Evidence for the receipt of DNA damage stimuli by PML nuclear domains

Journal of Pathology

Volumn 211, Issue 4, 2007, Pages 471-480

  Varadaraj, A ^a   Dovey, C L ^a,b   Laredj, L ^a   Ferguson, B ^a   Alexander, C E ^a   Lubben, N ^a,c   Wylie, A H ^a   Rich, T ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

CHK2; DNA damage; HCT116; IRIF; PML

Indexed keywords

DNA; PROMYELOCYTIC LEUKEMIA PROTEIN;

APOPTOSIS; ARTICLE; CELL AGING; CELL CYCLE PROGRESSION; CELL NUCLEUS INCLUSION BODY; CELL STRAIN HCT116; CELL TRANSFORMATION; CELL TYPE; CONTROLLED STUDY; DNA DAMAGE; FIBROBLAST; HUMAN; HUMAN CELL; IONIZING RADIATION; IRRADIATION; PRIORITY JOURNAL; PROTEIN DOMAIN; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL AGING; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; CELL NUCLEUS; DNA DAMAGE; FIBROBLASTS; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKEMIA, PROMYELOCYTIC, ACUTE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RADIATION, IONIZING; SIGNAL TRANSDUCTION;

EID: 33847377085     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2126     Document Type: Article

References (32)

1. Borden KL. Pondering the promyelocytic leukemia protein (PML) puzzle: possible functions for PML nuclear bodies. Mol Cell Biol 2002;15:5259-5269.
2. Dellaire G, Bazett-Jones DP. PML nuclear bodies: dynamic sensors of DNA damage and cellular stress. Bioessays 2004;9:963-977.
3. Wang ZG, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R, et al. PML is essential for multiple apoptotic pathways. Nature Genet 1998;20:266-272.
4. Bernardi R, Pandolfi PP. Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene 2003;8:9048-9057.
5. Xu ZX, Timanova-Atanasova A, Zhao RX, Chang KS. PML colocalizes with and stabilizes the DNA damage response protein TopBP1. Mol Cell Biol 2003;23:4247-4256.
6. Daniels MJ, Marson A, Venkitaraman AR. PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein. Nature Cell Biol 2004;11:1114-1121.
7. Yang S, Kuo C, Bisi JE, Kim MK. PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nature Cell Biol 2002;11:865-870.
8. Eskiw CH, Dellaire G, Mymryk JS, Bazett-Jones DP. Size, position and dynamic behavior of PML nuclear bodies following cell stress as a paradigm for supramolecular trafficking and assembly. J Cell Sci 2003;116:4455-4466.
9. Everett RD, Murray J. ND10 components relocate to sites associated with herpes simplex virus type 1 nucleoprotein complexes during virus infection. J Virol 2005;79:5078-5089.
10. Wiesmeijer K, Molenaar C, Bekeer IM, Tanke HJ, Dirks RW. Mobile foci of Sp100 do not contain PML: PML bodies are immobile but PML and Sp100 proteins are not. J Struct Biol 2002;140:180-188.
11. Dellaire G, Ching RW, Dehghani H, Ren Y, Bazett-Jones DP. The number of PML nuclear bodies increases in early S phase by a fission mechanism. J Cell Sci 2006;119:1026-1033.
12. Beech SJ, Lethbridge KJ, Killick N, McGlincy N, Leppard KN. Isoforms of the promyelocytic leukemia protein differ in their effects on ND10 organization. Exp Cell Res 2005;307:109-117.
13. Dovey CL, Varadaraj A, Wyllie AH, Rich T. Stress responses of PML nuclear domains are ablated by ataxin-1 and other nucleoprotein inclusions. J Pathol 2004;4:877-883.
14. Carbone R, Pearson M, Minucci S, Pelicci PG. PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage. Oncogene 2002;21:1633-1640.
15. Condemine W, Takahashi Y, Zhu J, Puvion-Dutilleul F, Guegan S, Janin A, et al. Characterization of endogenous human promyelocytic leukemia isoforms. Cancer Res 2006;66:6192-6198.
16. Everett RD, Lomonte P, Sternsdorf T, van Driel R, Orr A. Cell cycle regulation of PML modification and ND10 composition. J Cell Sci 1999;112:4581-4588.
17. Chan JY, Li L, Fan YH, Mu ZM, Zhang WW, Chang KS. Cell-cycle regulation of DNA damage-induced expression of the suppressor gene PML. Biochem Biophys Res Commun 1997;240:640-646.
18. Fletcher L, Yen TJ, Muschel RJ. DNA damage in HeLa cells induced arrest at a discrete point in G2 phase as defined by CENP-F localization. Radiat Res 2003; 159:604-611.
19. Brown KD, Rathi A, Kamath R, Beardsley DI, Zhan Q, Mannino JL, et al. The mismatch repair system is required for S-phase checkpoint activation. Nature Genet 2003;33:80-84.
20. Yu Q, La-Rose J, Zhang H, Takemura H, Kohn KW, Pommier Y. UCN-01 inhibits p53 up-regulation and abrogates gamma- radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. Cancer Res 2002;62:5743-5748.
21. Yang S, Jeong JH, Brown AL, Lee CH, Pandolti PP, Chung JH, et al. PML activates CHK2 by mediating CHK2 autophosphorylation. J Biol Chem 2006;281:26645-26654.
22. Tang J, Xie W, Yang X. Association of caspase-2 with the promyelocytic leukaemia protein nuclear bodies. Cancer Biol Ther 2005;4:645-649.
23. Ahn J, Urist M, Prives C. The Chk2 protein kinase. DNA Repair (Amst) 2004;3:1039-1047.
24. Waldman T, Lengauer C, Kinzler KW, Vogelstein B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 1996;381:713-716.
25. Eskiw CH, Dellaire G, Bazett-Jones DP. Chromatin contributes to structural integrity of promyelocytic leukaemia bodies through a SUMO-1-independent mechanism. J Biol Chem 2004;279:9577-9585.
26. Barkova J, Horejsi Z, Koed K, Kramer A, Tort F, Guldberg P, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005;434:864-870.
27. Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, et al. Activation of the DNA damage check-point and genomic instability in human precancerous lesions. Nature 2005;434:907-913.
28. Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu. NC, Bonner WM, Barrett JC. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nature Cell Biol 2004;6:168-170.
29. Seker H, Rubbi C, Linke SP, Bowman ED, Garfield S, Hansen L, et al. UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML. Oncogene 2003;22:1620-1628.
30. Kurki S, Latonen L, Laiho M. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. J Cell Sci 2003;116:3917-3925.
31. Salomoni P, Bernardi R, Bergmann S, Changou A, Tuttle S, Pandolfi PP. The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage. Blood 2005;105:3686-3690.
32. Boe SO, Haave M, Jul-Larsen A, Grudic A, Bjerkvig R, Lonning PE. Promyelocytic leukemia nuclear bodies are predetermined processing sites for damaged DNA. J Cell Sci 2006;119:3284-3295.