메뉴 건너뛰기




Volumn 68, Issue 6, 2007, Pages 1371-1377

Jekyll and Hyde, the p53 protein, pleiotropics antagonisms and the thrifty aged hypothesis of senescence

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN P53;

EID: 33947669479     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.10.043     Document Type: Article
Times cited : (7)

References (60)
  • 1
    • 0000055057 scopus 로고
    • Pleiotropy, natural selection, and the evolution of senescence
    • Williams G.C. Pleiotropy, natural selection, and the evolution of senescence. Evolution 11 (1957) 398-411
    • (1957) Evolution , vol.11 , pp. 398-411
    • Williams, G.C.1
  • 2
    • 21644472973 scopus 로고    scopus 로고
    • Reflections on an unsolved problem of biology: the evolution of senescence and death
    • Clark W. Reflections on an unsolved problem of biology: the evolution of senescence and death. Adv Gerontol 14 (2004) 7-20
    • (2004) Adv Gerontol , vol.14 , pp. 7-20
    • Clark, W.1
  • 3
    • 10944272639 scopus 로고    scopus 로고
    • Aging, tumor suppression and cancer: high wire-act!
    • Campisi J. Aging, tumor suppression and cancer: high wire-act!. Mech Ageing Dev 126 (2005) 51-58
    • (2005) Mech Ageing Dev , vol.126 , pp. 51-58
    • Campisi, J.1
  • 4
    • 0034977941 scopus 로고    scopus 로고
    • Evolution of thermal dependence of growth rate of Escherichia coli populations during 20,000 generations in a constant environment
    • Cooper V., Bennett A., and Lenski R. Evolution of thermal dependence of growth rate of Escherichia coli populations during 20,000 generations in a constant environment. Evol Int J Org Evol 55 (2001) 889-896
    • (2001) Evol Int J Org Evol , vol.55 , pp. 889-896
    • Cooper, V.1    Bennett, A.2    Lenski, R.3
  • 6
    • 0033805483 scopus 로고    scopus 로고
    • The evolution of senescence under curtailed life span in laboratory populations of Musca domestica (the houseflly)
    • Reed D., and Bryant E. The evolution of senescence under curtailed life span in laboratory populations of Musca domestica (the houseflly). Heredity 85 (2000) 115-121
    • (2000) Heredity , vol.85 , pp. 115-121
    • Reed, D.1    Bryant, E.2
  • 7
    • 0348252202 scopus 로고    scopus 로고
    • Quantitative genetic tests of recent senescence theory: age-specific mortality and male fertility in Drosophila melanogaster
    • Snoke M., and Promislow D.E.L. Quantitative genetic tests of recent senescence theory: age-specific mortality and male fertility in Drosophila melanogaster. Heredity 91 (2003) 546-556
    • (2003) Heredity , vol.91 , pp. 546-556
    • Snoke, M.1    Promislow, D.E.L.2
  • 8
    • 19944432549 scopus 로고    scopus 로고
    • What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?
    • Leroi A., Bartke A., de Benedictis G., et al. What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?. Mech Ageing Dev 126 (2005) 421-429
    • (2005) Mech Ageing Dev , vol.126 , pp. 421-429
    • Leroi, A.1    Bartke, A.2    de Benedictis, G.3
  • 9
    • 33646484802 scopus 로고    scopus 로고
    • Spend less, live longer. The "thrifty aged" hypothesis
    • Zafon C. Spend less, live longer. The "thrifty aged" hypothesis. Med Hypotheses 67 (2006) 15-20
    • (2006) Med Hypotheses , vol.67 , pp. 15-20
    • Zafon, C.1
  • 10
    • 0037067656 scopus 로고    scopus 로고
    • p53: Good cop/bad cop
    • Sharpless N.E., and DePinho R.A. p53: Good cop/bad cop. Cell 110 (2002) 9-12
    • (2002) Cell , vol.110 , pp. 9-12
    • Sharpless, N.E.1    DePinho, R.A.2
  • 11
    • 15544377794 scopus 로고    scopus 로고
    • Molecular and evolutionary basis of the cellular stress response
    • Kültz D. Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol 67 (2005) 225-257
    • (2005) Annu Rev Physiol , vol.67 , pp. 225-257
    • Kültz, D.1
  • 12
    • 0035195557 scopus 로고    scopus 로고
    • The evolution of diverse biological responses to DNA damage: insights from yeast and p53
    • Wahl G.M., and Carr A.M. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nature Cell Biol 3 (2001) E277-E286
    • (2001) Nature Cell Biol , vol.3
    • Wahl, G.M.1    Carr, A.M.2
  • 14
    • 0035082454 scopus 로고    scopus 로고
    • The p53 tumor suppressor: critical regulator of life and death in cancer
    • Fisher D. The p53 tumor suppressor: critical regulator of life and death in cancer. Apoptosis 6 (2001) 7-15
    • (2001) Apoptosis , vol.6 , pp. 7-15
    • Fisher, D.1
  • 15
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: the cell's response to p53
    • Vousden K., and Lu X. Live or let die: the cell's response to p53. Nature Rev Cancer 2 (2002) 594-604
    • (2002) Nature Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.1    Lu, X.2
  • 16
    • 0037075898 scopus 로고    scopus 로고
    • Activation of the p53 tumor suppressor protein
    • Vousden K. Activation of the p53 tumor suppressor protein. Biochim Biophys Acta 1602 (2002) 47-59
    • (2002) Biochim Biophys Acta , vol.1602 , pp. 47-59
    • Vousden, K.1
  • 17
    • 0037202381 scopus 로고    scopus 로고
    • Molecular strategies in metazoan genomic evolution
    • Saccone C., Barome P., D'Erchia A., et al. Molecular strategies in metazoan genomic evolution. Gene 300 (2002) 195-201
    • (2002) Gene , vol.300 , pp. 195-201
    • Saccone, C.1    Barome, P.2    D'Erchia, A.3
  • 18
    • 0035555650 scopus 로고    scopus 로고
    • Activation and activities of the p53 tumour suppressor protein
    • Bálint E., and Vousden K. Activation and activities of the p53 tumour suppressor protein. Br J Cancer 85 (2001) 1813-1823
    • (2001) Br J Cancer , vol.85 , pp. 1813-1823
    • Bálint, E.1    Vousden, K.2
  • 19
    • 0034037470 scopus 로고    scopus 로고
    • Demystified: apoptosis
    • Afford S., and Randhawa S. Demystified: apoptosis. Mol Pathol 53 (2000) 55-63
    • (2000) Mol Pathol , vol.53 , pp. 55-63
    • Afford, S.1    Randhawa, S.2
  • 20
    • 0032919804 scopus 로고    scopus 로고
    • Assessing apoptosis: a critical survey
    • Hall P. Assessing apoptosis: a critical survey. Endocr Relat Cancer 6 (1999) 3-8
    • (1999) Endocr Relat Cancer , vol.6 , pp. 3-8
    • Hall, P.1
  • 21
    • 0035049060 scopus 로고    scopus 로고
    • Apoptosis and its clinical impact
    • Gastman B. Apoptosis and its clinical impact. Head Neck 23 (2001) 409-425
    • (2001) Head Neck , vol.23 , pp. 409-425
    • Gastman, B.1
  • 22
    • 0035206383 scopus 로고    scopus 로고
    • Mechanisms of p53-dependent apoptosis
    • Schuler M., and Green D. Mechanisms of p53-dependent apoptosis. Biochem Soc Trans 29 (2001) 684-688
    • (2001) Biochem Soc Trans , vol.29 , pp. 684-688
    • Schuler, M.1    Green, D.2
  • 23
    • 0036260527 scopus 로고    scopus 로고
    • Does p53 affect organismal aging?
    • Donehower L.A. Does p53 affect organismal aging?. J Cell Physiol 192 (2002) 23-33
    • (2002) J Cell Physiol , vol.192 , pp. 23-33
    • Donehower, L.A.1
  • 24
    • 27944445760 scopus 로고    scopus 로고
    • Mesenchymal stem cell aging
    • Fehrer C., and Lepperdinger G. Mesenchymal stem cell aging. Exp Gerontol 40 (2005) 926-930
    • (2005) Exp Gerontol , vol.40 , pp. 926-930
    • Fehrer, C.1    Lepperdinger, G.2
  • 25
    • 12344273381 scopus 로고    scopus 로고
    • Variation in the human TP53 gene affects old age survival and cancer mortality
    • van Heemst D., Mooijaart S., Beekman M., et al. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol 40 (2005) 11-15
    • (2005) Exp Gerontol , vol.40 , pp. 11-15
    • van Heemst, D.1    Mooijaart, S.2    Beekman, M.3
  • 26
    • 27844596799 scopus 로고    scopus 로고
    • Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span
    • Bauer J., Poon P., Glatt-Deeley H., Abrams J., and Helfand S. Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr Biol 15 (2005) 2063-2068
    • (2005) Curr Biol , vol.15 , pp. 2063-2068
    • Bauer, J.1    Poon, P.2    Glatt-Deeley, H.3    Abrams, J.4    Helfand, S.5
  • 27
    • 25644440744 scopus 로고    scopus 로고
    • Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
    • Varela I., Cadinanos J., Pendas A., et al. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 437 (2005) 564-568
    • (2005) Nature , vol.437 , pp. 564-568
    • Varela, I.1    Cadinanos, J.2    Pendas, A.3
  • 28
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37 (1965) 614-636
    • (1965) Exp Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 29
    • 14644410453 scopus 로고    scopus 로고
    • The signals and pathways activating cellular senescence
    • Ben-Porath I., and Weinberg R. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 37 (2005) 961-976
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 961-976
    • Ben-Porath, I.1    Weinberg, R.2
  • 30
    • 0033552638 scopus 로고    scopus 로고
    • Twenty years of p53 research: structural and functional aspects of the p53 protein
    • May P., and May E. Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene 18 (1999) 7621-7636
    • (1999) Oncogene , vol.18 , pp. 7621-7636
    • May, P.1    May, E.2
  • 31
    • 1042266548 scopus 로고    scopus 로고
    • Modulation of mammalian life span by the short isoform of p53
    • Maier B., Gluba W., Bernier B., et al. Modulation of mammalian life span by the short isoform of p53. Genes Dev 18 (2004) 306-319
    • (2004) Genes Dev , vol.18 , pp. 306-319
    • Maier, B.1    Gluba, W.2    Bernier, B.3
  • 32
    • 1542781659 scopus 로고    scopus 로고
    • When cell get stressed: an integrative view of cellular senescence
    • Ben-Porath I., and Weinberg R. When cell get stressed: an integrative view of cellular senescence. J Clin Invest 113 (2004) 8-13
    • (2004) J Clin Invest , vol.113 , pp. 8-13
    • Ben-Porath, I.1    Weinberg, R.2
  • 33
    • 33144490082 scopus 로고    scopus 로고
    • How does cellular senescence prevent cancer?
    • Lynch M. How does cellular senescence prevent cancer?. DNA Cell Biol 25 (2006) 69-78
    • (2006) DNA Cell Biol , vol.25 , pp. 69-78
    • Lynch, M.1
  • 34
    • 0033761072 scopus 로고    scopus 로고
    • Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage
    • Gewirtz D. Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage. Breast Cancer Res Treat 62 (2000) 223-235
    • (2000) Breast Cancer Res Treat , vol.62 , pp. 223-235
    • Gewirtz, D.1
  • 35
    • 85047694328 scopus 로고    scopus 로고
    • Cellular senescence in cancer treatment: friend or foe?
    • Kahlem P., Dörken B., and Schmitt C. Cellular senescence in cancer treatment: friend or foe?. J Clin Invest 113 (2004) 169-174
    • (2004) J Clin Invest , vol.113 , pp. 169-174
    • Kahlem, P.1    Dörken, B.2    Schmitt, C.3
  • 36
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
    • Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120 (2005) 513-522
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 37
    • 0035059672 scopus 로고    scopus 로고
    • From cells to organisms: can we learn about aging from cells in culture?
    • Campisi J. From cells to organisms: can we learn about aging from cells in culture?. Exp Gerontol 36 (2001) 607-618
    • (2001) Exp Gerontol , vol.36 , pp. 607-618
    • Campisi, J.1
  • 38
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
    • Krtolica A., Parrinello S., Lockectt S., Desprez P., and Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci USA 98 (2001) 12072-12077
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12072-12077
    • Krtolica, A.1    Parrinello, S.2    Lockectt, S.3    Desprez, P.4    Campisi, J.5
  • 39
    • 24344438713 scopus 로고    scopus 로고
    • The thorny path linking cellular senescence to organismal aging
    • Patil C., Mian I., and Campisi J. The thorny path linking cellular senescence to organismal aging. Mech Ageing Dev 126 (2005) 1040-1045
    • (2005) Mech Ageing Dev , vol.126 , pp. 1040-1045
    • Patil, C.1    Mian, I.2    Campisi, J.3
  • 40
    • 4644250302 scopus 로고    scopus 로고
    • From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing
    • Magalhaes J. From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing. Exp Cell Res 300 (2004) 1-10
    • (2004) Exp Cell Res , vol.300 , pp. 1-10
    • Magalhaes, J.1
  • 43
    • 24344447780 scopus 로고    scopus 로고
    • p63 deficiency activates a program of cellular senescence and leads to accelerated aging
    • Keyes W., Wu Y., Vogel H., Guo X., Lowe S., and Mills A. p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev 19 (2005) 1986-1999
    • (2005) Genes Dev , vol.19 , pp. 1986-1999
    • Keyes, W.1    Wu, Y.2    Vogel, H.3    Guo, X.4    Lowe, S.5    Mills, A.6
  • 44
    • 28244499304 scopus 로고    scopus 로고
    • Identification of differentially expressed proteins in senescent human embryonic fibroblasts
    • Trogaukus I., Saridaki A., Panayotou G., and Gonos E. Identification of differentially expressed proteins in senescent human embryonic fibroblasts. Mech Ageing Dev 127 (2006) 88-92
    • (2006) Mech Ageing Dev , vol.127 , pp. 88-92
    • Trogaukus, I.1    Saridaki, A.2    Panayotou, G.3    Gonos, E.4
  • 45
    • 0033660404 scopus 로고    scopus 로고
    • Viral oncogenes as tools to study replicative senescence oh human cells
    • Jansen-Dürr P. Viral oncogenes as tools to study replicative senescence oh human cells. Exp Gerontol 35 (2000) 1151-1155
    • (2000) Exp Gerontol , vol.35 , pp. 1151-1155
    • Jansen-Dürr, P.1
  • 46
    • 0346256784 scopus 로고    scopus 로고
    • Metabolic analysis of senescence human fibroblasts reveals a role for AMP in cellular senescence
    • Zwerschke W., Mazurek S., Stöckl P., Hütter E., Eigenbrodt E., and Jansen-Dürr P. Metabolic analysis of senescence human fibroblasts reveals a role for AMP in cellular senescence. Biochem J 376 (2003) 403-411
    • (2003) Biochem J , vol.376 , pp. 403-411
    • Zwerschke, W.1    Mazurek, S.2    Stöckl, P.3    Hütter, E.4    Eigenbrodt, E.5    Jansen-Dürr, P.6
  • 47
    • 20844449238 scopus 로고    scopus 로고
    • AMP-Activated protein kinase induces a p53-dependent metabolic checkpoint
    • Jones R., Plas D., Kubek S., et al. AMP-Activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 18 (2005) 283-293
    • (2005) Mol Cell , vol.18 , pp. 283-293
    • Jones, R.1    Plas, D.2    Kubek, S.3
  • 48
    • 0035929571 scopus 로고    scopus 로고
    • Enhanced gluconeogenesis and increased energy storage as hallmarks of aging in Saccharomyces cerevisiae
    • Lin S.S., Manchester J.K., and Gordon J.I. Enhanced gluconeogenesis and increased energy storage as hallmarks of aging in Saccharomyces cerevisiae. J Biol Chem 276 (2001) 36000-36007
    • (2001) J Biol Chem , vol.276 , pp. 36000-36007
    • Lin, S.S.1    Manchester, J.K.2    Gordon, J.I.3
  • 50
    • 13844257506 scopus 로고    scopus 로고
    • The non-existent aging program: how does it work?
    • Bredesen D. The non-existent aging program: how does it work?. Aging Cell 3 (2004) 255-259
    • (2004) Aging Cell , vol.3 , pp. 255-259
    • Bredesen, D.1
  • 51
    • 0001028861 scopus 로고    scopus 로고
    • Ageing and typical survivorship curves result from optimal resource allocation
    • Cichon M., and Kozlowski J. Ageing and typical survivorship curves result from optimal resource allocation. Evol Ecol Res 2 (2000) 857-870
    • (2000) Evol Ecol Res , vol.2 , pp. 857-870
    • Cichon, M.1    Kozlowski, J.2
  • 52
    • 0026648469 scopus 로고
    • Comparative life spans of species: why do species have the life spans they do?
    • Kirkwood T.B.L. Comparative life spans of species: why do species have the life spans they do?. Am J Clin Nutr 55 (1992) 1191S-1195S
    • (1992) Am J Clin Nutr , vol.55
    • Kirkwood, T.B.L.1
  • 53
    • 0038324381 scopus 로고    scopus 로고
    • From the stress theory of aging to energetic and evolutionary expectations for longevity
    • Parsons P.A. From the stress theory of aging to energetic and evolutionary expectations for longevity. Biogerontology 4 (2003) 63-73
    • (2003) Biogerontology , vol.4 , pp. 63-73
    • Parsons, P.A.1
  • 54
    • 0345166830 scopus 로고    scopus 로고
    • Ageing purpose: another thrifty genotype
    • Zafon C. Ageing purpose: another thrifty genotype. Med Hypotheses 61 (2003) 482-485
    • (2003) Med Hypotheses , vol.61 , pp. 482-485
    • Zafon, C.1
  • 56
    • 0037470501 scopus 로고    scopus 로고
    • The endocrine regulation of aging by insulin-like signals
    • Tatar M., Bartke A., and Antebi A. The endocrine regulation of aging by insulin-like signals. Science 299 (2003) 1346-1351
    • (2003) Science , vol.299 , pp. 1346-1351
    • Tatar, M.1    Bartke, A.2    Antebi, A.3
  • 57
    • 32044435126 scopus 로고    scopus 로고
    • Coordination and communication between the p53 and IGF-I-AKT-TOR signal transduction pathways
    • Levine A., Feng Z., Mak T., You H., and Jin S. Coordination and communication between the p53 and IGF-I-AKT-TOR signal transduction pathways. Genes Dev 20 (2006) 267-275
    • (2006) Genes Dev , vol.20 , pp. 267-275
    • Levine, A.1    Feng, Z.2    Mak, T.3    You, H.4    Jin, S.5
  • 58
    • 0031196766 scopus 로고    scopus 로고
    • The p53/IGF-1 receptor axis in the regulation of programmed cell death
    • Neuberg M., Buckbinder L., Seizinger B., and Kley N. The p53/IGF-1 receptor axis in the regulation of programmed cell death. Endocrine 7 (1997) 107-109
    • (1997) Endocrine , vol.7 , pp. 107-109
    • Neuberg, M.1    Buckbinder, L.2    Seizinger, B.3    Kley, N.4
  • 59
    • 0032973417 scopus 로고    scopus 로고
    • The IGF axis and programmed cell death
    • Butt A., Firth S., and Baxter R. The IGF axis and programmed cell death. Immunol Cell Biol 77 (1999) 256-262
    • (1999) Immunol Cell Biol , vol.77 , pp. 256-262
    • Butt, A.1    Firth, S.2    Baxter, R.3
  • 60
    • 32244440985 scopus 로고    scopus 로고
    • The myth and reality of reversal of aging by hormesis
    • Sonneborn J. The myth and reality of reversal of aging by hormesis. Ann NY Acad Sci 1057 (2005) 165-176
    • (2005) Ann NY Acad Sci , vol.1057 , pp. 165-176
    • Sonneborn, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.