Systemic T helper 2 cell activation is not sufficient for antigen-induced eosinophil recruitment into the airways

International Archives of Allergy and Immunology

Volumn 122, Issue SUPPL. 1, 2000, Pages 20-24

  Nakajima, Hiroshi ^a   Nakao, Atsuhito ^a   Kumano, Kotaro ^a   Yamamoto, Hiroshi ^b   Iwamoto, Itsuo ^a  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Airway; BALB c mice; C57BL 6 mice; CD4+ T cells; Eosinophils; IgE; IL 5

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 5; OVALBUMIN;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; TH2 CELL; TRACHEA;

EID: 0034105139     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053626     Document Type: Article

References (16)

1. De Monchy JGR, Kauffman HF, Venge P, Koeter GH, Jansen HM, Sluiter HJ, De Vries K: Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am Rev Respir Dis 1985;131:373-376.
2. Frew AJ, Kay AB: The relationship between infiltrating CD4+ lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reaction in man. J Immunol 1988;141:4158-4164.
3. Metzger WJ, Zavala D, Richerson HB, Moseley P. Iwamota P, Monick M, Sjoerdsma K, Hunninghake GW: Local allergen challenge and bronchoalveolar lavage of allergic asthmatic lungs: Description of the model and local airway inflammation. Am Rev Respir Dis 1987; 135:433-440.
4. Kay AB, Ying S, Varney V, Gaga M, Durham SR. Moqhel R, Wardlaw AJ, Hamid Q: Messenger RNA expression of the cytokine gene cluster, IL-3, IL-4, IL-5, and GM-CSF in allergen-induced late-phase cutaneous reactions in atopic subjects. J Exp Med 1991;173:775-778.
5. Durham SR, Ying S, Varney VA, Jacobson MR, Sudderick RM, Mackay IS, Kay AB, Hamid QA: Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and GM-CSF in the nasal mucosa after local allergen provocation: Relationship to tissue eosinophilia. J Immunol 1992;148:2390-2394.
6. Nakajima H, Iwamoto I, Tomoe S, Matsumura R, Tomioka H, Takatsu K, Yoshida S: CD4+ T lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am Rev Respir Dis 1992;146: 374-377.
7. Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG: Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med 1996;183:195-201.
8. Iwamoto I, Nakajima H, Endo H, Yoshida S: Interferon-γ regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells. J Exp Med 1993;177:573-576.
9. Gavett SH, O'Hearn DJ, Li X, Huang S-K, Finkelman FD, Wills-Karp M: Interleukin-12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med 1995;182:1527-1536.
10. Iwamoto I, Kumano K, Kasai M, Kurasawa K, Nakao A: Interleukin-12 prevents antigen-induced eosinophil recruitment into mouse airways. Am J Respir Crit Care Med 1996;154: 1257-1260.
11. Wills-Karp M: Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 1999;17:255-281.
12. Dialynas DP, Quan ZS, Wall KA, Pierres A, Quintas J, Lohen MR, Pierres M, Fitch FW: Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J Immunol 1983;131:2445-2451.
13. Spitalny GL, Havell EA: Monoclonal antibody to murine γ-interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities. J Exp Med 1984;159:1560-1565.
14. Ovary Z: Passive cutaneous anaphylaxis; in Weir DM (ed): Handbook of Experimental Immunology. Oxford, Blackwell Scientific Publications. 1986, pp 33.1-33.9.
15. Paul WE, Seder RA: Lymphocyte responses and cytokines, Cell 1994;76:241-251.
16. Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature 1996;383:787-793.