Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract

Nitric Oxide - Biology and Chemistry

Volumn 15, Issue 1, 2006, Pages 30-39

  Pergola, Carlo ^a   Rossi, Antonietta ^a   Dugo, Paola ^b   Cuzzocrea, Salvatore ^b   Sautebin, Lidia ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Blackberry extract; Cyanidin 3 O glucoside; ERK 1 2; iNOS; Macrophages; NF B

Indexed keywords

ANTHOCYANIN; ANTHOCYANOSIDE; ANTIINFLAMMATORY AGENT; CYANIDIN 3 O ARABINOSIDE; CYANIDIN 3 O GALACTOSIDE; CYANIDIN 3 O GLUCOSIDE; CYANIDIN 3 O XYLOSIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MALVIDIN 3 O GLUCOSIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; NITRITE; PELARGONIDIN 3 O GLUCOSIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLACKBERRY; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INHIBITION KINETICS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; RAT;

ANIMALS; ANTHOCYANINS; ANTI-INFLAMMATORY AGENTS; CELL SURVIVAL; FRUIT; GLUCOSIDES; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PLANT EXTRACTS; RATS; ROSACEAE;

RUBUS;

EID: 33745495744     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.niox.2005.10.003     Document Type: Article

References (47)

1. Wang H., Cao G., and Prior R.L. Oxygen radical absorbing capacity of anthocyanins. J. Agric. Food Chem. 45 (1997) 304-309
2. Wang S.Y., and Lin H. Antioxidant activity in fruits and leaves of blackberry, raspberry and strawberry varies with cultivar and development stage. J. Agric. Food Chem. 48 (2000) 140-146
3. Miller A.B. Diet and cancer: a review. Rev. Oncol. 3 (1990) 87-95
4. Yang C.S., and Wang Z.Y. Tea and cancer. J. Natl. Cancer I. 85 (1993) 1038-1049
5. E.J. Middleton, C. Kandaswami, The impact of plant flavonoids on mammalian biology: implications for immunity inflammation and cancer, in: J.H Harborne, A.R. Liss (Eds.), The Flavonoids: Advances in Research Since, Chapman and Hall, New York, pp. 619-652.
6. Sautebin L., Rossi A., Serraino I., Dugo P., Di Paola R., Mondello L., Genovese T., Britti D., Peli A., Dugo G., Caputi A.P., and Cuzzocrea S. Effect of anthocyanins contained in a blackberry extract on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat. Planta Med. 70 (2004) 745-752
7. Kaul T.N., Middleton E.J., and Ogra P.L. Antiviral effect of flavonoids on human viruses. J. Med. Virol. 15 (1985) 71-79
8. Wei Y.Q., Zhao X., Kariya Y., Fukata H., Teshigawana K., and Uchida A. Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res. 54 (1994) 4952-4957
9. Plaumann B., Fritsche M., Rimpler H., Brandner G., and Hess R.D. Flavonoids activate wild-type p53. Oncogene 13 (1996) 1605-1614
10. Cao G., Sofic E., and Prior R. Antioxidant and prooxidant behaviour of flavonoids: structure-activity relationship. Free Radic. Biol. Med. 22 (1997) 749-760
11. Noda Y., Kaneyuki T., Mori A., and Packer L. Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin. J. Agric. Food Chem. 50 (2002) 166-171
12. Serraino I., Dugo L., Dugo P., Mondello L., Mazzon E., Dugo G., Caputi A.P., and Cuzzocrea S. Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. Life Sci. 73 (2003) 1097-1114
13. Amorini A.M., Lazzarino G., Galvano F., Fazzina G., Tavazzi B., and Galvano G. Cyanidin-3-O-beta-glucopyranoside protects myocardium and erythrocytes from oxygen radical-mediated damages. Free Radic. Res. 37 (2003) 453-460
14. Hobbs A.J., Higgs A., and Moncada S. Inhibition of nitric oxide synthase as a potential therapeutic target. Annu. Rev. Pharmacol. Toxicol. 39 (1999) 191-220
15. Mayer B., and Hemmens B. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem. Sci. 22 (1997) 477-481
16. Szabo C. Alterations in nitric oxide production in various forms of circulatory shock. New Horiz. 3 (1995) 2-32
17. MacMicking J., Xie Q.W., and Nathan C. Nitric oxide and macrophages function. Annu. Rev. Immunol. 15 (1997) 323-350
18. Ohshima H., and Bartsch H. Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat. Res. 305 (1994) 253-264
19. Alderton W.K., Cooper C.E., and Knowles R.G. Nitric oxide synthases: structure, function, and inhibition. Biochem. J. 357 (2001) 593-615
20. Wang Y., and Marsden P.A. Nitric oxide synthases: gene structure and regulation. Adv. Pharmacol. 34 (1995) 71-90
21. Lowenstein C.J., Alley E.W., Raval P., Snowman A.M., Snyder S.H., Russel S.W., and Murphy W.J. Macrophages nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 90 (1993) 9730-9734
22. Kujubu D.A., Fletcher B.S., Varnum B.C., Lim R.W., and Herschman H.R. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J. Biol. Chem. 266 (1991) 12866-12872
23. Baeuerle P. The inducible transcription activator NF-κB: regulation by distinct protein subunits. Biochim. Biophys. Acta 1072 (1991) 63-80
24. Griseavage J.M., Wilk S., and Ignarro L.J. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB. Proc. Natl. Acad. Sci. USA 93 (1996) 3308-3312
25. Surh Y.J., Chun K.S., Cha H.H., Han S.S., Keum Y.S., Park K.K., and Lee S.S. Molecular mechanism underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutation Res. 480 (2001) 243-268
26. Hirano M., Osada S., Aoki T., Hirai S., Hosaka M., Inoue J., and Ohno S. MEK kinase is involved in tumor necrosis factor alpha-induced NF-κB activation and degradation of IκBα. J. Biol. Chem. 271 (1996) 13234-13238
27. Malinin N.L., Boldin M.P., Kovalenko A.V., and Wallach D. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385 (1997) 540-544
28. Dugo P., Mondello L., Errante G., Zappia G., and Dugo G. Identification of anthocyanins in berries by narrowbore high performance liquid chromatography with electrospray ionization detection. J. Agric. Food Chem. 49 (2001) 3987-3992
29. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay. J. Immunol. Methods 65 (1983) 55-63
30. Salter M., Knowles R.G., and Moncada S. Widespread tissue distribution, species distribution and changes in activity of Ca(2+)-dependent and Ca(2+)-independent nitric oxide synthases. FEBS Lett. 291 (1991) 145-149
31. Rossi A., Serraino I., Dugo P., Di Paola R., Mondello L., Genovese T., Morabito D., Dugo G., Sautebin L., Caputi A.P., and Cuzzocrea S. Protective effects of anthocyanins from blackberry in a rat model of acute lung inflammation. Free Radic. Res. 37 (2003) 891-900
32. Martin S., Giannone G., Andriantsitohaina R., and Martinez M.C. Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis. Br. J. Pharmacol. 139 (2003) 1095-1102
33. Matsumoto H., Inaba H., Kishi M., Tominaga S., Hirayama M., and Tsuda T. Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms. J. Agric. Food Chem. 49 (2001) 1546-1551
34. Felgines C., Texier O., Besson C., Fraisse D., Lamaison J.L., and Remesy C. Blackberry anthocyanins are slightly bioavailable in rats. J. Nutr. 132 (2002) 1249-1253
35. Nguyen T., Brunson D., Crespi C.L., Penman B.W., Wishnok J.S., and Tannenbaum S.R. DNA damage and mutation in human cells exposed to nitric oxide in vivo. Proc. Natl. Acad. Sci. USA 89 (1992) 3030-3034
36. Iyenger R.D., Stuehr J., and Marletta M.A. Macrophages synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. Proc. Natl. Acad. Sci. USA 84 (1987) 6369-6373
37. Wilson K.T., Ramanujam K.S., Mobley H.L., Musselman R.F., James S.P., and Meltzed S.J. Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line. Gastroenterology 111 (1996) 1524-1533
38. Xu J.W., Ikeda K., and Yamori Y. Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, atypical anthocyanin pigment. Hypertension 44 (2004) 217-222
39. Xu J.W., Ikeda K., and Yamori Y. Cyanidin-3-glucoside regulates phosphorylation of endothelial nitric oxide synthase. FEBS Lett. 574 (2004) 176-180
40. Calderone A. The therapeutic effect of natriuretic peptides in heart failure; differential regulation of endothelial and inducible nitric oxide synthases. Heart Fail. Rev. 8 (2003) 55-70
41. Jugdutt B.I. Nitric oxide and cardioprotection during ischemia-reperfusion. Heart Fail. Rev. 7 (2002) 391-405
42. Chan M.M., Mattiacci J.A., Hwang H.S., Shah A., and Fong D. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Biochem. Pharmacol. 60 (2000) 1539-1548
43. Zhang X., Laubach V.E., Alley E.W., Edwards K.A., Sherman P.A., Russell S.W., and Murphy W.J. Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-γ. J. Leukoc. Biol. 59 (1996) 575-585
44. Taylor B.S., and Geller D.A. Molecular regulation of the human inducible nitric oxide synthase (iNOS) gene. Shock 13 (2000) 413-424
45. Ajizian S.J., English B.K., and Meals E.A. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. J. Infect. Dis. 179 (1999) 939-944
46. Lahti A., Lahde M., Kankaanranta H., and Moilanen E. Inhibition of extracellular signal-regulated kinase suppresses endotoxin-induced nitric oxide synthesis in mouse macrophages and in human colon epithelial cells. J. Pharmacol. Exp. Ther. 294 (2000) 1188-1194
47. Hou D.X., Fujii M., Terahara N., and Yoshimoto M. Molecular mechanisms behind the chemopreventive effects of anthocyanidins. J. Biomed. Biotechnol. 2004 (2004) 321-325