Superantigen immune stimulation activates epithelial STAT-1 and PI 3-K: PI 3-K regulation of permeability

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 279, Issue 5 42-5, 2000, Pages

  McKay, Derek M ^a   Botelho, Fernando ^a   Ceponis, Peter J M ^a   Richards, Carl D ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Intestine; Phosphati dylinositol 3' kinase; Staphylococcus aureus enterotoxin B

Indexed keywords

ENTEROTOXIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; OLIGONUCLEOTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; STAT PROTEIN; SUPERANTIGEN; TRANSCRIPTION FACTOR;

ARTICLE; BLOOD; CELL MEMBRANE PERMEABILITY; ELECTROPHORETIC MOBILITY; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MONONUCLEAR CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; TRANSCRIPTION INITIATION;

EID: 0033662859     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.279.5.g1094     Document Type: Article

References (46)

1. IL-3 and IL-4 activate cyclic nucleotide phosphodiesterase 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells
2. A rapid micro-preparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
3. Cytokines: Sources, receptors and signaling
4. Role of IL-4 in macromolecular transport across human intestinal epithelium
5. Distribution and kinetics of superantigen gene expression in mouse spleen
6. Regulation of gene expression with double-stranded phosphorothioate oligonucleotides
7. Genistein augments prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum
8. Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3'-kinase pathway. Lack of evidence for STAT6 involvement
9. Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
10. Colonic epithelial physiology is altered in response to the bacterial superantigen Yersinia pseudotuberculosis mitogen (YPM)
11. STAT1 implication in the immune response to superantigens in vivo
12. Interferon γ and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators
13. Does gene therapy call for 'STAT' immunity and inflammation at the epithelial barrier?
14. STATs: Signal transducers and activators of transcription
15. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor κB super-repressor in human intestinal epithelial cells
16. EGF induces nuclear translocation of STAT-2 without tyrosine phosphorylation in intestinal epithelial cells
17. Reconstitution of cultured intestinal epithelial monolayers with a mucosal derived T lymphocyte cell line: Modulation of epithelial phenotype dependent on lymphocyte basolateral membrane apposition
18. Stress-induced phosphorylation of STAT1 at ser727 requires p38 mitogen-activated protein kinase whereas IFNγ uses a different signaling pathway
19. STAT3 and STAT5B are targets of two different signal pathways activated by the hematopoietin receptors and control transcription via separate cytokine response elements
20. Interferon-γ signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP and IRF-1 transcription factors
21. Epithelial transport and barrier abnormalities evoked by superantigen-activated immune cells are inhibited by IL-10, but not IL-4
22. Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction
23. Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers
24. Interleukin 10 prevents cytokine-induced disruption of T84 monolayers barrier integrity and limits chloride secretion
25. Cytokine regulation of epithelial permeability and ion transport
26. 2
27. Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the JAK/STAT pathway
28. Receptors for interleukin (IL)-4 do not associate with the common γ chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells
29. Structure and function of a new STAT-induced STAT inhibitor
30. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanism: Evidence for STAT3-dependent and -independent pathways
31. IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6
32. Inhibition of ornithine decarboxylase induces STAT3 tyrosine phosphorylation and DNA binding in IEC-6 cells
33. Regulation of c-myc expression by IFNγ through STAT-1-dependent and -independent pathways
34. Intestinal epithelial cells both express and respond to interleukin 15
35. Oncostatin M inhibits IL-1-induced expression of IL-8 and granulocyte-macrophage colony-stimulating factor by synovial and lung fibroblasts
36. Interleukin10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action
37. Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma
38. Effects of interferon-γ and tumour necrosis factor α on epithelial HLA class II expression on jejunal mucosal biopsy specimens cultured in vitro
39. Changes in barrier function of a model intestinal epithelium by intraepithelial lymphocytes requires new protein synthesis by epithelial cells
40. Signaling by distinct classes of phosphoinositide 3-kinases
41. The SIE binding element confers sis/PDGF inducibility onto the c-fos promoter
42. Targeted disruption of interferon-γ-dependent intercellular adhesion molecule-1 (ICAM-1) expression using dominant-negative STAT1
43. Targeted disruption of STAT6 DNA binding activity by an oligonucleotide decoy blocks IL-4-driven Th2 cell response
44. Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation. Evidence for an interleukin-13-driven phosphatidylinositol 3-kinase-dependent survival mechanism
45. Interferon-γ-induced JAK2 and STAT1 signaling in a human salivary gland cell line