Murine succinate semialdehyde dehydrogenase (SSADH) deficiency, a heritable disorder of GABA metabolism with epileptic phenotype

IUBMB Life

Volumn 57, Issue 9, 2005, Pages 639-644

  Gibson, K M ^a,e   Jakobs, C ^b   Pearl, P L ^c   Snead, O C ^d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Epilepsy; GABA; Gamma hydroxybutyric acid; Knockout mice; Oxidative damage; Pharmacotherapy; Succinic semialdehyde dehydrogenase deficiency

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 HYDROXYBUTYRIC ACID; ADENOVIRUS VECTOR; ETHOSUXIMIDE; NCS 382; RECEPTOR BLOCKING AGENT; SUCCINATE SEMIALDEHYDE DEHYDROGENASE; TAURINE; UNCLASSIFIED DRUG; VIGABATRIN;

4 AMINOBUTYRIC ACID METABOLISM; ABSENCE; ACCURACY; AMINO ACID SYNTHESIS; DISEASE ASSOCIATION; EEG ABNORMALITY; ENZYME DEFICIENCY; EPILEPTIC STATE; GENE TARGETING; GRAND MAL SEIZURE; HERITABILITY; HUMAN; INBORN ERROR OF METABOLISM; LETHALITY; MOLECULAR MECHANICS; MYOCLONUS SEIZURE; NERVE DEGENERATION; NEUROCHEMISTRY; NEUROPHYSIOLOGY; NONHUMAN; OXIDATION; PATHOPHYSIOLOGY; PERINATAL PERIOD; PHENOTYPE; PROTEIN DEGRADATION; REVIEW; SUCCINATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY; VIRAL GENE THERAPY;

ANIMALS; DISEASE MODELS, ANIMAL; EPILEPSY, ABSENCE; GAMMA-AMINOBUTYRIC ACID; HUMANS; METABOLISM, INBORN ERRORS; MICE; MICE, KNOCKOUT; PHENOTYPE; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE;

ADENOVIRIDAE; ANIMALIA; MURINAE;

EID: 27444432811     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1080/15216540500264588     Document Type: Review

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