.1    Matsuura, I.2    He, D.3    Wang, G.4    Shuai, K.5    Liu, F.6


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