Enzyme-catalyzed side reactions with molecular oxygen may contribute to cell signaling and neurodegenerative diseases

Neurochemical Research

Volumn 32, Issue 4-5, 2007, Pages 871-891

  Bunik, Victoria I ^a   Schloss, John V ^b   Pinto, John T ^c   Gibson, Gary E ^c,d   Cooper, Arthur J L ^c,d  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b Mann Biomedical Park   (United States)

^c BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Ketoglutarate dehydrogenase complex; Branched chain keto acid dehydrogenase complex; Carbanion intermediates; Pyridoxal 5 phosphate; Pyruvate dehydrogenase complex; Thiamine diphosphate

Indexed keywords

2 OXOACID DEHYDROGENASE; ALPHA TOCOPHEROL; AROMATIC LEVO AMINO ACID DECARBOXYLASE; CARBON DIOXIDE; CARBOXYLYASE; CYSTEINE SULFINATE DECARBOXYLASE; DNA; DOPAMINE; GLUTAMATE DECARBOXYLASE; GLUTAMATE RECEPTOR; HYDROGEN PEROXIDE; LIPID; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE; ORNITHINE DECARBOXYLASE; OXOGLUTARATE DEHYDROGENASE; OXYGEN; PHENYLACETALDEHYDE SYNTHASE; PYRIDOXAL 5 PHOSPHATE; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RIBULOSEBISPHOSPHATE CARBOXYLASE; SEROTONIN; SYNTHETASE; THIAMINE; THIOREDOXIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZINC ION;

ALZHEIMER DISEASE; CATALYSIS; CELL DAMAGE; COMPARATIVE STUDY; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME SUBSTRATE; GENE MUTATION; HUMAN; HUNTINGTON CHOREA; HYPOTHESIS; MACROMOLECULE; METABOLIC STRESS; MITOCHONDRION; MOLECULAR BIOLOGY; NERVOUS TISSUE; NEUROCHEMISTRY; NEUROPATHOLOGY; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PARKINSON DISEASE; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; REVIEW; SIGNAL TRANSDUCTION; WERNICKE KORSAKOFF SYNDROME;

ANIMALS; ANTIOXIDANTS; CATALYSIS; HUMANS; MUTATION; NEURODEGENERATIVE DISEASES; OXIDATION-REDUCTION; OXYGEN; OXYGEN CONSUMPTION; PYRIDOXAL PHOSPHATE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIAMINE PYROPHOSPHATE;

EID: 33947579630     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-006-9239-z     Document Type: Review

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