Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation

Journal of Immunology

Volumn 164, Issue 9, 2000, Pages 4659-4664

  Frucht, David M ^a,b   Aringer, Martin ^b   Galon, Jérôme ^b   Danning, Carol ^b   Brown, Martin ^b   Fan, Samuel ^b   Centola, Michael ^b   Wu, Chang You ^c   Yamada, Nubuo ^d   El Gabalawy, Hani ^b   O'Shea, John J ^b  

^a Building 10 ^*  (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STAT4 PROTEIN;

ARTICLE; CELLULAR IMMUNITY; CORRELATION FUNCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE ACTIVATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 18144438839     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.9.4659     Document Type: Article

References (22)

1. Morel, P. A., and T. B. Oriss. 1998. Crossregulation between Th1 and Th2 cells. Crit. Rev. Immunol. 18:275.
2. Trinchieri, G. 1995. Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12. IFN-γ). J. Rheum. 22:17.
3. Trinchieri, G. 1998. Proinflarnmatory and immunoregulatory functions of interleukin-12. Int. Rev. Immunol. 16:365.
4. Bacon, C. M., E. F. Petricoin III, J. R. Ortaldo, R. C. Rees, A. C. Larner, J. A. Johnston, and J. J. O'Shea. 1995. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. USA 92:7307.
5. Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, Jr., and K. M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181:1755.
6. Thierfelder, W. E., J. M, van Deursen, K. Yamamoto, R. A. Tripp, S. R. Sarawar, R. T. Carson, M. Y. Sangster, D. A. A. Vignali, P. C. Coherty, G. C. Grosveld, and J. N. Ihle. 1996. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382:171.
7. Kaplan, M. H., Y. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174.
8. Cho, S. S., C. M. Bacon, C. Sudarshan, R. C. Rees, D. Finbloom, R. Pine, and J. J. O'Shea. 1996. Activation of STAT4 by IL-12 and IFN-α: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J. Immunol. 157:4781.
9. Rogge, L., D. D'Ambrosio, M. Biffi, G. Penna, L. J. Minetti, D. H. Presky, L. Adorini, and F. Sinigaglia, 1998. The role of Stat4 in species-specific regulation of Th cell development by type 1 IFNs. J. Immunol. 161:6567.
10. Belardelli, F., and I. Gresser. 1996. The neglected role of type 1 interferon in the T cell response: implications for its clinical use. Immunol. Today 17:369.
11. Yamamoto, K., F. W. Quelle, W. E. Thierfelder, B. L. Kreider, D. J. Gilbert, N. A. Jenkins, N. G. Copeland, O. Silvennoinen, and J. N. Ihle. 1994. Stat4, a novel γ interferon activation site-binding protein expressed in early myeloid differentiation. Mol. Cell. Biol. 14:4342.
12. Bacon, C. M., D. W. McVicar, J. R. Ortaldo, R. C. Rees, J. J. O'Shea, and J. A. Johnston. 1995. Interleukin 12 (IL12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181:399.
13. Boehm, U., T. Klamp, M. Groot, and J. C. Howard. 1997. Cellular responses to interferon-γ Annu. Rev. Immunol. 15:749.
14. Grohmann, U., M. L. Belladonna, R. Bianchi, C. Orabona, E. Ayroldi, M. C. Fioretti, and P. Pucetti. 1998. IL-12 acts directly on DC to promote nuclear localization of NF-κB and primes DC for IL-12 production. Immunity 9:315.
15. Palucka, K. A., N. Taquet, F. Sanchez-Chapuis, and J. C. Gluckman. 1998. Dendritic cells as the terminal stage of monocyte differentiation. J. Immunol. 160: 4587.
16. Darnell, J. E., Jr. STATs and gene regulation. 1997. Science 277:1630.
17. Ihle, J. N. 1996. STATs: signal transducers and activators of transcription. Cell 84:331.
18. Van den Berg, W. B., and P. L. van Lent. 1996. The role of macrophages in chronic arthritis. Immunobiology 195:614.
19. Gordon, S. 1999. Macrophages and the immune response. In Fundamental Immunology. W. E. Paul, ed. Lippincott-Raven, Philadelphia, pp. 533-545.
20. Munder, M., M. Mallo, K. Eichmann, and M. Modolell. 1998. Murine macrophages secrete interferon γ upon combined stimulation with interleukin (IL)-12 and IL-18: a novel pathway of autocrine macrophage activation. J. Exp. Med. 187:2103.
21. + lymphoid dendritic cells. J. Exp. Med. 189:1981.
22. Chazerian, P., O. Meyer, and M. Kahn. 1992. Rheumatoid arthritis-like disease after α-interferon therapy. Ann. Intern. Med. 116:427.