DNA damage in HeLa cells induced arrest at a discrete point in G2 phase as defined by CENP-F localization

Radiation Research

Volumn 159, Issue 5, 2003, Pages 604-611

  Fletcher, Lynda ^a   Yen, Tim J ^b   Muschel, Ruth J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; CELL PROTEIN; DNA; PROTEIN CENP F; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL NUCLEUS MEMBRANE; CENTROMERE; CHROMOSOME CONDENSATION; CONTROLLED STUDY; DNA DAMAGE; DNA SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; MITOSIS; MITOSIS INHIBITION; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SEQUENCE ANALYSIS;

CHROMOSOMAL PROTEINS, NON-HISTONE; DNA DAMAGE; ETOPOSIDE; G2 PHASE; HELA CELLS; HUMANS; MICROFILAMENT PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037964265     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2003)159[0604:DDIHCI]2.0.CO;2     Document Type: Article

References (35)

1. L. Hartwell, T. Weinert, L. Kadyk and B. Garvik, Cell cycle checkpoints, genomic integrity, and cancer. Cold Spring Harbor Symp. Quant. Biol. 59, 259-263 (1994).
2. C. Featherstone and S. P. Jackson, DNA double-strand break repair. Curr. Biol. 9, R759-766 (1999).
3. 2 delay in human cancer cells. Oncogene 20, 3486-3496 (2001).
4. 2/M transition by p53. Oncogene 20, 1803-1815 (2001).
5. P. Chaturvedi, W. K. Eng, Y. Zhu, M. R. Mattern, R. Mishra, M. R. Hurle, X. Zhang, R. S. Annan, Q. Lu and B. B. Zhou, Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene 18, 4047-4054 (1999).
6. B. Furnari, N. Rhind and P. Russell, Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Science 277, 1495-1497 (1997).
7. A. Kumagai and W. G. Dunphy, Binding of 14-3-3 proteins and nulear export control the intracellular localization of the mitotic inducer Cdc25. Genes Dev. 13, 1067-1072 (1999).
8. A. Lopez-Girona, B. Furnari, O. Mondesert and P. Russell, Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature 397, 172-175 (1999).
9. 2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501-1515 (1997).
10. Y. Sanchez, C. Wong, R. S. Thoma, R. Richman, Z. Wu, H. Piwnica-Worms and S. J. Elledge, Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25. Science 277, 1497-1501 (1997).
11. 2/M cell cycle checkpoint. Proc. Natl. Acad. Sci. USA 96, 3706-3711 (1999).
12. Q. Zhan, M. J. Antinore, X. W. Wang, F. Carrier, M. L. Smith, C. C. Harris and A. J. Fornace, Jr., Association with Cdc2 and inhibition of Cdc2/cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene 18, 2892-2900 (1999).
13. 2 arrest after DNA damage. Science 282, 1497-1501 (1998).
14. 2/M-phase transition. Mol. Cell Biol. 18, 546-557 (1998).
15. T. A. Chan, H. Hermeking, C. Lengauer, K. W. Kinzler and B. Vogelstein, 14-3-3σ is required to prevent mitotic catastrophe after DNA damage. Nature 401, 616-620 (1999).
16. 2 checkpoint through cyclin B1. Proc. Natl. Acad. Sci. USA 96, 2147-2152 (1999).
17. 2 arrest in response to overexpression of p53. Mol. Biol. Cell. 10, 3607-3622 (1999).
18. E. I. Azzam, S. M. de Toledo, M. J. Pykett, H. Nagasawa and J. B. Little, CDC2 is down-regulated by ionizing radiation in a p53-dependent manner. Cell Growth Differ. 8, 1161-1169 (1997).
19. 2/M arrest in response to DNA damage and in growth control after damage recovery. Oncogene 20, 3290-3300 (2001).
20. 2 phase. J. Biol. Chem. 275, 22627-22630 (2000).
21. 2-phase-specific expression. EMBO J. 17, 5015-5025 (1998).
22. 2-M. Mol. Cell Biol. 20, 5602-5618 (2000).
23. Q. Wang, G. P. Zambetti and D. P. Suttle, Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Mol. Cell Biol. 17, 389-397 (1997).
24. M. I. Sandri, R. J. Isaacs, W. M. Ongkeko, A. L. Harris, I. D. Hickson, M. Broggini and F. Vikhanskaya, p53 regulates the minimal promoter of the human topoisomerase IIα gene. Nucleic Acids Res. 24, 4464-4470 (1996).
25. J. B. Rattner, A. Rao, M. J. Fritzler, D. W. Valencia and T. J. Yen, CENP-F is a ca 400 kDa kinetochore protein that exhibits a cell cycle dependent localization. Cell Motil. Cytoskeleton 26, 214-226 (1993).
26. 2 and is rapidly degraded after mitosis. J. Cell Biol. 130, 507-518 (1995).
27. A. Baez, K. Torres, E. M. Tan, Y. Pommier and C. A. Casiano, Expression of proliferation-associated nuclear autoantigens, p330d/CENP-F and PCNA, in differentiation and in drug-induced growth inhibition using two-parameter flow cytometry. Cell Prolif 29, 183-196 (1996).
28. 2 cycle checkpoint in mammalian cells. Nature 372, 467-470 (1994).
29. 2 block induced by DNA damage: A caffeine-resistant component independent of Cdc25C, MPM-2 phosphorylation, and H1 kinase activity. Cancer Res. 58, 2639-3645 (1998).
30. E. J. Bernhard, A. Maity, R. J. Muschel and W. G. McKenna, Effects of ionizing radiation on cell cycle progression. A review. Radiat. Environ. Biophys. 34, 79-83 (1995).
31. T. D. Griffith and L. J. Tolmach, Lethal response of HeLa cells to x-irradiation in the latter part of the generation cycle. Biophys. J. 16, 303-318 (1976).
32. L. L. Vindelov and I. J. Christensen, A review of techniques and results obtained in one laboratory by an integrated system of methods designed for routine clinical flow cytometric DNA analysis. Cytometry 11, 753-770 (1990).
33. 2-phase arrest in irradiated HeLa cells treated with staurosporine or caffeine. Radiat. Res. 140, 393-400 (1994).
34. C. L. Rieder and R. W. Cole, Entry into mitosis in vertebrate somatic cells is guarded by a chromosome damage checkpoint that reverses the cell cycle when triggered during early but not late prophase. J. Cell Biol. 142, 1013-1022 (1998).
35. 2 delay, revealing a potential checkpoint in early mitosis. Cancer Res. 62, 241-250 (2002).