Contributions of studies on uncoupling proteins to research on metabolic diseases

Journal of Internal Medicine

Volumn 245, Issue 6, 1999, Pages 637-642

  Ricquier, Daniel ^a,b   Fleury, C ^a   Larose, M ^a   Sanchis, D ^a   Pecqueur, C ^a   Raimbault, S ^a   Gelly, C ^a   Vacher, D ^a   Cassard Doulcier, A M ^a   Levi Meyrueis C ^a   Champigny, O ^a   Miroux, B ^a   Bouillaud, F ^a  

^a CNRS   (France)

^b CNRS CEREMOD   (France)

Author keywords

Energy expenditure; Mitochondria; Obesity; Thermogenesis

Indexed keywords

ADENOSINE DIPHOSPHATE; MESSENGER RNA; OXYGEN; UNCOUPLING PROTEIN;

ADIPOCYTE; AMINO ACID SEQUENCE; BROWN ADIPOSE TISSUE; CONFERENCE PAPER; ENERGY EXPENDITURE; HUMAN; METABOLIC REGULATION; NUCLEOTIDE SEQUENCE; OBESITY; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; THERMOGENESIS;

ADIPOCYTES; ADIPOSE TISSUE, BROWN; AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; ENERGY METABOLISM; HUMANS; ION CHANNELS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METABOLIC DISEASES; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; PROTEINS; UNCOUPLING AGENTS;

EID: 0033029041     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.1999.00492.x     Document Type: Conference Paper

References (27)

1. 1 Nicholls DG, Locke R. Brown fat thermogenesis. Physiol Rev 1984; 64: 1-64.
2. + leak in mitochondria and its relevance to metabolic rate. Nature 1993; 362: 628-30.
3. 3 Rolfe D. Brand M. Contribution of mitochondrial proton leak to skeletal muscle respiration and to standard metabolic rate. Am J Physiol 1996: 271: C1380-89.
4. 4 Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Gen 1997; 15: 269-72.
5. 5 Gimeno R, Dembski M, Weng X, Deng N, Shyjan A, Gimeno A et al. Cloning and charaterization of an uncoupling protein homolog. A potential modulator of human thermogenesis. Diabetes 1997; 46: 900-906.
6. 6 Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo A, Seydoux J et al. Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett 1997; 408: 39-42.
7. 7 Vidal-Puig A, Solanes G, Grujic D, Flier J, Lowell B. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun 1997; 235: 79-82.
8. 8 Cannon B, Nedergaard J. Biochemistry of an inefficient tissue. Essays Biochem 1985; 20: 111-64.
9. 9 Himms-Hagen J. Brown adipose tissue thermogenesis: interdisciplinary studies. FASEB J 1990; 4: 2890-98.
10. 10 Himms-Hagen J, Ricquier D. Brown adipose tissue. In: Bray G, Bouchard C & James WPT, eds. Handbook of Obesity. New York: Marcel Dekker, 1997: 415-41.
11. 11 Oppert JM, Vohl MC, Chagnon M, Dionne FT, Cassard-Doulcier AM, Ricquier D et al. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat. Intern J Obes 1994; 18: 526-31.
12. 12 Cassard-Doulcier AM, Bouillaud F, Chagnon M, Gelly C, Dionne FT, Oppert JM et al. The Bel I polymorphism of the human uncoupling protein (ucp) gene is due to a point mutation in the 5′ -flanking region. Intern J Obes 1996; 20: 278-9.
13. 13 Clément K, Ruiz JR, Cassard-Doulcier AM, Bouillaud F, Häger J, Basdevant A et al. The effects of the uncoupling protein (UCP) gene variant and the Trp64Arg mutation of the ß3-adrenergic receptor gene on weight gain in morbid obesity. Int J Obes 1996; 20: 1062-6.
14. 14 Fumeron F, Durack-Brown I, Betoulle D, Cassard-Doulcier AM, Tuzet S, Bouillad F et al. Polymorphisms of the uncoupling protein (UCP) and ß3 adrenoceptor genes in obese people submitted to a low calorie diet. Int J Obes 1996; 20: 1051-4.
15. 15 Porter RK, Hulbert AJ, Brand MD. Allometry of mitochondrial proton leak: influence of membrane surface area and fatty acid composition. Am J Physiol 1996; 271: R51550-60.
16. 16 Walker JE. The mitochondrial transporter family. Curr Opin Struct Biol 1992; 2: 519-26.
17. 17 Larrouy DP, Laharrague G, Carrera N, Viguerie-Bascands C, Levi-Meyrueis C, Fleury et al. Kupffer cells are a dominant site of uncoupling protein-2 expression in rat liver. Biochem Biophys Res Commun 1997: 235: 760-64.
18. 18 Boss O, Samec S, Dulloo A, Seydoux J, Muzzin P, Giacobino JP. Tissue-dependent upregulation of rat uncoupling protein-2 in response to fasting or cold. FEBS Lett 1997; 412: 111-14.
19. 19 Aubert J, Champigny O, Saint-Marc P, Negrel R, Collins R, Ricquier D et al. Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells. Biochem Biophys Res Commun 1997; 238: 608-11.
20. 20 Gong DW, He Y, Kolras M, Reitman M. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, ß3-adrenergicagonists and leptin. J Biol Chem 1997; 272: 24129-32.
21. 21 Groop L. Proceedings of the 16th International Diabetes Federation Congress. Helsinki, July 20-25, 1997. Abstract No. 0081.
22. 22 Saker L. Proceedings of the 16th International Diabetes Federation Congress. Helsinki, July 20-25, 1997. Abstract No. 0707.
23. 23 Millet L, Vidal H, Andrealli F, Larrouy D, Riou J-P, Ricquier D, Laville M, Langin D. Increased uncoupling protein-2 and uncoupling protein-3 mRNA expression during fasting in obese and lean humans. J Clin Invent 1997; 100: 2665-70.
24. 24 Enerbäck S, Jacobsson A, Simpson E, Guerra C, Yamashita H. Harper M et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 1997; 387: 90-94.
25. 25 Bouchard C, Pérusse L, Chagon YC, Warden C, Ricquier D. Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Hum Mol Gen 1997; 6: 1887-9.
26. 26 Luft R. The development of mitochondrial medicine. Proc Natl Acad Sci USA 1994; 91: 8731-8.
27. 27 Zhou T, Shimabukuro M, Koyama K, Lee L, Wang M, Trieu F et al. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci USA 1997; 94: 6386-90.