Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice)

Neurochemistry International

Volumn 50, Issue 4, 2007, Pages 653-659

  Sauer, S W ^a   Kolker S ^a   Hoffmann, G F ^a   ten Brink, H J ^b   Jakobs, C ^b   Gibson, K M ^c   Okun, J G ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Glutathione; Krebs cycle enzymes; Mitochondrial dysfunction; Mitochondrial energy metabolism; Respiratory chain complexes; Succinic semialdehyde dehydrogenase deficiency

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTATHIONE; SUCCINATE SEMIALDEHYDE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DYSFUNCTION; BRAIN REGION; CITRIC ACID CYCLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; ENERGY METABOLISM; HIPPOCAMPUS; MOUSE; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY CHAIN;

ANIMALS; BRAIN; BRAIN DISEASES, METABOLIC, INBORN; CITRIC ACID CYCLE; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT; ENERGY METABOLISM; GAMMA-AMINOBUTYRIC ACID; GLUTATHIONE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL DISEASES; OXIDATIVE STRESS; SODIUM OXYBATE; SUBCELLULAR FRACTIONS; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE;

MAMMALIA; MURINAE; MUS;

EID: 33847323112     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2006.12.009     Document Type: Article

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