TGF-β does not inhibit IL-12- and IL-2-induced activation of Janus kinases and STATs

Journal of Immunology

Volumn 162, Issue 5, 1999, Pages 2974-2981

  Sudarshan, Chitra ^a,b   Galon, Jérôme ^a   Zhou, Yong Jie ^a   O'Shea, John J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; PHOSPHOTRANSFERASE; STAT1 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE ACTIVATION; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CELL LINE; DNA-BINDING PROTEINS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-2; JANUS KINASE 1; JANUS KINASE 2; MILK PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 12; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; STAT4 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033106371     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Brunda, M. J. 1994. Interleukin-12. J. Leukocyte Biol. 55:280.
2. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
3. Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C. Y. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficienl mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 4:471.
4. Presky, D. H., H. Yang, L. J. Minetti, A. O. Chua, N. Nabavi, C. Y. Wu, M. K. Gately, and U. Gubler. 1996. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93:14002.
5. Zou, J., D. H. Presky, C. Y. Wu, and U. Gubler. 1997. Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits β1 and β2 and JAK kinases. J. Biol. Chem. 272:6073.
6. O'Shea JJ. 1997. Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are we there yet? Immunity 7:1.
7. Bacon, C. M., D. W. McVicar, J. R. Ortaldo, R. C. Rees, J. J. O'Shea, and J. A. Johnston. 1995. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181:399.
8. Bacon, C. M., E. F. R. Petricoin, J. R. Ortaldo, R. C. Rees, A. C. Larner, J. A. Johnston, and J. J. O'Shea. 1995. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. USA 92:7307.
9. Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. J. Darnell, and K. M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat) 3 and Stat4. J. Exp. Med. 181:1755.
10. Ihle, J. N. 1996. STATs: signal transducers and activators of transcription. Cell 84:331.
11. Kehrl, J. H., L. M. Wakefield, A. B. Roberts, S. Jakowlew, M. Alvarez-Mon, R. Derynck, M. B. Sporn, and A. S. Fauci. 1986. Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J. Exp. Med. 163:1037.
12. Rook, A. H., J. H. Kehrl, L. M. Wakefield, A. B. Roberts, M. B. Sporn, D. B. Burlington, H. C. Lane, and A. S. Fauci. 1986. Effects of transforming growth factor β on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness. J. Immunol. 136:3916.
13. Ruegemer, J. J., S. N. Ho, J. A. Augustine, J. W. Schlager, M. P. Bell, D. J. McKean, and R. T. Abraham. 1990. Regulatory effects of transforming growth factor-β on IL-2- and IL-4-dependent T cell-cycle progression. J. Immunol. 144:1767.
14. Ortaldo, J. R., A. T. Mason, J. J. O'Shea, M. J. Smyth, L. A. Falk, I. C. Kennedy, D. L. Longo, and F. W. Ruscetti. 1991. Mechanistic studies of transforming growth factor-β inhibition of IL-2-dependent activation of CD3 large granular lymphocyte functions: regulation of IL-2R β (p75) signal transduction. J. Immunol. 146:3791.
15. Holter, W., F. S. Kalthoff, W. F. Pickl, C. Ebner, O. Majdic, D. Kraft, and W. Knapp. 1994. Transforming growth factor-β inhibits IL-4 and IFN-γ production by stimulated human T cells. Int. Immunol. 6:469.
16. Malygin, A. M., S. Meri, and T. Timonen. 1993. Regulation of natural killer cell activity by transforming growth factor β and prostaglandin E2. Scand. J. Immunol. 37:71.
17. Ye, J., J. R. Ortaldo, K. Conlon, R. Winkler-Pickett, and H. A. Young. 1995. Cellular and molecular mechanisms of IFN-γ production induced by IL-2 and IL-12 in a human NK cell line. J. Leukocyte Biol. 58:225.
18. Shull, M. M., I. Ormsby, A. B. Kier, S. Pawlowski, R. J. Diebold, M. Yin, R. Allen, C. Sidman, G. Proetzel, D. Calvin, et al. 1992. Targeted disruption of the mouse transforming growth factor-β 1 gene results in multifocal inflammatory disease. Nature 359:693.
19. Kulkarni, A. B., C.-G. Huh, D. Becker, A. Geiser, M. Lyght, K. C. Flanders, A. B. Roberts, M. B. Sporn, J. M. Ward, and S. Karlsson. 1993. Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA 90:770.
20. Pazdrak, K., L. Justement, and R. Alam. 1995. Mechanism of inhibition of eosinophil activation by transforming growth factor-β: inhibition of Lyn, MAP, Jak2 kinases and STAT1 nuclear factor. J. Immunol. 155:4454.
21. Bright, J. J., L. D. Kerr, and S. Sriram. 1997. TGF-β inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes. J. Immunol. 159:175.
22. + suppressor T cell, NY4.2, in the prevention of autoimmune IDDM in NOD mice. J. Autoimmun. 10:299.
23. Panek, R. B., Y. J. Lee, and E. N. Benveniste. 1995. TGF-β suppression of IFN-γ-induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2, or signal transducers and activators of transcription, or modification of IFN-γ enhanced factor X expression. J. Immunol. 154:610.
24. Nandan, D., and N. E. Reiner. 1997. TGF-β attenuates the class II transactivator and reveals an accessory pathway of IFN-γ action. J. Immunol. 158:1095.
25. Lee, Y. J., Y. Han, H. T. Lu, V. Nguyen, H. Qin, P. H. Howe, B. A. Hocevar, J. M. Boss, R. M. Ransohoff, and E. N. Benveniste. 1997. TGF-β suppresses IFN-γ induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression. J. Immunol. 158:2065.
26. Kawamura, M., D. W. McVicar, J. A. Johnston, T. B. Blake, Y. Q. Chen, B. K. Lal, A. R. Lloyd, D. J. Kelvin, J. E. Staples, J. R. Ortaldo, et al. 1994. Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc. Natl. Acad. Sci. USA 91:6374.
27. Johnston, J. A., M. Kawamura, R. A. Kirken, Y. Q. Chen, T. B. Blake, K. Shibuya, J. R. Ortaldo, D. W. McVicar, and J. J. O'Shea. 1994. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370:151.
28. Haspel, R. L., M. Salditt-Georgieff, and J. E. J. Darnell. 1996. The rapid inactivation of nuclear tyrosine phosphorylaled Stat1 depends upon a protein tyrosinc phosphatase. EMBO J. 15:6262.
29. Bacon, C. M., P. J. Tortolani, A. Shimosaka, R. C. Rees, D. L. Longo, and J. J. O'Shea. 1995. Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3. FEBS Lett. 370:63.
30. Ryan, J. J., L. J. McReynolds, A. Keegan, L. H. Wang, E. Garfein, P. Rothman, K. Nelms, and W. E. Paul. 1996. Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. Immunity 4:123.
31. Zhou, Y. J., E. P. Hanson, Y. Q. Chen, K. Magnuson, M. Chen, P. G. Swann, R. L. Wange, P. S. Changelian, and J. J. O'Shea. 1997. Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity. Proc. Natl. Acad. Sci. USA 94:13850.
32. Bellone, G., M. Aste-Amezaga, G. Trinchieri, and U. Rodeck. 1995. Regulation of NK cell functions by TGF-β 1. J. Immunol. 155:1066.
33. Desai, B. B., P. M. Quinn, A. G. Wolitzky, P. K. Mongini, R. Chizzonite, and M. K. Gately. 1992. IL-12 receptor. II. Distribution and regulation of receptor expression. J. Immunol. 148:3125.
34. Stahl, N., T. J. Farruggella, T. G. Boulton, Z. Zhong, J. E. J. Darnell, and G. D. Yancopoulos. 1995. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267:1349.
35. Heim, M. H., I. M. Kerr, G. R. Stark, and J. E. J. Darnell. 1995. Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267:1347.
36. Cho, S. S., C. M. Bacon, C. Sudarshan, R. C. Rees, D. Finbloom, R. Pine, and J. J. O'Shea. 1996. Activation of STAT4 by IL-12 and IFN-α: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J. Immunol. 157:4781.
37. Shuai, K., G. R. Stark, I. M. Kerr, and J. E. J. Darnell. 1993. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science 261:1744.
38. Shuai, K., C. M. Horvath, L. H. Huang, S. A. Qureshi, D. Cowburn, and J. E. J. Darnell. 1994. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76: 821.
39. Yu, C. R., J. X. Lin, D. W. Fink, S. Akira, E. T. Bloom, and A. Yamauchi. 1996. Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-α. J. Immunol. 157:126.
40. Massague, J. 1996. TGFβ signaling: receptors, transducers, and Mad proteins. Cell 85:947.
41. Macias-Silva, M., S. Abdollah, P. A. Hoodless, R. Pirone, L. Attisano, and J. L. Wrana. 1996. MADR2 is a substrate of the TGF β receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87:1215.
42. Chen, X., M. J. Rubock, and M. Whitman. 1996. A transcriptional partner for MAD proteins in TGF-β signalling. [Published erratum appears in 1996 Nature 384:648.] Nature 383:691.
43. Piskurich, J. F., Y. Wang, M. W. Linhoff, L. C. White, and J. P.-Y. Ting. 1998. Identification of distinct regions of 5′ flanking DNA that mediate constitutive, IFN-γ, STAT1, and TGF-β-regulated expression of the class II transactivator gene. J. Immunol. 160:233.
44. Moses, H. L., E. Y. Yang, and J. A. Pietenpol. 1990. TGF-β stimulation and inhibition of cell proliferation: new mechanistic insights. Cell 63:245.
45. Laiho, M., J. A. DeCaprio, J. W. Ludlow, D. M. Livingston, and J. Massague. 1990. Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation. Cell 62:175.
46. Ahuja, S. S., F. Paliogianni, H. Yamada, J. E. Balow, and D. T. Boumpas. 1993. Effect of transforming growth factor β on early and late activation events in human T cells. J. Immunol. 150:3109.
47. Reynisdottir, I., K. Polyak, A. Iavarone, and J. Massague. 1995. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev. 9:1831.
48. kip1 mRNA and protein in murine B cells. J. Immunol. 160:770.